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| 1 | Prognostic factors of refractory NSCLC patients receiving anlotinib hydrochloride as the third-or further-line treatment显示文摘Objective:Anlotinib hydrochloride is a multitarget tyrosine kinase inhibitor that targets vascular endothelial growth factor receptor,fibroblast growth factor receptor,platelet-derived growth factor receptor,c-Kit,and c-MET;therefore,it exhibits both antitumor and anti-angiogenetic activities.A phase III trial has shown that anlotinib improved progression-free survival(PFS)and overall survival(OS)in patients with advanced non-small cell lung cancer(NSCLC),who presented with progressive disease or intolerance after standard chemotherapy.This study aimed to analyze the characteristics of patients receiving anlotinib treatment to determine the dominant populations who are fit for the treatment.Methods:Data were collected from March 2015 to January 2017 from a randomized,double-blind,placebo-controlled,multicenter,phase III trial of anlotinib(ALTER0303).A total of 437 patients were enrolled and randomly allocated(2:1)to the anlotinib and placebo groups.Kaplan–Meier analysis and log-rank test were performed to compare PFS and OS.Cox proportional hazards model was adopted for multivariate prognostic analysis.Results:Multivariate analysis indicated that high post-therapeutic peripheral blood granulocyte/lymphocyte ratio and elevated alkaline phosphatase levels were independent risk factors for PFS.Meanwhile,elevated thyroid-stimulating hormone,blood glucose,and triglyceride levels;hypertension;and hand–foot syndrome were independent protective factors of PFS.High posttherapeutic peripheral blood granulocyte/lymphocyte ratio,an Eastern Cooperative Oncology Group(ECOG)score≥2,and the sum of the maximal target lesion length at baseline were independent risk factors of OS,and hypertriglyceridemia was an independent protective factor of OS.Conclusions:This study preliminarily explored the possible factors that affected PFS and OS after anlotinib treatment in patients with advanced refractory NSCLC,and the baseline characteristics of the therapeutically dominant populations were then identified. | Jing Wang Yizhuo Zhao Qiming Wang Li Zhang Jianhua Shi Zhehai Wang Ying Cheng Jianxing He Yuankai Shi Hao Yu Yang Zhao Weiqiang Chen Yi Luo Xiuwen Wang Kejun Nan Faguang Jin Jian Dong Baolan Li Zhujun Liu Baohui Han Kai Li | 2018 | Cancer Biology & Medicine2018，15，4： | 46 |
| 2 | Episodic rifting of continental marginal basins and tectonic events since 10 Ma in the South China Sea显示文摘Integrated study on the tectonic, basin filling and thermal evolution of the Tertiary basins on the northern margin of the South China Sea has indicated that the rift continental margin on the northern South China Sea is not a passive margin and that the western margin is characteristic of the transformextension. Episodic rifting and the thermal events since 10 Ma in the area have been documented by the integrated analysis of dynamic process. It has been clarified that the tectono-thermal events have exerted a significant influence on basin features and hydrocarbon accumulation, and particularly, the westward collision of the Lusong Island Arc, the generation of densely spaced faults in the Pearl River Mouth Basin, the rapid subsidence, high heat flow and large-scale over pressure and thermal-fluid breakthrough in the Yinggehai and the Qiongdongnan basins have proved to be the important factors determining the formation of oil and gas in these basins. | Sitian Li Changsong Lin Qiming Zhang Shigong Yang Peikan Wu | 1999 | Chinese Science Bulletin1999，44，1： | 27 |
| 3 | Dental stem cell and dental tissue regeneration显示文摘The teeth are highly differentiated chewing organs formed by the development of tooth germ tissue located in the jaw and consist of the enamel, dentin, cementum, pulp, and periodontal tissue. Moreover, the teeth have a complicated regulatory mechanism, special histologic origin, diverse structure, and important function in mastication, articulation, and aesthetics. These characteristics, to a certain extent, greatly complicate the research in tooth regeneration. Recently, new ideas for tooth and tissue regeneration have begun to appear with rapid developments in the theories and technologies in tissue engineering. Numerous types of stem cells have been isolated from dental tissue, such as dental pulp stem cells (DPSCs), stem cells isolated from human pulp of exfoliated deciduous teeth (SHED), periodontal ligament stem cells (PDLSCs), stem cells from apical papilla (SCAPs), and dental follicle cells (DFCs). All these cells can regenerate the tissue of tooth. This review outlines the cell types and strategies of stem cell therapy applied in tooth regeneration, in order to provide theoretical basis for clinical treatments. | Qiming Zhai Zhiwei Dong Wei Wang Bei Li Yan Jin | 2019 | Frontiers of Medicine2019，13，2： | 23 |
| 4 | BMAL1 knockout macaque monkeys display reduced sleep and psychiatric disorders显示文摘Circadian disruption is a risk factor for metabolic, psychiatric and age-related disorders, and non-human primate models could help to develop therapeutic treatments. Here, we report the generation of BMAL1 knockout cynomolgus monkeys for circadian-related disorders by CRISPR/Cas9 editing of monkey embryos. These monkeys showed higher nocturnal locomotion and reduced sleep, which was further exacerbated by a constant light regimen. Physiological circadian disruption was reflected by the markedly dampened and arrhythmic blood hormonal levels. Furthermore, BMAL1-deficient monkeys exhibited anxiety and depression, consistent with their stably elevated blood cortisol, and defective sensory processing in auditory oddball tests found in schizophrenia patients. Ablation of BMAL1 up-regulated transcriptional programs toward inflammatory and stress responses, with transcription networks associated with human sleep deprivation, major depressive disorders, and aging. Thus, BMAL1 knockout monkeys are potentially useful for studying the physiological consequences of circadian disturbance, and for developing therapies for circadian and psychiatric disorders. | Peiyuan Qiu Jian Jiang Zhen Liu Yijun Cai Tao Huang Yan Wang Qiming Liu Yanhong Nie Fang Liu Jiumu Cheng Qing Li Yun-Chi Tang Mu-ming Poo Qiang Sun Hung-Chun Chang | 2019 | National Science Review2019，6，1： | 21 |
| 5 | Effects of dietary arginine levels on growth performance,body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco)显示文摘This experiment was conducted to investigate the effects of dietary arginine levels on growth performance, body composition, serum biochemical indices and resistance ability against ammonia-nitrogen stress in juvenile yellow catfish(Pelteobagrus fulvidraco). Five isonitrogenous and isolipidic diets(42%protein and 9% lipid) were formulated to contain graded levels of arginine(2.44%, 2.64%, 2.81%, 3.01% and3.23% of diet), by supplementing L-Arginine HCI. Seven hundred juvenile yellow catfish with an initial average body weight of 1.13 ± 0.02 g were randomly divided into 5 groups with 4 replicates of 35 fish each and each group was fed one of the diets. After 56 d feeding, fish were exposed to 100 mg/L of ammonia-nitrogen for 72 h. The results showed that weight gain(WG) and specific growth rate(SGR) in2.64% and 2.81% groups were significantly higher than those in 3.23% group(P < 0.05). The feed conversation ratio(FCR) in 2,64%, 2,81% and 3.01% groups was significantly decreased when compared with3,23% group. The protein efficiency ratio(PER) in 2.64% group was significantly higher than that in 2.44%and 3.23% groups(P < 0.05). The condition factor(CF) of fish was significantly higher in 2.81% group than that in 2,44% group(P < 0.05). Dietary arginine levels had no significant effect on hepatosomatic index(HSI), viscerosomatic index(VSI), and whole-body dry matter, crude protein, crude lipid, ash contents, as well as serum total protein(TP), triglyceride(TG), glucose(GLU), urea nitrogen(UN) contents and aspartate aminotransferase(AST), alanine aminotransferase(ALT) activities(P> 0.05). After the fish were challenged to ammonia-nitrogen for 72 h, their cumulative mortality rate in 2.81% group was significantly lower than that in 2.44% group(P < 0.05). The results suggested that dietary arginine level at 2.81%could optimize anti-ammonia-nitrogen stress ability of juvenile yellow catfish and a level of 3.23%arginine seemed to depress the growth performance of fish and decreased their tolerance to the ammonia-nitrogen stress under current study. A quadratic regression analysis based on WG indicated that the optimal dietary arginine requirement of juvenile yellow catfish was estimated to be 2.74% of the diet(6.45% of dietary protein) under current culture conditions. | Qiming Chen Hongxia Zhao Yanhua Huang Junming Cao Guoxia Wang Yuping Sun Yongjuan Li | 2016 | Animal Nutrition2016，，3： | 19 |
| 6 | Microstructure and Properties of Cu-Cr-Zr Alloy after Rapidly Solidified Aging and Solid Solution Aging显示文摘The structure and properties of Cu-Cr-Zr alloy were studied after rapidly solidified aging and solid solution aging.At the early stage of aging (500℃ for 15 min), the hardness and the conductivity of the alloy rapidly solidified are 143 HV and 72% IACS, respectively. Under the same aging condition, the hardness and electrical conductivity of the alloy solid solution treated can reach 86 HV and 47% lACS, respectively. The microstructure was analyzed, and the grain size after rapid solidification is much smaller than that after solid solution treatment. By rapidly solidified aging the fine precipitates distribute inside the grains and along the grain boundary, while by solid solution aging there are large Cr particles along the grain boundary. | Ping LIU Juanhua SU Qiming DONG Hejun LI | 2005 | Journal of Materials Science & Technology2005，21，4： | 14 |
| 7 | Advances and problems in hydrocarbon exploration in the Tazhong area, Tarim Basin显示文摘Located in the middle of the Tarim Basin, Tazhong is a typical area of compound reservoirs rich in oil and gas found in the Carboniferous, Silurian and Ordovician strata. The proved, probable and possible reserves (3P reserves) in the area amount to 5×108 tons, so it is of great significance to study the advances and problems in hydrocarbon exploration in the Tazhong area. On the basis of exploration history and analysis of scientific problems, we outline eight achievements: distribution characteristics of reservoirs, stages of reservoir formation, different sources of oil and gas and their respective contributions, the effective regional caprock and reservoir-caprock combinations dominating the vertical distribution of hydrocarbon reservoirs, the control of the Tazhong Palaeo-uplift on reservoir formation and establishing geologic models, structure balance belts influencing the reconstruction and residual potential of reservoirs after accumulation, the rules and mechanisms of fractures controlling oil and gas, and the types of favorable reservoirs and their characteristics of controlling oil and gas distribution. We further point out the main problems about the oil and gas exploration in the Tazhong area and put forward some relevant proposals. | Zhou Xinyuan Pang Xiongqi Li Qiming Pang Hong Xiang Caifu Jiang Zhenxne Li Sumei Liu Luofu | 2010 | Petroleum Science2010，7，2： | 12 |
| 8 | Commissioning progress of the FAST显示文摘The Five-hundred-meter Aperture Spherical radio Telescope(FAST) was completed with its main structure installed on September 25, 2016, after which it entered the commissioning phase. This paper aims to introduce the commissioning progress of the FAST over the past two years. To improve its operational reliability and ensure effective observation time, FAST has been equipped with a real-time information system for the active reflector system and hierarchical commissioning scheme for the feed support system, which ultimately achieves safe operation of the two systems. For meeting the high-performance indices, a highprecision measurement system was set up based on the effective control methods that were implemented for the active reflector system and feed support system. Since the commissioning of the FAST, a low-frequency ultra-wideband receiver and 19-beam1.05-1.45 GHz receiver have been mainly used. Telescope efficiency, pointing accuracy, and system noise temperature were completely tested and ultimately achieved the acceptance indices of the telescope. The FAST has been in the process of national acceptance preparations and has begun to search for pulsars. In the future, it will still strive to improve its capabilities and expand its application prospects. | Peng Jiang YouLing Yue HengQian Gan Rui Yao Hui Li GaoFeng Pan JingHai Sun DongJun Yu HongFei Liu NingYu Tang Lei Qian JiGuang Lu Jun Yan Bo Peng ShuXin Zhang QiMing Wang Qi Li Di Li | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 11 |
| 9 | Hydrocarbon Accumulation Conditions of Ordovician Carbonate in Tarim Basin显示文摘基于形成水库的条件,水库的差异和多级式的烃充电的差别的全面分析是为在 Tarim 盆的奥陶纪的碳酸盐烃累积的关键因素。经历四个主要免职构造的周期,奥陶纪碳酸盐形成了一个稳定的结构的框架与巨大高举,在哪个是礁石银行类型和不顺从类型的发达水库,并且在古苏格兰的、迟了的 Hercynian 期间导致多级式的烃充电和累积并且迟了喜玛拉雅。与低矩阵孔和奥陶纪碳酸盐的渗透,第二等的答案毛孔和大洞用作主要水库空间。多相的构造运动形成了广泛地在 paleo 高举附近散布的不顺从水库;并且礁石银行水库被二种沉积外形带控制,也就是陡峭的斜坡和轻轻的斜坡。异乎寻常的碳酸盐水池被水库控制的广泛的分发,没有明显的边水或底部水,复杂油 / 气体 / 水关系和严重异质描绘。和多时期烃累积的低孔和低渗透水库导致了油 / 气体 / 水的分发和生产的差别和建筑群。烃的分发被在来源岩石和 paleo 高举的革命之间的时间空间的关系控制。heterogenetic 碳酸盐水库和迟了阶段的煤气的充电是做 oil/ 气体阶段的主要因素复杂。形成在的 paleo 高举的斜坡区域古生代基于全面评估是主要碳酸盐探索方向。Tazhong 的北斜坡的奥陶纪高举, Lunnan 和它的圆周区域是实际探索域。Yengimahalla-Hanikatam 和 Markit 斜坡是为碳酸盐探索的重要代替目标。Gucheng, Tadong,在 Lunnan 和 Tazhong-Bachu 区域的寒武纪的白云石的深层是为研究和风险探索的有利方向。 | LI Qiming WU Guanghui PANG Xiongqi PAN Wenqin LUO Chunshu WANG Chenglin LI Xinsheng ZHOU Bo | 2010 | Acta Geologica Sinica(English Edition)2010，84，5： | 10 |
| 10 | A two-step lineage reprogramming strategy to generate functionally competent human hepatocytes from fibroblasts显示文摘Terminally differentiated cells can be generated by lineage reprogramming,which is,however,hindered by incomplete conversion with residual initial cell identity and partial functionality. Here, we demonstrate a new reprogramming strategy by mimicking the natural regeneration route, which permits generating expandable hepatic progenitor cells and functionally competent human hepatocytes. Fibroblasts were first induced into human hepatic progenitor-like cells (hHPLCs), which could robustly expand in vitro and efficiently engraft in vivo. Moreover, hHPLCs could be efficiently induced into mature human hepatocytes (hiHeps) in vitro, whose molecular identity highly resembles primary human hepatocytes (PHHs). Most importantly, hiHeps could be generated in large quantity and were functionally competent to replace PHHs for drug-metabolism estimation, toxicity prediction and hepatitis B virus infection modeling. Our results highlight the advantages of the progenitor stage for successful lineage reprogramming. This strategy is promising for generating other mature human cell types by lineage reprogramming. | Bingqing Xie Da Sun Yuanyuan Du Jun Jia Shicheng Sun Jun Xu Yifang Liu Chengang Xiang Sitong Chen Huangfan Xie Qiming Wang Guangya Li Xuehui LYU Hui Shen Shiyu Li Min Wu Xiaonan Zhang Yue Pu Kuanhui Xiang Weifeng Lai Peng Du Zhenghong Yuan Cheng Li Yan Shi Shichun Lu Hongkui Deng | 2019 | Cell Research2019，29，9： | 9 |
| 11 | MicroRNA 145 may play an important role in uveal melanoma cell growth by potentially targeting insulin receptor substrate-1显示文摘 | Li Yang Huang Qiming Shi Xuehui Jin Xiang Shen Li Xu Xiaolin Wei Wenbin | 2014 | Chinese Medical Journal2014，，8： | 9 |
| 12 | Land Subsidence in Xiong’an New Area,China Revealed by InSAR Observations显示文摘In 2017,China’s central government approved the national strategy to build Xiong’an New Area(XNA,100 km southwest to Beijing),which was announced as a'millennium strategy'and a'demo area'for a sustainable,modern,and innovative urban model.Xiong’an will draw in as much as$380 billion investment and is expected to help accelerate the development of the wider Beijing-Tianjin-Hebei(Jingjinji)Area.In this paper,present subsidence in the XNA area is investigated using InSAR observations for the first time.The 24 SAR images acquired by European Space Agency’s Sentinel-1 satellites during the period from June 2017 to July 2018 suggest that in the north of Xiong County,the subsidence rate reaches up to 90 mm/y,which is highly correlated with the exploitation of geothermal drilling.As the construction in the XNA area will significantly accelerate and its high-quality development,the InSAR findings could provide valuable information for future sustainable urban planning and underground infrastructure construction. | Keren DAI Peilian RAN Zhenhong LI Julian AUSTIN Jan-Peter MULLER Qiming ZENG Jingfa ZHANG Leyin HU | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 8 |
| 13 | Successful Applications of Generic Atmospheric Correction Online Service for InSAR (GACOS) to the Reduction of Atmospheric Effects on InSAR Observations显示文摘The tremendous development of Synthetic Aperture Radar(SAR)missions in recent years facilitates the study of smaller amplitude ground deformation over greater spatial scales using longer time series.However,this poses greater challenges for correcting atmospheric effects due to the wider coverage of SAR imagery than ever.Previous attempts have used observations from Global Positioning System(GPS)and Numerical Weather Models(NWMs)to separate atmospheric delays,but they are limited by(1)The availability(and distribution)of GPS stations;(2)The low spatial resolution of NWM;And(3)The difficulties in quantifying their performance.To overcome these limitations,we have developed the Generic Atmospheric Correction Online Service for InSAR(GACOS)which utilizes the high-resolution European Centre for Medium-Range Weather Forecasts(ECMWF)products using an Iterative Tropospheric Decomposition(ITD)model.This enables the reduction of the coupling effects of the troposphere turbulence and stratification and hence achieves equivalent performances over flat and mountainous terrains.GACOS comprises a range of notable features:(1)Global coverage;(2)All-weather,all-time usability;(3)Available with a maximum of two-day latency;And(4)Indicators available to assess the model’s performance and feasibility.In this paper,we demonstrate some successful applications of the GACOS online service to a variety of geophysical studies. | Chen YU Zhenhong LI Lin BAI Jan-Peter MULLER Jingfa ZHANG Qiming ZENG | 2021 | Journal of Geodesy and Geoinformation Science2021，4，1： | 8 |
| 14 | GRAIN LENGTH AND AWN 1 negatively regulates grain size in rice显示文摘Grain size is an important factor determining yield in rice. Here, we identified a recessive mutant gene, grain length and awn 1 (gla1), which caused a significant increase in grain length and weight, and was associated with long awns. The gla1 mutation was mapped to a single-nucleotide polymorphism in a gene encoding a cytoplasmically-localized mitogen-activated protein kinase (MAPK) phosphatase. Overexpression of GLA1 caused a decrease in grain length, and the GLA1 protein interacted with OsMAPK6. These results suggest that GLA1 may serve as a negative regulator of the OsMAPKK4-OsMAPK6 cascade, controlling grain size via the dephosphorylation of OsMAPK6. | Tao Wang Ting Zou Zhiyuan He Guoqiang Yuan Tao Luo Jun Zhu Yueyang Liang Qiming Deng Shiquan Wang Aiping Zheng Huainian Liu Lingxia Wang Ping Li Shuangcheng Li | 2019 | Journal of Integrative Plant Biology2019，61，10： | 7 |
| 15 | Transformative hyaluronic acid-based active targeting supramolecular nanoplatform improves long circulation and enhances cellular uptake in cancer therapy显示文摘Hyaluronic acid(HA) is a natural ligand of tumor-targeted drug delivery systems(DDS) due to the relevant CD44 receptor overexpressed on tumor cell membranes. However, other HA receptors(HARE and LYVE-1) are also overexpressing in the reticuloendothelial system(RES). Therefore,polyethylene glycol(PEG) modification of HA-based DDS is necessary to reduce RES capture.Unfortunately, pegylation remarkably inhibits tumor cellular uptake and endosomal escapement,significantly compromising the in vivo antitumor efficacy. Herein, we developed a Dox-loaded HA-based transformable supramolecular nanoplatform(Dox/HCVBP) to overcome this dilemma. Dox/HCVBP contains a tumor extracellular acidity-sensitive detachable PEG shell achieved by a benzoic imine linkage.The in vitro and in vivo investigations further demonstrated that Dox/HCVBP could be in a 'stealth' state at blood stream for a long circulation time due to the buried HA ligands and the minimized nonspecific interaction by PEG shell. However, it could transform into a 'recognition' state under the tumor acidic microenvironment for efficient tumor cellular uptake due to the direct exposure of active targeting ligand HA following PEG shell detachment. Such a transformative concept provides a promising strategy to resolve the dilemma of natural ligand-based DDS with conflicting two processes of tumor cellular uptake and in vivo nonspecific biodistribution. | Lu Zhong Lu Xu Yanying Liu Qingsong Li Dongyang Zhao Zhenbao Li Huicong Zhang Haotian Zhang Qiming Kan Yongjun Wang Jin Sun Zhonggui He | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 7 |
| 16 | Effects of dissolved organic matter from sewage sludge on sorption of tetrabromobisphenol A by soils显示文摘Sorption of tetrabromobisphenol A (TBBPA) by soil influences its fate and transport in the environment. The presence of dissolved organic matter (DOM) may complicate the sorption process in soil. The effects of DOM from sewage sludge on TBBPA sorption by three soils were investigated using batch equilibration experiments in the study. DOM was observed to be sorbed on the soils and the isotherms could be fitted by the Langmuir model. The effects of DOM on TBBPA sorption were dependent on the characteristics of soils and the concentrations of DOM present. TBBPA sorption by Henan (HN) soil (sandy loam) and Liaoning (LN) soil (loamy clay) was promoted in the presence of DOM at low concentration ( 90 mg organic carbon (OC)/L), and the sorption was promoted by HN soil and inhibited by LN soil at DOM added concentration of 180 mg OC/L. TBBPA sorption by Guangxi (GX) soil (silt loam) was always inhibited in the presence of DOM. It was also found that the amount of TBBPA sorbed decreased with the increase in the solution pH value in the absence of DOM. The influencing mechanisms of DOM on the sorption of TBBPA by soils were also discussed. | Zhaohai SUN Hongxia YU | 2008 | Journal of Environmental Sciences2008，20，9： | 6 |
| 17 | Timing and history of marine hydrocarbon accumulation in Tarim craton显示文摘Based on the analyses of hydrocarbon inclu-sions, K-Ar dating of authigenic illites and oil/gas-watercontact retrospection as well as other methods, the marineprimary reservoirs in the cratonic region of the Tarim Basinare found to have been formed in the late Caledonian toearly Hercynian, late Hercynian, and Himalayan, and oil andgas adjusted and redistributed in the Yanshanian (Jurassic toCretaceous) and Himalayan (Tertiary). The analyses alsoshow that the remaining primary oil accumulations aremostly formed in the late Hercynian, and the secondary oilreservoirs resulted from the adjustment and redistribution ofthe earlier accumulations during the Yanshanian and Hima-layan (especially late Himalayan), of which the Himalayan isalso the major stage of gas accumulation. The primary oilreservoirs formed in the late Hercynian mostly occur withinthe Paleozoic formation, whereas the secondary reservoirsformed in the Himalayan in the Mesozoic. The late adjust-ment and redistribution of reservoirs in the craton region ofthe Tarim Basin is ubiquitous because of the intensified tec-tonic movements since the Mesozoic, especially Cenozoic andintrusion of the high- to over-mature gas. Furthermore, thelower amplitude of reservoirs in the craton region also makesthem easier to be adjusted and redistributed. Therefore, theremaining paleo-uplift and palaeo-slope developed in rela-tively stable tectonic regions are the main potential areas forthe middle-large marine reservoirs in the Tarim Basin. | ZHAO Jingzhou~(1,2) & LI Qiming~3 1. Department of Petroleum Geology, Xi’an Petroleum Institute, Xi’an 710065, China 2. Research Institute of Petroleum Exploration and Development, PetroChina, Beijing 100083, China 3. Tarim Oilfield Company, Kuerle, Xinjiang 841000, China | 2002 | Chinese Science Bulletin2002，47，S1： | 5 |
| 18 | Anlotinib as third- or further-line therapy for short-term relapsed small-cell lung cancer: subgroup analysis of a randomized phase 2 study (ALTER1202)显示文摘Patients with small-cell lung cancer (SCLC) relapse within months after completing previous therapies. This study aimed to investigate the efficacy and safety of anlotinib as third- or further-line therapy in patients with short-term relapsed SCLC from ALTER1202. Patients with short-term relapsed SCLC (disease progression within 3 months after completing ≥ two lines of chemotherapy) in the anlotinib (n = 67) and placebo (n = 34) groups were analyzed. The primary endpoint was progression-free survival (PFS). The secondary endpoints included overall survival, objective response rate (ORR), disease control rate, and safety. Anlotinib significantly improved median PFS/OS (4.0 vs. 0.7 months, P < 0.0001)/(7.3 vs. 4.4 months, P = 0.006) compared with placebo. The ORR was 4.5%/2.9% in the anlotinib/placebo group (P = 1.000). The DCR in the anlotinib group was higher than that in the placebo group (73.1% vs. 11.8%, P < 0.001). The most common adverse events (AEs) were hypertension (38.8%), loss of appetite (28.4%), and fatigue (22.4%) in the anlotinib group and gamma-glutamyl transpeptidase elevation (20.6%) in the placebo group. No grade 5 AEs occurred. For patients with short-term relapsed SCLC, third- or further-line anlotinib treatment was associated with improved survival benefit. Further studies are warranted in this regard. | Jianhua Shi Ying Cheng Qiming Wang Kai Li Lin Wu Baohui Han Gongyan Chen Jianxing He Jie Wang Haifeng Qin Xiaoling Li | 2022 | Frontiers of Medicine2022，16，5： | 5 |
| 19 | Logical and Innovative Construction of Digital Twin City显示文摘This paper first introduces the background and basic concept of digital twin city,then analyzes the relationship between digital twin city and smart city.Next,it introduces the primary supporting technologies for the construction of a digital twin city,and finally summarizes the current application status and development trends regarding digital twin city.The authors argue that digital twin technology will face challenges in regards to data,basic knowledge base,system integration,and talent issues if it is to be more widely applied in the construction of the smart city.Additionally,the authors propose institutional and technical suggestions for solving these problems at the macro and micro levels. | Xinchang ZHANG Shaoying LI Qiming ZHOU Ying SUN | 2021 | Journal of Geodesy and Geoinformation Science2021，4，4： | 5 |
| 20 | The diversity of denitrifying bacteria in the alpine meadow soil of Sanjiangyuan natural reserve in Tibet Plateau显示文摘This is the first time to describe the diversity of denitrifying bacteria in Sanjiangyuan natural reserve in Tibet Plateau by investigating the molecular diversity and phylogenetic analysis of nirK and nosZ genes using PCR-RFLP and sequencing. Four soil samples were collected from alpine meadow communities from over an altitude of 4600 m which had different physicochemical properties by principal component analysis (PCA). For the genes fragment of nirK and nosZ, the diverse PCR products were characterized by cloning, restriction fragment length polymorphism (RFLP) analysis and sequenced. A total of 253 nirK clones and 283 nosZ clones were received in four samples, and 78 operational taxonomic units (OTUs) of nirK and 120 OTUs of nosZ by the restriction enzymes MspI and RsaI digested. The analysis of environmental factors showed that altitude and C/N ratio in soil may be the key factors to the denitrifying bacteria community. 36 nirK clones and 17 nosZ clones were sequenced, and their levels of nucleotide identity were from 69% to 98% and 57% to 97%, respectively. The phylogenetic tree was constructed using the Clustal W and Mega softwares, and all the sequenced clones could be subdivided into 4 groups. Some of clone sequences were related to the nirK and nosZ genes belonging to three phylogenetic subdivisions (α-, β- and γ subclasses of the Proteobacteria), while most of the clones were closely related to the genes of the uncultured bacteria. The sequence distributions were not clear relating to the sample sites in the tree. | ZHANG Yuguang LI Diqiang WANG Huimin XIAO Qiming LIU Xueduan | 2006 | Chinese Science Bulletin2006，51，10： | 4 |
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