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| 1 | Procalcitonin and intestinal ischemia:A review of the literature显示文摘Intestinal ischemia is common after emergency gastrointestinal or cardiovascular surgery.At present,there are no diagnostic tools for the early diagnosis of intestinal ischemia.In the last decade,procalcitonin(PCT)has been suggested as a marker of this condition.Here,we review the use of PCT as a diagnostic tool for intestinal ischemia.Two reviewers independently searched the Pub Med and EMBASE databases for articles on intestinal ischemia and PCT.They then considered(1)the criteria applicable to preclinical and clinicaldata;and(2)PCT’s predictive value in the diagnosis of intestinal ischemia.Article quality was rated according to the STAndards for Reporting of Diagnostic accuracy.Between 1993 and 2014,seven studies(including two preclinical studies and five clinical studies)dealt with the use of PCT to diagnose intestinal ischemia.Procalcitonin’s sensitivity,specificity,positive predictive value and negative predictive value ranged between 72%and 100%;68%and 91%;27%and 90%and 81%and 100%,respectively.The area under the receiver operating characteristic curve ranged from 0.77 to 0.92.In view of the preclinical and clinical data,we consider that PCT can be used in daily practice as a tool for diagnosing intestinal ischemia. | Cyril Cosse Charles Sabbagh Sad Kamel Antoine Galmiche Jean-Marc Regimbeau | 2014 | World Journal of Gastroenterology2014，20，47： | 9 |
| 2 | Rabeprazole test for the diagnosis of gastro-oesophageal reflux disease: Results of a study in a primary care setting显示文摘瞄准:为了决定病人的 rabeprazole 测试的诊断价值,由全科医生看。方法:有 GERD 暗示的症状的 83 个病人被全科医生在这个多中心注册,使随机化并且双窗帘学习。所有病人收到了 rabeprazole (20 mg 出价) 或安慰剂一个星期。GERD 的诊断在内视镜检查法或反常食道的 24-h pH 测试在粘膜裂缝的存在上被建立。如果病人们报导至少,“ 7 点 Likert 上的症状的清楚的改进”可伸缩,测试被认为阳性。结果:为 rabeprazole 和安慰剂的测试的敏感分别地是 83% 和 40% 。相应特性,积极、否定的预兆的价值是 45% 和 67% , 71% 和 71% ,和 62% 和 35% 分别地。操作特征(巨鸟) 分析的接收装置证实最好差别对待截止对应于对“清楚的改进”的描述。结论:禁止者(PPI ) 测试的质子泵的差的特性不支持如此的一条途径在一个主要照顾背景建立 GERD 的诊断。 | Stanislas Bruley des Varannes Sylvie Sacher-Huvelin Fabienne Vavasseur Claude Masliah Marc Le Rhun Philippe Aygalenq Sylvie Bonnot-Marlier Yves Lequeux Jean Paul Galmiche | 2006 | World Journal of Gastroenterology2006，12，16： | 4 |
| 3 | Characterization of two rat models of cystic fibrosis—KO and F508del CFTR—Generated by Crispr-Cas9显示文摘Background: Genetically engineered animals are essential for gaining a proper understanding of the disease mechanisms of cystic fibrosis(CF). The rat is a relevant laboratory model for CF because of its zootechnical capacity, size, and airway characteristics, including the presence of submucosal glands.Methods: We describe the generation of a CF rat model(F508 del) homozygous for the p.Phe508 del mutation in the transmembrane conductance regulator(Cftr) gene. This model was compared to new Cftr-/-rats(CFTR KO). Target organs in CF were examined by histological staining of tissue sections and tooth enamel was quantified by micro-computed tomography. The activity of CFTR was evaluated by nasal potential difference(NPD) and short-circuit current measurements. The effect of VX-809 and VX-770 was analyzed on nasal epithelial primary cell cultures from F508 del rats.Results: Both newborn F508 del and Knock out(KO) animals developed intestinal obstruction that could be partly compensated by special diet combined with an osmotic laxative. The two rat models exhibited CF phenotypic anomalies such as vas deferens agenesis and tooth enamel defects. Histology of the intestine, pancreas, liver, and lungs was normal. Absence of CFTR function in KO rats was confirmed ex vivo by short-circuit current measurements on colon mucosae and in vivo by NPD, whereas residual CFTR activity was observed in F508 del rats. Exposure of F508 del CFTR nasal primary cultures to a combination of VX-809 and VX-770 improved CFTR-mediated Cl-transport.Conclusions: The F508 del rats reproduce the phenotypes observed in CFTR KO animals and represent a novel resource to advance the development of CF therapeutics. | Elise Dreano Marc Bacchetta Juliette Simonin Louise Galmiche Claire Usal Lotfi Slimani Jérémy Sadoine Laurent Tesson Ignacio Anegon Jean-Paul Concordet Aurélie Hatton Lucile Vignaud Danielle Tondelier Isabelle Sermet-Gaudelus Marc Chanson Charles-Henry Cottart | 2019 | Animal Models and Experimental Medicine2019，2，4： | 3 |
| 4 | Saccharomyces boulardii Does Not Prevent Relapse of Crohn’s Disease显示文摘 | Arnaud Bourreille Guillaume Cadiot Gérard Le Dreau David Laharie Laurent Beaugerie Jean–Louis Dupas Philippe Marteau Patrick Rampal Dominique Moyse Ashraf Saleh Marie–Emmanuelle Le Guern Jean–Paul Galmiche | 2013 | Clinical Gastroenterology and Hepatology2013，，8： | 3 |
| 5 | The endoscopic assessment of esophagitis: A progress report on observer agreement显示文摘 | D Armstrong JR Bennett AL Blum J Dent FT De Dombal JP Galmiche L Lundell M Margulies JE Richter SJ Spechler GN Tytgat L Wallin | 1996 | Gastroenterology1996，，1： | 2 |
| 6 | Convergent Rayleigh-Taylor experiments on the Nova laser phys显示文摘 | Cherfils C Glendinning S G Galmiche D | 1999 | PhysRev Left1999，83，26： | 2 |
| 7 | Rho kinase blockade prevents inflammation via nuclear factor κB inhibition: evidence in Crohn’s disease and experimental colitis显示文摘 | Jean-Pierre Segain Diane Raingeard de la Blétière Vincent Sauzeau Arnaud Bourreille Gréory Hilaret Chrystelle Cario-Toumaniantz Pierre Pacaud Jean-Paul Galmiche Gervaise Loirand | 2003 | Gastroenterology2003，，5： | 2 |
| 8 | Tenatoprazole,a novel proton pump inhibitor with a pro- longed plasma half-life: effects on intragastric pH andcomparison with esomeprazole in healthy volunteers 显示文摘 | Galmiche J P Bruley Des Varannes S Ducrotte P | 2004 | Aliment Pharma Ther2004，19，6： | 1 |
| 9 | The expression of p16 is not correlated with HPV status in CIN I 显示文摘 | Galmiche L Coste-Burel M Lopes P | 2006 | Histopathology2006，48，6： | 1 |
| 10 | Functional esophageal disor- ders 显示文摘 | Galmiche JP Clouse RE Balint A | 2006 | Gastmentemlogy2006，130，5： | 1 |
| 11 | Advances in pulsed phase video thermography显示文摘 | Maldague X Galmiche F Ziadi A | 2002 | Infrared Physics & Technology2002，43，： | 1 |
| 12 | Stromal cells from human long term marrow cultures are mesenchymal cells that differentiate following a vascular smooth muscle differentiation pathway显示文摘 | Galmiche M C K oteliansky V E Briere J | 1993 | Blood1993，82，1： | 1 |
| 13 | A comparative study of the early effects of tenatoprazole 40 mg and esomeprazole 40mg on intragastric pH in healthy volunteers显示文摘 | Galmiche JP Sacher-Huvelin S Bruley des Varannes S | | 0，，： | 1 |
| 14 | Tenatoprazole,a novel proton pump inhibitor with a prolonged plasma half-life:effects on intragastric pH and comparison with esomeprazole in healthy volunteers显示文摘 | Galmiche JP Bruley Des Varannes S Ducrotté P | | 0，，： | 1 |
| 15 | TheN-terminal 34kDa fragment of Helicobacter pylorivacuolating cytotoxin targets mitochondria and inducescytochrome c release显示文摘 | GALMICHE A RASSOW J DOYE A | 2000 | EMBO J2000，19，： | 1 |
| 16 | Respiratory manifestations of gastro- oesophageal reflux disease显示文摘 | GALMICHE J P ZERBIB F BRULEY DES VARANNES S | 2008 | Aliment Pharmacol Ther2008，27，： | 1 |
| 17 | Treatment of gastroesophageal reflux disease in adults:an individualized approach显示文摘 | Galmiche JP Stephenson K | 2004 | Dig Dis2004，22，2： | 1 |
| 18 | Proximal gastric tone in gastro-oesophageal reflux disease 显示文摘 | Des Varannes SB Ropert A Lamouliatte H Quinton A Galmiche JP | 1999 | Eur J Gastroenterol Hepatol1999，11，5： | 1 |
| 19 | Molecular a- nalysis of the effect of short-chain fatty acids on intestinal cell proliferation显示文摘 | Blottire H M Buecher B Galmiche J P | 2003 | The Proceedings of the Nutrition Society2003，62，1： | 1 |
| 20 | Endoscopy-negative reflux disease显示文摘 | Galmiche JP des Varannes SB | 2001 | Curr Gastroenterol Rep2001，3，3： | 1 |
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