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| 1 | Overexpressed miR-9 promotes tumor metastasis via targeting E-cadherin in serous ovarian cancer显示文摘MicroRNAs (miRNAs ) 玩在在各种各样的癌症的发展和前进的关键角色。不正常的 miR-9 表示仍然保持模糊,并且卵巢的癌症的变形前进上的一致都没被到达。在这研究,从生物信息学分析的结果证明 E-cadherin mRNA 的 3-UTR 被 miR-9 直接调整。酶记者试金结果证实 miR-9 能直接指向这 3-UTR。在卵巢的癌症织物的 miR-9 和 E-cadherin 表示被 qRT-PCR 确定。移植和侵略被在 SKOV3 和 A2780 愈合弯屈和 Transwell 系统试金检测。qRT-PCR 和西方的污点被执行检测上皮 ? 间充质的联系转变的 mRNA 和蛋白质。Immunofluorescence 技术被用来分析表示和 E-cadherin, N-cadherin,和 vimentin 的 subcellular 本地化。结果证明 miR-9 经常与配对的主要的相比是在变形浆液的卵巢的癌症织物的 upregulated。miR-9 的 Upregulation 能 downregulate E-cadherin 的表示但是 upregulate 间充质的标记(N-cadherin 和 vimentin ) 的表示。miR-9 的 Overexpression 能在卵巢的癌症支持房间移植和侵略,并且这些进程能有效地经由 miR-9 禁止者被禁止。因此,我们的学习证明 miR-9 可以经由指向 E-cadherin 和一条新奇潜在的治疗学的途径控制卵巢的癌症的转移支持卵巢的癌症转移。 | Bo Zhou Hongbin Xu Meng Xia Chaoyang Sun Na Li Ensong Guo Lili Guo Wanying Shan Hao Lu Yifan Wu Yuan Li Degui Yang Danhui Weng Li Meng Junbo Hu Ding Ma Gang Chen Kezhen Li | 2017 | Frontiers of Medicine2017，11，2： | 10 |
| 2 | Sand-fixing characteristics of Carex brunnescens and its application with straw checkerboard technique in restoration of degraded alpine meadows显示文摘Carex brunnescens(Pers.), a typical clonal species, is considered to be the only herb found to date that can develop on sand dunes in Maqu alpine region of northwestern China. However, the characteristics that C. brunnescens resists to harsh alpine environment have not been documented. In this study, we conducted a field investigation to determine the morphological, reproductive, and sand-fixing characteristics of C. brunnescens. Concomitantly, we transplanted the belowground rhizomes of C. brunnescens to sand dunes and compared the abilities to restore degraded alpine meadows among sand dunes that had no further treatment(SD+N), sand dunes that had straw checkerboard technique but no transplanted rhizomes of C. brunnescens(SD+SCT), and sand dunes that had both SCT and transplanted rhizomes of C. brunnescens(SD+SCT+P). We found that belowground vertical rhizomes and horizontal rhizomes(including branching rhizomes and main rhizomes) of C. brunnescens were highly developed and that population reproduction was dominated by horizontal rhizomes. C. brunnescens exhibited a significant sand-fixation effect under following conditions: population density was 145–156 ramets/m^2, vegetation cover was 31.2%–39.3%, total length of belowground rhizomes was 11,223 cm/m^2, total length of belowground first-order roots was 9161–10,524 cm/m^2, fresh weight of aboveground part was 198.5–212.6 g/m^2, and fresh weight of belowground part was 578.8–612.4 g/m^2. It should be particularly noted that SD+SCT+P treatment(sand dunes that had both straw checkerboard technique and transplanted rhizomes of C. brunnescens) was the best and SD+N(sand dunes that had no further treatment) was the worst in terms of following biotic indicators: total number of reproductive ramets, total number of belowground rhizomes, and fresh weight of aboveground and belowground parts of C. brunnescens, contents of soil organic carbon, available nitrogen, microbial biomass carbon, and microbial biomass nitrogen. It implies that applying SCT in sand dunes and transplanting belowground rhizomes to sand dunes with SCT could improve both soil fertility and growth of C. brunnescens. These results suggest that the SCT-promoted high reproductive abilities of belowground rhizomes of C. brunnescens can successfully facilitate the establishment of ramets and can thus be an effective strategy to restore degraded vegetation in Maqu alpine region of northwestern China. | KANG Jianjun ZHAO Ming TAN Yanrong ZHU li BING Danhui ZHANG Yangdong TONG Shengli | 2017 | Journal of Arid Land2017，9，5： | 4 |
| 3 | Chemotherapy initiation with single-course methotrexate alone or combined with dactinomycin versus multi-course methotrexate for low-risk gestational trophoblastic neoplasia: a multi-centric randomized clinical trial显示文摘We aimed to evaluate the effectiveness and safety of single-course initial regimens in patients with low-risk gestational trophoblastic neoplasia(GTN).In this trial (NCT01823315),276 patients were analyzed.Patients were allocated to three initiated regimens:single-course methotrexate(MTX),single-course MTX+dactinomycin(ACTD),and multi-course MTX(control arm).The primary endpoint was the complete remission(CR)rate by initial drug(s).The primary CR rate was 64.4%with multi-course MTX in the control arm.For the single-course MTX arm,the CR rate was 35.8%by one course;it increased to 59.3%after subsequent multi-course MTX,with non-inferiority to the control(difference-5.1%,95%confidence interval(CI)-19.4%to 9.2%,P=0.014).After further treatment with multi-course ACTD,the CR rate(93.3%)was similar to that of the control(95.2%,P=0.577).For the single-course MTX+ACTD arm,the CR rate was 46.7%by one course,which increased to 89.1%after subsequent multi-course,with non-inferiority(difference 24.7%,95%CI 12.8%-36.6%,P<0.001)to the control.It was similar to the CR rate by MTX and further ACTD in the control arm(89.1%vs.95.2%,P=0.135).Four patients experienced recurrence,with no death,during the 2-year follow-up.We demonstrated that chemotherapy initiation with single-course MTX may be an alternative regimen for patients with low-risk GTN. | Lili Chen Ling Xi Jie Jiang Rutie Yin Pengpeng Qu Xiuqin Li Xiaoyun Wan Yaxia Chen Dongxiao Hu Yuyan Mao Zimin Pan Xiaodong Cheng Xinyu Wang Qingli Li Danhui Weng Xi Zhang Hong Zhang Quanhong Ping Xiaomei Liu Xing Xie Beihua Kong Ding Ma Weiguo Lu | 2022 | Frontiers of Medicine2022，16，2： | 2 |
| 4 | Changes of plant species diversity and biomass with reclaimed marshes restoration显示文摘Wetland restoration had been implemented for more than two decades in Sanjiang Plain,Northeast China.To assess the restoration effi ciency of wetland vegetation,we investigated plants composition of community,plant species diversity and aboveground biomass of restored sites in a chronosequence of restoration(1,2,3,6,8,11,15 and 25 years)in the Sanjiang Nature Reserve.As comparison,we also investigated the same factors in a cropland and a natural marsh adjacent to the restored sites.The results showed that wetland plant species can invade quickly after croplands were abandoned when there were suitable hydrology conditions.On the early stage of the restoration,weeds were main plant species in the restored sites.Wetland species appeared at the same time but diff ered from the dominant species from the adjacent natural marshes.Common native wetland species could dominance the community after 3-year restoration.Species richness and diversity increased on the early stage,and then decreased to the similar level of the natural marsh with the extension of restoration.Plant biomass could restore easier than the species composition and diversity.Our results indicated that plant species composition and diversity of abandoned reclaimed wetlands can restore gradually by natural succession in Sanjiang Plain.However,25-year restoration site had similarity index of only 56%with the natural marsh,which revealed that two decades are not enough for complete restoration of vegetation. | Xin Jin Xiaoxin Sun Haixing Li Danhui Zhao Dong Li Lei Wang Xiuling Man | 2021 | Journal of Forestry Research2021，32，1： | 2 |
| 5 | Physiology and patha physiology of mitochondrial DNA显示文摘 | Hongzhi Li Danhui Liu Jianxin Lu | 2012 | Adv Exp Med Bi- ol2012，942，： | 1 |
| 6 | Correlation of TWIST2 up-regulation and epithelial–mesenchymal transition during tumorigenesis and progression of cervical carcinoma显示文摘 | Yan Li Wei Wang Wenwen Wang Runfeng Yang Tian Wang Tiefen Su Danhui Weng Tao Tao Wei Li Ding Ma Shixuan Wang | 2011 | Gynecologic Oncology2011，，1： | 1 |
| 7 | Magnetic field sensor based on asymmetric optical fiber taper and magnetic fluid显示文摘 | Ming Deng Danhui Liu Decai Li | 2014 | Physical2014，，： | 1 |
| 8 | Solidification of Mg-Zn-Zr Alloys:Grain Growth Restriction,Dendrite Coherency and Grain Size显示文摘The solidification characterization of Mg-xZn-0.5Zr(x=0,1,3,4,5 wt%)alloys has been extensively investigated through thermal analysis,microstructure characterization and thermodynamic calculations.The impact of Zn content on the grain growth restriction,dendrite coherency and thus the final grain size has been investigated and discussed.Increasing Zn content,the grain size of Mg-xZn-0.5Zr alloy was firstly refined and then coarsened with the finest grain size of^50μm for the Mg-3 Zn-0.5 Zr(ZK31)alloy.Significant effects of the grain size on the mechanical properties were observed in the investigated alloys.The combination of growth restriction factor theory and dendrite coherency point provides a reasonable explanation of the grain size results.It helps to further understand the mechanisms of grain refinement and grain coarsening related to solute content,providing reference for alloy design and grain size prediction. | Pei Li Danhui Hou En-Hou Han Rongshi Chen Zhiwei Shan | 2020 | Acta Metallurgica Sinica(English Letters)2020，33，11： | 1 |
| 9 | Effect of the cyclin-dependent kinases inhibitor p27 on resistance of ovarian cancer multicellular spheroids to anticancer chemotherapy显示文摘 | Hui Xing Shixuan Wang Keqin Hu Wenming Tao Jing Li Qinglai Gao Xiaokui Yang Danhui Weng Yunpin Lu Ding Ma | 2005 | Journal of Cancer Research and Clinical Oncology2005，，8： | 1 |
| 10 | An ab initio study on boundaries for characterizing cooperative effect of hydrogen bonds by intermolecular compression显示文摘The cooperative effect plays a significant role in understanding the intermolecular donor-acceptor interactions of hydrogen bonds(H-bonds, D-H···A). Here, using the coupled-cluster singles and doubles with perturbative triple excitations(CCSD(T)) method of high-precision ab initio calculations, we show that the intermolecular H-bonded systems with different D and A atoms reproduce the structural changes predicted by the well-known cooperative effect upon intermolecular compression. That is, with decreasing intermolecular distance, the D-H bond length first increases and then decreases, while the H···A distance decreases. On the contrary, when D and A are the same, as the intermolecular distance decreases, the D-H bond length decreases without increasing. This obvious difference means that the cooperative effect may not be generally characterized by intermolecular compression. Interestingly, further analyses of many intermolecular systems confirm that this failure has boundaries, i.e., cooperative systems at their respective equilibrium positions have a smaller core-valence bifurcation(CVB) index(<0.022) and stronger binding energies(>0.25 eV), showing a clear linear inverse relationship related to H-bond strength. These findings provide an important reference for the comprehensive understanding of H-bonds and its calculation methods. | Rui Liu Rui Wang Danhui Li Yu Zhu Xinrui Yang Zhigang Wang | 2023 | Chinese Chemical Letters2023，34，7： | 0 |
| 11 | Refractory black carbon aerosols in rainwater in the summer of 2019 in Beijing:Mass concentration,size distribution and wet scavenging ratio显示文摘Black carbon(BC)aerosols in the atmosphere play a significant role in climate systems due to their strong ability to absorb solar radiation.The lifetime of BC depends on atmospheric transport,aging and consequently on wet scavenging processes(in-cloud and below-cloud scavenging).In this study,sequential rainwater samples in eight rainfall events collected in 2 mm interval were measured by a tandem system including a single particle soot photometer(SP2)and a nebulizer.The results showed that the volume-weighted average(VWA)mass concentrations of refractory black carbon(rBC)in each rainfall event varied,ranging from 10.8 to 78.9μg/L.The highest rBC concentrations in the rainwater samples typically occurred in the first fraction from individual rainfall events.The geometric mean median mass-equivalent diameter(MMD)decreased under precipitation,indicating that rBC with larger sizes was relatively aged and preferentially removed by wet scavenging.A positive correlation(R2=0.73)between the VWA mass concentrations of rBC in rainwater and that in ambient air suggested the important contribution of scavenging process.Additionally,the contributions of in-cloud and below-cloud scavenging were distinguished and accounted for 74%and 26%to wet scavenging,respectively.The scavenging ratio of rBC particles was estimated to be 0.06 on average.This study provides helpful information for better understanding the mechanism of rBC wet scavenging and reducing the uncertainty of numerical simulations of the climate effects of rBC. | Shandong Lei Baozhu Ge Hang Liu Jiannong Quan Danhui Xu Yuting Zhang Weijie Yao Lu Lei Yu Tian Qi Liao Xiaoyong Liu Jie Li Jinyuan Xin Yele Sun Pingqing Fu Junji Cao Zifa Wang Xiaole Pan | 2023 | Journal of Environmental Sciences2023，，10： | 0 |
| 12 | Comrades plus Brothers: Sino-Soviet Border Re-lations in the 1950s显示文摘中苏边界关系的发展变化,有着深厚的中苏两党两国关系演变的背景。1950年代,随着中苏两国同盟关系的建立和巩固,在社会主义阵营共同利益和中苏国家关系意识形态标准的约束下,中苏国界成为两国共同的边界,苏联的国防力量承担着保卫中国边界的任务。中共搁置历史遗留的中苏边界问题,双方边界关系呈现出同志加兄弟的亲密状态。1958年中国准备解决中苏边界问题后,尽管中苏两党分歧加深,但在中共加强同苏联团结的总方针指导下,有关中苏边界的调研工作平稳进行。中苏边界一直是一条基本和睦的边界。 | Li Danhui*Wu Ying | 2005 | Social Sciences in China2005，26，2： | 0 |
| 13 | Adjuvant chemotherapy versus adjuvant concurrent chemoradiotherapy after radical surgery for early-stage cervical cancer:a randomized,non-inferiority,multicenter trial显示文摘We conducted a prospective study to assess the non-inferiority of adjuvant chemotherapy alone versus adjuvant concurrent chemoradiotherapy (CCRT) as an alternative strategy for patients with early-stage (FIGO 2009 stage IB–IIA) cervical cancer having risk factors after surgery. The condition was assessed in terms of prognosis, adverse effects, and quality of life. This randomized trial involved nine centers across China. Eligible patients were randomized to receive adjuvant chemotherapy or CCRT after surgery. The primary end-point was progression-free survival (PFS). From December 2012 to December 2014, 337 patients were subjected to randomization. Final analysis included 329 patients, including 165 in the adjuvant chemotherapy group and 164 in the adjuvant CCRT group. The median follow-up was 72.1 months. The three-year PFS rates were both 91.9%, and the five-year OS was 90.6% versus 90.0% in adjuvant chemotherapy and CCRT groups, respectively. No significant differences were observed in the PFS or OS between groups. The adjusted HR for PFS was 0.854 (95% confidence interval 0.415–1.757;P = 0.667) favoring adjuvant chemotherapy, excluding the predefined non-inferiority boundary of 1.9. The chemotherapy group showed a tendency toward good quality of life. In comparison with post-operative adjuvant CCRT, adjuvant chemotherapy treatment showed non-inferior efficacy in patients with early-stage cervical cancer having pathological risk factors. Adjuvant chemotherapy alone is a favorable alternative post-operative treatment. | Danhui Weng Huihua Xiong Changkun Zhu Xiaoyun Wan Yaxia Chen Xinyu Wang Youzhong Zhang Jie Jiang Xi Zhang Qinglei Gao Gang Chen Hui Xing Changyu Wang Kezhen Li Yaheng Chen Yuyan Mao Dongxiao Hu Zimin Pan Qingqin Chen Baoxia Cui Kun Song Cunjian Yi Guangcai Peng Xiaobing Han Ruifang An Liangsheng Fan Wei Wang Tingchuan Xiong Yile Chen Zhenzi Tang Lin Li Xingsheng Yang Xiaodong Cheng Weiguo Lu Hui Wang Beihua Kong Xing Xie Ding Ma | 2023 | Frontiers of Medicine2023，17，1： | 0 |
| 14 | Neogene integrative stratigraphy,biotas,and paleogeographical evolution of the Qinghai-Tibetan Plateau and its surrounding areas显示文摘The remarkable uplift of the Tibetan Plateau in the Neogene had great impacts on the climate and environment of East Asia and even the world.Therefore,establishment of the Neogene stratigraphic framework of the Tibetan Plateau is of great significance to research in various fields of geosciences.Based on marine sediments,the international chronostratigraphic system of the Neogene is divided into six stages in the Miocene and two stages in the Pliocene.Since the beginning of the Cenozoic,the share of terrestrial strata on continents has increased rapidly.By the Neogene,it had far exceeded that of marine strata,and almost all deposits on the Tibetan Plateau and its surrounding areas were terrestrial strata.In China,the Miocene includes five stages and the Pliocene includes two stages.Except for the Tunggurian of the Miocene,which has a lower boundary at 15 Ma,the other stages have the same paleomagnetic definitions and time intervals as the corresponding international marine stages.Mammalian fossils play a very important role in the division and correlation of Cenozoic terrestrial strata,and rodent,carnivore,proboscidean,perissodactyl and artiodactyl fossils are especially important in Neogene terrestrial biostratigraphy.There are many basins with well-exposed strata and abundant mammalian fossils in the Tibetan Plateau.The lower boundary stratotype sections of the Neogene Xiejian and Bahean stages are located respectively in the Xining and Linxia basins,and there are precise paleomagnetic dates in coordination with mammalian fossils.The lower boundary stratotypes of other stages can also be effectively determined in the Tibetan Plateau.Many first appearing mammalian genera in East Asia also appeared in the Tibetan Plateau and its surrounding areas,especially in the Linxia Basin on the northeast margin and in the Siwaliks on the southwest margin.Among them,Prodeinotherium first appeared at the bottom of the Miocene in the Siwaliks,and the earliest Hipparion of the Old World first appeared at the bottom of the Bahean Stage in the Linxia Basin.Carbon and oxygen isotope analysis of enamel and paleosols of Cenozoic sediments and mammal fossils in the Tibetan Plateau and its surrounding areas have been used to reconstruct the climate,environment and vegetation development characteristics,and revealed that these changes were not only related to global change,but also had regional features.Evidence of the Late Miocene C4plant expansion event based on carbon isotope changes comes from the southern margin of the Tibetan Plateau,but in sharp contrast,δ13C indicates that there was still no clear or significant C4plant signal on the northern margin of the Tibetan Plateau until the end of the Neogene.Theδ18O analysis shows that there were several major climate change events in the Cenozoic,especially in the Late Miocene at about 7 Ma,when positive drift ofδ18O indicates that the northern and southern sides of the Tibetan Plateau were changing to drier environments.The strong uplift of the Tibetan Plateau in the Late Miocene strengthened the thermal contrast between sea and land,which strengthened monsoon circulation and led to the expansion of C4vegetation in South Asia.However,the East Asian summer monsoon,which can bring atmospheric precipitation and a climate suitable for C4plants to northern China,was not enough to affect the northern Tibetan Plateau.The Tibetan Plateau on the whole rose to an altitude of about 3000 m in the Miocene,becoming a barrier to mammalian migration;it reached its modern altitude of more than 4000 m in the Pliocene,thus forming a cryosphere environment,which led to the emergence of ancestral types of the Ice Age fauna. | Tao DENG Xiaomin FANG Qiang LI Shiqi WANG Feixiang WU Sukuan HOU Jiao MA Qigao JIANGZUO Danhui SUN Yan ZHENG Qinqin SHI Boyang SUN Lu LI | 2024 | Science China Earth Sciences2024，67，4： | 0 |
| 15 | Export fluctuation and overcapacity in China’s manufacturing industry--The inspection of the causes of excess capacity from the perspective of external demand显示文摘Intuitively speaking,there is an inverse proportional relationship between exports and overcapacity,which means in export’s busy season enterprises would expand output and improve capacity utilisation rate but control yields to avoid dull sale in slack season,causing exacerbated excess capacity.However,this is just the reflections of“sales effect”on overcapacity by export fluctuation.For some enterprises,there is indeed“competition effect”which may alleviate overcapacity because enterprises face even more fierce domestic competition for the sake of weak exports and may increase the utilisation load of existing capacity in order to cut costs.A test is conducted in this paper to verify the relationship between export fluctuation and excess capacity based on data of China's manufacturing industry from 2001 to 2013.The overall results indicate that export fluctuation is not the significant cause for excess capacity.In the small and medium-sized enterprises or in industries with higher proportion of non-state capital,the negative relationship between exports and excess capacity is more obvious,with“sales effect”taking a dominant position.On the other hand,under the influence of“competition effect”,the relationship between the two may be positive.Thus,external demand shocks exert different influence on the alleviation of excess capacity of different industries,and extensively driven exports may not have anticipated effect on the dissolution of the excess capacity.To regulate overcapacity with the aid of external market,a fair and orderly competition environment should be provided to the export subjects of different size and ownerships. | Liu Hang Li Ping Yang Danhui | 2017 | China Finance and Economic Review2017，6，1： | 0 |
| 16 | China-U.S. Detente and China's Aid to Vietnam to Resist U.S. Intervention ——The Vietnam Factor in China's Foreign-Policy Readjustment显示文摘1968年11月至1973年5月中国调整外交战略、实现与美国和解的进程中始终存在着越南因素的影响。中国在处理并存的援越抗美革命外交方针与缓和对美关系务实外交方针这对矛盾时,对越美和谈的态度及对越物质援助的方针相应地不断发生变化。中国以越南问题为轴心推动了美国调整对华政策的步伐,中美关系解冻。随着越战的结束,双方着手进一步落实联合抗苏的战略构想。但与此同时,中越之间的裂痕逐渐加深,越南最终投入了苏联的怀抱。 | Li Danhui | 2003 | Social Sciences in China2003，24，2： | 0 |
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