3篇
您的检索式：作者名="Junfen Cheng"
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| 1 | Postnatal feeding with high-fat diet induces obesity and precocious puberty in C57BL/6J mouse pups: a novel model of obesity and puberty显示文摘童年肥胖和肥胖相关的新陈代谢的复杂并发症被一本高脂肪的出生后的食谱导致。然而,一个合适的动物模型的缺乏在肥胖研究仍然是可观的挑战。在当前的学习,我们在断奶以后在哺乳期间并且到小狗提供了高脂肪的饮食(HFD ) 给水坝。我们也与导致 HFD 的出生后的肥胖开发了 C57BL/6J 老鼠小狗的一个新奇模型。结果证明用 HFD 喂在小狗导致胖免职和肥胖。而且, HFD 更 potently 比女小狗增加了男性的身体重量(BW ) 。喂 HFD 的女小狗是肥胖的,经历了早熟的发身,并且显示出在视下丘的增加的 kisspeptin 表示。然而,父母肥胖和早熟的发身没在导致 HFD 的出生后的重量获得和小狗的发身发作上施加 synergistic 效果。有趣地,有正常 BW 的一些喂 HFD 的崽也展出了早熟的发身。这发现建议了那篇食谱作文然而并非 BW 扳机发身发作。我们的模型建议肥胖和早熟的发身的好构造有效性。而且,我们的模型能也被用来探索在 dietinduced 之间的相互的相互作用出生后的童年肥胖和发身。 | Rahim Ullah Yan Su Yi Shen Chunlu Li Xiaoqin Xu Jianwei Zhang Ke Huang Naveed Rauf Yang He Jingjing Cheng Huaping Qin Yu-Dong Zhou Junfen Fu | 2017 | Frontiers of Medicine2017，11，2： | 5 |
| 2 | Analysis of Powdery Mildew Resistance in Wild Melon MLO Mutants显示文摘Wild species have a potential value in crop breeding. Explore MLO gene which related with powdery mildew natural resistance is very important for improving the quality of melon. Resistance to powdery mildew was examined in cultivar and wild species by leaf inoculation. The wild germplasms showed resistance to powdery mildew Race1. Cloning and sequence analysis of the Cm MLO2 gene identified an 85 bp difference between the wild and cultivated species. The Cm MLO2 gene was expressed in the wild germplasm after fluorescence-labeled Agrobacterium-mediated transformation. A positive transgenic plant showed successful invasion by powdery mildew Race1. These results suggested that the wild species might have failed to encode the MLO protein, thereby resulting in the MLO-negative regulation of powdery mildew, which in turn resulted in the broad-spectrum resistance of the wild species to powdery mildew. | CHENG Hong KONG Weiping Lü Junfen LI Jiping | 2015 | Horticultural Plant Journal2015，1，3： | 5 |
| 3 | The multifaceted role of placental growth factor in the pathogenesis and progression of bronchial asthma and pulmonary fibrosis:Therapeutic implications显示文摘Placental growth factor(PlGF)is a glycosylated dimeric protein that is homologous to vascular endothelial growth factor(VEGF).PlGF expression is upregulated in patients with bronchial asthma,suggesting that it plays a role in the pathogenesis of asthma.Bronchial asthma is characterized by chronic airway inflammation and airway hyperresponsiveness(AHR).After recurrent asthma attacks,pulmonary fibrosis develops and leads to airway remo-deling and a further decline in lung function.In this review,we focused on the pivotal role of PlGF in chronic airway inflammation,AHR,and airway remodeling during bronchial asthma.Furthermore,we summarized data showing that PlGF may be a potential therapeutic target in bronchial asthma. | Dan Huang Gege Liu Zhiyi Xu Shushu Chen Cuili Wang Dewei Liu Jiahao Cao Junfen Cheng Bin Wu Dong Wu | 2023 | Genes & Diseases2023，10，4： | 0 |
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