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| 1 | Gender differences in adolescent dry eye disease:a health problem in girls显示文摘AIM: To evaluate the signs and symptoms of dry eye disease(DED) in adolescents. METHODS: This was a cross-sectional, case-control study and outpatients aged 10 to 19y were recruited from six eye clinics of various practices and locations in Japan, and 253 non-DED subjects and 70 DED patients were enrolled. Participants were examined for DED-related signs. Patients were also interviewed to ascertain the presence or absence of six common DED-related symptoms: dryness, irritation, pain, eye fatigue, blurring, and photophobia. Main outcome measures were differences in signs and symptoms of dry eye disease between boys and girls.RESULTS: Of the 323 adolescents recruited, 70(21.7%) were diagnosed with DED. Significant differences between the non-DED and DED groups were found for short tear break-up time(BUT; ≤5s; P=0.000) and superficial punctate keratopathy(SPK; staining score ≥3; P=0.000). Late adolescent girls reported fewer symptoms than late adolescent boys, although their DED-related signs were worse compared to other groups. The prevalence and severity of DED were similar in the Tokyo area compared with suburban and local areas but myopic errors were worse. CONCLUSION: We find that adolescents reported symptoms of DED similar to those found in adults, and the majority have short BUT-type DED. The prevalence and severity of DED in late adolescent girls is comparable with adults. Adolescents with DED are underserved and we believe that DED is a hidden but potentially serious health problem for this age group. | Masahiko Ayaki Motoko Kawashima Miki Uchino Kazuo Tsubota Kazuno Negishi | 2018 | International Journal of Ophthalmology(English edition)2018，11，2： | 5 |
| 2 | Evaluation of optical function using a new point spread function analysissystem in Cataractous and psuedophakic eye:preliminary result显示文摘 | Kazuno N Katsubiko K Kazuhiko O | 2006 | Jpn J Ophthalmol2006，50，1： | 1 |
| 3 | Evaluation of optical function using a new point spread function analysis system in cataractous and pseudophakic eyes:preliminary results显示文摘 | Kazuno N Katsuhiko K Kazuhiko O | | 0，，： | 1 |
| 4 | Identification of mitochondrial DNA polymorphisms that alter mitochondrial matrix p H and intracellular calcium dynamics显示文摘 | Kazuno AA Munakata K Nagai T | 2006 | PLoS Genet2006，2，8： | 1 |
| 5 | Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells显示文摘 | Murakami Y Kazuno H Emura T | 2000 | Int J Oncol2000，17，2： | 1 |
| 6 | Optic canal decompression: significance of the simultancous optic canal sheath incision 显示文摘 | Uemura T Iisaka Y Kazuno T | 1978 | Neurol Med Chir1978，18，2： | 1 |
| 7 | Thrombinsen sitive protein-2 ( TSP2 ) expression is inversely correlated with vascularity in glioma显示文摘 | Kazuno M Tokunaga T Oshika Y | 1999 | Eur J Cancer1999，35，3： | 1 |
| 8 | Thrombinsen sitive protein-2( TSP2 ) expression is inversely correlated with vascularity in glioma显示文摘 | Kazuno M Tokunaga T Oshika Y | 1999 | Eur J Cancer1999，35，3： | 1 |
| 9 | Smelting reduction behavior of synthetic chromite in molten slag显示文摘 | Satoh M Kazuno M Katayama H G | 1988 | Trans IS I J1988，28，1： | 1 |
| 10 | Association of mitochondrial complex I subunit gene NDUFV2 at 18p11 with bipolar disorder in Japanese and the National Institute of Mental Health pedigrees显示文摘 | Washizuka S Iwamoto K Kazuno AA | 2004 | Biol Psychiatry2004，56，7： | 1 |
| 11 | Different mechanisms of acquired resistance to fluorinated pyrimidinesin human colorectal cancer cells.显示文摘 | Y Murakami H Kazuno T Emura H Tsujimoto N Suzuki M Fukushima | 2000 | International Journal of Oncology2000，，： | 1 |
| 12 | Evaluation of optical function using a new point spread function analysis system in cataractous and pseudophakic eyes:Preliminary resuits显示文摘 | Kazuno N Katsuhiko K Kazuhiko O | 2006 | Jpn J Ophthalmol2006，50，1： | 1 |
| 13 | Different mechanisms of acquired resistance to fluorinated pyrimidines in human colorectal cancer cells显示文摘 | Murakami Y Kazuno H Emura T | 2000 | Int J Oncol2000，17，2： | 1 |
| 14 | Relationships between mitochondrial DNA subhaplogroups and intracellular calcium dynamics 显示文摘 | Kazuno A A Munakata K Tanaka M | 2008 | Mitochondrion2008，8，2： | 1 |
| 15 | Elschnig pearl formation along the neodymium:YAG laser posterior capsulotomy margin显示文摘 | Daijiro Kurosaka Katsuhiko Kato Hiroyo Kurosaka Mami Yoshino Kunihiko Nakamura Kazuno Negishi | 2002 | Journal of Cataract & Refractive Surgery2002，，10： | 1 |
| 16 | Mass spectrometric identification and quantification of glycosyl flavonoids, including dihydrochalcones with neutral loss scan mode 显示文摘 | Kazuno S Yanagida M Shindo N | 2005 | Anal Biochem2005，347，： | 1 |
| 17 | Thoracoseopic esophagectomy while in a prone position for esophageal cancer: a preceding anterior approach method显示文摘 | Ozawa S Ito E Kazuno A | 2013 | Surgical endoscopy2013，27，1： | 1 |
| 18 | Effect of chromatic aberration on contrast sensitivity in pseudophakic eyes 显示文摘 | Kazuno N Kazuhiko O Norio H | 2001 | Arch Ophthalmol2001，119，8： | 1 |
| 19 | Multi-sequential surface plasmon resonance analysis of haptoglobin-lectin complex in sera of patients with malignant and benign prostate diseases 显示文摘 | Kazuno S Fujimura T Arai T | 2011 | Anal Biochem2011，419，2： | 1 |
| 20 | Carbon Dioxide: Clinical Applications for Abdominal Aortic Aneurysm with Chronic Renal Insufficiency as Contrast Media in Endovascular Aneurysm Repair 显示文摘 | Kazuno K Kadohama T Nakanishi S | 2012 | The Journal of Japanese College of Angiology2012，52，： | 1 |
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