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| 1 | Plasma phospholipid transfer protein (PLTP) modulates adaptive immune functions through alternation of T helper cell polarization显示文摘客观:血浆 phospholipid 转移蛋白质(PLTP ) 是脂蛋白新陈代谢的一个关键决定因素,并且动物和人的研究收敛显示 PLTP 支持 atherogenesis 和它的 thromboembolic 复杂并发症。而且, PLTP 调制发炎和有免疫力的回答,这最近被报导了。尽管从我们的组的更早的研究证明 PLTP 能修改巨噬细胞激活,在 T-cell-mediated 有免疫力的回答的调整的 PLTP 的含意从来没被调查过并且因此在现在的学习被探讨。途径和结果:在现在的学习,我们证明在老鼠的那 PLTP 缺乏在 CD4 + Th0 房间极化上有深刻效果,与向在正常、病理学的条件下面的反煽动性的 Th2 显型的移动。在接触超敏性的一个模型,对有 hapten-2,4-dinitrofluorobenzene (DNFB ) 的皮肤促进感受性的显著地损害的回答在 PLTP 缺乏的老鼠被观察与相比野类型(WT ) 老鼠。有趣地,在老鼠的 PLTP 缺乏没在外部血在全部的白血房间,淋巴细胞, granulocytes,或单核白血球的计数上施加效果。而且, PLTP 缺乏没修改 CD4 + 和 CD8 + T 淋巴细胞子集的数量。然而, PLTP 缺乏,与 Th2 显型的 upregulation 联系了,被重要减少在 pro-Th1 cytokine interleukin 的生产伴随 18 由附件房间。结论:第一次,这个工作向支持 inflammatory Th1 显型在 CD4 + T 房间的极化为 PLTP 报导一个生理的角色。 | Catherine Desrumau Stephanie Lemaire-Ewing Nicolas Ogier Akadiri Yessoufou Arlette Hammann Anabelle Sequeira-Le Grand Valerie Deckert Jean-Paul Pais de Barros Naig Le Guern Julien Guy Naim A Khan Laurent Lagrost | 2016 | Cellular & Molecular Immunology2016，13，6： | 3 |
| 2 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 3 | A new case of Mycoplasma hominis mediastinitis and sternal osteitis after cardiac surgery显示文摘 | Le Guern R Lo'fez C Loobuyck V | 2015 | Int J Infect Dis2015，31，1： | 1 |
| 4 | Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes显示文摘 | Debono MW Le Guern J Canton T | 1993 | Eur J Pharmacol1993，235，23： | 1 |
| 5 | Noninvasive assessment of systolic pulmonary artery pressure in systemic lupus erythematosus:retrospective analysis of93 patients显示文摘 | Fois E Le Guern V Dupuy A | 2010 | Clin Exp Rheumatol2010，28，： | 1 |
| 6 | A new case of My- coplasma hominis mediastinitis and sternal osteitis after cardiac surgery显示文摘 | Le Guern R Loiez C Loobuyck V | 2015 | Int J Infect Dis2015，31，： | 1 |
| 7 | Effect of route of administration on the pharmacokinetic behavior of enantiomers of nefopam and desmethylnefopam显示文摘 | Chawla J Le Guern ME Alquier C | 2003 | Ther Drug Monit2003，25，2： | 1 |
| 8 | PCDH19-related infantile epileptic eneephalopathy : an unusual X-linked inheritance disorder 显示文摘 | Depienne C Le Guern E | 2012 | Hum Mutat2012，33，4： | 1 |
| 9 | Cognitive function and99mTc-ECD brain SPECT are significantly correlated in patients with primary Sjgren syndrome:a case-control study显示文摘 | Le Guern V Belin C Henegar C | 2010 | Ann Rheum Dis2010，69，1： | 1 |
| 10 | X-linked Charcot-Mooth-Tooth disease with connexin 32 mutations:clinical and electrophysiology study显示文摘 | Birouk N Le Guern E Maisonobe T | 1998 | Neurology1998，50，4： | 1 |
| 11 | Evalua- tion of a new molecular test,the BD max cdiff,for detec- tion of toxigenic clostridium difficile in fecal samples显示文摘 | Le Guern R Herwegh S Grandbastien BA | 2012 | J Clin Microbiol2012，50，9： | 1 |
| 12 | Apert syndrome, an antenatal ultrasound detected ease显示文摘 | Parent P Le Guern H Munck MR | 1994 | Genet Couns1994，5，3： | 1 |
| 13 | Geochemical study of elements condensed during cooling of a gaseous volcanic phase: Mount Etna in 1976显示文摘 | Joron J L Le Guern F Treuil M | 1982 | Bull Volcanol1982，45，3： | 1 |
| 14 | Role of Calcium Ions in the Mechanism of Action of a Lignosulphonate Used to Modify the Wettability of Plastics for Their Separation by Flotation 显示文摘 | Le Guern C P Conil R Houot | 2000 | Minerals Engineering2000，13，1： | 1 |
| 15 | Mechanism of energy transfer in the lava lake of Niragongo ( Zaire), 1959-1977 显示文摘 | Le Guern F | 1987 | Journal of Volcanology and Geothermal Research1987，31，： | 1 |
| 16 | Inhibition by riluzole of electrophysiological responses mediated by rat kainate and NMDA receptors expressed in Xenopus oocytes显示文摘 | Debono MW Le Guern J Canton T | 1993 | Eur J Pharmacol1993，235，23： | 1 |
| 17 | Role of calcium ions in the mechanism of action of a lignosulphonate used to modify the wettability of plastics for their separation by flotation显示文摘 | C. Le Guern P. Conil R. Houot | 1999 | Minerals Engineering1999，，1： | 1 |
| 18 | Therapeutic apheresis for myositises 显示文摘 | Le Guern V Guillevin L | 2007 | Transfusion and Apheresis Science (S1473--0502)2007，36，： | 1 |
| 19 | Hygroma Kystique du cou: diagnostic antenatal,facteurs pronostiques,conduite a tenir; A propos de 42 cas显示文摘 | Bernard P Chabaud JJ Le Guern H | 1991 | J Gynecol Obstet Biol Reprod1991，20，： | 1 |
| 20 | Systemic lupus erythematosus and pregnancy显示文摘 | Le Guern V Pannier E Goffinet F | 2008 | Presse Med2008，37，11： | 1 |
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