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| 1 | The Tea Tree Genome Provides Insights into Tea Flavor and Independent Evolution of Caffeine Biosynthesis显示文摘茶是世界有巨大的经济、药用、文化的重要性的最旧、很流行的包含咖啡因的饮料。这里,我们在场第一个高质量的核苷酸序列充满重复(80.9%) ,栽培的茶树山茶 sinensis 的 3.02-Gb 染色体。我们证明茶树的一种非常地大的染色体尺寸从一些 LTR retrotransposon 家庭的慢、稳定、长期的扩大被结果。除了一个最近的整个染色体的复制事件,基因的系特定的扩大把新陈代谢的生合成与 flavonoid 联系了被发现,它提高 catechin 生产,萜烯酶激活,和应力公差,为茶风味和改编的重要特征。我们相对可可子和咖啡表明一个独立人士和茶咖啡因合成小径的快速的进化。在 25 山茶种类之中的比较研究表明那更高的表情大多数 flavonoid- 和咖啡因铺平 -- 然而并非 theanine 相关的基因贡献 catechins 和咖啡因的增加的生产并且因此提高处理茶的适用性和茶质量。这些新奇调查结果为进一步的 metabolomic 和典型生合成小径的功能的 genomic 精炼铺平道路并且将帮助开发将最后满足并且吸引世界范围的更多的茶喝酒者的茶风味的一个更多样化的集合。 | En-Hua Xia Hai-Bin Zhang Jun Sheng Kui Li Qun-Jie Zhang Changhoon Kim Yun Zhang Yuan Liu Ting Zhu Wei Li Hui Huang Yan Tong Hong Nan Cong Shi Chao Shi Jian-Jun Jiang Shu-Yan Mao Jun-Ying Jiao Dan Zhang Yuan Zhao You-Jie Zhao Li-Ping Zhang Yun-Long Liu Ben-Ying Liu Yue Yu Sheng-Fu Shao De-Jiang Ni Evan E. Eichler Li-Zhi Gao | 2017 | Molecular Plant2017，10，6： | 113 |
| 2 | Cancer statistics in China and United States,2022:profiles,trends,and determinants显示文摘Background:The cancer burden in the United States of America(USA)has decreased gradually.However,China is experiencing a transition in its cancer profiles,with greater incidence of cancers that were previously more common in the USA.This study compared the latest cancer profiles,trends,and determinants between China and USA.Methods:This was a comparative study using open-source data.Cancer cases and deaths in 2022 were calculated using cancer estimates from GLOBOCAN 2020 and population estimates from the United Nations.Trends in cancer incidence and mortality rates in the USA used data from the Surveillance,Epidemiology,and End Results program and National Center for Health Statistics.Chinese data were obtained from cancer registry reports.Data from the Global Burden of Disease 2019 and a decomposition method were used to express cancer deaths as the product of four determinant factors.Results:In 2022,there will be approximately 4,820,000 and 2,370,000 new cancer cases,and 3,210,000 and 640,000 cancer deaths in China and the USA,respectively.The most common cancers are lung cancer in China and breast cancer in the USA,and lung cancer is the leading cause of cancer death in both.Age-standardized incidence and mortality rates for lung cancer and colorectal cancer in the USA have decreased significantly recently,but rates of liver cancer have increased slightly.Rates of stomach,liver,and esophageal cancer decreased gradually in China,but rates have increased for colorectal cancer in the whole population,prostate cancer in men,and other seven cancer types in women.Increases in adult population size and population aging were major determinants for incremental cancer deaths,and case-fatality rates contributed to reduced cancer deaths in both countries.Conclusions:The decreasing cancer burden in liver,stomach,and esophagus,and increasing burden in lung,colorectum,breast,and prostate,mean that cancer profiles in China and the USA are converging.Population aging is a growing determinant of incremental cancer burden.Progress in cancer prevention and care in the USA,and measures to actively respond to population aging,may help China to reduce the cancer burden. | Changfa Xia Xuesi Dong He Li Maomao Cao Dianqin Sun Siyi He Fan Yang Xinxin Yan Shaoli Zhang Ni Li Wanqing Chen | 2022 | Chinese Medical Journal2022，，5： | 827 |
| 3 | Localization and Dynamic Change of Saikosaponin in Root of Bupleurum chinense显示文摘Anatomical, histochemical and phytochemical methods were used to investigate the structure, the localization and content changes of total saikosaponin and saikosaponin-a of the roots of Bupleurum chinense DC. at different developmental stages. Results showed that saikosaponin was mainly distributed in pericycle and primary phloem in the young root; but in the mature root, it was mainly distributed in vascular cambium and secondary phloem. During the whole growth period from the pre-blossom, blossom, fruit, and fruit mature periods until the pre-withering period, it was in the fruit mature period that both the total saikosaponin content and the saikosaponin-a content reached the highest level. So the last 20 d of October was considered as the right collecting season for the drug of B. chinense. In addition, the quality of 1-year-old drug was better than that of 2-year-old drug due to its higher saikosaponin content. On the other hand, judging from the external characteristics of the drug, the one with an acerose taproot and more lateral roots was of better quality. The results offered theoretical bases for selecting medicinal material of high quality and determining the most appropriate harvesting stage and part of B. chinense. | Ling-Ling Tan Xia Cai Zheng-Hai Hu Xi-Lu Ni | 2008 | Journal of Integrative Plant Biology2008，50，8： | 21 |
| 4 | Over-expression of NYGGF4 inhibits glucose transport in 3T3-L1 adipocytes via attenuated phosphorylation of IRS-1 and Akt显示文摘 | Chun-mei ZHANG Xiao-hui CHEN Bin WANG Feng LIU Xia CHI Mei-ling TONG Yu-hui NI Rong-hua CHEN Xi-rong GUO | 2009 | Acta Pharmacologica Sinica2009，30，1： | 17 |
| 5 | Discrimination of abiogenic and biogenic alkane gases显示文摘We have combined the analytical data of the carbon isotope distribution pattern, R/Ra and CH4/3He values of abiogenic and biogenic (referring to the thermogenic and bacterial or microbial) alkane gases in China with those of alkane gases from USA, Russia, Germany, Australia and other countries. Four discrimination criteria are derived from this comparative study: 1) Carbon isotopic composition is generally greater than -30‰ for abiogenic methane and less than -30‰ for biogenic methane; 2) Abiogenic alkane gases have a carbon isotopic reversal trend (δ 13C1> δ 13C2> δ 13C3> δ 13C4) with δ 13C1>-30‰ in general; 3) Gases with R/Ra >0.5 and δ 13C11 δ 13C2>0 are of abiogenic origin; 4) Gases (meth- ane) with CH4/3He≤106 are of abiogenic origin, whereas gases with CH4/3He≥1011 are of biogenic origin. | DAI JinXing ZOU CaiNeng ZHANG ShuiChang LI Jian NI YunYan HU GuoYi LUO Xia TAO ShiZhen ZHU GuangYou MI JingKui LI ZhiSheng HU AnPing YANG Chun ZHOU QingHua SHUAI YanHua ZHANG Ying MA ChengHua | 2008 | Science China Earth Sciences2008，51，12： | 17 |
| 6 | Structure, evolution and regional tectonic implications of the Queshan metamorphic core complex in eastern Jiaodong Peninsula of China显示文摘The Queshan MCC is an important example of a crustal extensional structure in the eastern Jiaodong Peninsula along the southeastern margin of the NCC in the Early Cretaceous. The MCC is a typical Cordilleran-type core complex with a three-layered structure:(1) the upper plate is constituted by the Cretaceous supradetachment basin and Paleoproterozoic basement;(2) the lower plate comprises the Neoarchean high-grade metamorphic complexes and late Mesozoic granitic intrusions; and(3) the two plates are separated by a master detachment fault. A series of late NEN-oriented brittle faults superimposed on and destructed the early MCC. Petrology, geometry, kinematics, macro- and micro-structures and quartz c-axis fabrics imply that the MCC has a progressive exhumation history from middle-lower to subsurface level(via middle-upper crustal level) under the nearly WNW-ESE regional extensional regime. We present structural and geochronological evidence to constrain the exhumation of the Queshan MCC from ca. 135 to 113 Ma. Based on the comprehensive analysis of the different patterns of extensional structures in the Jiaodong and Liaodong Peninsula, we have defined the Jiao-Liao Early Cretaceou extensional province and further divided the crustal extension of it into two stages: the first stage was the intense flow of the middle-lower crust and the second stage was the extension of the middle-upper crust. Combining the tectonic setting, the lithosphere thinning in the Jiao-Liao Early Cretaceous extensional province can be considered a typical model for the response of crust-mantle detachment faulting under regional extension in East Asia. | XIA ZengMing LIU JunLai NI JinLong ZHANG TingTing SHI XingMing WU Yun | 2016 | Science China Earth Sciences2016，59，5： | 17 |
| 7 | Effects of inhaled nitric oxide in neonatal hypoxemic respiratory failure from a multicenter controlled trial显示文摘背景血氧不足的呼吸失败(HRF ) 是为要求好攻击的呼吸支持的新生的婴儿的最普通的原因之一。吸入的氮的氧化物(iNO ) 在发达国家作为附属物习惯性地被建立了到常规呼吸支持。学习是在资源与 HRF 在出生不满一月的婴儿调查 iNO 的效果的这的目的限制了状况没有或限制了表面活化剂的使用,高频率摆动的通风(HFOV ) 和身体外的膜 oxygenation.Methods A iNO 的功效的非使随机化的、开的、控制学习在 18 个月被进行。来自有 HRF (氧化索引 15 ) 的 28 所医院的合格术语和近期的出生不满一月的婴儿作为 iNO 或控制有希望地被注册进二个组。主要端点与 dosing 在关系被决定并且 iNO,内在的疾病的严厉,复杂并发症和负担预定的氧化改进和死亡。Intention-to-treat 原则为结果评价被采用。( ppm )对在 10 或 20 部分的 iNO 的反应被氧化在控制(在组之间)和比作 93 控制的基线(在内组) .Results 的参考每百万决定,在在 107 个对待的婴儿的 10 ppm 的 iNO 的起始的剂量显著地从第一个小时( P=0.046 )改进了氧化,与部分应答者的更多,非应答者不与随后的 20ppm 改进了氧化( P=0.018 )。在天坚持的这效果 1 和 3,并且而少数与表面活化剂(10% 对 27%) 被对待,导致了相对更低的死亡(11.2% 对 15%) , HFOV (5%) 或在两个的出生后的 corticosteroids (10%) 组织。在 28 天在的出生后的生活的全面结果对待 iNO 不与 perinatal 窒息,内在的疾病,血氧不足的严厉,或复杂并发症有关,但是到 iNO 的早使用。医院停留的费用不在新生的 HRF 在有表面活化剂或 HFOV 的相对有限的使用的两 groups.Conclusions 是显著地不同的,显著地,更多的应答者在在基线水平上在开始的三天内由改进氧化思考了的对待 iNO 的病人被发现。它为对适当预定和 iNO 的长期的结果的评价保证使随机化的、控制试用。 | WANG Yi-fei LIU Cui-qing GAO Xi-rong YANG Chang-yi SHAN Ruo-bing ZHUANG De-yi CHEN Dong-mei NI Li-ming WANG Hua XIA Shi-wen CHEN Chao | 2011 | Chinese Medical Journal2011，，8： | 16 |
| 8 | Prevalence, awareness, treatment, and control of hypertension in the non-dialysis chronic kidney disease patients显示文摘 | ZHENG Ying CAI Guang-yan CHEN Xiang-mei FU Ping CHEN Jiang-hua DING Xiao-qiang YU Xue-qing LIN Hong-li LIU Jian XIE Ru-juan WANG Li-ning NI Zhao-hui LIU Fu-you YIN Ai-ping XING Chang-ying WANG Li SHI Wei LIU Jian-she HE Ya-ni DING Guo-hua LI Wen-ge WU Guang-li MIAO Li-ning CHEN Nan SU Zhen MEI Chang-lin ZHAO Jiu-yang GU Yong BAI Yun-kai LUO Hui-min LIN Shan CHEN Meng-hua GONG Li YANG Yi-bin YANG Xiao-ping LI Ying WAN Jian-xin WANG Nian-song LI Hai-ying XI Chun-sheng HAO Li XU Yan FANG Jing-ai LIU Bi-cheng LI Rong-shan WANG Rong ZHANG Jing-hong WANG Jian-qin LOU Tan-qi SHAO Feng-min MEI Feng LIU Zhi-hong YUAN Wei-jie SUN Shi-ren ZHANG Ling ZHOU Chun-hua CHEN Qin-kai JIA Shun-lian GONG Zhi-feng GUAN Guang-ju XIA Tian ZHONG Liang-bao | 2013 | Chinese Medical Journal2013，，12： | 16 |
| 9 | Common Spectral Bands and Optimum Vegetation Indices for Monitoring Leaf Nitrogen Accumulation in Rice and Wheat显示文摘Real-time monitoring of nitrogen status in rice and wheat plant is of significant importance for nitrogen diagnosis, fertilization recommendation, and productivity prediction. With 11 field experiments involving different cultivars, nitrogen rates, and water regimes, time-course measurements were taken of canopy hyperspectral reflectance between 350-2 500 nm and leaf nitrogen accumulation (LNA) in rice and wheat. A new spectral analysis method through the consideration of characteristics of canopy components and plant growth status varied with phenological growth stages was designed to explore the common central bands in rice and wheat. Comprehensive analyses were made on the quantitative relationships of LNA to soil adjusted vegetation index (SAVI) and ratio vegetation index (RVI) composed of any two bands between 350-2 500 nm in rice and wheat. The results showed that the ranges of indicative spectral reflectance were largely located in 770-913 and 729-742 nm in both rice and wheat. The optimum spectral vegetation index for estimating LNA was SAVI (R822, R738) during the early-mid period (from jointing to booting), and it was RVI (R822, R738) during the mid-late period (from heading to filling) with the common central bands of 822 and 738 nm in rice and wheat. Comparison of the present spectral vegetation indices with previously reported vegetation indices gave a satisfactory performance in estimating LNA. It is concluded that the spectral bands of 822 and 738 nm can be used as common reflectance indicators for monitoring leaf nitrogen accumulation in rice and wheat. | WANG Wei YAO Xia TIAN Yong-chao LIU Xiao-jun NI Jun CAO Wei-xing ZHU Yan | 2012 | Journal of Integrative Agriculture2012，11，12： | 13 |
| 10 | Downregulation of STEAP4, a highly-expressed TNF-α-inducible gene in adipose tissue, is associated with obesity in humans显示文摘 | Chunsmei ZHANG Xia CHI Bin WANG Min ZHANG Yu-hui NI Rong-hua CHEN Xiao-nan LI Xi-rong GUO | 2008 | Acta Pharmacologica Sinica2008，29，5： | 11 |
| 11 | Factors influencing the concentration of negative air ions during the year in forests and urban green spaces of the Dapeng Peninsula in Shenzhen, China显示文摘Negative air ions(NAIs)benefit the mental and physical health of humans,but rapid urbanization can decrease the abundance of NAIs.Quantifying the spatial and seasonal distribution of NAIs and determining the factors that infl uence the concentration during urbanization is thus essential.In the present study of a typical developing urban district in southern China,negative air ion concentrations(NAICs)in 60 forests sites and 30 urban green spaces were quantifi ed on seven consecutive days in each of the four seasons.Large seasonal variations in NAIC were revealed in forests and urban green spaces with trough values in summer.NAIC progressively decreased from forests to urban green spaces and was infl uenced by local land morphology,vegetation characteristics,and climatic factors.The vast,heavily vegetated northeastern region was the richest area for NAIs,whereas the narrow central region(urbanized area)was the poorest,implying dramatic impacts of urbanization on the spatial distribution of NAIs.The relationship between air temperature and NAIC was better fi tted with a quadratic equation than a linear equation.Moreover,the NAIC was more sensitive to local morphology in urban green spaces than in urban forests,indicating the vulnerability of NAIs in urbanized areas.Therefore,the appropriate design of local urban morphology is critical. | Yafei Wang Zhuobiao Ni Di Wu Chen Fan Jiaqi Lu Beicheng Xia | 2020 | Journal of Forestry Research2020，31，6： | 11 |
| 12 | Hypoxia-induced factor-1 alpha upregulates vascular endothelial growth factor C to promote lymphangiogenesis and angiogenesis in breast cancer patients显示文摘Hypoxia-induced factor-1 alpha(HIF-1α)affects many effector molecules and regulates tumor lymphangiogenesis and angiogenesis during hypoxia.The aim of this study was to investigate the role of HIF-1αin the regulation of vascular endothelial growth factor C(VEGF-C)expression and its effect on lymphangiogenesis and angiogenesis in breast cancer.Lymphatic vessel density(LVD),microvessel density(MVD)and the expressions of HIF-1αand VEGF-C proteins were evaluated by immunohistochemistry in 75 breast cancer samples.There was a significant correlation between HIF-1αand VEGF-C(P=0.014,r=0.273,Spearman's coefficient of correlation).HIF-1αand VEGF-C overexpression was significantly correlated with higher LVD(P=0.003 and P=0.017,respectively),regional lymph nodal involvement(P=0.002 and P=0.004,respectively)and advanced tumor,node,metastasis(TNM)classification(P=0.001 and P=0.01,respectively).Higher MVD was observed in the group expressing higher levels of HIF-1αand VEGF-C(P=0.033 and P=0.037,respectively).Univariate analysis showed shorter survival time in patients expressing higher levels of HIF-1αand VEGF-C.HIF-1αwas also found to be an independent prognostic factor of overall survival in multivariate analysis.The results suggest that HIF-1αmay affect VEGF-C expression,thus acting as a crucial regulator of lymphangiogenesis and angiogenesis in breast cancer.This study highlights promising potential of HIF-1αas a therapeutic target against tumor lymph node metastasis. | Xiaojian Ni Yingchun Zhao Jingjing Ma Tiansong Xia Xiaoan Liu Qiang Ding Xiaoming Zha Shui Wang | 2013 | The Journal of Biomedical Research2013，27，6： | 10 |
| 13 | Experimental cancer gene therapy by multiple anti-survivin hammerhead ribozymes显示文摘为癌症改进基因治疗的功效,我们设计了指向 survivin mRNA 的暴露的区域的四撞木鲛 ribozyme 侵入人体气管粘膜的病菌(到 R4 的 R1 ) 。除了在里面 vitro 描述,由教材扩展包括了劈开的顺序特性的一颗决心,为细胞增长并且为的试金在 vivo 肿瘤,生长被用来为 ribozyme 效率得分。survivin 表示的产生抑制经由 caspase-3-dependent 小径导致了有丝分裂的大祸和房间死亡。重要地, ribozyme 侵入人体气管粘膜的病菌的管理在一个 hepato 细胞的癌异种皮移植老鼠模型禁止了肿瘤生长。R1, R3 和 R4 ribozymes 的合作表示 synergistically 压制了 survivin 并且当这联合指向 survivin 抄本的所有主要形式,生产了大多数有势力反癌症效果。带在这份报告描述的多重撞木鲛 ribozymes 的侵入人体气管粘膜的病菌对癌症提供了柔韧的基因治疗策略。 | Qi Fei Hongyu Zhang Lili Fu Xinlan Dai Baomei Gao Min Ni Chao Ge Jinjun Li Xia Ding Yuwen Ke Xuebiao Yao Jingde Zhu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，6： | 10 |
| 14 | Current status of neonatal acute respiratory disorders: a one-year prospective survey from a Chinese neonatal network显示文摘我们进行了的背景一未来,新生的尖锐呼吸混乱(甘松)的发生,管理和结果的 multicenter 调查,并且在一个中国新生的 network.Methods 数据以新生的特别护理单位( NICU )评估了相关 perinatal 风险因素和呼吸治疗的功效有希望地从婴儿在 2004-2005 被收集,甘松在 life.Results 的开始的 3 天期间定义为呼吸悲痛和氧要求的存在 2677 甘松 w 的一个总数有 711 (5.44%) 与呼吸悲痛症候群(RDS ) , 589 (4.51%) 肺的感染, 409 (3.13%) 胎粪渴望症候群, 658 (5.03%) 羊膜的液体的渴望并且 239 (1.83%) 短暂 tachypnoea。胎粪渴望症候群与母亲的混乱与胎儿的悲痛,从剖腹产的短暂 tachypnoea,和 RDS 有最高的率。帮助机械通风在 53.4% 甘松,并且在上面被使用有 84.7% , 52.3% , 39.8% , 24.5% ,和 53.6% 的五混乱分别地。在这些混乱的相应死亡是 31.4% , 13.6% , 17.8% , 4.1% 和 5.0% , respectively.Surfactant 被提供给 33.9% RDS。在所有 RDS 婴儿,如果收到表面活化剂,幸存率是78.8%,并且63.4%如果不( P 0.001 )这研究提供了的 .Conclusions NICU 基于承认的发生和甘松的死亡,先进呼吸治疗的思考效率,它应该是为在 NICU 在的呼吸支持的当前的开发的引用省并且 亚provincial 层次,在通过一种合作方式在新兴的区域升级照顾的标准认为努力正当。 | QIAN Li-ling LIU Cui-qing GUO Yun-xia JIANG Ye-jun NI Li-ming XIA Shi-wen LIU Xiao-hong ZHUANG Wan-zhu XIAO Zhi-hui WANG San-nan ZHOU Xiao-yu SUN Bo | 2010 | Chinese Medical Journal2010，，20： | 10 |
| 15 | Expression of OTUB1 in hepatocellular carcinoma and its effects on HCC cell migration and invasion显示文摘 | Qinggan Ni Jiahui Chen Xia Li Xiaodong Xu Nannan Zhang Ang Zhou Bin Zhou Qian Lu Zhong Chen | 2017 | Acta Biochimica et Biophysica Sinica2017，49，8： | 9 |
| 16 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 17 | WheatOmics:A platform combining multiple omics data to accelerate functional genomics studies in wheat显示文摘Dear Editor,Mold-breaking progress in whole-genome sequencing and rapid accumulation of multi-omics data have revolutionized the research strategies of functional genomics in wheat(Wang et al.,2018).However,how to access these vast multi-omics data and to extract key information on genes of in-terest,is still challenging for most wet-lab or field wheat re-searchers who have little bioinformatic experiences and cannot access the expensive computational resources.Here,we pre-sent WheatOmics(http://gffzz513af15b15bc4712hcfw06nubko5v6bfp.ffgz.tsg.suse.edu.cn/,previously designated as Triticeae Multi-omics Center,http://gffzz601e21d286504235hcfw06nubko5v6bfp.ffgz.tsg.suse.edu.cn/),a free,web-accessible,and user-friendly platform.WheatOmics not only empowers the effective access to the visualized multi-omics data of user-interested genes but also offers several distinctive and practical toolkits that can ease almost every aspect of wheat functional genomics studies(Figure 1A). | Shengwei Ma Meng Wang Jianhui Wu Weilong Guo Yongming Chen Guangwei Li Yanpeng Wang Weiming Shi Guangmin Xia Daolin FU Zhensheng Kang Fei Ni | 2021 | Molecular Plant2021，14，12： | 9 |
| 18 | Efficacy of maximal androgen blockade versus castration alone in the treatment of advanced prostate cancer: a retrospective clinical experience from a Chinese medical centre显示文摘在这回顾的研究,我们与先进前列腺癌症在中国病人独自评估了并且比较最大的雄激素封锁(MAB ) 对阉割的功效和毒性。从 1996 ~ 2004,有先进前列腺癌症的 608 个病人在学习被包括。病人们回顾地根据不同治疗学的政体被划分成二个组。608 个病人, 300 个病人与 MAB (加 nonsteroidal antiandrogens 的阉割) 并且留下被对待 308 独自与阉割被对待。这些病人的 2 年、 5 年的全面幸存率分别地是 73.7% 和 56% 。Multivariate 分析证明在有变形前列腺癌症的病人, MAB 与没有前进的幸存(PFS ) 的改进被联系不仅(到 10 个月增加了) 而且在死亡风险的 20.6% 减小与阉割相比独自一个。相反, MAB 的功效不比为有 nonmetastatic 前列腺癌症的病人独自一个的阉割优异。在有 MAB 的病人之中,有趣地,那些使用的 bicalutamide 用 flutamide 比那些有更长的 PFS;这是特别在有变形前列腺癌症的病人。几乎所有毒性,由于荷尔蒙,治疗对温和中等、可管理。得出结论在中国,荷尔蒙治疗,包括的 MAB 和阉割独自一个,是为先进前列腺癌症的标准治疗。为有 nonmetastatic 前列腺癌症的病人,阉割可能独自足够地实际、有效。在有变形前列腺癌症的病人,然而, MAB 独自在阉割上有优异功效。MAB 应该与变形前列腺癌症为病人被认为首要的标准治疗,是清楚的。 | Xue-Qin Chen Ying Huang Xiang Li Peng Zhang Rui Huang Juan Xia Ni Chen Qiang Wei Yu-Chun Zhu Yu-Ru Yang Hao Zeng | 2010 | Asian Journal of Andrology2010，12，5： | 9 |
| 19 | Gender differences in efficacy of primary percutaneous coronary intervention in patients with ST-elevation myocardial infarction显示文摘背景经皮的冠的干预(一种总线标准)的临床的结果在学习在在病人在主要一种总线标准的策略上把性差别的影响与尖锐圣片断举起作比较瞄准了的 men.This 比那在女人是更差的心肌的梗塞( STEMI ) .Methods 经历了的有 STEMI 的 259 个病人主要在 12 小时症状发作以内的一种总线标准是 enrolled.The 男组由 143 个男人组成了>没有年龄 lim , 55 年,和一个女组包括了 116 | LIU Yu WANG Le-feng YANG Xin-chun GE Yong-gui WANG Hong-shi XU Li LI Wei-ming NI Zhu-hua XIA Kun CHI Yong-hui LI Qiang ZHANG Da-peng WU Xiao-qing SUN Hao GUO Zong-sheng | 2008 | Chinese Medical Journal2008，，23： | 9 |
| 20 | Platelet function monitoring guided antiplatelet therapy in patients receiving high-risk coronary interventions显示文摘 | Xu Li Wang Lefeng Yang Xinchun Li Kuibao Sun Hao Zhang Dapeng Wang Hongshi Li Weiming Ni Zhuhua Xia Kun Liu Yu | 2014 | Chinese Medical Journal2014，，19： | 8 |
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