6篇
您的检索式：作者名="Kenneth Aldape"
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| 1 | Clinical Validation of a Next-Generation Sequencing Screen for Mutational Hotspots in 46 Cancer-Related Genes显示文摘 | Rajesh R. Singh Keyur P. Patel Mark J. Routbort Neelima Reddy Bedia Barkoh Brian Handal Rashmi Kanagal-Shamanna Wesley O. Greaves L. Jeffrey Medeiros Kenneth Aldape Rajyalakshmi Luthra | 2013 | The Journal of Molecular Diagnostics2013，，： | 1 |
| 2 | Aber- rant NF-KB activity is critical in focal necrosis formation of human glioblastoma by regulation of the expression of tissue factor显示文摘 | XIE TONG-XIN KENNETH D ALDAPE | 2008 | INT J ONCOL2008，33，1： | 1 |
| 3 | PKM2 Phosphorylates Histone H3 and Promotes Gene Transcription and Tumorigenesis显示文摘 | Weiwei Yang Yan Xia David Hawke Xinjian Li Ji Liang Dongming Xing Kenneth Aldape Tony Hunter W.K. Alfred Yung Zhimin Lu | 2012 | Cell2012，，4： | 1 |
| 4 | Phase II study of CCI-779 in patients with recurrent glioblastoma multiforme显示文摘 | Susan M. Chang Patrick Wen Timothy Cloughesy Harry Greenberg David Schiff Charles Conrad Karen Fink H. Ian Robins Lisa Angelis Jeffrey Raizer Kenneth Hess Ken Aldape Kathleen R. Lamborn John Kuhn Janet Dancey Michael D. Prados | 2005 | Investigational New Drugs2005，，4： | 1 |
| 5 | Detection of human cytomegalovirus in different histological types of gliomas显示文摘 | Michael E. Scheurer Melissa L. Bondy Kenneth D. Aldape Thomas Albrecht Randa El-Zein | 2008 | Acta Neuropathologica2008，，1： | 1 |
| 6 | Tumor-associated methylation of the putative tumor suppressor AJAP1 gene and association between decreased AJAP1 expression and shorter survival in patients with glioma显示文摘Allelic loss of the short arm of chromosome 1 has been observed frequently in a wide spectrum of cancers,most frequently in oligodendroglioma.In our previous studies,we evaluated 177 oligodendroglial tumor samples and identified the AJAP1 gene(formerly Shrew1) in the consensus region of deletion.AJAP1 is a transmembrane protein found in adheren junctions and functions to inhibit glioma cell adhesion and migration.Whereas a putative tumor suppressor gene,we did not detect AJAP1 gene mutations.In subsequent studies,we found that AJAP1 was underexpressed in oligodendrogliomas relative to normal brain tissues.Bioinformatic analysis revealed the presence of CpG islands in the promoter of AJAP1.Methylation analysis of the AJAP1 promoter identified hypermethylation in 21% of oligodendrogliomas(n = 27),and the degree of methylation correlated with low levels of AJAP1 expression(P = 0.045).The AJAP1 promoter was also highly methylated in a wide spectrum of cell lines(n = 22),including cell lines of glioblastoma.Analysis of the National Cancer Institute's REMBRANDT dataset,which contains 343 glioma samples,indicated that low AJAP1 gene expression was associated with decreased survival.Thus,both genetic(gene deletion) and epigenetic alterations(promoter methylation) are likely mechanisms that inactivate the putative tumor suppressor AJAP1 in gliomas,which contributes to poor prognosis. | David Cogdell Woonbok Chung Yuexin Liu J. Matthew McDonald Kenneth Aldape Jean-Pierre J. Issa Gregory N. Fuller Wei Zhang | 2011 | Chinese Journal of Cancer2011，30，4： | 1 |
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