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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014，5，2： | 5 |
| 2 | Photocatalytic oxidation of ethanol:isotopic labeling and transient reaction显示文摘 | Mugli D S Larson S A Falconer J L | 1996 | J Phys Chem1996，100，15： | 3 |
| 3 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980，85，： | 1 |
| 4 | Pollen-medi- ated gene flow from Kentucky bluegrass under cultivated field conditions显示文摘 | JOHNSON P G Larson S R Anderton A L | 2006 | Crop Science2006，46，5： | 1 |
| 5 | A survey of thyroidgland scintigraphy显示文摘 | CRAWFORDE S GUARASCI DT LARSON S A | 2009 | J Nucl Med Technol2009，37，3： | 1 |
| 6 | Does the relation of blood pressure to coronary heart disease risk change with aging The Framingham heart study显示文摘 | Franklin S S Larson M G Khan S A | 2001 | Circulation2001，103，： | 1 |
| 7 | Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia显示文摘 | O'Brien S G Guilhot F Larson R A | | New England Journal of Medicine0，，： | 1 |
| 8 | Clinical characteristics of severe supracondylar humerus fractures in children显示文摘 | Garg S Weller A Larson AN | 2014 | J Pediatr Orthop2014，34，1： | 1 |
| 9 | Individual and combined effects of peroxisome proliferator-activated receptor and {gamma}agonists,fenofibrate and rosiglitazone,on biomarkers of lipid and glucose metabolism in healthy nondiabetie volunteers显示文摘 | Wagner J A Larson P J Weiss S | 2005 | J Clin Pharmacol2005，45，5： | 1 |
| 10 | Traumatic intracranial aneurysms显示文摘 | Larson P S Reisner A Morassutti D J | | 0，，01： | 1 |
| 11 | Safety and tolerability of intraputaminal delivery of CERE-120 (adeno-associated virus serotype 2–neurturin) to patients with idiopathic Parkinson’s disease: an open-label, phase I trial显示文摘 | William J Marks Jill L Ostrem Leonard Verhagen Philip A Starr Paul S Larson Roy AE Bakay Robin Taylor Deborah A Cahn-Weiner A Jon Stoessl C Warren Olanow Raymond T Bartus | 2008 | Lancet Neurology2008，，5： | 1 |
| 12 | Disorders of sex development : clinically relevant genes involved in gonadal differentiation显示文摘 | Larson A NJ Nokoff S Travers | 2012 | Discov Med2012，14，78： | 1 |
| 13 | Predicting the effects of tillage and crop residue management on soil erosion显示文摘 | GUPTA S C ONSTAD C A LARSON W E | 1979 | Soil Water Conserv1979，34，： | 1 |
| 14 | Learning crowdsourced user preferences for visual summarization of image collections显示文摘 | Rudinac S Larson M and Hanjalic A | 2013 | IEEE Transactions on Multimedia2013，15，6： | 1 |
| 15 | Sustainable tourism development in remote re- gions Questions arising from research in the North Kimberley, Australia显示文摘 | Larson S Herr A | 2008 | Regional Environmental Change2008，，8： | 1 |
| 16 | Development of an alternative approach to protein crystallization 显示文摘 | McPherson A Nguyen C Larson S B | 2007 | J Struct Funct Gen2007，8，4： | 1 |
| 17 | Chondrocranial,hyobranchial and internal oral morphology in larvae of the basal bufonid genus Melanphryniscus(Amphibia:Anura)显示文摘 | Larson P.M de Sá R.O Diego A | | 0，，： | 1 |
| 18 | Repurposing CRISPR as an RNA-guided platform for seguence- specific control of gene expression显示文摘 | Qi L S Larson M H Gilbert L A | 2013 | Cell2013，152，5： | 1 |
| 19 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999，27，10： | 1 |
| 20 | The satisfaction with life scale' 显示文摘 | DIENER E EMMONMS R A LARSON R J GRIF- FIN S | 1985 | Journal of Personality Assessment1985，49，： | 1 |
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