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| 1 | Efficacy of long-term rifaximin treatment for hepatic encephalopathy in the Japanese显示文摘BACKGROUND Hepatic encephalopathy(HE)is a complication of liver cirrhosis and can result in neuropsychological and neuromuscular dysfunctions in patients.Rifaximin,an antibiotic,has been reported to decrease the occurrence of overt HE and also improve cognitive function in studies from Europe and the United States of America.There is not enough evidence of the relationship between the long-term use of rifaximin and its clinical effects in the Japanese.AIM To determine the clinical effects of long-term rifaximin therapy in decompensated liver cirrhosis patients,with overt HE or hyperammonemia.METHODS In this single-center retrospective observational cohort study,we reviewed the data of 38 patients who had taken rifaximin at the dose of 1200 mg/d for more than 24 wk.The primary outcome measured was the efficacy of long-term rifaximin use,and secondary outcome measured was the safety of its long-term use as determined by its influence on portosystemic shunts as well as Escherichia coli-related infections.Moreover,we compared the prognosis between the rifaximin group and control cases,matched for hepatic elasticity assessed by magnetic resonance ela-stography,age,and Child-Pugh classification.RESULTS Of the 38 patients included in the study,12(31.6%)had overt HE,27(71.1%)had complications of esophageal varices,and 9(23.7%)had hepatocellular carcinoma(HCC).The control group was matched for age,Child-Pugh classification,liver stiffness,and presence of HCC.The median of serum ammonia level before treatment was 104μg/dL(59-297),and 2 wk after treatment,it significantly decreased to 85μg/dL(34-153)(P=0.002).A significantly low value of 80.5μg/dL(44-150)was maintained 24 wk after treatment.The long-term use of rifaximin did not cause a decline in liver function.Diarrhea occurred in 2 patients,who improved with the administration of probiotics,and there were no cases of aborted rifaximin therapy owing to adverse events.In patients with Child C,the survival was short,but there was no significant difference compared with that of the control group.CONCLUSION Rifaximin therapy improves overt HE.The long-term use of rifaximin in the Japanese is effective and safe. | Shinya Nishida Koichi Hamada Noriyuki Nishino Daizo Fukushima Ryota Koyanagi Yoshinori Horikawa Yoshiki Shiwa Satoshi Saitoh | 2019 | World Journal of Hepatology2019，11，6： | 3 |
| 2 | Novel technique of abdominal wall nerve block for laparoscopic colostomy: Rectus sheath block with transperitoneal approach显示文摘A 62-year-old man who had acute rectal obstruction due to a large rectal cancer is presented. He underwent emergency laparoscopic colostomy. We used the laparoscopic puncture needle to inject analgesia with the novel transperitoneal approach. In this procedure, both ultrasound and laparoscopic images assisted with the accurate injection of analgesic to the correct layer. The combination of laparoscopic visualization and ultrasound imaging ensured infiltration of analgesic into the correct layer without causing damage to the bowel. Twentyfour hours postoperatively, the patient's pain intensity as assessed by the numeric rating scale was 0-1 during coughing, and a continuous intravenous analgesic was not needed. Colostomy is often necessary in colon obstruction. Epidural anesthesia for postoperative pain cannot be used in patients with a coagulation disorder. We report the use of a novel laparoscopic rectus sheath block for colostomy. There has been no literature described about the nerve block with transperitoneal approach. The laparoscopic rectus sheath block was performed safely and had enough analgesic efficacy for postoperative pain. This technique could be considered as an optional anesthetic regimen in acute situations. | Jun Nagata Jun Watanabe Yusuke Sawatsubashi Masaki Akiyama Koichi Arase Noritaka Minagawa Takayuki Torigoe Kotaro Hamada Yoshifumi Nakayama Keiji Hirata | 2017 | World Journal of Gastrointestinal Surgery2017，9，8： | 2 |
| 3 | Relation between d-density wave of electron and staggered flux of spinon显示文摘 | Hamada Koichi Yolshioka Daijiro | 2003 | Physica C2003，38，： | 1 |
| 4 | An Economic Analysis of the Duty-Free Zones显示文摘 | Hamada Koichi | 1974 | Journal of International Economics1974，4，3： | 1 |
| 5 | An economic analysis of the duty-free zone 显示文摘 | HAMADA Koichi 1974 | 1974 | JournalofInternationalEconomics1974，，4： | 1 |
| 6 | The brain drain,international integration of markets for professionals andunemployment :a theoretical analysis 显示文摘 | BHAGWATI JAGDISH N HAMADA KOICHI | 1974 | Journal of Development Economics1974，1，1： | 1 |
| 7 | Liability Rules and Income Distribution in Products Liability显示文摘 | Hamada Koichi | | 0，，： | 1 |
| 8 | Comparison of Methimazole and Propylthiouracil in Patients with Hyperthyroidism Caused by Graves’ Disease显示文摘 | Hirotoshi Nakamura Jaeduk Yoshimura Noh Koichi Itoh Shuji Fukata Akira Miyauchi Noboru Hamada | 2007 | The Journal of Clinical Endocrinology & Metabolism2007，，： | 1 |
| 9 | Secondary osteochondromatosis in the subacromial bursa:a report of two cases and review of the literature显示文摘 | Jun'ichiro Hamada Kazuya Tamai Koichi Saotome | 2004 | J Orthop Sci2004，9，： | 1 |
| 10 | Physiological Functions of Pten in Mouse Tissues显示文摘 | Hiroyuki Kishimoto Koichi Hamada Mary Saunders | 2003 | Cell Structure and Function2003，28，7： | 1 |
| 11 | The Choice BetweenFlexible Exchange Rates, Capital Control and the Currency Board in Asian Countries: A Perspective from the 'Impossible Trinity'显示文摘 | Koichi Hamada Yosuke Takeda | 2001 | The Japanese Economic Review2001，52，4： | 1 |
| 12 | Monetary and International Factors behind Japan's Lost Decade显示文摘 | Koichi Hamada Yasushi Okada | 2009 | Journal of the Japanese and International Economies2009，，2： | 1 |
| 13 | An Economic Analysis of the Duty Free Zone显示文摘 | Hamada Koichi | 1974 | Journal of International Economic1974，，3： | 1 |
| 14 | Prognostic Factors After Pulmonary Metastasectomy for Colorectal Cancer and Rationale for Determining Surgical Indications: A Retrospective Analysis显示文摘 | Tomohiko Iida Hiroaki Nomori Mitsutoshi Shiba Jun Nakajima Sakae Okumura Hirotoshi Horio Haruhisa Matsuguma Norihiko Ikeda Ichiro Yoshino Yuichi Ozeki Keigo Takagi Tomoyuki Goya Masafumi Kawamura Chikuma Hamada Koichi Kobayashi | 2013 | Annals of Surgery2013，，6： | 1 |
| 15 | The Brain Drain,International Integration of Markets for Professionals and Unemployment:A theoretical Analysis显示文摘 | Bhagwati Jagdish Koichi Hamada | | 0，，01： | 1 |
| 16 | Trial design and rationale of TY-51924 as a novel Na + /H + exchanger inhibitor in patients with ST-elevation acute myocardial infarction undergoing percutaneous coronary intervention显示文摘 | Masaharu Ishihara Masanori Asakura Kazuo Kimura Koichi Nakao Chikuma Hamada Atsushi Hirayama | 2013 | Journal of Cardiology2013，，： | 1 |
| 17 | Distinct Roles of Ephrin-B2 Forward and EphB4 Reverse Singaling in Endothelia Cells显示文摘 | Koichi Hamada Yuichi Oike Yasuhiro Ito | 2003 | Arterioscler Thromb Vasc Biol2003，23，： | 1 |
| 18 | Apolipoprotein E genotype, serum lipids, and colorectal adenomas in Japanese men显示文摘 | Sachiko Shinomiya Jun Sasaki Chikako Kiyohara Emiko Tsuji Hisako Inoue Tomomi Marugame Koichi Handa Hitomi Hayabuchi Hiroaki Hamada Hiroyuki Eguchi Yoshitaka Fukushima Suminori Kono | 2001 | Cancer Letters2001，，1： | 1 |
| 19 | Pten deftciency in melanocytes results in resistance to hair graying and susceptibility to carcinogen-induced melanomagenesis显示文摘 | Tae Inoue-Narita Koichi Hamada Takehiko Sasaki | 2008 | Cancer Res2008，68，： | 1 |
| 20 | Periostin and bone marrow fibrosis显示文摘 | Eijiro Oku Taisuke Kanaji Yuka Takata Koichi Oshima Ritsuko Seki Satoshi Morishige Rie Imamura Korenori Ohtsubo Michitoshi Hashiguchi Koichi Osaki Kazuaki Yakushiji Kohji Yoshimoto Hideaki Ogata Hirofumi Hamada Kenji Izuhara Michio Sata Takashi Okamura | 2008 | International Journal of Hematology2008，，1： | 1 |
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