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| 1 | Wogonoside inhibits tumor growth and metastasis in endometrial cancer via ER stress-Hippo signaling axis显示文摘Wogonoside,a bioactive flavonoid component derived from Scutellaria baicalensis Georgi,has been reported to inhibit tumor growth in mice bearing various types of cancer cells such as breast cancer,lung cancer,and leukemia cells.However,whether wogonoside could inhibit tumor growth of endometrial cancer has not been elucidated.In this study,we explored the function of wogonoside on tumor growth and the underlying mechanism on endometrial cancer.Firstly,we investigated the effect of wogonoside on endometrial cancer cells and found that wogonoside could significantly decrease cell proliferation and metastasis.Mechanistically,wogonoside could aggravate the extent of ER stress and upregulate the phosphorylation level of Mammalian Ste20-like kinase 1,leading to the activation of the Hippo signaling pathway.Taken together,in vitro and in vivo data demonstrated that wogonoside could be a potent inducer of ER stress and could be further developed into a promising therapy for endometrial cancer. | Shaorong Chen Zhuna Wu Yumin Ke Pingping Shu Caihong Chen Ruying Lin Qirong Shi | 2019 | Acta Biochimica et Biophysica Sinica2019，51，11： | 8 |
| 2 | Preparation, characterization, antimicrobial and cytotoxicity studies of copper/zincloaded montmorillonite显示文摘Background: A series of modified montmorillonites(Mt) including zinc-loaded Mt(Zn-Mt), copper-loaded Mt(Cu-Mt), copper/zinc-loaded Mt with different Cu/Zn ratio(Cu/Zn-Mt-1, Cu/Zn-Mt-2, Cu/Zn-Mt-3) were prepared by an ion-exchange reaction, and characterized using X-ray diffraction(XRD), fourier transformed infrared spectroscopy(FTIR) and transmission electron microscopy(TEM). The specific surface areas, antimicrobial activity and cytotoxicity of the modified Mt were investigated.Results: In the modified Mt, hydrated Cu ions and Zn ions were exchanged in the interlayer space of Mt and the particles were irregular shapes. The results showed that Cu/Zn-Mt enhanced antibacterial and antifungal activity compared with Zn-Mt and Cu-Mt possibly due to the synergistic effect between Cu and Zn. Among the Cu/Zn-Mt with different Cu/Zn raitos, Cu/Zn-Mt with a Cu/Zn ratio of 0.98 or 0.51 showed higher antimicrobial activity against gram-negative bacteria(Escherichia coli), gram-positive bacteria(Staphylococcus aureus), fungi(Candida albicans).Moreover, the antimicrobial activity of Cu/Zn-Mt was correlated with its specific surface area. Cytotoxicity studies on IPEC-J2 cell showed a slight cytotoxicity of Cu/Zn-Mt.Conclusions: The current data provide clear evidence that in terms of its antimicrobial activity and relatively low toxicity, the Cu/Zn-Mt holds great promise for applications in animal husbandry. | Lefei Jiao Fanghui Lin Shuting Cao Chunchun Wang Huan Wu Miaoan Shu Caihong Hu | 2017 | Journal of Animal Science and Biotechnology2017，8，3： | 4 |
| 3 | Similar Ability of FbaA with M Protein to Elicit Protective Immunity Against Group A Streptococcus Challenge in Mice显示文摘Group A streptococcus(GAS),an important human pathogen,can cause various kinds of infections including superficial infections and potentially lethal infections,and the search for an effective vaccine to prevent GAS infections has been ongoing for many years. This paper compares the immunogenicity and immunoprotection of FbaA(an Fn-binding protein expressed on the surface of GAS) with that of M protein,the best immunogen of GAS. Assay for immune response showed that FbaA,similar to M protein,could induce protein-specific high IgG titer in BALB/c mice. Furthermore,following GAS challenge,the mice immunized with FbaA showed the same protective rate as those with M protein. These results indicate that FbaA is similar in ability to M protein in inducing protective immunity against GAS challenge in mice. | Cuiqing Ma Caihong Li Xiurong Wang Ruihong Zeng Xiaolin Yin Huidong Feng Lin Wei | 2009 | Cellular & Molecular Immunology2009，6，1： | 4 |
| 4 | Dihydromyricetin promotes apoptosis, suppresses proliferation and tumor necrosis factor-α-mediated nuclear factor kappa-B activation in nasopharyngeal carcinoma CNE-2 cells显示文摘OBJECTIVE: To investigate the efficacy of dihydromyricetin(DMY) on nasopharyngeal carcinoma(NPC) cell proliferation, apoptosis and to reveal the underlying mechanism in vitro experiments.METHODS: The CNE-2 cell line was treated with different concentrations of DMY and the effects of DMY on cell viability and proliferation were evaluated using cell counting kit-8(CCK-8) assay and plate colony formation assay. Cellular apoptosis was detected by flow cytometry following Annexin V fluorescein isothiocyanate/propidine iodide staining.Nuclei morphology was observed under a fluorescence microscope following Hoechst 333258 staining. The expression of phosphorylated inhibitor of nuclear factor kappa-B kinase subunit beta(p-IKKβ), phosphorylated inhibitor of nuclear factor kappa-B kinase subunit alpha(p-IKKα), inhibitor of nuclear factor kappa-B alpha(IκB-α), nuclear factor kappa-B(NF-κB)/p65 was examined by Western blot analysis and the nuclear translocation of NF-κB/p65 was observed using a confocal laser scanning microscopy.RESULTS: DMY inhibited the proliferative capability and colony formation of NPC CNE-2 cells. Meanwhile, DMY induced apoptosis of CNE-2 cells in a dose and time-dependent manner via upregulating B-cell lymphoma-2 associated X, but downregulating B-cell lymphoma-2 and pro-caspase-3. Importantly, we found that DMY suppressed tumor necrosis factor alpha(TNF-α)-mediated NF-κB activation via inhibiting p-IKKβ, p-IKKα and blocking NF-κB subunit p65.CONCLUSION: Our experiments demonstrated that DMY had significant antiproliferative and apoptosisinducing effects on CNE-2 cells. Additionally, DMY promoted inactivation of p-IKKβ, p-IKKα,and blocked the nuclear translocation of NF-κB subunit p65. These results suggest that DMY may be an important therapeutic approach for NPC. | LI Caihong SHI Jinlian HUANG Bo DING Hang LIN Hanguang ZENG Jincheng ZHAO Yang LUO Guoqing | 2021 | Journal of Traditional Chinese Medicine2021，41，3： | 3 |
| 5 | Generation and characterization of stable pig pregastrulation epiblast stem cell lines显示文摘Pig epiblast-derived pluripotent stem cells are considered to have great potential and broad prospects for human therapeutic model developme nt and livestock breeding.Despite on going attempts since the 1990s,no stably defined pig epiblast-derived stem cell line has bee n established.Here,guided by in sights from a large-scale sin gle-cell tran scriptome an alysis of pig embryos from embryonic day(E)0 to E14,specifically,the tracing of pluripotency changes during epiblast development,we developed an in vitro culture medium for establishing and maintaining stable pluripotent stem cell lines from pig E10 pregastrulation epiblasts(pgEpiSCs).Enabled by chemical inhibition of WNT-related signaling in combination with growth factors in the FGF/ERK,JAK/STAT3,and Activin/Nodal pathways,pgEpiSCs maintain their pluripotency transcriptome features,similar to those of E10 epiblast cells,and normal karyotypes after more than 240 passages and have the potential to differentiate into three germ layers.Strikingly,ultradeep in situ Hi-C analysis revealed functional impacts of chromatin 3D-spatial associations on the transcriptional regulation of pluripote ncy marker genes in pgEpiSCs.I n practice,we con firmed that pgEpiSCs readily tolerate at least three rounds of successive gene editi ng and gene rated cloned gen e-edited live piglets.Our findings deliver on the long-a nticipated promise of pig pluripote nt stem cells and open new avenues for biological research,animal husbandry,and regenerative biomedicine. | Minglei Zhi Jinying Zhang Qianzi Tang Dawei Yu Shuai Gao Dengfeng Gao Pengliang Liu Jianxiong Guo Tang Hai Jie Gao Suying Cao Zimo Zhao Chongyang Li Xiaogang Weng Mengnan He Tianzhi Chen Yingjie Wang Keren Long Deling Jiao Guanglei Li Jiaman Zhang Yan Liu Yu Lin Daxin Pang Qianqian Zhu Naixin Chen Jingjing Huang Xinze Chen Yixuan Yao Jingcang Yang Zicong Xie Xianya Huang Mengxin Liu Ran Zhang Qiuyan Li Yiliang Miao Jianhui Tian Xingxu Huang Hongsheng Ouyang Bofeng Liu Wei Xie Qi Zhou Zhonghua Liu Caihong Zheng Mingzhou Li Jianyong Han | 2022 | Cell Research2022，32，4： | 3 |
| 6 | Insights into the functional group transformation of a Chinese brown coal during slow pyrolysis by combining various experiments显示文摘 | Lin Xiongchao Wang Caihong Keiko Ideta | 2014 | Fuel2014，118，： | 1 |
| 7 | A rare variant in COL11A1 is strongly associated with adult height in Chinese Han population显示文摘Human height is a highly heritable trait in which multiple genes are involved. Recent genome-wide association studies(GWASs) have identified that COL11A1 is an important susceptibility gene for human height. To determine whether the variants of COL11A1 are associated with adult and children height,we analyzed splicing and coding single-nucleotide variants across COL11A1 through exome-targeted sequencing and two validation stages with a total 20,426 Chinese Han samples. A total of 105 variants were identified by exome-targeted sequencing, of which 30 SNPs were located in coding region. The strongest association signal was chr1_103380393 with P value of 4.8 * 10^(-7). Chr1_103380393 also showed nominal significance in the validation stage(P = 1.21 * 10^(-6)). Combined analysis of 16,738 samples strengthened the original association of chr1_103380393 with adult height(P_(combined)= 3.1 * 10^(-8)), with an increased height of 0.292sd(standard deviation) per G allele(95% CI:0.19-0.40). There was no evidence(P = 0.843) showing that chr1_103380393 altered child height in 3688 child samples. Only the group of 12-15 years showed slight significance with P value of 0.0258.This study firstly shows that genetic variants of COL11A1 contribute to adult height in Chinese Han population but not to children height, which expand our knowledge of the genetic factors underlying height variation and the biological regulation of human height. | Changbing Shen Xiaodong Zheng Jing Gao Caihong Zhu Randy Ko Xianfa Tang Chao Yang Jinfa Dou Yan Lin Yuyan Cheng Lu Liu Shuangjun Xu Gang Chen Xianbo Zuo Xianyong Yin Liangdan Sun Yong Cui Sen Yang Xuejun Zhang Fusheng Zhou | 2016 | Journal of Genetics and Genomics2016，43，9： | 1 |
| 8 | Wi-Fi based non-invasive detection of indoor wandering using LSTM model显示文摘Wandering is a significant indicator in the clinical diagnosis of dementia and other related diseases for elders.Reliable monitoring of long-term continuous movement in indoor setting for detection of wandering movement is challenging because most elders are prone to forget to carry or wear sensors that collect motion information daily due to their declining memory.Wi-Fi as an emerging sensing modality has been widely used to monitor human indoor movement in a noninvasive manner.In order to continuously monitor individuals’indoor motion and reliably identify wandering movement in a non-invasive manner,in this work,we develop a LSTMbased deep classification method that is able to differentiate the wandering-causedWi-Fi signal change from the others.Specifically,we first use the off-the-shelf Wi-Fi devices to capture a resident’s indoor motion information,enabling to collect a group ofWi-Fi signal streams,which will be split into variablesize segments.Second,the deep network LSTM is adopted to develop wandering detection method that is able to classify every variable-size segment of Wi-Fi signals into categories according to the well-known wandering spatiotemporal patterns.Last,experimental evaluation conducted on a group of realworld Wi-Fi signal streams shows that our proposed LSTMbased detection method is workable and effective to identify indoor wandering behavior,obtaining an average value of 0.9286,0.9618,0.9634 and 0.9619 for accuracy,precision,recall and F-1 score,respectively. | Qiang LIN Yusheng HAO Caihong LIU | 2021 | Frontiers of Computer Science2021，15，6： | 0 |
| 9 | Angiotensin-converting enzyme 2 regulates mitochondrial function to preserve dorsal root ganglion neuron lipid metabolism after peripheral nervous injury显示文摘Mitochondrial function affected lipids metabolism.However,studies examining the nervous system have primarily focused on metabolism of glucose and have largely neglected to examine the metabolism of fatty acids.We investigated the effects of angiotensin-converting enzyme 2(ACE2)on mitochondrial function in DRG neuron lipid meta'bolism.The expression of long chain acyl-CoA synthetase(ACSL1-6)and genes related to mitochondrial function in DRGs of ACE2 knockout mice and Ad-ACE2-treated chronic constriction injury(CCI)rats were analyzed by q-PCR.Under the same condition,the lipid peroxide(LPO)content,fatty acid content. | Zhang Yidan Lin CaiHong Cao Jing Zang Weidong | 2021 | 解剖学杂志2021，44，S01： | 0 |
| 10 | Experimental Characterization and Model Verification of Thermal Conductivity from Mesoporous to Macroporous SiOC Ceramics显示文摘Based on the chemical cross-linking method,this paper uses polydimethylsiloxane with various viscosities of 10 cSt,20 cSt,50 cSt,and 100 cSt to synthesize mesoporous and macroporous SiOC ceramics.Their thermal conductivities are measured by using 3ωmethod with high accuracy.Three typical models for their thermal conductivities,i.e.,series model(SM),maxwell-Eucken 1 model(ME1),and effective medium theory(EMT)model,are utilized to derive the empirical formula through the multi-parameter linear optimization algorithm,which agrees well with the experimental results.The effects of pore size and specific surface area on the overall thermal conductivity of the porous structure are explored.Interestingly,it is found that the thermal conductivities of both gas phase and solid phase inside the porous structure increase with the increasing pore size at the nanometer scale,but the overall thermal conductivity of the porous structure decreases with the increasing pore size.Scanning electron microscopy graphs corroborate that the extension of the heat transfer route and the barrier of more pores between the solid phases together cause the reduction of the gas-solid coupling thermal conductivity of SiOC ceramics with larger pore size.On the contrary,the miniaturization of individual particles through modulating the synthesis parameters can increase the number of small pores in the sample itself to meet the pseudo-lattice vibration conditions,which results in the increment of the gas-solid coupling thermal conductivity and the overall thermal conductivity of the porous structure.These findings would provide meaningful guidance for designing SiOC porous ceramic super-insulation materials with extremely low thermal conductivity. | QIU Lin DU Yanbo BAI Yangyang FENG Yanhui ZHANG Xinxin WU Jin WANG Xiaotian XU Caihong | 2021 | Journal of Thermal Science2021，30，2： | 0 |
| 11 | Exploration on Innovation in Planning and Design of Pastoral Complex显示文摘Based on the background and development of the pastoral complex,it is believed that the pastoral complex is an inevitable trend of the development of modern agriculture and it is the product of agriculture developing to a higher stage following agricultural industrial park,beautiful countryside,characteristic town,and whole area tourism. Combined with many years of planning and design practice of Wuhan Modern Urban Agriculture Planning and Design Institute,this paper summarized ideas of construction and operation of the pastoral complex,and discussed the construction of pastoral complex planning system,in the hope of providing certain reference for planning of pastoral complex in the whole country in the new period. Finally,through the overview of development history and highlight of urban agriculture in Wuhan,it came up with measures and recommendations for development of pastoral complex in Wuhan City. | Qin LI Chao ZHOU Qiaofeng DONG Zhonghua HE Caihong XIAO Yumin LIN | 2017 | Asian Agricultural Research2017，9，10： | 0 |
| 12 | Intelligent Fast Cell Association Scheme Based on Deep Q-Learning in Ultra-Dense Cellular Networks显示文摘To support dramatically increased traffic loads,communication networks become ultra-dense.Traditional cell association(CA)schemes are timeconsuming,forcing researchers to seek fast schemes.This paper proposes a deep Q-learning based scheme,whose main idea is to train a deep neural network(DNN)to calculate the Q values of all the state-action pairs and the cell holding the maximum Q value is associated.In the training stage,the intelligent agent continuously generates samples through the trial-anderror method to train the DNN until convergence.In the application stage,state vectors of all the users are inputted to the trained DNN to quickly obtain a satisfied CA result of a scenario with the same BS locations and user distribution.Simulations demonstrate that the proposed scheme provides satisfied CA results in a computational time several orders of magnitudes shorter than traditional schemes.Meanwhile,performance metrics,such as capacity and fairness,can be guaranteed. | Jinhua Pan Lusheng Wang Hai Lin Zhiheng Zha Caihong Kai | 2021 | China Communications2021，18，2： | 0 |
| 13 | Polynomial-Time Assignment-Based Cell Association with Generic Utility Functions显示文摘Cell association is a significant research issue in future mobile communication systems due to the unacceptably large computational time of traditional schemes.This article proposes a polynomial-time cell association scheme which not only completes the association in polynomial time but also fits for a generic optimization objective function.On the one hand,traditional cell association as a non-deterministic polynomial(NP)hard problem with a generic utility function is heuristically transformed into a 2-dimensional assignment optimization and solved by a certain polynomial-time algorithm,which significantly saves computational time.On the other hand,the scheme jointly considers utility maximization and load balancing among multiple base stations(BSs)by maintaining an experience pool storing a set of weighting factor values and their corresponding performances.When an association optimization is required,a suitable weighting factor value is taken from the pool to calculate a long square utility matrix and a certain polynomial-time algorithm will be applied for the association.Comparing with several representative schemes,the proposed scheme achieves large system capacity and high fairness within a relatively short computational time. | Lusheng Wang Chao Fang Hai Lin Min Peng Caihong Kai | 2022 | China Communications2022，19，9： | 0 |
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