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| 1 | 肿瘤恶性转化与C/EBPβ和STAT3基因相关(英文)显示文摘The inference of transcriptional networks that regulate transitions into physiological or pathological cellular states remains a central challenge in systems biology. A mesenchymal phenotype is the hallmark of tumour aggressiveness in human malignant glioma,but the regulatory programs responsible for implementing the associated molecular signature are largely unknown. Here we show that reverse-engineering and an unbiased interrogation of a glioma-specific regulatory network reveal the transcriptional module that activates expression of mesenchymal genes in malignant glioma. Two transcription factors (C/EBPβ and STAT3) emerge as synergistic initiators and master regulators of mesenchymal transformation. Ectopic co-expression of C/EBPβ and STAT3 reprograms neural stem cells along the aberrant mesenchymal lineage,whereas elimination of the two factors in glioma cells leads to collapse of the mesenchymal signature and reduces tumour aggressiveness. In human glioma,expression of C/EBPβ and STAT3 correlates with mesenchymal differentiation and predicts poor clinical outcome. These results show that the activation of a small regulatory module is necessary and sufficient to initiate and maintain an aberrant phenotypic state in cancer cells. | Maria Stella Carro Wei Keat Lim Mariano Javier Alvarez Robert J. Bollo Evan Y. Snyder Erik P. Sulman Sandrine L. Anne Fiona Doetsch Howard Colman Anna Lasorella Ken Aldape Andrea Califano Antonio Iavarone | 2010 | 中华神经外科疾病研究杂志2010，9，1： | 16 |
| 2 | Dual destructive and protective roles of adaptive immunity in neurodegenerative disorders显示文摘Inappropriate T cell responses in the central nervous system(CNS)affect the pathogenesis of a broad range of neuroinflammatory and neurodegenerative disorders that include,but are not limited to,multiple sclerosis,amyotrophic lateral sclerosis,Alzheimer’s disease and Parkinson’s disease.On the one hand immune responses can exacerbate neurotoxic responses;while on the other hand,they can lead to neuroprotective outcomes.The temporal and spatial mechanisms by which these immune responses occur and are regulated in the setting of active disease have gained significant recent attention.Spatially,immune responses that affect neurodegeneration may occur within or outside the CNS.Migration of antigen-specific CD4+T cells from the periphery to the CNS and consequent immune cell interactions with resident glial cells affect neuroinflammation and neuronal survival.The destructive or protective mechanisms of these interactions are linked to the relative numerical and functional dominance of effector or regulatory T cells.Temporally,immune responses at disease onset or during progression may exhibit a differential balance of immune responses in the periphery and within the CNS.Immune responses with predominate T cell subtypes may differentially manifest migratory,regulatory and effector functions when triggered by endogenous misfolded and aggregated proteins and cell-specific stimuli.The final result is altered glial and neuronal behaviors that influence the disease course.Thus,discovery of neurodestructive and neuroprotective immune mechanisms will permit potential new therapeutic pathways that affect neuronal survival and slow disease progression. | Kristi M Anderson Katherine E Olson Katherine A Estes Ken Flanagan Howard E Gendelman R Lee Mosley | 2014 | Translational Neurodegeneration2014，3，1： | 8 |
| 3 | Vascular endothelial growth factor and basic flbroblast growth factor induce expression of CX- CR4 on human endothelial ceils 显示文摘 | Rosalba S Ken W Howard A | 1999 | Am J Pathol1999，154，4： | 1 |
| 4 | A tectono-geomorphic model of the hydrogeology of deeply weathered crystalline rock: Evidence from Uganda显示文摘 | Richard Taylor Ken Howard | 2000 | Hydrogeology Journal2000，，3： | 1 |
| 5 | 新版《彼得·格莱姆斯》登台大都会歌剧院显示文摘饰演彼得·格莱姆斯的男高音歌唱家安东尼-狄安·葛瑞菲(Anthony Deon Griffey)站矿在大都会歌剧院的巨大舞台上,身体微微右倾,遥望着观众席及更远处的“海”。受到全自治市人的谴责,格莱姆斯的精神崩溃了,仿佛被撕成两半。是格莱姆斯无法适应自治市的生活还是确为异类?或许兼而有之。 | 谢晶晶(编译) Ken Howard | 2008 | 歌剧2008，，4： | 1 |
| 6 | High- temperature phase transition in SrZrO3 显示文摘 | Kenned Y B J Howard C J | 1999 | Phys Rev B1999，59，： | 1 |
| 7 | Reduced Pretreatment Ipsilateral Middle Cerebral Artery Cerebral Blood Flow Is Predictive of Symptomatic Hemorrhage Post–Intra-Arterial Thrombolysis in Patients With Middle Cerebral Artery Occlusion显示文摘 | Rishi Gupta Howard Yonas James Gebel Steven Goldstein Michael Horowitz Stephen Z. Grahovac Lawrence R. Wechsler Maxim D. Hammer Ken Uchino Tudor G. Jovin | 2006 | Stroke2006，，10： | 1 |
| 8 | Evaluation of heterogeneity and field-scale groundwater flow regime in a leaky till aquitard显示文摘 | Richard E. Gerber Joseph I. Boyce Ken W. Howard | 2001 | Hydrogeology Journal2001，，1： | 1 |
| 9 | Insertion of interleukin-2(IL-2) and interleukin-12 (IL-12) genes into vaccinia virus results in effective anti-tumor responses without toxicity显示文摘 | Howard L K Ken F Christopher S D | 2002 | Vaccine2002，20，1314： | 1 |
| 10 | 歌剧《秦始皇》印象显示文摘本以为《秦始皇》最后彩排只为招待传媒,不会有多少人。进入纽约大都会歌剧院,楼下最好的座位挤满了记者,平时最贵的300美元一张票的二楼正中位置也排满了记者们的大口径摄像机。 | 薛炎 Ken Howard Metropolitan Opera | 2007 | 歌剧2007，，2： | 1 |
| 11 | Quantitative Perihematomal Blood Flow in Spontaneous Intracerebral Hemorrhage Predicts In-Hospital Functional Outcome显示文摘 | Ashis H. Tayal Rishi Gupta Howard Yonas Tudor Jovin Ken Uchino Maxim Hammer Lawrence Wechsler James M. Gebel | 2007 | Stroke2007，，： | 1 |
| 12 | First-ever FDPS() at work on Azurite field development显示文摘 | Harry Howard Ken Hampshire Jeffrey Moore | 2009 | Offshore2009，69，11： | 1 |
| 13 | Plasma apolipoprotein A1 as a biomarker for Parkinson disease显示文摘 | Judy K. Qiang Yvette C. Wong Andrew Siderowf Howard I. Hurtig Sharon X. Xie Virginia M.‐Y. Lee John Q. Trojanowski Dora Yearout James B. Leverenz Thomas J. Montine Matt Stern Susan Mendick Danna Jennings Cyrus Zabetian Ken Marek Alice S. Chen‐Plotkin | 2013 | Ann Neurol2013，，1： | 1 |
| 14 | 在纽约大都会歌剧院看歌剧显示文摘2010年圣诞前,去纽约大都会歌院观看了两出歌剧,在卡尼基音乐厅欣赏了一场青年乐队的演奏,然后与朋友一行十三人去南美四国旅游。在这四国之中,秘鲁的文化古迹最为丰富、阿根廷较现代、巴西人口众多但逍遥快乐、智利拥有南美最廉洁的政府。 | 刘靖之 Ken Howard | 2011 | 音乐爱好者2011，，4： | 0 |
| 15 | 《凡尔赛的幽灵》亮相圣路易斯歌剧院显示文摘18年前,1991年12月,美国作曲家约翰·科里利亚诺(John Corigliano)的歌剧《凡尔赛的幽灵》在大都会歌剧院首演两场便大获成功。该剧也是大都会歌剧院委约创作制度的产物。该剧自1991年首演后,仅有芝加哥抒情歌剧院及德国汉诺威歌剧院演出过,没有其他歌剧院愿意承担风险演出该剧,原计划于2009~2010演出季在大都会歌剧院举行的复排演出也因为财政原因(金融危机)而被迫搁浅。 | 普罗 Ken Howard | 2009 | 歌剧2009，，8： | 0 |
| 16 | 布里顿《比利·巴德》在圣达菲歌剧院上演显示文摘如今,人们将越来越多的注意力放在了歌唱家的外貌和演技上,这让许多歌剧爱好者怀着一种复杂的心情。诚然,如果歌手不仅演技好,而且外形与他们塑造的角色相称的话,无疑会增加歌剧的戏剧感染力。不过,歌唱在歌剧中依然是首要的,唱演俱佳才能让歌剧成为一门让人尊敬的艺术。 | 旋隽 Ken Howard | 2008 | 歌剧2008，，10： | 0 |
| 17 | 岂能以首演成败论英雄显示文摘去年12月,我没有在中国游历,因为“中国”进驻了纽约。谭盾的歌剧《秦始皇》于12月21日作世界首演。也许《歌剧》杂志的大多数读者无法亲自欣赏聆听这场备受国际音乐界瞩目的歌剧首演。 | 司马勤 李正欣 Ken Howard Metropolitan Opera | 2007 | 歌剧2007，，2： | 0 |
| 18 | 缺席金牌卡司《霍夫曼》依旧博得满堂座显示文摘歌剧《霍夫曼的故事》(Les Contes dHoffmann)是大都会歌剧院本季度最受瞩目的制作,因为一年半前宣布时,打出的是金字招牌的演员阵容:主角由墨西哥金童罗兰多·维拉宗(Rolando Villazon)担纲,与他号称最佳拍档的俄罗斯辣妹安娜·涅特里布科(Anna Netrebko)要一人唱四个女角,而堪称是当今乐坛演马克王(Marke)第一人的雷内·帕普(Rene Pape),则准备诠释四个霍夫曼的死对头。除了维拉宗,其他两人都是要首次饰演这些角色。 | 谢朝宗 Ken Howard Metropolitan Opera | 2010 | 歌剧2010，，1： | 0 |
| 19 | 欺骗、激情与谋杀——毛姆的《书信》被搬上歌剧舞台显示文摘圣达菲歌剧院在过去20年中发生了翻天覆地的变化。歌剧院迎来了新任总经理查尔斯·麦凯(Charles McKay),他是自约翰·克罗斯比1957年创建歌剧院以来的第三任最高领导者。克罗斯比钟爱理查·施特劳斯的歌剧,因此每年上演一部理查·施特劳斯的歌剧成为剧院的传统,如今这一惯例已不复存在。 | 李绚 Ken Howard | 2009 | 歌剧2009，，10： | 0 |
| 20 | 《原子博士》:现代、现实、现在显示文摘大都会歌剧院难得安排了新制作的《原子博士》,于10月13日盛大首演。全球乐评云集,堪称盛况空前。当晚坐在我右边的是德国柏林特派的音乐电台主持,而左边则是几年前退休的《纽约时报》艺术版编辑约翰·洛克威尔(John Rockwell)。半场休息的时候,在大都会的传媒接待室里,行家遍及每一角落,连英国《歌剧》杂志编辑都说,这一次他被特别安排来纽约,就是为了这一场演出! | 李正欣 Ken Howard | 2008 | 歌剧2008，，11： | 0 |
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