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| 1 | Clinical outcomes following salvage Gamma Knife radiosurgery for recurrent glioblastoma显示文摘Glioblastoma multiforme(GBM) is the most common malignant primary brain tumor with a survival prognosis of 14-16 mo for the highest functioning patients. Despite aggressive, multimodal upfront therapies, the majority of GBMs will recur in approximately six months. Salvage therapy options for recurrent GBM(r GBM) are an area of intense research. This study compares recent survival and quality of life outcomes following Gamma Knife radiosurgery(GKRS) salvage therapy. Following a Pub Med search for studies usingGKRS as salvage therapy for malignant gliomas, nine articles from 2005 to July 2013 were identified which evaluated rG BM treatment. In this review, we compare overall survival following diagnosis, overall survival following salvage treatment, progression-free survival, time to recurrence, local tumor control, and adverse radiation effects. This report discusses results for rG BM patient populations alone, not for mixed populations with other tumor histology grades. All nine studies reported median overall survival rates(from diagnosis, range:16.7-33.2 mo; from salvage, range:9-17.9 mo). Three studies identified median progression-free survival(range:4.6-14.9 mo). Two showed median time to recurrence of GBM. Two discussed local tumor control. Six studies reported adverse radiation effects(range:0%-46% of patients). The greatest survival advantages were seen in patients who received GKRS salvage along with other treatments, like resection or bevacizumab, suggesting that appropriately tailored multimodal therapy should be considered with each rG BM patient. However, there needs to be a randomized clinical trial to test GKRS for rG BM before the possibility of selection bias can be dismissed. | Erik W Larson Halloran E Peterson Wayne T Lamoreaux Alexander R MacKay Robert K Fairbanks Jason A Call Jonathan D Carlson Benjamin C Ling John J Demakas Barton S Cooke Christopher M Lee | 2014 | World Journal of Clinical Oncology2014,5,2: | 5 |
| 2 | The progression from hypertension to congestive heart failure 显示文摘 | Levy D Larson M G Vasan R S | 1996 | JAMA1996,275,20: | 1 |
| 3 | Genome scan of systemic biomarkers of vascular inflammation in the Framingham Heart Study; evidence for susceptibility loci on 1q显示文摘 | Dupuis J Larson M G Vasan R S | 2005 | Atherosclerosis2005,182,2: | 1 |
| 4 | A dynamic estimator for tracking the state of a power system显示文摘 | DebsA S Larson R E | 1970 | IEEE Transactions on Power Apparatus arid Systems1970,89,7: | 1 |
| 5 | Diurnal variation of radon and mixing heights along a coast: a case study 显示文摘 | Hsu S A Larson R E Bressan D J | 1980 | Journal of Geophysical Research1980,85,: | 1 |
| 6 | Pollen-medi- ated gene flow from Kentucky bluegrass under cultivated field conditions显示文摘 | JOHNSON P G Larson S R Anderton A L | 2006 | Crop Science2006,46,5: | 1 |
| 7 | Binding and insertion of alpha-helical anti-microbial peptides in POPC bilay- ers studied by molecular dynamics simulations 显示文摘 | Kandasamy S K Larson R G | 2004 | Chemistry and physics of lipids2004,132,1: | 1 |
| 8 | Amelioration of ischemia- reperfusion injury with cyclic peptide blockade of ICAM-1 显示文摘 | Merchant S Gurule D Larson R | 2003 | Am J Physiol Heart Circ Physiol2003,284,4: | 1 |
| 9 | Imatinib compared with interferon and low-dose cytarabine for newly diagnosed chronic-phase chronic myeloid leukemia显示文摘 | O'Brien S G Guilhot F Larson R A | | New England Journal of Medicine0,,: | 1 |
| 10 | Validation of an Automated Cough Detection Algorithm for Tracking Recovery of Pulmonary Tuberculosis Patients显示文摘 | Larson S Comina G Gilman R H | 2012 | PLoS ONE2012,7,10: | 1 |
| 11 | Asymmetric frontal brain activity, cortisol, and behavior associated with fearful temperament in rhesus monkeys显示文摘 | Kalin N H Larson C Shelton S E Davidson R J | 1998 | Behavioral Neuroscience1998,112,2: | 1 |
| 12 | Optimal server location on a network operating as an M/G/1queue显示文摘 | Berman O Larson R C Chiu S S | 1985 | Oper Res1985,33,: | 1 |
| 13 | Obesity and systemic oxidative stress:clinical correlates of oxidative stress in the Fram- ingham Study显示文摘 | Keaney J F Jr Larson M G Vasan R S | 2003 | Aeterioscler Thromb Vasc Biol2003,23,3: | 1 |
| 14 | Magnetic lineations in the Pacific Jurassic quiet zone 显示文摘 | Cande S C Larson R L LaBrecque J L | 1978 | Earth and Planetary Science Letters1978,41,: | 1 |
| 15 | Reduced fertility associated with low progesterone postbreeding and increased milk urea nitrogen in lactating cows显示文摘 | LARSON S F BUTLER W R CURRIE W B | 1997 | Journal of Dairy Science1997,80,: | 1 |
| 16 | Impact of high - normal blood pressure on the risk of cardiovascular disease 显示文摘 | Vasari R S Larson M G Leip E P | 2001 | N Engl J Med2001,345,18: | 1 |
| 17 | The economics of air pollution health risks in Russia: a case study of Volgograd 显示文摘 | Larson B A Avaliani S Golub A Rosen S Shaposhnikov D Strukova E Vincent J R Wolff S K | 1999 | World development1999,27,10: | 1 |
| 18 | The satisfaction with life scale' 显示文摘 | DIENER E EMMONMS R A LARSON R J GRIF- FIN S | 1985 | Journal of Personality Assessment1985,49,: | 1 |
| 19 | A theory of attribute equivalence in databases with application to schema integration显示文摘 | Larson J A Navathe S B ElMasri R | 1989 | IEEE Trans Software Eng1989,16,4: | 1 |
| 20 | Impact of high normal blood pressure on the risk of cardiovascular disease显示文摘 | Vasan R S Larson M G Leip E P | 2001 | N Engl J Med2001,345,18: | 1 |