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| 1 | Annexin A2 as a biomarker for hepatocellular carcinoma in Egyptian patients显示文摘AIM To investigate the clinical utility of serum annexin A2(ANXA2) as a diagnostic marker for early hepatocellular carcinoma(HCC).METHODS This study was performed in HCC Clinic of Ain Shams University Hospitals, Cairo, Egypt and included: Group 1: Fifty patients with early stage HCC(Barcelona Clinic Liver Cancer stage A); Group 2: Twenty five patients with chronic liver disease; and Control Group: Fifteen healthy, age-and sex-matched subjects who were seronegative for viral hepatitis markers. The followinglaboratory investigations were done: Viral hepatitis markers [hepatitis B surface antigen and hepatitis C virus(HCV) antibodies], HCV RNA in HCV antibody-positive patients, serum alpha fetoprotein(AFP), and serum ANXA2 levels.RESULTS In this study, 88% of HCC patients(n = 44) were HCVpositive, while HBV infection represented only 8% of all HCC patients(n = 4); and two patients were negative for both viral markers. A highly significant difference was found between patients with HCC and chronic liver disease as well as controls with regard to serum ANXA2 levels(130, IQR 15-240; 15, IQR 15-17; and 17, IQR 15-30 ng/m L, respectively). The area under the curve of ANXA2 was 0.865; the cut-off value was established to be 18 ng/mL with a diagnostic sensitivity of 74% and a specificity of 88%, while the sensitivity and specificity of AFP at the cut-off value of 200 ng/dL were 20% and 100%, respectively.CONCLUSION Serum ANXA2 may serve as a biomarker for the early detection of HCC. | Mohamed K Shaker Hanzada I Abdel Fattah Ghada S Sabbour Iman F Montasser Sara M Abdelhakam Eman El Hadidy Rehab Yousry Ahmed K El Dorry | 2017 | World Journal of Hepatology2017，9，9： | 4 |
| 2 | Therapeutic face of RNAi: in vivo challenges显示文摘 | BORNA H IMANI S IMAN M | 2015 | Expert Opin Biol Ther2015，15，2： | 1 |
| 3 | Effect of annealing twins on Hall-Perch relation in polycrystalline materials显示文摘 | PANDE C S RATH B B IMAN M A | 2004 | Mater Sci Eng A2004，367，： | 1 |
| 4 | A robust measure of uncertaintyimportance for use in fault tree system analysis 显示文摘 | Iman R L Hora S C | 1990 | RiskAnalysis1990，10，3： | 1 |
| 5 | Ascites and spontaneous bacterial peritonitis in fulminant hepatic failure显示文摘 | Dh Iman RK Makhar IA GK JA IN S et aI | 2000 | Am J Gastroenterol2000，95，： | 1 |
| 6 | Improved synthesis of 6-amino-6-deoxy-D-galactono-1, 6-1actam and D- mannono-1, 6-1actarn from corresponding unprotected D-hexono-1, 4-lactones 显示文摘 | Ludovic C Imane S Gilles D | 2004 | Tetrahedron2004，60，： | 1 |
| 7 | The Anatomy of the Grid:Enabling Scalable Virtual Organizations显示文摘 | FOSTER I IMAN C TUECKE1 S | 2001 | International Journal Supercomputer Applications2001，15，3： | 1 |
| 8 | lnvitro evaluation and modification of pectinate gel beads containing trimethyl chitosan, as a multi-particulate system for delivery of water-soluble macromolecules to colon显示文摘 | Atyabi F Majzoob S Iman M | 2005 | Carbohydrate Polymers2005，61，： | 1 |
| 9 | Alphamelanocytestimulating hormone regulation of tyrosinase in Cloudman S91 mouse melanoma cell cultures 显示文摘 | FULLER B B LUNSFORD J B IMAN D S | 1987 | J Biol Chem1987，262，： | 1 |
| 10 | A fault-toler- ant control Strategy for cascaded H-bridge Multilevel rectifiers 显示文摘 | IMAN - E1NI H FARHANGI S SCHANEN J L | 2010 | Journal of Power Electronics2010，10，1： | 1 |
| 11 | Development of an On-line Rotor Crack Detection and Monitoring Sys- tem 显示文摘 | Iman I Scheibel J Azzaro S H | 1999 | Journal of Vibration Acoustics Stress and Reliability in Design1999，111，3： | 1 |
| 12 | A modular strategy for control and voltage balancing of cascaded H-bridge rectifiers显示文摘 | Iman Eini H Schanen J L Farhangi S | 2008 | IEEE Transactions on Power Electronics2008，23，5： | 1 |
| 13 | Natural History of Antibodies to Deamidated Gliadin Peptides and Transglutaminase in Early Childhood Celiac Disease显示文摘 | Edwin Liu Marcella Li Lisa Emery Iman Taki Kathy Barriga Claudio Tiberti George S Eisenbarth Marian J Rewers Edward J Hoffenberg | 2007 | Journal of Pediatric Gastroenterology and Nutrition2007，，3： | 1 |
| 14 | Development of an on-line ro- tor crack detection and monitoring system 显示文摘 | IMAN I SCHEIBEL J Azzaro S H | 1999 | Journal of Vibra- tion Acoustics Stress and Rehability in Design1999，111，3： | 1 |
| 15 | A robust measure of uncertainty importance for use in fault tree system analysis显示文摘 | Iman R L Hora S C | 1990 | Risk Anal1990，10，3： | 1 |
| 16 | A robust measure of uncertainty importance for use in fault tree system analysis显示文摘 | Iman R L Hora S C | 2006 | Risk Analysis2006，26，13： | 1 |
| 17 | Assessment of lead in cosmeticproducts 显示文摘 | Iman A S Sami A E Neptune S | 2009 | Regulatory Toxicology and Pharmacology2009，54，2： | 1 |
| 18 | Micron-scale polystyrene capsules with magnetic Fe3O4 inside显示文摘 | Iman M Celebbi S S | 1999 | Reactive Polym1999，24，： | 1 |
| 19 | Foamed articles based on potato starch,corn fibers and poly (vinyl alcohol)显示文摘 | Chiellini E Cinelli P Iman S H | 2006 | Polym Degrad Stab2006，91，： | 1 |
| 20 | Cervica I artery dissection:Patho Iogy,epidemio Iogy and management显示文摘 | Kim Y K Schu Iman S | 2009 | Thromb Res2009，123，6： | 1 |
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