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| 1 | Kinsenoside attenuates osteoarthritis by repolarizing macrophages through inactivating NF-κB/MAPK signaling and protecting chondrocytes显示文摘The objective was to investigate the effect of kinsenoside(Kin) treatments on macrophage polarity and evaluate the resulting protection of chondrocytes to attenuate osteoarthritis(OA) progression.RAW264.7 macrophages were polarized to M1/M2 subtypes then administered with different concentrations of Kin. The polarization transitions were evaluated with quantitative real-time polymerase chain reaction(q RT-PCR), confocal observation and flow cytometry analysis. The mechanism of Kin repolarizing M1 macrophages was evaluated by Western blot. Further, macrophage conditioned medium(CM) and IL-1β were administered to chondrocytes. Micro-CT scanning and histological observations were conducted in vivo on anterior cruciate ligament transection(ACLT) mice with or without Kin treatment. We found that Kin repolarized M1 macrophages to the M2 phenotype. Mechanistically, Kin inhibited the phosphorylation of IκBα, which further reduced the downstream phosphorylation of P65 in nuclear factor-κB(NF-κB) signaling. Moreover, Kin inhibited mitogen-activated protein kinases(MAPK) signaling molecules p-JNK, p-ERK and p-P38. Additionally, Kin attenuated macrophage CM and IL-1β-induced chondrocyte damage. In vivo, Kin reduced the infiltration of M1 macrophages,promoted M2 macrophages in the synovium, inhibited subchondral bone destruction and reduced articular cartilage damage induced by ACLT. All the results indicated that Kin is an effective therapeutic candidate for OA treatment. | Feng Zhou Jingtian Mei Xiuguo Han Hanjun Li Shengbing Yang Minqi Wang Linyang Chu Han Qiao Tingting Tang | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 35 |
| 2 | Longitudinal Measurement of Hemodynamic Changes within the Posterior Optic Nerve Head in Rodent Nonarteritic Anterior Ischemic Optic Neuropathy显示文摘ObjectiveTo assess the in vivo dynamic blood flow features of posterior optic nerve head (ONH) in rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). MethodsrNAION was established with Rose Bengal and argon green laser in Sprague-Dawley rats. Fundus photography and fundus fluorescein angiography (FFA) were performed to assess the dynamic changes of optic disc in morphology in 90 days and in blood perfusion in 3 hours after the induction of disease. Histological examinations were performed to evaluate the success of modeling. Thedynamic blood flow kinetics of posterior ONH in rNAION were measured by Laser Doppler Flowmetry (LDF) on the day 3, 7, 14, 21, and 40 after the disease induction. One-way ANOVA, Student'st-test and Bonferroni adjustment were used for multiple comparisons of kinetic measurements of blood flow. ResultsOptic disc edema and subsequent resolution associated with the development of optic disc pallor were observed in rNAION. FFA showed that the optic disc was hypofluorescence in the early phase and hyperfluorescence in the late phase. Histological studies suggested edema and loosened tissues of ONH, loss of retinal ganglion cells (RGCs), optic nerve substance and gliosis. Compared to the naive rats, the blood flow kinetics of posterior ONH in rNAION significant reduced at each time point after modeling (F=175.06,P<0.0001). The reductions were specifically remarkable in 14 days after the disease induction (AllP<0.01). Conclusions Continuous blood perfusion reduction was found in rNAION, with significant alteration in 14 days after disease induction. Our results provided important information for understanding the hemodynamic changes in rNAION. | Jin Ma Ting Chen Yiwei Wang Chan Zhao Donghui Li Meng Wang Linyang Gan Yong Zhong | 2018 | Chinese Medical Sciences Journal2018，33，4： | 2 |
| 3 | A Liquid Metal Reaction System for Advanced Material Manufacturing显示文摘CONSPECTUS:Liquid metal exhibits the unique advantages of both the liquid and metal,including excellent deformability,high thermal conductivity,and electrical conductivity.The exploration of liquid metal is a new opportunity and revolution for the application of metal materials,including the flexible devices,catalysis,microfluidic,and drug delivery.In addition to the above applications,the characteristics of excellent inclusive ability with the majority of the elements and abundant vacancies in the bulk make it a new type of reaction medium different from traditional aqueous and organic solutions,exhibiting great potential in the precise construction of materials.To date,the research of using liquid metal as a reaction system to synthesize materials is still in its infancy.When acting as a reaction system,the vacancies inside and the smooth layering surfaces without grain boundaries allow liquid metals to encapsulate heterogeneous atoms,confine the precursors in atomically thick layers and realize the self-limiting growth of 2D material.Besides,the good rheological property makes it possible to construct 2D arrays on its surface.Except for the properties mentioned above,as a kind of metal,its excellent electrical conductivity and ductility provide a new idea for the preparation of composite materials in the energy field.Indeed,liquid metals provide attractive prospects in manufacturing advanced materials including 2D materials and functional composite materials.Thus,this Account aims to focus on the controllable fabrication of 2D materials and functional composite materials by liquid metals.Based on the characteristics of the surface layering and solidification and of excellent fluidity,the self-limited growth and ordered arrangement of 2D materials on liquid metal surfaces can be achieved,which enriches the material structures and leads to new properties.By constructing an in situ synthesis and observation system,the growth and assembly behavior of 2D materials on the liquid metal can be observed directly.Combining the electrical property,deformability,ductility,and high inclusive ability with other materials,the liquid metal reaction system can also realize the preparation of new functional composite materials toward various applications,such as the energy field.Except for the 2D materials and functional composite materials mentioned here,liquid metals also provide more possibilities for fabricating other promising materials,like wafer-scale semiconductors,magic-angle graphene,flexible functional materials,biomedical materials,and so on.The research concerning the manufacturing of advanced materials on liquid metals is still in its infancy.We believe that the development of related technologies offering in-depth investigation and theoretical understanding on liquid metals will lay a solid foundation for the basic research and practical application of more advanced materials. | Mengqi Zeng Linyang Li Xiaohui Zhu Lei Fu | 2021 | Accounts of Materials Research2021，2，8： | 1 |
| 4 | Numerical simulation of combustion characteristics and NOx emission in a 300 MWe utility boiler with different outer second-air vane angles显示文摘 | Zeng Linyang Li Zhengqi | 2010 | Energy & Fuels2010，24，： | 1 |
| 5 | Review of PPP-RTK:achievements,challenges,and opportunities显示文摘The PPP–RTK method,which combines the concepts of Precise of Point Positioning(PPP)and Real-Time Kinematic(RTK),is proposed to provide a centimeter-accuracy positioning service for an unlimited number of users.Recently,the PPP–RTK technique is becoming a promising tool for emerging applications such as autonomous vehicles and unmanned logistics as it has several advantages including high precision,full flexibility,and good privacy.This paper gives a detailed review of PPP–RTK focusing on its implementation methods,recent achievements as well as challenges and opportunities.Firstly,the fundamental approach to implement PPP–RTK is described and an overview of the research on key techniques,such as Uncalibrated Phase Delay(UPD)estimation,precise atmospheric correction retrieval and modeling,and fast PPP ambiguity resolution,is given.Then,the recent efforts and progress are addressed,such as improving the performance of PPP–RTK by combining multi-GNSS and multi-frequency observations,single-frequency PPP–RTK for low-cost devices,and PPP–RTK for vehicle navigation.Also,the system construction and applications based on the PPP–RTK method are summarized.Moreover,the main issues that impact PPP–RTK performance are highlighted,including signal occlusion in complex urban areas and atmosphere modeling in extreme weather events.The new opportunities brought by the rapid development of low-cost markets,multiple sensors,and new-generation Low Earth Orbit(LEO)navigation constellation are also discussed.Finally,the paper concludes with some comments and the prospects for future research. | Xingxing Li Jiaxin Huang Xin Li Zhiheng Shen Junjie Han Linyang Li Bo Wang | 2022 | Satellite Navigation2022，3，3： | 1 |
| 6 | Solid-liquid-core optical fiber biosensor for highly sensitive and selective detection of 4-chlorophenol in water显示文摘A novel solid-liquid-core fiber-optic biosensor was fabricated for highly sensitive and selective detection of 4-chlorophenol in water.The sensor comprised horseradish peroxidase(HRP)-coated U-shaped liquidcore optical fiber(LCOF)and 4-chlorophenol permselective polymer membrane.The U-shaped LCOF was flled with ethanol suspension of SiO_(2)particles and the polymer membrane was composed of molecularly imprinted polymer,sulfonated polyethersulfone,and polysulfone.The morphology,composition,and surface luminous properties of the sensing region were examined.The effects of the diameter and content of SiO_(2)particles and temperature of 4-chlorophenol solutions on the sensitivity of the biosensors were investigated.Further,the sensitivity,selectivity,response time,and limit of detection(LOD)of the biosensors was investigated.In addition,the effects of fiber core materials on the light transmission in sensing region were investigated and a biosensor sensing model was established.The proposed sensor exhibited high selectivity for 4-chlorophenol with satisfactory sensitivity,LOD,and response time:-1.18(μg/L)^(-1),30μg/L,and 400 s,respectively.The results are expected to aid in the development of methods for enhancing sensitivity of fiber-optic sensors and surface luminous intensity of optical fibers. | Cangxu Feng Jianwei Zhang Chao Bian Linyang Li Rong Hu Haixing Chang Fei Peng Xiaofeng Peng Nianbing Zhong | 2023 | Chinese Chemical Letters2023，34，12： | 1 |
| 7 | Photocatalytic synergistic biofilms enhance tetracycline degradation and conversion显示文摘Tetracyclines are refractory pollutants that cause persistent harm to the environment and human health.Therefore,it is urgently necessary to develop methods to promote the efficient degradation and conversion of tetracyclines in wastewater.This report proposes a photobiocatalytic synergistic system involving the coupling of GeO_(2)/Zn-doped phosphotungstic acid hydrate/TiO_(2)(GeO_(2)/Zn-HPW/TiO_(2))-loaded photocatalytic optical hollow fibers(POHFs)and an algalebacterial biofilm.The GeO_(2)/Zn-HPW/TiO_(2) photocatalyst exhibits a broad absorption edge extending to 1000 nm,as well as high-efficiency photoelectric conversion and electron transfer,which allow the GeO_(2)/Zn-HPW/TiO_(2)-coated POHFs to provide high light intensity to promote biofilm growth.The resulting high photocatalytic activity rapidly and stably reduces the toxicity and increases the biodegradability of tetracycline-containing wastewater.The biofilm enriched with Salinarimonas,Coelastrella sp.,and Rhizobium,maintains its activity for the rapid photocatalytic degradation and biotransformation of intermediates to generate the O_(2) required for photocatalysis.Overall,the synergistic photocatalytic biofilm system developed herein provides an effective and efficient approach for the rapid degradation and conversion of water containing high concentrations of tetracycline. | Chuanbao Xiao Jilin Yuan Linyang Li Nianbing Zhong Dengjie Zhong Quanhua Xie Haixing Chang Yunlan Xu Xuefeng He Min Li | 2023 | Environmental Science and Ecotechnology2023，，2： | 0 |
| 8 | High-speed adaptive photoacoustic microscopy显示文摘Optical-resolution photoacoustic microscopy(OR-PAM)is capable of observing the distribution of optical absorbers inside bio-tissues with a high spatial resolution of micrometers.Unfortunately,due to the employment of a tight optical focus,it suffers from a limited depth of field(DOF),making it challenging to achieve highresolution imaging of targets with arbitrary surfaces.Here,we propose a high spatiotemporal adaptive photoacoustic focusing mechanism through integrating a high-speed optical focuser,a time-of-flight contour deriving algorithm,and the rotary-scanning photoacoustic microscopy.The developed system,named high-speed adaptive photoacoustic microscopy(HA-PAM),features an ultrashort focus-shifting time of 5 ms and an enlarged DOF of up to 5 mm.With the assistance of the proposed mechanism,we can achieve a homogeneous lateral resolution of 6μm over a 10 mm circular imaging domain within 5 s.We demonstrate the advantages of HA-PAM through imaging phantoms with curved surfaces,subcutaneous tumor-bearing mice,resected rabbit kidneys,and pulsating mouse brains.The imaging results suggest that this approach provides a high and consistent spatial resolution for imaging bio-tissues with arbitrary surfaces without sacrificing the imaging speed,and has the potential to extend the fundamental and clinical applications of OR-PAM. | LINYANG LI WEI QIN TINGTING LI JUNNING ZHANG BAOCHEN LI LEI XI | 2023 | Photonics Research2023，11，12： | 0 |
| 9 | General synthesis of 2D rare-earth oxide single crystals with tailorable facets显示文摘Two-dimensional(2D)rare-earth oxides(REOs)are a large family of materials with various intriguing applications and precise facet control is essential for investigating new properties in the 2D limit.However,a bottleneck remains with regard to obtaining their 2D single crystals with specific facets because of the intrinsic non-layered structure and disparate thermodynamic stability of different facets.Herein,for the first time,we achieve the synthesis of a wide variety of high-quality 2D REO single crystals with tailorable facets via designing a hard-soft-acid-base couple for controlling the 2D nucleation of the predetermined facets and adjusting the growth mode and direction of crystals.Also,the facet-related magnetic properties of 2D REO single crystals were revealed.Our approach provides a foundation for further exploring other facet-dependent properties and various applications of 2D REO,as well as inspiration for the precise growth of other non-layered 2D materials. | Linyang Li Fangyun Lu Wenqi Xiong Yu Ding Yangyi Lu Yao Xiao Xin Tong Yao Wang Shuangfeng Jia Jianbo Wang Rafael GMendes Mark HRümmeli Shengjun Yuan Mengqi Zeng Lei Fu | 2022 | National Science Review2022，9，5： | 0 |
| 10 | Recent advances in photoelectrochemical sensors for detection of ions in water显示文摘Over the last 50 years,the explosive adoption of modern agricultural practices has led to an enormous increase in the emission of non-biodegradable and highly biotoxic ions into the hydrosphere.Excess intake of such ions,even essential trace elements such as Cu^(2+)and F^(-),can have serious consequences on human health.Therefore,to ensure safe drinking water and regulate wastewater discharge,photoelectrochemical(PEC)online sensors were developed,with advantages such as low energy consumption,inherent miniaturization,simple instrumentation,and fast response.However,there is no publicly available systematic review of the recent advances in PEC ion sensors available in the literature since January 2017.Thus,this review covers the various strategies that have been used to enhance the sensitivity,selectivity,and limit of detection for PEC ion sensors.The photoelectrochemically active materials,conductive substrates,electronic transfer,and performance of various PEC sensors are discussed in detail and divided into sections based on the measurement principle and detected ion species.We conclude this review by highlighting the challenges and potential future avenues of research associated with the development of novel high-performance PEC sensors. | Linyang Li Junlian Chen Chuanbao Xiao Yihao Luo Nianbing Zhong Quanhua Xie Haixing Chang Dengjie Zhong Yunlan Xu Mingfu Zhao Qiang Liao | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 11 | Gallium bismuth halide GaBi-X2 (X = I, Br, CI) monolayers with distorted hexagonal framework: Novel room- temperature quantum spin Hall insulators显示文摘有大拓扑地重要的体积差距的量旋转霍尔(QSH ) 绝缘体为 QSH 效果的未来应用是关键的。在这些之中,组 III-V 单层和他们的卤化物,有主席结构(常规六角形的框架) ,是广泛地学习了。用第一原则的计算,我们为 functionalized 组 III-V 单层提出一个新结构模型,它由矩形的 GaBi-X 2 组成(X = 我, Br, Cl ) 有一个弄歪的六角形的框架(DHF ) 的单层。这些结构与主席结构比 GaBi-X 2 单层有一个远更低的精力。显著地, DHF GaBi-X 2 单层都是 QSH 绝缘体,它展出从 0.17 ~ 0.39 eV 的可观的重要 bandgaps。bandgaps 能被使用联合力量的不同纺纱轨道广泛地调节,导致一个弄歪的迪拉克锥。 | Linyang Li Ortwin Leenaerts Xiangru Kong Xin Chen Mingwen Zhao Francois M. Peeters | 2017 | Nano Research2017，10，6： | 0 |
| 12 | Synthesis and application of highly sensitive fluorescent probe for Hg2+ regulated by sulfur显示文摘Rhodamine-based fluorescent probe is widely used in chemical analysis, environmental analysis and life sciences area due to their excellent optical properties. Based on the thiophilic property of Hg^(2+), using C = S structural motif as the core segment, our group have designed and synthesized three novel probes containing cinnamyl aldehyde with different substituents, exhibiting high selectivity and excellent sensitivity. The structure-property relationships of these probes have been investigated that the optical change caused by electron withdrawing effect and heavy atom effect. Furthermore, these Hg^(2+) probes could be applied in living mice imaging, which provide a promising tool for quantitative mercury(Ⅱ) ion imaging in living organism. | Siyue Ma Linyang Li Mengyao She Yan Mo Shengyong Zhang Ping Liu Jianli Li | 2017 | Chinese Chemical Letters2017，28，10： | 0 |
| 13 | Separation and analysis of six fractions in low temperature coal tar by column chromatography显示文摘The low temperature coal tar(CT)is taken as the raw material,and the extraction and column chromatography are used for detailed and accurate characterization in this paper.The n-heptane soluble fraction(CT-HS)and insoluble fraction(CT-HI)were obtained by n-heptane Soxhlet extraction.The extraction rate of CT-HS reached 92.79%(mass),which indicated that there are few heavy compounds in it.Further,different solvents(methylbenzene,benzene,ethyl acetate,methylbenzene-ethanol)were used to elute CT-HS by chromatographic column to obtain five fractions(saturates,aromatics,heteroatoms,phenolics and resins,named CT-SA,CT-AR,CT-HE,CT-PH,CT-RE,respectively).The yields of CTSA,CT-AR,CT-HE,CT-PH,CT-RE are 42.12%,10.43%,2.19%,9.50%and 6.63%(mass),respectively.Gas chromatography-mass spectrometry analysis of eluting components show that alkanes are the main components in CT,followed by polycyclic aromatics,and the corresponding fractions are CT-SA and CT-AR,respectively.The relative content of aliphatics in CT-SA is 76.93%,and the relative content of aromatics in CT-AR is 75.05%.This separation technology effectively separates and enriches different components in CT,and the activation energy required for the pyrolysis process of a single eluting fraction is lower than that of CT,which is expected to provide an important reference for the separation,analysis and conversion of complex oil products such as coal-oil co-processing products,coal tar and other complex heavy carbon oil products. | Shuangtai Liu Lei He Qiuxiang Yao Xi Li Linyang Wang Jing Wang Ming Sun Xiaoxun Ma | 2023 | Chinese Journal of Chemical Engineering2023，58，6： | 0 |
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