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| 1 | Proposal and evaluation of a new norm index-based QSAR model to predict pEC50 and pCC50 activities of HEPT derivatives显示文摘anti-HIV 药的搜索和发展当前是药理学研究的最迫切的任务之一。在这个工作,一个量的结构活动关系( QSAR )模型基于某新标准索引,被获得到一系列超过 150 HEPT 衍生物(1-[( 2-hydroxyethoxy )甲基]发现他们的 pEC 50(对病毒的 cytopathic 效果完成 MT-4 房间的50%保护的要求的有效集中)和 pCC 50的-6-(phenylthio)thymine)(减少可见性的要求的细胞毒素的集中50%嘲笑感染了房间)活动。模型效率然后用 leave-one-out 十字确认(LOO-CV ) 和 y 随机化测试被验证。结果显示这个新模型是有效的并且能为 pEC 50 和 pCC 50 的预言向令人满意的结果提供更高的 R 火车 2 和更高的 R 测试 2 。由使用力量途径,这个模型的适用性领域进一步被调查,没有反应孤立点为涉及这个工作的 HEPT 衍生物被检测。有参考方法的比较结果证明这个新方法能为预言 anti-HIV HEPT 衍生物的 pEC 50 和 pCC 50 导致重要改进。而且,在这现在的研究显示出的结果建议 anti-HIV HEPT 衍生物的这二绝对不同的活动 pEC 50 和 pCC 50 能与一个完全类似的 QSAR 模型一起被预言很好,它显示这个模型可能有潜力进一步为 HEPT 衍生物的另外的生物活动被利用。 | Kanwal Shahid Qiang Wang Qingzhu Jia Lei Li Xue Cui Shuqian Xia Peisheng Ma | 2016 | Chinese Journal of Chemical Engineering2016，24，10： | 2 |
| 2 | Biodiesel Production from Rubber Seed Oil using Activated Cement Clinker as Catalyst显示文摘 | Jolius Gimbun Shahid Ali Chitra Charan Suri Charan Kanwal Liyana Amer Shah Nurul Hidayah Muhamad @ Ghazali Chin Kui Cheng Said Nurdin | 2013 | Procedia Engineering2013，，： | 1 |
| 3 | 基于范数指数定量构效关系预测β-环糊精络合常数(英文)显示文摘环糊精在药剂学领域中是一类重要的包结化合物,其中络合物稳定常数(log K)是一个关键评价参数.本研究基于扩展距离矩阵提出了一组范数指数,利用多种计算方法构建了系列定量构效关系模型,并对233种化合物与β-环糊精的log K进行了计算预测.计算结果表明基于扩展距离矩阵范数建立的系列定量构效关系模型均能较好预测log K;其中利用最小二乘-支撑向量机方法建立的模型预测效果最好,其预测结果的相关性系数R和留一、留十交叉验证相关性系数(QLOO,QLTO)分别为0.9587、0.8775和0.8732.与文献方法对比结果表明,本工作的预测结果在准确性和稳定性上有着显著的改善,且能分辨同分异构体.本课题组前期研究成果和本项工作表明基于范数指数构建的定量构效关系不仅适用于计算化合物的基础物理化学性质,还能应用到化学反应过程相关常数的准确预测. | 钱海城 KANWAL Shahid 贾青竹 王强 计惠芬 朱志臣 夏淑倩 马沛生 | 2015 | 物理化学学报2015，31，5： | 1 |
| 4 | Basal Application of Zinc to Improve Mung Bean Yield and Zinc-Grains-Biofortfication显示文摘Worldwide,the dietary deficiency of zinc(Zn)is prevailing in almost all arid and semi-arid regions.Zinc deficiency is not only the major constraint of lower yield,but also dietary Zn deficiency in cereals grains may cause increasing malnutrition and chronic health problems in human.Exogenous application of Zn through basal soil nutrition might be a useful option to recover Zn deficiency in mung bean.Therefore,field study was conducted to optimize the optimum level and method of Zn nutrition to enhance crop yield and Zn biofortification of mung bean through basal application.Zinc was applied at 0,5,10 and 15 kg/ha as basal application and side dressing,and in combination(50%basal application+50%side dressing).The results highlighted that Zn nutrition prominently improved the mung bean yield as compared with control(no Zn applied).The maximum grains yield and Zn concentration in grains were obtained where Zn was applied at 15 kg/ha as basal application as compared with all other combinations.Better improvement in grain yield was due to significant increase in more number of pods and grain size owing to well-developed root system,improved leaf area index and high chlorophyll contents in mung beans leaves.Amongst all applied Zn nutrition’s the basal application of Zn(15 kg/ha)was a viable option to get higher yield and Zn biofortification of mung bean. | Aroosa Kanwal Muhammad Bismillah Khan Mubshar Hussain Muhammad Naeem Muhammad Shahid Rizwan Muhammad Zafar-ul-Hye | 2020 | Phyton-International Journal of Experimental Botany2020，89，1： | 0 |
| 5 | Biochemical association between the prevalence of genetic polymorphism and myocardial infarction显示文摘Genetic polymorphism has a vital role in the pathogenesis and development of myocardial infarction(MI).Single nucleotide polymorphism at any one of the amino acid sequences can result in a diseased state.A single gene can exhibit genetic polymorphism at more than one position giving rise to different variants.Genetic polymorphism of angiotensinogen(AGT)M235T,AGT T174M,and angiotensin-1-converting enzyme(ACE)I/D,endothelial nitric oxide synthase(eNOS),and methylenetetrahydrofolate reductase(MTHFR)can be a risk factor for MI.However,it is important to study the prevalence of genetic polymorphisms of these genes among different populations.MI is influenced by genetic polymorphism of various genes,including AGT,ACE,eNOS,MTHFR,etc.However,the association of genetic polymorphism of these genes varies among different populations,but different ethnic groups could show contradictory results.These genes have shown a positive association with risks of MI in some populations,whereas the results have not been consistent with every ethnic group.In this article,we have summarized the genetic variations in the aforementioned genes and their association with MI. | MOMINA SHAHID KANWAL REHMAN MUHAMMAD SAJID HAMID AKASH SHALEEM SUHAIL SUMBAL RASHEED MUHAMMAD IMRAN MOHAMMED AASSIRI | 2023 | BIOCELL2023，47，3： | 0 |
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