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| 1 | Myocardial infarction secondary prevention study (MISPS)显示文摘Background Traditional Chinese medicine (TCM), especially herbal medicine, has been widely used in China and now is also being increasingly used in other countries for the treatment of cardiovascular diseases. Although many studies have demonstrated that certain Chinese herbal products are effective and safe for the treatment of cardiovascular diseases, most of these lack sufficient quality. Therefore, large randomized clinical trials and further scientific research to determine its safety, effectiveness are necessary.QiShen YiQi Dripping Pills (QSYQDP) is a herbal preparation clinically used in the treatment and prevention of coronary artery disease. Preliminary observations have shown its safety and effectiveness. Methods/Design This randomized, controlled trial will recruit 3600 patients with a history of myocardial infarction. Patients will be randomized into two groups by a Centr-Randomized System. One group receives QSYQDP, the other group receive aspirin. This trial protocol will describe eligibility criteria, detailed information on the treatment definition, blinding, endpoints, statistical methods, sample size determination, data management, legal aspects, and the current status of the trial. Discussion This trial is one of the first randomized, controlled clinical trial to evaluate the efficacy and safety of traditional Chinese herbal medicine in the treatment and secondary prevention of coronary artery disease. The results of this study should help to define the role of TCM in modern medical care, as well as to provide the management strategy for CAD patients in China and other countries. | Hongcai SHANG Guohua DAI Junhua HANG Yaozu XIANG Yang WANG Junping ZHANG Wuxun DU Jingyuan MAO Chen YAO Weiliang WENG Tiancai WEN Boli ZHANG | 2006 | Journal of Geriatric Cardiology2006，3，2： | 14 |
| 2 | The biological effect of metal ions on the granulation of aerobic granular activated sludge显示文摘As a special biofilm structure,microbial attachment is believed to play an important role in the granulation of aerobic granular activated sludge(AGAS).This experiment was to investigate the biological effect of Ca^(2+),Mg^(2+),Cu^(2+),Fe^(2+),Zn^(2+),and K+which are the most common ions present in biological wastewater treatment systems,on the microbial attachment of AGAS and flocculent activated sludge(FAS),from which AGAS is always derived,in order to provide a new strategy for the rapid cultivation and stability control of AGAS.The result showed that attachment biomass of AGAS was about 300%higher than that of FAS without the addition of metal ions.Different metal ions had different effects on the process of microbial attachment.FAS and AGAS reacted differently to the metal ions as well,and in fact,AGAS was more sensitive to the metal ions.Specifically,Ca^(2+),Mg^(2+),and K+could increase the microbial attachment ability of both AGAS and FAS under appropriate concentrations,Cu^(2+),Fe^(2+),and Zn^(2+)were also beneficial to the microbial attachment of FAS at low concentrations,but Cu^(2+),Fe^(2+),and Zn^(2+)greatly inhibited the attachment process of AGAS even at extremely low concentrations.In addition,the acylated homoserine lactone(AHL)-based quorum sensing system,the content of extracellular polymeric substances and the relative hydrophobicity of the sludges were greatly influenced by metal ions.As all these parameters had close relationships with the microbial attachment process,the microbial attachment may be affected by changes of these parameters. | Wen Hao Yaochen Li Junping Lv Lisha Chen Jianrong Zhu | 2016 | Journal of Environmental Sciences2016，28，6： | 8 |
| 3 | Performance and role of N-acyl-homoserine lactone(AHL)-based quorum sensing(QS) in aerobic granules显示文摘The present study investigated the relationship between N-acyl-homoserine lactone(AHL)-based quorum sensing(QS) and the physico-chemical properties of aerobic granules.Stable mature granules were observed in SBR2 and SBR3 with average diameters of 0.96,and1.49 mm,respectively. The sludge densities of aerobic granules in SBR2 and SBR3 were1.0246,and 1.0201 g/mL,respectively,which were higher than that of flocculent sludge in SBR1(1.0065 g/mL). The results showed that the activity of AHL-based QS in SBR2 and SBR3 amounted to 2.4- and 2.1-fold induction,however,that in SBR1 with flocculent sludge was1.6-fold induction. In addition,the results also showed that the activity of AHL-based QS in the three reactors rose in the feast condition,and then dropped with the consumption of substrate. However,the activity of AHL-based QS in these three reactors recovered again in prolonged starvation. Furthermore,the results showed that the enhancement of AHL-based QS favored the extracellular polymeric substance production of microorganisms in activated sludge. Thus,it could be concluded that aerobic granules showed higher AHL-based QS than flocculent sludge,which resulted from the higher sludge density of aerobic granules than flocculent sludge. AHL-based QS was related to the metabolism energy in the feast condition; however,in prolonged starvation,microorganisms would emit more AHL-like molecules to protect themselves to resist starvation. Moreover,the enhancement of AHL-based QS favored the EPS component productivity of the microorganisms in activated sludge,which contributed to maintain the aerobic granular structure. | Yaochen Li Junping Lv Chen Zhong Wen Hao Yaqin Wang Jianrong Zhu | 2014 | Journal of Environmental Sciences2014，26，8： | 6 |
| 4 | Development of small molecule extracellular signal-regulated kinases(ERKs) inhibitors for cancer therapy显示文摘The mitogen-activated protein kinase(MAPK)/extracellular signal-regulated kinase 1/2(ERK1/2) signaling pathway is widely activated by a variety of extracellular stimuli, and its dysregulation is associated with the proliferation, invasion, and migration of cancer cells. ERK1/2 is located at the distal end of this pathway and rarely undergoes mutations, making it an attractive target for anticancer drug development. Currently, an increasing number of ERK1/2 inhibitors have been designed and synthesized for antitumor therapy, among which representative compounds have entered clinical trials. When ERK1/2 signal transduction is eliminated, ERK5 may provide a bypass route to rescue proliferation, and weaken the potency of ERK1/2 inhibitors. Therefore, drug research targeting ERK5 or based on the compensatory mechanism of ERK5 for ERK1/2 opens up a new way for oncotherapy. This review provides an overview of the physiological and biological functions of ERKs, focuses on the structure-activity relationships of small molecule inhibitors targeting ERKs, with a view to providing guidance for future drug design and optimization, and discusses the potential therapeutic strategies to overcome drug resistance. | Xiaoli Pan Junping Pei Aoxue Wang Wen Shuai Lu Feng Faqian Bu Yumeng Zhu Lan Zhang Guan Wang Liang Ouyang | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
| 5 | Physiological and anatomical changes in two rapeseed (Brassica napus L.) genotypes under drought stress conditions显示文摘Understanding the mechanisms of drought resistance in crop species is crucial for the selection and breeding of tolerant rapeseed(Brassica napus L.)varieties.The present study aimed to assess the physiological and anatomical responses of two rapeseed genotypes,P287(drought-tolerant)and T88(drought-sensitive)under three intensities of drought stress.All physiological and anatomical parameters related to drought acclimation were significantly altered in both genotypes under stress conditions.At the fourth-leaf stage,the relative water content,chlorophyll content,protein content,malondialdehyde content,and the activities of peroxidase and catalase in P287 were significantly higher than those in T88,particularly under severe drought conditions.After rehydration,all physiological indexes recovered rapidly,especially in P287.In addition,under drought stress,compared with T88,P287 had thicker palisade tissue,thinner spongy tissue,higher ratio of chloroplast length to chloroplast width,higher stomatal density and stomatal closure rate.Overall,the interaction between physiological and anatomical features improved the drought tolerance of P287 under drought stress conditions. | Jiacheng Zhu Dongfang Cai Jianping Wang Jinhua Cao Yancheng Wen Junping He Lei Zhao Dongguo Wang Shufen Zhang | 2021 | Oil Crop Science2021，6，2： | 2 |
| 6 | Targeted thrombolysis strategies for neuroprotective effect显示文摘Stroke is usually treated by systemic thrombolytic therapy if the patient presents within an appropriate time window. There is also widespread interest in the development of thrombolytic agents that can be used in cases of delayed presentation. Current agents that can be used in cases of delayed presentation of nerve damage by thrombus. Current systemic thrombolytic therapy is associated with adverse effects such as fibrinogenolysis and bleeding. In an attempt to increase the efficacy, safety, and specificity of thrombolytic therapy, a number of targeted thrombolytic agents have been studied in recent years. This review focuses on the concepts underlying targeted thrombolytic therapy and describes recent drug developments in this field. | Junping Zhang Guoxing Ma Zhimin Lv Yu Zhou Chunguang Wen Yaqing Wu Ruian Xu | 2014 | Neural Regeneration Research2014，9，13： | 2 |
| 7 | Association between sleep duration and incidence of type 2 diabetes in China: the REACTION study显示文摘Backgrounds: Inadequate sleep duration is associated with a higher risk of type 2 diabetes and the relationship is nonlinear. We aim to assess the curve relationship between night sleep duration and the incidence of type 2 diabetes in China.Methods: A cohort of 11,539 participants from the REACTION study without diabetes at baseline (2011) were followed until 2014 for the development of type 2 diabetes. The average number of hours of sleep per night was grouped. Incidence rates and odds ratios (ORs) were calculated for the development of diabetes in each sleep duration category.Results: Compared to people who sleep for 7 to 8 h/night, people with longer sleep duration (≥9 h/night) had a greater risk of type 2 diabetes (OR: 1.27;95% CI: 1.01-1.61), while shorter sleep (<6 h/night) had no significant difference in risk of type 2 diabetes. When the dataset was stratified based on selected covariates, the association between type 2 diabetes and long sleep duration became more evident among individuals <65 years of age, male, body mass index <24 kg/m2 or with hypertension or hyperlipidemia, no interaction effects were observed. Furthermore, compared to people persistently sleeping 7 to 9 h/night, those who persistently slept ≥9 h/night had a higher risk of type 2 diabetes. The optimal sleep duration was 6.3 to 7.5 h/night.Conclusions: Short or long sleep duration was associated with a higher risk of type 2 diabetes. Persistently long sleep duration increased the risk. | Hongzhou Liu Gang Chen Junping Wen Anping Wang Yimin Mu Jingtao Dou Weijun Gu Li Zang Saichun Zhang Zhaohui Lyu | 2022 | Chinese Medical Journal2022，，10： | 1 |
| 8 | Involvement of rose aquaporin RhPIP1;1 in ethylene-regulated petal expansion through interaction with RhPIP2;1显示文摘 | Wen Chen Xia Yin Lei Wang Ji Tian Ruoyun Yang Daofeng Liu Zhenhao Yu Nan Ma Junping Gao | 2013 | Plant Molecular Biology2013，，3： | 1 |
| 9 | A SOA-based servcie discovery framework in Internet of Things显示文摘 | Li Peng Dong Junping Wen Junhao | 2011 | Journal of Convergence Information Technology2011，6，9： | 1 |
| 10 | Construction, detection and microarray analysis on Shigella dysenteriae A1 IroN, ShuA single, double mutants显示文摘In this study, we constructed single mutants MTS-1, MTS-2 of IroN and ShuA gene and double mutant MTS of them in Shigella dysenteriae A1 strain 51197 by insert and absence. The functional detection of every mutant was performed at the level of culture medium and cell experiment. The gene expression profiles of the mutants and the wild-type strains under iron- enriched and iron-limited conditions were analyzed by the SD51197 whole genomic microarray. The results showed that all the mutants grew obviously less well than the wild-type strains in L broth appending iron chelator DIP. The addition of iron to the cultures can stimulate the growth of mutants back to wild-type levels. In either the experiments on the ability of intracellular multiplication or the cell-to-cell spread in HeLa and U937 cell lines, mutants showed no obvious change in virulence compared with the parental strain SD51197. However when DIP was added to the cultured HeLa cells, the ability of intracellular multiplication of MTS-1, MTS-2, MTS has reduced about 23.4%, 25.2%, 43.6% respectively. The analysis of expression profiles under the iron-limited condition showed that the mutants were more sensitive for the changes of iron deficiency than the wild-type strains, many genes have been altered. Up-regulated genes mainly involved genes of transcription, coenzyme metabolism, amino acid transport and metabolism, and unknown functional genes, while down-regulated genes mainly involved genes of energy and carbohydrate metabolism and unknown function genes; the expression levels of known iron-transport associated genes generally showed up-regulated. The results demonstrated that iron-transport associated genes IroN, ShuA were likely to have some effects on the virulence and growth of S. dysenteriae. | BIN Wen, LIU Moqing, PENG Junping, SUN Lilian, XU Xingye, ZHANG Jinghai& JIN Qi Shengyang Pharmaceutical University, School of Pharmaceutical Engineering, Shengyang 110016, China State Key Laboratory for Molecular Virology and Genetic Engineering, Beijing 100176, China | 2006 | Science China(Life Sciences)2006，49，3： | 1 |
| 11 | Inhibition performance of 2-mercaptobenzothiazole derivatives in CO2 saturated solution and its adsorption behavior at Fe surface 显示文摘 | Zhang Junping Zhang Qiuyu Ren Hua Zhao Wen Zhang Hepeng | 2007 | Applied Surface Science2007，253，： | 1 |
| 12 | The Quantitative Law of Network Information Growth显示文摘 | Jingehuan Hou Tingxiao Wen Junping Qiu | 2004 | Chinese Business Review2004，3，2： | 1 |
| 13 | Semantic information retrieval research based on analysis 显示文摘 | LOU Wen QIU Junping | 2014 | OnlineInformation Review2014，38，1： | 1 |
| 14 | The approximate age of the planation surface and the incision of the Yellow River显示文摘 | Baotian Pan Zhenbo Hu Junping Wang Jef Vandenberghe Xiaofei Hu Yuhua Wen Qiong Li Bo Cao | 2010 | Palaeogeography Palaeoclimatology Palaeoecology2010，，： | 1 |
| 15 | Inhibition performance of 2-mercaptobenzothiazole derivatives in CO 2 saturated solution and its adsorption behavior at Fe surface显示文摘 | Junping Zhang Qiuyu Zhang Hua Ren Wen Zhao Hepeng Zhang | 2007 | Applied Surface Science2007，，18： | 1 |
| 16 | Association study of genetic variants of 17 diabetes‐related genes/loci and cardiovascular risk and diabetic nephropathy in the C hinese S he population (中国畲族人群17个糖尿病相关基因位点的遗传变异与心血管风险和糖尿病肾病的相关性)显示文摘 | Gang Chen Yuan Xu Yinghua Lin Xiaolan Lai Jin Yao Baoying Huang Zichun Chen Huibin Huang Xianguo Fu Lixiang Lin Shenghan Lai Junping Wen | 2013 | Journal of Diabetes2013，，2： | 1 |
| 17 | Optimum Application Time and Application Rate of Nitrogen Fertilizer in Brassica napus L.显示文摘To find proper nitrogen fertilizer application mode of rapeseed( Brassica napus L.),promote the high and stable yield of rapeseed,field experiment was carried out to study the effect of nitrogen fertilizer application modes on the yield and economic traits of Fengyou 10 rapeseed planted in two different fertility soils,and characteristics and differences of responses of different fertility soils to nitrogen fertilizer application modes were compared and analyzed. The results showed that the yield and related economic traits of rapeseed treated by nitrogen fertilizer were higher than the control group; in the nitrogen fertilizer treatment group,when the nitrogen fertilizer was applied as the base fertilizer and wintering fertilizer at the ratio of 7∶ 3,the rapeseed yield was higher than the control group and reached the highest; when the nitrogen fertilizer was applied as the base fertilizer,wintering fertilizer,and bud fertilizer at the ratio of 5∶ 3∶ 2,the rapeseed yield was significantly higher than the control group but was the lowest. These indicate that sufficient nitrogen supply is the basis for normal growth and development of rape seedlings. When the pure nitrogen fertilizer was at 192 kg/ha and the ratio of base fertilizer and wintering fertilizer was 7∶ 3,it can better coordinate the high yield of rapeseed and overall use of nitrogen fertilizer,and obtain higher rapeseed yield. | Junping HE Shufen ZHANG Jiacheng ZHU Jinhua CAO Yancheng WEN Dongfang CAI Lei ZHAO Dongguo WANG Jianping WANG | 2018 | Asian Agricultural Research2018，10，5： | 0 |
| 18 | Preliminary investigation and detection based on loop-mediated isothermal amplification(LAMP)of phytoplasmas associated with diseases in B.napus L.显示文摘In the last decade,some disease occurred on our experimental farms that had caused serious losses.They were not caused by fungi,bacteria or viruses.By loop-mediated isothermal amplification(LAMP)technique,the detection results pointed to the possible pathogen as phytoplasma.The investigation results implied that phytoplasmas could cause more than 13 kinds of symptoms in almost all parts of plants in B.napus L.,including witches’broom,multi-stems,aggregate main inflorescences,and flat stems.The incidences of these phytoplasma-associated diseases in our experimental farms rose from 1.61%in 2010 to 6.00%in 2021.Some phytoplasma infected plants died without any growing points.These studies would be helpful for detecting phytoplasmas diseases,selecting disease resistant germplasm and improving varieties with disease resistances in B.napus L. | Yancheng Wen Shufen Zhang Junping He Dongfang Cai Jiacheng Zhu Jianping Wang Jinhua Cao Kun Hu Lei Zhao Dongguo Wang Yizi Liu | 2022 | Oil Crop Science2022，7，4： | 0 |
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