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| 1 | The role of resistance and aerobic exercise training on insulin sensitivity measures in STZ-induced Type 1 diabetic rodents显示文摘 | Katharine E. Hall Matthew W. McDonald Kenneth N. Grisé Oscar A. Campos Earl G. Noble C.W. James Melling | 2013 | Metabolism2013，，： | 1 |
| 2 | Expression of Fc α/μ Receptor by Human Mesangial Cells: A Candidate Receptor for Immune Complex Deposition in IgA Nephropathy显示文摘 | Kenneth J. McDonald Angus J.M. Cameron Janet M. Allen Alan G. Jardine | 2002 | Biochemical and Biophysical Research Communications2002，，1： | 1 |
| 3 | Diastolic Heart Failure: Evidence of Increased Myocardial Collagen Turnover Linked to Diastolic Dysfunction显示文摘 | Ramón Martos John Baugh Mark Ledwidge Christina O’Loughlin Carmel Conlon Anil Patle Seamas C. Donnelly Kenneth McDonald | 2007 | Circulation2007，，7： | 1 |
| 4 | Depression increases risk of incident myocardial infarction among Veterans Administration patients with rheumatoid arthritis显示文摘 | Jeffrey F. Scherrer Katherine S. Virgo Angelique Zeringue Kathleen K. Bucholz Theodore Jacob Robert G. Johnson William R. True Robert M. Carney Kenneth E. Freedland Hong Xian Liron Caplan Jay McDonald Seth A. Eisen | 2009 | General Hospital Psychiatry2009，，4： | 1 |
| 5 | Diastolic Heart Failure: Evidence of Increased Myocardial Collagen Turnover Linked to Diastolic Dysfunction显示文摘 | Ramón Martos John Baugh Mark Ledwidge Christina O’Loughlin Carmel Conlon Anil Patle Seamas C. Donnelly Kenneth McDonald | 2007 | Circulation2007，，7： | 1 |
| 6 | Long-term Effects on Sexual Function of Five Antihypertensive Drugs and Nutritional Hygienic Treatment in Hypertensive Men and Women: Treatment of Mild Hypertension Study (TOMHS)显示文摘 | Richard H. Jr Grimm Gregory A. Grandits Ronald J. Prineas Robert H. McDonald Cora E. Lewis John M. Flack Carla Yunis Kenneth Svendsen Philip R. Liebson Patricia J. Elmer Jeremiah Stamler | 1997 | Hypertension1997，，1： | 1 |
| 7 | Heart‘omicsin’AGEing (HOMAGE):design,research objectives and characteristics of the common database显示文摘Heart failure is common in older people and its prevalence is increasing.The Heart 'omics' in AGEing(HOMAGE) project aims to provide a biomarker approach that will improve the early diagnosis of heart failure.A large clinical database,based on(1) prospective population studies or(2) cross-sectional,prospective studies or randomized controlled trials(RCTs) of patients at risk for or with overt cardiovascular disease will be constructed to determine most promising 'omics'-based biomarkers to identify the risk of developing heart failure and/or comorbidities.Population studies,patient cohorts and RCTs are eligible for inclusion in the common database,if they received ethical approval to obtain and share data and have baseline information on cardiovascular risk factors.Currently,the HOMAGE database includes 43,065 subjects,from 20 studies in eight European countries,including healthy subjects from three population studies in France,Belgium and Italy(n = 7,124),patients with heart failure(n = 4,312) from four cohorts in the UK,Spain and Switzerland and patients at high risk for cardiovascular disease(n = 31,629) in 13 cohorts.It is anticipated that more partners will join the consortium and enlarge the pooled data.This large merged database will be a useful resource with which to identify candidate biomarkers that play a role in the mechanism underlying the onset and progression of heart failure. | Lotte Jacobs Lutgarde Thijs Yu Jin Faiez Zannad Alexandre Mebazaa Philippe Rouet Florence Pinet Christophe Bauters Burkert Pieske Andreas Tomaschitz Mamas Mamas Javier Diez Kenneth McDonald John G F Cleland Hans-Peter Brunner-La Rocca Stephane Heymans Roberto Latini Serge Masson Peter Sever Christian Delles Stuart Pocock Timothy Collier Tatiana Kuznetsova Jan A Staessen | 2014 | The Journal of Biomedical Research2014，28，5： | 1 |
| 8 | Long-Term Statin Therapy in Patients With Systolic Heart Failure and Normal Cholesterol: Effects on Elevated Serum Markers of Collagen Turnover, Inflammation, and B-Type Natriuretic Peptide显示文摘 | Esam Abulhul Kenneth McDonald Ramon Martos Dermot Phelan J. Paul Spiers Martina Hennessy John Baugh Chris Watson Christina O’Loughlin Mark Ledwidge | 2012 | Clinical Therapeutics2012，，： | 1 |
| 9 | Natural History of Markers of Collagen Turnover in Patients With Early Diastolic Dysfunction and Impact of Eplerenone显示文摘 | George J. Mak Mark T. Ledwidge Chris J. Watson Dermot M. Phelan Ian R. Dawkins Niamh F. Murphy Anil K. Patle John A. Baugh Kenneth M. McDonald | 2009 | Journal of the American College of Cardiology2009，，18： | 1 |
| 10 | Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma显示文摘Allelic loss of the short arm of chromosome 1 has been observed frequently in a wide spectrum of cancers,most frequently in oligodendroglioma.In our previous studies,we evaluated 177 oligodendroglial tumor samples and identified the AJAP1 gene(formerly Shrew1) in the consensus region of deletion.AJAP1 is a transmembrane protein found in adheren junctions and functions to inhibit glioma cell adhesion and migration.Whereas a putative tumor suppressor gene,we did not detect AJAP1 gene mutations.In subsequent studies,we found that AJAP1 was underexpressed in oligodendrogliomas relative to normal brain tissues.Bioinformatic analysis revealed the presence of CpG islands in the promoter of AJAP1.Methylation analysis of the AJAP1 promoter identified hypermethylation in 21% of oligodendrogliomas(n = 27),and the degree of methylation correlated with low levels of AJAP1 expression(P = 0.045).The AJAP1 promoter was also highly methylated in a wide spectrum of cell lines(n = 22),including cell lines of glioblastoma.Analysis of the National Cancer Institute's REMBRANDT dataset,which contains 343 glioma samples,indicated that low AJAP1 gene expression was associated with decreased survival.Thus,both genetic(gene deletion) and epigenetic alterations(promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas,which contributes to poor prognosis. | David Cogdell Woonbok Chung Yuexin Liu J. Matthew McDonald Kenneth Aldape Jean-Pierre J. Issa Gregory N. Fuller Wei Zhang | 2011 | Chinese Journal of Cancer2011，30，4： | 1 |
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