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| 1 | Therapeutic efficiency of everolimus and lapatinib in xenograft model of human colorectal carcinoma with KRAS mutation显示文摘 | Céline Chu Marie‐Sophie No?l‐Hudson Valérie Boige Diane Goéré Sylvie Marion Mélanie Polrot Ludovic Bigot Patrick Gonin Robert Farinotti Laurence Bonhomme‐Faivre | 2013 | Fundamental & Clinical Pharmacology2013，，4： | 2 |
| 2 | J-M Loiseaux,O Meplan,and E Merle-Lucotte,The Thorium Molten Salt Reactor:Moving on from the Msbr显示文摘 | Ludovic Matbieu D Heuer R Brissot C Garzenne | 2006 | Progress in Nuclear Energy2006，48，： | 1 |
| 3 | Modulation of the polyamine biosynthetic pathway in transgenic rice confers tolerance to droughtstress显示文摘 | TERESA C LUDOVIC B PAUL C | 2004 | Proc Natl Acad Sci USA2004，101，： | 1 |
| 4 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 5 | Improved synthesis of 6-amino-6-deoxy-D-galactono-1, 6-1actam and D- mannono-1, 6-1actarn from corresponding unprotected D-hexono-1, 4-lactones 显示文摘 | Ludovic C Imane S Gilles D | 2004 | Tetrahedron2004，60，： | 1 |
| 6 | Modulation of the poly- amine biosynthetic pathway in transgenic rice confers tolerance to drought stress 显示文摘 | Teresa C Ludovic B Paul C | 2004 | Proceedings of the Na- tional Academy of Sciences2004，101，： | 1 |
| 7 | MIL-96, a porous aluminum trimesate 3D structure on strutted from a hexagonal network of 18-membered rings and tri- nuclearunits 显示文摘 | Loiseau T Ludovic L L Volkringer C | 2006 | J Am Chem Soc2006，128，10： | 1 |
| 8 | Dynamic estimation of urban traffic noise: Influence of traffic and noise source representations 显示文摘 | Arnaud C Ludovic L Joel L | 2007 | Applied Acoustics In Press Corrected Proof2007，6，： | 1 |
| 9 | Bisphenol a Disrupts the Intestinal Lipid Metabolism显示文摘 | LUDOVIC L C LYDIE I D M PHILIPPE B | 2012 | Toxicology Let- ters2012，21，3： | 1 |
| 10 | Transgenicwheat plants expressing an oat arginine decarboxylasecDNA exhibit increases in polyamine content in vegeta-tive tissue and seeds显示文摘 | Ludovic B Zhu C F Ignacio R | 2008 | Molecular Breeding2008，22，： | 1 |
| 11 | Calculations of one-electron redox potentials of oxoiron ( Ⅳ ) porphyrln complexes 显示文摘 | Ludovic C Michael B | 2014 | Journal of Chemical Theory and Computation2014，10，： | 1 |
| 12 | Potential risks of metal toxicity in contaminated sediments of Deule river in northern France显示文摘 | Beatriz L C Ludovic L Adeline C | 2011 | Joural of Hazardous Materi- als2011，86，： | 1 |
| 13 | Using a Delphi process and the Analytic Hierarchy Process (AHP) to evaluate the complexity of projects 显示文摘 | LUDOVIC A FRANCK M JEAN C B | 2011 | Volume 38 Issue 5 May 20112011，，： | 1 |
| 14 | Tree and shrub diversity and abundance in fragmented littoral forest of southeastern Madagasear显示文摘 | MARC W C RAKOTONASKON F LUDOVIC R | 2002 | Biodiversity and Conservation2002，11，： | 1 |
| 15 | Analytical Modeling of Drawbeads in Sheet Metal Forming显示文摘 | LUDOVIC C MARION M GERARD F | 2003 | Journal of Materials Processing Technology2003，133，3： | 1 |
| 16 | Bisphenol a Disrupts the Intestinal Lipid Metabolism显示文摘 | LUDOVIC L C LYDIE I D M PHILIPPE B | 2012 | Toxicology Letters2012，211，： | 1 |
| 17 | A fuzzy-possibilistic scheme of study for objects with indeterminate boundaries: application to French Polynesian reef scapes显示文摘 | SERGE A LUDOVIC R YANNICK C | 2000 | IEEE Transaction on Geoscience and Remote Sensing2000，38，1： | 1 |
| 18 | Hierar- chical space-time block code recognition using correla- tion matrices显示文摘 | VINCENT C KOFFI Y LUDOVIC C | 2008 | IEEE Transactions on Wireless Com- munications2008，7，9： | 1 |
| 19 | Association between a genomic polymorphism within the CD14 locus and septic shock susceptibility and mortality rate显示文摘 | SEBASTIEN G ALAIN C LUDOVIC D | 2002 | Crit Care Med2002，30，5： | 1 |
| 20 | Lateral light scattering in papaer-MTF simulation and measurement 显示文摘 | Ludovic C Magnus N Per E | 2011 | Optics Ex- press2011，19，25： | 1 |
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