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| 1 | Management of cytokine release syndrome related to CAR-T cell therapy显示文摘Chimeric antigen receptor T (CAR-T) cell therapy is a novel cellular immunotherapy that is widely used to treat hematological malignancies, including acute leukemia, lymphoma, and multiple myeloma. Despite its remarkable clinical effects, this therapy has side effects that cannot be underestimated. Cytokine release syndrome (CRS) is one of the most clinically important and potentially life-threatening toxicities. This syndrome is a systemic immune storm that involves the mass cytokines releasing by activated immune cells. This phenomenon causes multisystem damages and sometimes even death. In this study, we reported the management of a patient with recurrent and refractory multiple myeloma and three patients with acute lymphocytic leukemia who suffered CRS during CAR-T treatment. The early application of tocilizumab, an anti-IL-6 receptor antibody, according to toxicity grading and clinical manifestation is recommended especially for patients who suffer continuous hyperpyrexia, hypotensive shock, acute respiratory failure, and whose CRS toxicities deteriorated rapidly. Moreover, low doses of dexamethasone (5-10 mg/day) were used for refractory CRS not responding to tocilizumab. The effective management of the toxicities associated with CRS will bring additional survival opportunities and improve the quality of life for patients with cancer. | Hongli Chen Fangxia Wang Pengyu Zhang Yilin Zhang Yinxia Chen Xiaohu Fan Xingmei Cao Jie Liu Yun Yang Baiyan Wang Bo Lei Liufang Gu Ju Bai Lili Wei Ruili Zhang Qiuchuan Zhuang Wanggang Zhang Wanhong Zhao Aili He | 2019 | Frontiers of Medicine2019，13，5： | 21 |
| 2 | Quantitative description of characteristics of high-capacity channels in unconsolidated sandstone reservoirs using in situ production data显示文摘Quantitative description of the high-capacity channels in unconsolidated sandstone reservoirs,into which water was injected to improve oil recovery,is a hot topic in the fi eld of reservoir development. This paper presents a novel approach to describing quantitatively the characteristics of connected macropores in unconsolidated sandstone reservoirs using in situ production data. Based on physical simulation for formation mechanisms of high capacity channels and interwell tracer test data,a mathematical model was established to describe high-capacity channels by grey correlation theory,glow mechanism of fluid in porous media and reservoir engineering,and a program was developed to describe quantitatively the channel characteristics. The predicted results were consistent with fi eld monitoring data(80%) ,so this model could be economically and effectively used to identify high-capacity channels. | Wang Xuezhong Wang Jianyong Wang Chuanfei Zeng Liufang Liu Xuewei | 2010 | Petroleum Science2010，7，1： | 15 |
| 3 | 基于设计院承建EPC工程总承包几个问题探讨显示文摘随着我国市场经济的不断发展,EPC工程总承包模式发展速度越来越快。EPC工程总承包是对工程的设计、采购、施工等实行全过程承包。当今,国内设计院也开始承建EPC工程总承包事业。凭借设计院自身的设计优势,设计院承建EPC工程总承包能发挥设计的主导作用。基于设计院本身的特点,设计院承建EPC工程总承包还存在一系列问题。该文主要是对设计院的设计部门、合同管理、人才培养这三个方面所产生的代表性问题进行分析和探讨,提供一些有益参考。 | 王旭 苏华 刘芳 陈雷 Liufang YangXiaoqing XiaYunxue Chenlei ZhouShunsheng CaiZhentao | 2014 | 科技资讯2014，12，36： | 9 |
| 4 | Primary investigation on GISH-NOR in cotton显示文摘Six loci of nucleolar organizer region (NOR) were detected in genomic in situ hybridization (GISH) of cotton (Gossypium). NOR was the characteristic of 45S rDNA but could be generated by genomic DNA (gDNA) extracted from Gossypium species as probe. With twice FISH to the same mitotic cell of G. herbaceum or G. hirsutum, number, position and size for NORs generated from 45S rDNA and gDNA were identified largely similar or even the same. The NORs with gDNA as probe were therefore permanently defined as GISH-NORs. GISH-NORs from G. hirsutum and G. raimondii mitotic images were all terminal types. Four and two GISH-NORs from G. herbaceum (var. africanum) were terminal and centromere types, respectively. Six GISH-NORs in G. hirsutum were chromosome mapped with two in A- and four in D-subgenomes. There were also GISH-NORs in mitotic image of G. raimondii with its own gDNA as probe. From mitotic image of G. herbaceum with its own gDNA as probe, GISH-NOR could not be observed but non-whole- recovery of hybridized signals was distinguished. These non-whole-recovery of hybridized signals were detected on long arm terminals of most chromosomes and especially existed in nearly half long arm of a pair of chromosomes in G. herbaceum gDNA probed itself GISH image, which may be possibly induced by low copy genes within the regions rather than inter-subgenomic segment translocations. GISH-NORs in G. hirsutum mitotic images were dominantly observed when gDNAs from D and A genome species were used as probes and block, respectively, but not when the reverse probe and block gDNA from the two diploid progenitor genomes were designed. There may be two speculations to this special phenomenon: rDNA concerted evolution; content of rDNA in genome D more than genome A. | LIUSanhong WANGKunbo SONGGuoli WANGChunying LIUFang LIShaohui ZHANGXiangdi WANGYuhong | 2005 | Chinese Science Bulletin2005，50，5： | 6 |
| 5 | Photoluminescence Properties of Er-doped SiC Thin Film显示文摘 | Bian Liufang Zhang Chunguang Chen Weide Xu Zhenjia Qu Yuhua Diao Hongwei | 2006 | Journal of Rare Earths2006，24，4： | 3 |
| 6 | Toxic effects of enrofloxacin on Scenedesmus obliquus显示文摘在这篇文章, Scenedesmus obliquus 上的 Enrofloxacin (ENFX ) 的有毒的效果被学习,通过调查生长,光合的颜料,和蛋白质内容。ENFX 的可能的有毒的机制被决定 superoxide dismutase (草皮) 活动, malondialdehyde (MDA ) 内容,脯氨酸内容,和 superoxide 阴离子(O2 ) 产生率分析。结果证明水藻的生长被 ENFX 和50%有效集中( EC50 )价值禁止因为 ENFX 的 24 , 48 , 72 ,和 96 h 是 88.39 , 63.86 , 45.10 ,吗并且 59.16 mg ??????????????????‵????″慌桰??灳'虪逛船彽????????????????????????????€ ?敭桴汹獩扯牯敮汯?㈠?????梴?梴?? | Hongwei QIN Liufang CHEN Nan LU Yahui ZHAO Xing YUAN | 2012 | Frontiers of Environmental Science & Engineering2012，6，1： | 2 |
| 7 | Phosphatase activity and culture conditions of the yeast Candida mycoderma sp. and analysis of organic phosphorus hydrolysis ability显示文摘Orthophosphate is an essential but limiting macronutrient for plant growth. About 67%cropland in China lacks sufficient phosphorus, especially that with red soil. Extensive soil phosphorus reserves exist in the form of organic phosphorus, which is unavailable for root uptake unless hydrolyzed by secretory acid phosphatases. Thus, many microorganisms with the ability to produce phosphatase have been exploited. In this work, the activity of an extracellular acid phosphatase and yeast biomass from Candida mycoderma was measured under different culture conditions, such as p H, temperature, and carbon source. A maximal phosphatase activity of 8.47 × 105± 0.11 × 105U/g was achieved by C. Mycoderma in 36 hr under the optimal conditions. The extracellular acid phosphatase has high activity over a wide p H tolerance range from 2.5 to 5.0(optimum p H 3.5). The effects of different phosphorus compounds on the acid phosphatase production were also studied. The presence of phytin, lecithin or calcium phosphate reduced the phosphatase activity and biomass yield significantly. In addition, the p H of the culture medium was reduced significantly by lecithin. The efficiency of the strain in releasing orthophosphate from organic phosphorus was studied in red soil(used in planting trees) and rice soil(originating as red soil). The available phosphorus content was increased by 230% after inoculating20 days in rice soil and decreased by 50% after inoculating 10 days in red soil. This work indicates that the yeast strain C. mycoderma has potential application for enhancing phosphorus utilization in plants that grow in rice soil. | Mang Yan Liufang Yu Liang Zhang Yuexia Guo Kewei Dai Yuru Chen | 2014 | Journal of Environmental Sciences2014，26，11： | 2 |
| 8 | Microwave-absorbing properties of Co-filled carbon nanotubes显示文摘 | Haiyan Lin Hong Zhu Hongfan Guo Liufang Yu | 2007 | Materials Research Bulletin2007，，10： | 2 |
| 9 | Prediction and identification of HLA-A 0201-restricted epitopes from leukemia-associated protein MLAA-22 which elicit cytotoxic T lymphocytes 显示文摘 | JingLi Ju Bai Liufang Gu | 2014 | Med Oncol2014，，31： | 1 |
| 10 | Investigation of a novel biomarker, neuropilin-1, and its application for poor prognosis in acute myeloid leukemia patients显示文摘 | Jianqiang Zhao Liufang Gu Chengliang Li Weiguo Ma Zengfeng Ni | 2014 | Tumor Biology2014，，： | 1 |
| 11 | Inter-leukin-17 synergizes with IFNgamma or TNFalpha to pro-mote inflammatory mediat or release and intercellular adhe-sion molecule-1(ICAM-1) expression in human interverte-bral disccells显示文摘 | GABR M A JING Liufang HELBLING A R | | 0，，1： | 1 |
| 12 | Investigation of the microwave-absorbing properties of Fe-filled carbon nanotubes显示文摘 | Haiyan Lin Hong Zhu Hongfan Guo Liufang Yu | 2007 | Materials Letters2007，，16： | 1 |
| 13 | Antioxidativeand antitumour activities of solid quercetin metal(II)complexes 显示文摘 | ZHOU Jing WANG Liufang WANG Jinyi | 2001 | Transition Metal chemistry2001，26，12： | 1 |
| 14 | MOEA/D with adaptive weight adjustment显示文摘 | QI Yutao MA Xiaoliang LIUFang | 2014 | Evolutionary Computation2014，22，2： | 1 |
| 15 | Design oftheJointBearingFlexibleLaminated MembraneCoupling显示文摘 | Shentu Liufang Zhang Xiangyan | 2004 | Mechanical Science and Technology2004，23，1： | 1 |
| 16 | 显示文摘 | LIUFang ZHUBing YUJing-li etal(刘芳 朱兵 于景丽 等) | 2010 | 生物技术通报2010，，6： | 1 |
| 17 | Synthesis,characterization,antioxidative and antitumor activities of solidquercetin rare earth(III)complexes显示文摘 | ZHOU Jing WANG Liufang WANG Jinyi | 2001 | Journal of InorganicBiochemistry2001，83，1： | 1 |
| 18 | 显示文摘 | GUOxun(郭勋) LIUFang(刘芳) LUGuo-Yuan(陆国元) | | ChinJOrgChem(YoujiHuaxue)0，，： | 1 |
| 19 | 显示文摘 | LiuShourong(刘寿荣) LiuFang(刘方) | 1997 | 金属热处理学报1997，18，04： | 1 |
| 20 | 显示文摘 | FanXenjie(范文捷) LiuFang(刘芳) DongYanli(董艳丽)etal | 2008 | 稀有金属材料与工程2008，37，1： | 1 |
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