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| 1 | Novel Graphene Biosensor Based on the Functionalization of Multifunctional Nano-bovine Serum Albumin for the Highly Sensitive Detection of Cancer Biomarkers显示文摘A simple,convenient,and highly sensitive bio-interface for graphene field-effect transistors(GFETs) based on multifunctional nano-denatured bovine serum albumin(nano-dBSA) functionalization was developed to target cancer bio-markers.The novel graphene–protein bioelectronic interface was constructed by heating to denature native BSA on the graphene substrate surface.The formed nano-d BSA film served as the cross-linker to immobilize monoclonal antibody against car-cinoembryonic antigen(anti-CEA mAb) on the graphene channel activated by EDC and Sulfo-NHS.The nano-dBSA film worked as a self-protecting layer of graphene to prevent surface contamination by lithographic processing.The improved GFETbiosensor exhibited good specificity and high sensitivity toward the target at an ultralow concentration of 337.58 fg mL-1.The electrical detection of the binding of CEA followed the Hill model for ligand–receptor interaction,indicating the negative binding cooperativity between CEA and anti-CEA mAb with a dissociation constant of 6.82×10-10M.The multifunctional nano-dBSA functionalization can confer a new function to graphene-like 2D nanomaterials and provide a promising bio-functionalization method for clinical application in biosensing,nanomedicine,and drug delivery. | Lin Zhou Kun Wang Hao Sun Simin Zhao Xianfeng Chen Dahong Qian Hongju Mao Jianlong Zhao | 2019 | Nano-Micro Letters2019，11，2： | 1 |
| 2 | Cadmium( II) Removal by Modified Zeolitefrom Micro-polluted Water显示文摘 | Li Mingyu Zhu Xiaoqiang Lin Dahong Chen Weiling andRen Gang | 2011 | Environmental EngineeringScience2011，28，10： | 1 |
| 3 | Enteric Mucosal Immune Response might Trigger the Immunomodulation Activity of Ganoderma lucidum Polysaccharide in Mice显示文摘 | Hongyan Zhao Yingying Luo Cheng Lu Na Lin Cheng Xiao Shuhong Guan De-an Guo Zhenli Liu Dahong Ju Xiaojuan He Aiping Lu | 2010 | Planta Med2010，，03： | 1 |
| 4 | Enteric Mucosal Immune Response might Trigger the Immunomodulation Activity of Ganoderma lucidum Polysaccharide in Mice显示文摘 | Hongyan Zhao Yingying Luo Cheng Lu Na Lin Cheng Xiao Shuhong Guan De-an Guo Zhenli Liu Dahong Ju Xiaojuan He Aiping Lu | 2010 | Planta Med2010，，03： | 1 |
| 5 | A Collaborative Minor in Computational Physics显示文摘 | Kevin Daimi, Xiaohui Zhong Dahong Li Qinghua Lin | 2014 | US-China Education Review(A)2014，4，7： | 0 |
| 6 | Alkaloid Dimers Isolated from Thalictrum baicalense Have Antitumor Activities显示文摘Comprehensive Summary A pair of heterodimeric isoquinoline alkaloid enantiomers,(+)thaliberberine A,five new thalifaberine-type aporphine-benzylisoquinoline(ABl)alkaloids,thalicultratines M-Q,and thirteen known analogues were isolated from the roots of Thalictrum baicalense Turcz.ex Ledeb.The structures were determined by extensive spectroscopic methods and ECD calculations.Thaliberberine A featuring a novel carbon skeleton coupled by two different classes of isoquinoline alkaloids,protoberberine and phthalidoisoquinoline,represents the first natural product with the berberine skeleton substituted at C-6.Plausible biosynthetic routes of 1 are proposed. | Jingjing Xue Yuetong Wang Fangshen Liu Hangao Yang Bin Lin Zhanlin Li Yongkui Jing Dahong Li Huiming Hua | 2022 | Chinese Journal of Chemistry2022，40，15： | 0 |
| 7 | β-Carboline alkaloids from the roots of Peganum harmala L.显示文摘This study reports the isolation of four newβ-carboline alkaloids(1−4)and six previously identified alkaloids(5−10)from the roots of Peganum harmala L.Among these compounds,1 and 2 were characterized as rareβ-carboline-quinazoline dimers exhibiting axial chirality.Compound 3 possessed a unique 6/5/6/7 tetracyclic ring system with an azepine ring,and compound 4 was a novel annomontineβ-carboline.The structures of these compounds were elucidated by spectroscopic data and quantum mechanical calculations.The biosynthetic pathways of 1−3 were proposed.Additionally,the cytotoxicity of some isolates against four cancer cell lines(HL-60,A549,MDA-MB-231,and DU145)was evaluated.Notably,compound 4 exhibited significant cytotoxicity against HL-60,A549,and DU145 cells with IC_(50) values of 12.39,12.80,and 30.65μmol·L^(−1),respectively.Furthermore,compound 2 demonstrated selective cytotoxicity against HL-60 cells with an IC_(50) value of 17.32μmol·L^(−1). | LI Shengge ZHANG Qin WANG Yuetong LIN Bin LI Dahong HUA Huiming HU Xu | 2024 | Chinese Journal of Natural Medicines2024，22，2： | 0 |
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