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| 1 | Evacuated tube transport technologies (ET3)^(tm):a maximum value global transportation network for passengers and cargo显示文摘Evacuated Tube Transport Technologies(ET3) offers the potential for more than an order of magnitude improvement in transportation efficiency,speed,cost,and effectiveness.An ET3 network may be optimized to sustainably displace most global transportation by car,ship,truck,train,and jet aircraft.To do this,ET3 standards should adhere to certain key principals:maximum value through efficiency,reliability,and simplicity;equal consideration for passenger and cargo loads;optimum size;high speed/high frequency operation;demand oriented;random accessibility;scalability;high granularity;automated control;full speed passive switching;open standards of implementation;and maximum use of existing capacities,materials,and processes. | Daryl OSTER Masayuki KUMADA Yaoping ZHANG | 2011 | Journal of Modern Transportation2011，19，1： | 25 |
| 2 | Key vacuum technology issues to be solved in evacuated tube transportation显示文摘Evacuated tube transportation(ETT) will be one of the ultra-large-scale vacuum application areas.This paper lists some key vacuum technology issues in ETT:(1) how to construct ultra-large-scale vacuum chamber with lower cost and high reliability,(2) how to evacuate gas out of the ETT tube in short time,(3) how to release heat or reduce temperature in the vacuum tube,(4) how to avoid vacuum discharge,(5) how to make vehicles with airproof shells and life support system,and(6) how to detect leaks and find leak positions efficiently.At the same time,some solutions are proposed. | Yaoping ZHANG Daryl OSTER Masayuki KUMADA Jianye YU Shengshan LI | 2011 | Journal of Modern Transportation2011，19，2： | 13 |
| 3 | Hepatitis C virus enhances incidence of idiopathic pulmonary fibrosis显示文摘AIM: To investigate the cumulative development incidence and predictive factors for idiopathic pulmonary fibrosis in hepatitis C virus (HCV) positive patients. METHODS: We studied 6150 HCV infected patients who were between 40-70 years old (HCV-group). Another 2050 patients with hepatitis B virus (HBV) were selected as control (HBV-group). The mean observation period was 8.0 ± 5.9 years in HCV-group and 6.3 ± 5.5 years in HBV-group. The primary goal is the development of idiopathic pulmonary fibrosis (IPF) in both groups. The cumulative appearance rate of IPF and independent factors associated with the incidence rate of IPF were calculated using the Kaplan- Meier method and the Cox proportional hazard model. All of the studies were performed retrospectively by collecting and analyzing data from the patient records in our hospital. RESULTS: Fifteen patients in HCV-group developedIPF. On the other hand, none of the patients developed IPF in HBV-group. In HCV-group, the cumulative rates of IPF development were 0.3% at 10th year and 0.9% at 20th year. The IPF development rate in HCV-group was higher than that in HBV-group (P = 0.021). The IPF development rate in patients with HCV or HBV was high with statistical significance in the following cases: (1) patients ≥ 55 years (P < 0.001); (2) patients who had smoking index (package per day × year) of ≥ 20 (P = 0.002); (3) patients with liver cirrhosis (P = 0.042). CONCLUSION: Our results indicate that age, smoking and liver cirrhosis enhance the development of IPF in HCV positive patients. | Yasuji Arase Fumitaka Suzuki Yoshiyuki Suzuki Norio Akuta Masahiro Kobayashi Yusuke Kawamura Hiromi Yatsuji Hitomi Sezaki Tetsuya Hosaka Miharu Hirakawa Satoshi Saito Kenji Ikeda Hiromitsu Kumada | 2008 | World Journal of Gastroenterology2008，14，38： | 8 |
| 4 | Phase III study of sorafenib after transarterial chemoembolisation in Japanese and Korean patients with unresectable hepatocellular carcinoma显示文摘 | Masatoshi Kudo Kazuho Imanaka Nobuyuki Chida Kohei Nakachi Won-Young Tak Tadatoshi Takayama Jung-Hwan Yoon Takeshi Hori Hiromitsu Kumada Norio Hayashi Shuichi Kaneko Hirohito Tsubouchi Dong Jin Suh Junji Furuse Takuji Okusaka Katsuaki Tanaka Osamu Matsui | 2011 | European Journal of Cancer2011，，14： | 5 |
| 5 | Long‐term entecavir treatment reduces hepatocellular carcinoma incidence in patients with hepatitis B virus infection显示文摘 | Tetsuya Hosaka Fumitaka Suzuki Masahiro Kobayashi Yuya Seko Yusuke Kawamura Hitomi Sezaki Norio Akuta Yoshiyuki Suzuki Satoshi Saitoh Yasuji Arase Kenji Ikeda Mariko Kobayashi Hiromitsu Kumada | 2013 | Hepatology2013，，： | 5 |
| 6 | Apparent diffusion coefficient in cervical cancer of the uterus: comparison with the normal uterine cervix显示文摘 | Shinji Naganawa Chiho Sato Hisashi Kumada Takeo Ishigaki Shunichi Miura Osamu Takizawa | 2005 | European Radiology2005，，1： | 4 |
| 7 | Alpha-fetoprotein and des-gamma-carboxy-prothrombin at twenty-four weeks after interferon-based therapy predict hepatocellular carcinoma development显示文摘AIM: To investigate risk factors for development of hepatocellular carcinoma(HCC) in patients with hepatitis C virus-related liver cirrhosis(LC-C).METHODS: To evaluate the relationship between clinical factors including virological response and the development of HCC in patients with LC-C treated with interferon(IFN) and ribavirin, we conducted a multicenter, retrospective study in 14 hospitals in Japan. All patients had compensated LC-C with clinical or histological data available. HCC was diagnosed by the presence of typical hypervascular characteristics on computed tomography and/or magnetic resonance imaging.RESULTS: HCC was diagnosis in 50(21.6%) of 231 LC-C patients during a median observation period of 3.8 years after IFN and ribavirin therapy. Patients who developed HCC were older(P = 0.018) and had higher serum levels of pretreatment alpha-fetoprotein(AFP)(P = 0.038). Multivariate analysis revealed the following independent risk factors for HCC development: history of treatment for HCC [P < 0.001, odds ratio(OR) = 15.27, 95%CI: 4.98-59.51], AFP levels of ≥ 10 ng/m L(P = 0.009, OR = 3.89, 95%CI: 1.38-11.94), and des-γ-carboxy prothrombin(DCP) levels of ≥ 40 m AU/mL at 24 wk after the completion of IFN and ribavirin therapy(P < 0.001, OR = 24.43, 95%CI: 4.11-238.67).CONCLUSION: We suggested that the elevation of AFP and DCP levels at 24 wk after the completion of IFN and ribavirin therapy were strongly associated with the incidence of HCC irrespective of virological response among Japanese LC-C patients. | Satoshi Shakado Shotaro Sakisaka Kazuaki Chayama Takeshi Okanoue Joji Toyoda Namiki Izumi Akihiro Matsumoto Tetsuo Takehara Akio Ido Yoichi Hiasa Kentaro Yoshioka Hideyuki Nomura Yoshiyuki Ueno Masataka Seike Hiromitsu Kumada | 2015 | World Journal of Hepatology2015，7，27： | 3 |
| 8 | Serum Mac-2 binding protein is a novel biomarker for chronic pancreatitis显示文摘AIM: To determine the efficacy of Mac-2 binding protein(Mac-2bp) for diagnosis of chronic pancreatitis.METHODS: Fifty-nine healthy volunteers(HV), 162 patients with chronic pancreatitis(CP), and 94 patients with pancreatic ductal adenocarcinoma(PDAC) were enrolled in this study. We measured serum Mac-2bp using our developed enzyme-linked immunosorbent assay kit. Additional biochemical variables were measured using an automated analyzer(including aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, triglyceride, C-reactive protein, and amylase levels) or chemiluminescent enzyme immunoassay(carbohydrate antigen 19-9 and carcinoembryonic antigen). The ability of Mac-2bp to predict CP diagnosis accurately was assessed using receiver operating characteristic(ROC) analyses.RESULTS: Serum Mac-2bp levels were significantly increased in CP patients compared to HV(P < 0.0001) and PDAC patients(P < 0.0001). Area under the ROC curve values of Mac-2bp for the discrimination of CP from HV and PDAC were 0.727 and 0.784, respectively. Multivariate analyses demonstrated that serum Mac-2bp levels were independent determinants for CP diagnosis from HV and PDAC patients. Immunohistological staining showed that Mac-2bp was expressed faintly in the pancreas tissues of both CP and PDAC patients. Serum aspartate aminotransferase, alanine aminotransferase, γ-glutamyltransferase, alkaline phosphatase, and triglyceride levels were significantly higher in patients with CP or PDAC. Serum Mac-2bp levels were highly correlated with protein levels of alanine aminotransferase, γ-glutamyltransferase, and C-reactive protein, but not amylase, suggesting that the damaged liver produces Mac-2bp. CONCLUSION: Measurement of serum Mac-2bp may be a novel and useful biomarker for CP diagnosis as well as liver fibrosis in the general population. | Tomohiro Maekawa Yoshihiro Kamada Yusuke Ebisutani Makiko Ueda Tomoki Hata Koichi Kawamoto Shinji Takamatsu Kayo Mizutani Mayuka Shimomura Tomoaki Sobajima Hironobu Fujii Kotarosumitomo Nakayama Kimihiro Nishino Makoto Yamada Takashi Kumada Toshifumi Ito Hidetoshi Eguchi Hiroaki Nagano Eiji Miyoshi | 2016 | World Journal of Gastroenterology2016，22，17： | 3 |
| 9 | Long-term continuous entecavir therapy in nucleos(t)ide-na?ve chronic hepatitis B patients显示文摘 | Atsushi Ono Fumitaka Suzuki Yusuke Kawamura Hitomi Sezaki Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitou Yasuji Arase Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Rie Mineta Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，3： | 3 |
| 10 | Simeprevir with Peginterferon/Ribavirin for Treatment-Na?ve Hepatitis C Genotype 1 Patients in Japan: CONCERTO-1, a Phase III Trial显示文摘 | Norio Hayashi Namiki Izumi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Hepatology2014，，： | 3 |
| 11 | Combining Clinical, Pathology, and Gene Expression Data to Predict Recurrence of Hepatocellular Carcinoma显示文摘 | Augusto Villanueva Yujin Hoshida Carlo Battiston Victoria Tovar Daniela Sia Clara Alsinet Helena Cornella Arthur Liberzon Masahiro Kobayashi Hiromitsu Kumada Swan N. Thung Jordi Bruix Philippa Newell Craig April Jian–Bing Fan Sasan Roayaie Vincenzo Mazzaf | 2011 | Gastroenterology2011，，5： | 3 |
| 12 | The long-term pathological evolution of chronic hepatitis C显示文摘 | M Yano H Kumada M Kage K Ikeda K Shimamatsu O Inoue E Hashimoto JH Lefkowitch J Ludwig K Okuda | 1996 | Hepatology1996，，6： | 2 |
| 13 | Effect of type 2 diabetes on risk for malignancies includes hepatocellular carcinoma in chronic hepatitis C显示文摘 | Yasuji Arase Mariko Kobayashi Fumitaka Suzuki Yoshiyuki Suzuki Yusuke Kawamura Norio Akuta Masahiro Kobayashi Hitomi Sezaki Satoshi Saito Tetsuya Hosaka Kenji Ikeda Hiromitsu Kumada Tetsuro Kobayashi | 2013 | Hepatology2013，，3： | 2 |
| 14 | Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options显示文摘 | Yoshiyuki Suzuki Kenji Ikeda Fumitaka Suzuki Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Hiroki Ishikawa Hideaki Watanabe Wenhua Hu Timothy Eley Fiona McPhee Eric Hughes Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，： | 2 |
| 15 | Poor Response to Pegylated Interferon and Ribavirin in Older Women Infected with Hepatitis C Virus of Genotype 1b in High Viral Loads显示文摘 | Hitomi Sezaki Fumitaka Suzuki Yusuke Kawamura Hiromi Yatsuji Tetsuya Hosaka Norio Akuta Masahiro Kobayashi Yoshiyuki Suzuki Satoshi Saitoh Yasuji Arase Kenji Ikeda Yuzo Miyakawa Hiromitsu Kumada | 2009 | Digestive Diseases and Sciences2009，，6： | 2 |
| 16 | Endoscopic papillectomy of minor papillar adenoma associated with pancreas divisum显示文摘Tumors of the minor papilla of the duodenum are quite rare.We successfully and safely treated an 18-mm adenoma of the minor papilla associated with pancreas divisum using endoscopic papillectomy.A 64-year-old man was admitted to our hospital for treatment of an asymptomatic mass in the minor papilla detected by upper gastrointestinal endoscopy.Endscopic analysis showed an 18-mm,whitish,sessile mass,located in the duodenum proximal to a normal-appearing major papilla.Endoscopic retrograde pancreatography did not reveal the pancreatic duct.Magnetic resonance cholangiopancreatography showed a lack of the ventral pancreatic duct.We suspected this case was associated with pancreatic divisum;therefore,we performed endoscopic papillectomy of the minor papilla tumor.Subsequently,endoscopic pancreatic stent placement in the minor papilla was done to prevent drainage disturbance.The patient has been asymptomatic without recurrence of tumor or stenosis of the Santorini orifice upon endoscopic examination for the past 2 years. | Akira Kanamori Takashi Kumada Seiki Kiriyama Yasuhiro Sone Makoto Tanikawa Yasuhiro Hisanaga Hidenori Toyoda Hiroki Kawashima Akihiro Itoh Yoshiki Hirooka Hidemi Goto | 2009 | World Journal of Gastroenterology2009，15，9： | 2 |
| 17 | Association of two polymorphisms of the IL28B gene with viral factors and treatment response in 1,518 patients infected with hepatitis C virus显示文摘 | Mariko Kobayashi Fumitaka Suzuki Norio Akuta Hitomi Sezaki Yoshiyuki Suzuki Tetsuya Hosaka Yusuke Kawamura Masahiro Kobayashi Satoshi Saitoh Yasuji Arase Kenji Ikeda Kazuaki Chayama Yuzo Miyakawa Hiromitsu Kumada | 2012 | Journal of Gastroenterology2012，，5： | 2 |
| 18 | Selection of a virus strain resistant to entecavir in a nucleoside-naive patient with hepatitis B of genotype H显示文摘 | Fumitaka Suzuki Norio Akuta Yoshiyuki Suzuki Hiromi Yatsuji Hitomi Sezaki Yasuji Arase Yusuke Kawamura Tetsuya Hosaka Masahiro Kobayashi Kenji Ikeda Mariko Kobayashi Sachiyo Watahiki Hiromitsu Kumada | 2007 | Journal of Clinical Virology2007，，2： | 2 |
| 19 | Predictive values of amino acid sequences of the core and NS5A regions in antiviral therapy for hepatitis C: a Japanese multi-center study显示文摘 | Takeshi Okanoue Yoshito Itoh Hiroaki Hashimoto Kohichiroh Yasui Masahito Minami Tetsuo Takehara Eiji Tanaka Morikazu Onji Joji Toyota Kazuaki Chayama Kentaro Yoshioka Namiki Izumi Norio Akuta Hiromitsu Kumada | 2009 | Journal of Gastroenterology2009，，9： | 2 |
| 20 | Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection显示文摘 | Hiromitsu Kumada Yoshiyuki Suzuki Kenji Ikeda Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Akio Ido Kazuhide Yamamoto Koichi Takaguchi Namiki Izumi Kazuhiko Koike Tetsuo Takehara Norifumi Kawada Michio Sata Hidetaka Miyagoshi Timothy Ele | 2014 | Hepatology2014，，6： | 2 |
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