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114篇 您的检索式:作者名="Louis M R"
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1Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi 2016Journal of Geriatric Cardiology2016,13,8:7
2Toxoplasma gondii : from animals to humans显示文摘Astrid M Tenter Anja R Heckeroth Louis M Weiss 2000International Journal for Parasitology2000,,12:4
3Distinct immunopeptide maps of the sarcoplasmic reticulum Ca2+ release channel in malignant hyperthermia显示文摘Knudson C M Mickelson J R Louis C F 1990Journal of Biological Chemistry1990,265,:1
4Restoring a sense of control during implementation 显示文摘Baronas A K Louis M R 1988MIS Quarterly1988,12,1:1
5The migration of organizational functions to the work unit level: Buffering, spanning, and bringing up boundaries显示文摘YAN A LOUIS M R 1999Human Relations1999,52,1:1
6Giant fusiform aneurysm of the cerebral arteries 显示文摘LITTLE J R ST LOUIS P WEINSTEIN M 1981Stroke1981,12,2:1
7Creatine increases IGF- I and myogenic regulatory factor mRNA in C2C12 cells显示文摘Louis M van Beneden R Dehoux M 2004FEBS Letters2004,557,13:1
8Synthesis and luminescent properties of sub-5 nm lanthanide oxides nanoparti-cles显示文摘Bazzi R Flores Gonzalez M A Louis C 2003Journal of Luminescence2003,,:1
9Thermal expansion behaviour of aluminum/SiC composites with bimodal particle distributions显示文摘Arpon R Molina J M Saravanan R A Garcia-Cordovilla C Louis E Narciso J 2003Acta Mater2003,51,11:1
10Distinct immunopeptide maps of the sareoplasmie reticulum Ca2 + re- lease channel in malignant hypethermia 显示文摘KNUDSON C M MICKELSON J R LOUIS C F 1990J Biol Chem1990,265,5:1
11Intra-abdominal laparoscopic pudendal canal decompression -a feasibility study 显示文摘Loukas M Louis R Tubbs RS 2008Surg Endosc2008,22,6:1
12Synthesis and properties of europium-based phosphors on the nanometer scale: Eu2O3, Gd2O3:Eu, and Y2O3:Eu显示文摘Bazzi R Flores M A Louis C 2004J Colloid and Interface Sci2004,273,:1
13Characterizing the unfolded states of proteins using single-molecule FRET spectroscopy and molecular simulations显示文摘Merchant K A Best R B Louis J M Gopich I V Eaton W A 0,,:1
14Transverse C-13 relaxation of CHD2 methyl isotopmers to detect slow conformational changes of protein side chains显示文摘Ishima R Louis J M Torchia D A 1999J Am Chem Soc1999,121,11:1
15Loss function based ranking in two-stage,hierarchical models显示文摘Lin R H Louis T A Paddock S M 0,,04:1
16Cultural Background and Individualistic-Collectivistic Values in Relation to Similarity,Perspective Taking,and Empathy 显示文摘HEINKE M S LOUIS W R 2009Journal of Applied Social Psychology2009,39,11:1
17Theory of Planned Behaviour,Identity and Intentions to Engage in Environmental Activism显示文摘FIELDING KS M R LOUIS WR 2008Journal of Environmental Psychology2008,28,4:1
18Mice lacking inhibitory leptin receptor signals are lean with normal endocrine function显示文摘Bjornholm M Münzberg H Leshan RL Villanueva EC Bates SH Louis GW Jones JC Ishida-Takahashi R Bjorbaek C Myers MG Jr 0,,:1
19Increased response of blood eosinophils to various chemotactic agents in quiescent Crohn disease显示文摘Denis MA Louis R Malaise M 2001Scand J Gastroenterol2001,36,2:1
20Synthesis and luminescent properties of sub-5-nm lanthanide oxides nanoparticles显示文摘Bazzi R Flores-Gonzalez M A Louis C Lebbou K Dujardin C Brenier A Zhang W Tillement O Bernstein E Perriat P 0,,0:1
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