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您的检索式：作者名="Ludovic Martin"
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| 1 | Theobroma cacao improves bone growth by modulating defective ciliogenesis in a mouse model of achondroplasia显示文摘A gain-of-function mutation in the fibroblast growth factor receptor 3 gene(FGFR3)results in achondroplasia(ACH),the most frequent form of dwarfism.Constitutive activation of FGFR3 impairs bone formation and elongation and many signal transduction pathways.Identification of new and relevant compounds targeting the FGFR3 signaling pathway is of broad importance for the treatment of ACH,and natural plant compounds are prime drug candidate sources.Here,we found that the phenolic compound(-)-epicatechin,isolated from Theobroma cacao,effectively inhibited FGFR3’s downstream signaling pathways.Transcriptomic analysis in an Fgfr3 mouse model showed that ciliary mRNA expression was modified and influenced significantly by the Indian hedgehog and PKA pathways.(-)-Epicatechin is able to rescue mRNA expression impairments that control both the structural organization of the primary cilium and ciliogenesis-related genes.In femurs isolated from a mouse model(Fgfr3^(Y367C/+))of ACH,we showed that(-)-epicatechin eliminated bone growth impairment during 6 days of ex vivo culture.In vivo,we confirmed that daily subcutaneous injections of(-)-epicatechin to Fgfr3^(Y367C/+) mice increased bone elongation and rescued the primary cilium defects observed in chondrocytes.This modification to the primary cilia promoted the typical columnar arrangement of flat proliferative chondrocytes and thus enhanced bone elongation.The results of the present proof-of-principle study support(-)-epicatechin as a potential drug for the treatment of ACH. | Ludovic Martin Nabil Kaci Catherine Benoist-Lasselin Marine Mondoloni Suzanne Decaudaveine Valentin Estibals Maxence Cornille Léa Loisay Justine Flipo Benoît Demuynck Maria de la Luz Cádiz-Gurrea Florent Barbault Salvador Fernández-Arroyo Laurent Schibler Antonio Segura-Carretero Emilie Dambroise Laurence Legeai-Mallet | 2022 | Bone Research2022，10，1： | 1 |
| 2 | Post-translational modifications of tau protein: Implications for Alzheimer’s disease显示文摘 | Ludovic Martin Xenia Latypova Faraj Terro | 2011 | Neurochemistry International2011，，4： | 1 |
| 3 | Morphology enabled dipole inversion for quantitative susceptibility mapping using structural consistency between the magnitude image and the susceptibility map显示文摘 | Jing Liu Tian Liu Ludovic de Rochefort James Ledoux Ildar Khalidov Weiwei Chen A. John Tsiouris Cynthia Wisnieff Pascal Spincemaille Martin R. Prince Yi Wang | 2011 | Neuroimage2011，，3： | 1 |
| 4 | Science:研究人员利用小分子SMARt-420逆转结核分枝杆菌的抗生素耐药性显示文摘在一项新的研究中,来自瑞典、法国、比利时和瑞士的一个研究团队发现一种方法逆转对一种用于治疗肺结核的抗生素药物产生的耐药性。在他们发表在Science期刊上的论文中.该团队描述了他们如何筛选激活用于活化ethionaide的不同通路的化合物。Ethionaide是一种被用来治疗肺结核的前体分子。在体内经过代谢后产生一种真正有疗效的药物。 | Nicolas Blondiaux Vanessa Mathys Karine Soetaert Mehdi Kiass Vincent Delorme Kamel Djaout Vincent Trebosc Christian Kemmer René Wintjens Alexandre Wohlkönig Rudy Antoine Ludovic Huot David Hot Mireia Coscolla Julia Feldmann Sebastien Gagneux Camille Locht Priscille Brodin Marc Gitzinger Benoit Déprez | 2017 | 现代生物医学进展2017，17，15： | 0 |
| 5 | 江诗丹顿总部大楼及制造中心显示文摘这栋建筑是瑞士最古老的钟表制造商江诗丹顿的制造与管理总部,包含了高度专业化的工厂空间、管理办公室、会议室以及餐饮设施,面积约7430m3。 | bernard tschumi joel rutten ludovic ghirardi jon chace robert holton valentin bontjes van beek kate linker phu hoang nicolas martin michaela metcalfe joel aviles justin moore adam dayem allis chee jane kim liz kim véronique descharrèires | 2016 | 城市环境设计2016，0，1： | 0 |
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