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| 1 | AFAP1-AS1: a rising star among oncogenic long non-coding RNAs显示文摘Long non-coding RNAs(lncRNAs)have become a hotspot in biomedical research.This interest reflects their extensive involvement in the regulation of the expression of other genes,and their influence on the occurrence and development of a variety of human diseases.Actin filament associated protein 1-Antisense RNA 1(AFAP1-AS1)is a recently discovered oncogenic lncRNA.It is highly expressed in a variety of solid tumors,and regulates the expression of downstream genes and signaling pathways through adsorption and competing microRNAs,or by the direct binding to other proteins.Ultimately,AFAP1-AS1 promotes proliferation,chemotherapy resistance,and resistance to apoptosis,maintains stemness,and enhances invasion and migration of tumor cells.This paper summarizes the research concerning AFAP1-AS1 in malignant tumors,including the clinical application prospects of AFAP1-AS1 as a potential molecular marker and therapeutic target of malignant tumors.We also discuss the limitations in the knowledge of AFAP1-AS1 and directions of further research.AFAP1-AS1 is expected to provide an example for studies of other lncRNA molecules. | Fang Xiong Kunjie Zhu Su Deng Hongbin Huang Liting Yang Zhaojian Gong Lei Shi Yi He Yanyan Tang Qianjin Liao Jianjun Yu Xiaoling Li Yong Li Guiyuan Li Zhaoyang Zeng Wei Xiong Shanshan Zhang Can Guo | 2021 | Science China(Life Sciences)2021，64，10： | 4 |
| 2 | High-resolution crustal velocity structure in the Shanxi rift zone and its tectonic implications显示文摘The Shanxi rift zone,located in the Trans-North China Orogen(TNCO)of the North China Craton(NCC),is wellknown for hosting large intraplate earthquakes in continental China.The TNCO is a suture zone formed by the amalgamation of the eastern and the western blocks of the NCC.After its formation,it was reactived and deformed by later tectonic activities,which result in complex lithospheric heterogeneities.Thus,the detailed crustal structure of the Shanxi rift zone is critical for understanding the tectonics and seismogenic mechanism in this area,which will shed new lights on the formation and dynamic evolution of the NCC.In this study,we applied ambient noise tomography based on 18 months continuous records from 108 seismic stations located in Shanxi and its surroundings,in order to constrain its detailed crustal structure.We measured 4437 Rayleigh wave phase velocity dispersion curves in the period of 5–45 s from the cross-correlation functions.Next,a surface wave direct inversion algorithm based on surface-wave ray tracing was used to resolve a 3-D S-wave velocity model in the upper 60 km with lateral resolution of~50–80 km.The tomographic images show that the sedimentary thickness of the Taiyuan Basin is less than 5 km.At depth of 0–10 km,we observe a good correlation between the imaged structural variations with geological and topographic features at the surface.For example,the center of rift shows low-velocity anomalies and the uplifting areas on both sides are characterized by high velocity anomalies.The western and eastern boundaries of the slow materials coincide with the faults that control the basin.The slow material extends from the shallow surface to depth of about 15 km but it getting smaller in shape at deeper depth.For the Taiyuan Basin,Linfen Basin,and Yuncheng Basin in the central and southern parts,the structure is dominant by slow materials in the upper crust but changes to strong high-velocity anomalies in the lower crust and the uppermost mantle at depth deeper than 25 km.We interprete these high-velocity anomalies to be associated with the cold remnant of the underplated basalt in the lower crust that were formed in early Tertiary before the basin was stretched.We also observe the low-velocity anomaly beneath the Datong volcanic area,which extends from the uppermost mantle to a depth of 20 km vertically and migrates from west to east laterally.It may reflect the upwelling channel of the magmatic material in Datong.Moreover,the strong low-velocity anomalies presented north of 38°N could be related to the heated crustal materials with paritial melting as a result of the intensive magmatic activities of the Datong Volcano since the Cenozoic.In our study region,seismicity mainly concentrates in the depth range of 5–20 km and we find that most earthquakes appear to occur in places where velocity changes from high to low rapidly,with slight higher concentration in the faster material areas.In summary,our high-resolution 3-D crustal velocity model provides important seismological constraints to understand the tectonic evolution and seismicity across the Shanxi rift zone. | Liting DOU Huajian YAO Lihua FANG Song LUO Meiqin SONG Xiaomei YAN Cheng CHENG | 2021 | Science China Earth Sciences2021，64，5： | 1 |
| 3 | Study on Applying Optimal Path to Land Valuation显示文摘As an important role in the urban land price syst em , the basic land price appraisal directs and reflects all kinds of land price in the real estate market. Using geographic information systems (GIS) with algorit hms and powerful analysis functions to valuate land will improve the rationality and convenience of land valuation. The objective of the study on basic land pri ce using the optimal path algorithm is to decrease the man-made error, enhance automatization, avoid make inconvenience by roadblock object. | WANG Wei DONG Fei SHI Lite CAO Fang | 2006 | Geo-Spatial Information Science2006，9，1： | 1 |
| 4 | Auricular vagus nerve acupressure for patients with emotional distress under the COVID-19 pandemic:A smartphone-based,randomized controlled trial显示文摘Objective: To confirm whether self-administered AVNA treatment is effective in improving emotional distressunder the COVID-19 pandemic.Methods: A smartphone-based online, randomized, controlled trial was designed from 26 February 2020 to 28April 2020 in four study sites, including Wuhan, Beijing, Shenyang, and Guangzhou of China. Local residentswho had considerable emotional distress with a score of the Hospital Anxiety and Depression Scale (HADS) ≥9 were recruited. Participants were randomly assigned to three times of AVNA (n = 191) per day, in morning,around noon, and in evening or usual care (UC, n = 215) once daily for 14 days. The primary outcome was theresponse rate, which was the proportion of participants whose Hospital Anxiety and Depression Scale (HADS)score reduced from baseline by ≥ 50%. The assessment was conducted at baseline, 3 days, and 14 days.Results: The AVNA group had a markedly higher response rate than the UC group at 3 days (35.6% vs. 24.9%,P = 0.02) and at 14 days (70.7% vs. 60.6%, P = 0.02). The AVNA group showed significantly greater reductionin scores of HADS at the two measurement points and BAI at 3 days (P ≤ 0.03), with average respective effectsize of 0.217 and 0.195. Participants with AVNA spent less time falling asleep and rated their sleep qualitybeing remarkably higher than those with UC at endpoint.Conclusion: During COVID-19 pandemic period, treatment with self-administrated AVNA was more effectivethan UC in reducing emotional distress of isolated populations. These findings support self-administered AVNAas a treatment option for patients with emotional distress under the COVID-19 pandemic or other emergentevents. | Peijing Rong Lei Wang Lingling Yu Junying Wang Yan Ma Liting Wang Suxia Li Chunzhi Tang Liming Lu Liang Li Jiazi Dong Jiliang Fang Liwei Hou Zongshi Qin Xiaolan Su Zhangjin Zhang | 2021 | TMR Modern Herbal Medicine2021，4，2： | 1 |
| 5 | Long non-coding RNA AFAP1-AS1 accelerates lung cancer cells migration and invasion by interacting with SNIP1 to upregulate c-Myc显示文摘Actin filament associated protein 1 antisense RNA 1(named AFAP1-AS1)is a long non-coding RNA and overexpressed in many cancers.This study aimed to identify the role and mechanism of AFAP1-AS1 in lung cancer.The AFAP1-AS1 expression was firstly assessed in 187 paraffin-embedded lung cancer and 36 normal lung epithelial tissues by in situ hybridization.The migration and invasion abilities of AFAP1-AS1 were investigated in lung cancer cells.To uncover the molecular mechanism about AFAP1-AS1 function in lung cancer,we screened proteins that interact with AFAP1-AS1 by RNA pull down and the mass spectrometry analyses.AFAP1-AS1 was highly expressed in lung cancer clinical tissues and its expression was positively correlated with lung cancer patients'poor prognosis.In vivo experiments confirmed that AFAP1-AS1 could promote lung cancer metastasis.AFAP1-AS1 promoted lung cancer cells migration and invasion through interacting with Smad nuclear interacting protein 1(named SNIP1),which inhibited ubiquitination and degradation of c-Myc protein.Upregulation of c-Myc molecule in turn promoted the expression of ZEB1,ZEB2,and SNAIL gene,which ultimately enhanced epithelial to mesenchymal transition(EMT)and lung cancer metastasis.Understanding the molecular mechanism by which AFAP1-AS1 promotes lung cancer's migration and invasion may provide novel therapeutic targets for lung cancer patients'early diagnosis and therapy. | Yu Zhong Liting Yang Fang Xiong Yi He Yanyan Tang Lei Shi Songqing Fan Zheng Li Shanshan Zhang Zhaojian Gong Can Guo Qianjin Liao Yujuan Zhou Ming Zhou Bo Xiang Xiaoling Li Yong Li Zhaoyang Zeng Guiyuan Li Wei Xiong | 2021 | Signal Transduction and Targeted Therapy2021，6，7： | 1 |
| 6 | Global methyl halide emissions from biomass burning during 2003-2021显示文摘Methyl halides(CH3Cl,CH3Br,and CH3I)are ozone-depleting substances.Biomass burning(BB)is an important source of methyl halides.The temporal variations and global spatial distribution of BB methyl halide emissions are unclear.Thus,global methyl halide emissions from BB during 2003e2021 were estimated based on satellite data.A significant decreasing trend(p<0.01)in global methyl halide emissions from BB was found between 2003 and 2021,with CH3Cl emissions decreasing from 302 to 220 Gg yr^(-1),CH3Br emissions decreasing from 16.5 to 11.7 Gg yr^(-1),and CH3I emissions decreasing from 8.9 to 6.1 Gg yr^(-1).From a latitudinal perspective,the northern high-latitude region(60e90N)was the only latitude zone with significant increases in BB methyl halide emissions(p<0.01).Based on an analysis of the drivers of BB methyl halide emissions,emissions from cropland,grassland,and shrubland fires were more correlated with the burned area,while BB emissions from forest fires were more correlated with the emissions per unit burned area.The non-BB emissions of CH3Cl increased from 4749 Gg yr^(-1)in 2003 to 4882 Gg yr^(-1)in 2020,while those of CH3Br decreased from 136 Gg yr^(-1)in 2003 to 118 Gg yr^(-1)in 2020(global total CH3I emissions are not available).The finding indicates that global CH3Cl and CH3Br emissions from sources besides BB increased and decreased during 2003e2020.Based on our findings,not only searching for unknown sources is important,but also re-evaluating known sources is necessary for addressing methyl halide emissions. | Xiaoyi Hu Di Chen Liting Hu Bowei Li Xinhe Li Xuekun Fang | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 7 | Research on Soil Conservation and Improvement Technology in Zhaoyang District显示文摘The environment of tobacco-growing soil directly affects the yield and quality of tobacco leaves.In order to solve problems of tobacco-growing soil degradation,low organic matter content and unbalanced soil nutrient supply and promote sustainable and healthy development of tobacco production,this paper comprehensively discussed conservation and improvement techniques of tobacco-growing soil based on existing problems in Zhaoyang District,aiming to provide reference for tobacco-growing soil conservation. | Jing YANG Shifu ZHONG Liting FANG Wei YAN Shixian PU Dianli MA Wenkai XIA Haohan GONG Mengsheng ZHANG Yeming FU Xia NI | 2024 | Agricultural Biotechnology2024，13，1： | 0 |
| 8 | Development of robust perovskite single crystal radiation detectors with high spectral resolution through synergetic trap deactivation and self-healing显示文摘Organic-inorganic halide perovskite single crystals(SCs)are promising materials for detecting ionizing radiation owing to their outstanding photoelectric conversion capability and inexpensive solution processability.However,the accuracy and stability of the detectors have been limited due to the charge traps and defects in SCs,especially when operated under high-precision photon-counting mode for energy spectrum acquisition.Here,we proposed a trap freezing deactivation route,which obviously suppressed dark current and noise by up to 97%and 92%,respectively.Furthermore,the bulk ion migration effect was essential for the ability to instantly self-heal defects induced by radiation damage at temperatures down to30C.Consequently,the detector exhibits a record high energy resolution of 7.5%at 59.5 keV for 241Amγ-ray source,which is the best solution-processed semiconductor radiation detectors at the same energy range.In addition,the detector maintains over 90%of its initial performance after 9 months of storage when tested in the air.Our results will represent a revision of the paradigm that high-spectral-resolution and robust radiation detectors can only be realized with high temperature grown inorganic semiconductor single crystals. | Lixiang Wang Yilong Song Liqi Li Liting Tao Minxing Yan Weihui Bi Xueying Yang Yuan Sun Qingfeng Dong Deren Yang Yanjun Fang | 2023 | InfoMat2023，5，9： | 0 |
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