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| 1 | Nonalcoholic fatty liver disease is a novel predictor of cardiovascular disease显示文摘AIM:To clarify whether nonalcoholic fatty liver disease(NAFLD)increases the risk of cardiovascular disease.METHODS:We carried out a prospective observational study with a total of 1637 apparently healthy Japanese men and women who were recruited from a health check-up program.NAFLD was diagnosed by abdominal ultrasonography.The metabolic syndrome(MS)was defined according to the modified National Cholesterol Education Program(NCEP)ATP Ⅲ criteria.Five years after the baseline evaluations,the incidence of cardiovascular disease was assessed by a self-administered questionnaire.RESULTS:Among 1221 participants available for outcome analyses,the incidence of cardiovascular disease was higher in 231 subjects with NAFLD at baseline(5 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage)than 990 subjects without NAFLD(3 coronary heart disease,6 ischemic stroke,and 1 cerebral hemorrhage).Multivariate analyses indicated that NAFLD was a predictor of cardiovascular disease independent of conventional risk factors(odds ratio 4.12,95% CI,1.58 to 10.75,P = 0.004).MS was alsoindependently associated with cardiovascular events.But simultaneous inclusion of NAFLD and MS in a multivariate model revealed that NAFLD but not MS retained a statistically significant correlation with cardiovascular disease.CONCLUSION:Although both of them were predictors of cardiovascular disease,NAFLD but not MS retained a statistically significant correlation with cardiovascular disease in a multivariate model.NAFLD is a strong predictor of cardiovascular disease and may play a central role in the cardiovascular risk of MS. | Masahide Hamaguchi Takao Kojima Noriyuki Takeda Chisato Nagata Jun Takeda Hiroshi Sarui Yutaka Kawahito Naohisa Yoshida Atsushi Suetsugu Takahiro Kato Junichi Okuda Kazunori Ida Toshikazu Yoshikawa | 2007 | World Journal of Gastroenterology2007，13，10： | 55 |
| 2 | Intraductal neoplasm of the intrahepatic bile duct: Clinicopathological study of 24 cases显示文摘AIM: To investigate the clinicopathological features of intraductal neoplasm of the intrahepatic bile duct (INihB). METHODS: Clinicopathological features of 24 cases of INihB, which were previously diagnosed as biliary papillomatosis or intraductal growth of intrahepatic biliary neoplasm, were reviewed. Mucin immunohistochemistry was performed for mucin (MUC)1, MUC2, MUC5AC and MUC6. Ki-67, P53 and β-catenin immunoreactivity were also examined. We categorized each tumor as adenoma (low grade), borderline (intermediate grade), and malignant (carcinoma in situ , high grade including tumors with microinvasion). RESULTS: Among 24 cases of INihB, we identified 24 tumors. Twenty of 24 tumors (83%) were composed of a papillary structure; the same feature observed in intraductal papillary neoplasm of the bile duct (IPNB). In contrast, the remaining four tumors (17%) showed both tubular and papillary structures. In three of the four tumors (75%), macroscopic mucin secretion was limited but microscopic intracellular mucin was evident. Histologically, 16 tumors (67%) were malignant, three (12%) were borderline, and five (21%) were adenoma. Microinvasion was found in four cases (17%). Immunohistochemical analysis revealed that MUC1 was not expressed in the borderline/adenoma group but was expressed only in malignant lesions (P = 0.0095). Ki-67 labeling index (LI) was significantly higher in the malignant group than in the borderline/adenoma group (22.2 ± 15.5 vs 7.5 ± 6.3, P < 0.01). In the 16 malignant cases, expression of MUC5AC showed borderline significant association with high Ki-67 LI (P = 0.0622). Nuclear expression of β-catenin was observed in two (8%) of the 24 tumors, and these two tumors also showed MUC1 expression. P53 was negative in all tumors. CONCLUSION: Some cases of INihB have a tubular structure, and are subcategorized as IPNB with tubular structure. MUC1 expression in INihB correlates positively with degree of malignancy. | Yoshiki Naito Hironori Kusano Osamu Nakashima Eiji Sadashima Satoshi Hattori Tomoki Taira Akihiko Kawahara Yoshinobu Okabe Kazuhide Shimamatsu Jun Taguchi Seiya Momosaki Koji Irie Rin Yamaguchi Hiroshi Yokomizo Michiko Nagamine Seiji Fukuda Shinichi Sugiyama Naoyo Nishida Koichi Higaki Munehiro Yoshitomi Masafumi Yasunaga Koji Okuda Hisafumi Kinoshita Masayoshi Kage Masamichi Nakayama Makiko Yasumoto Jun Akiba Hirohisa Yano | 2012 | World Journal of Gastroenterology2012，18，28： | 16 |
| 3 | Intracoronary Ultrasound Diagnosis of an Aortic Dissection Causing Anterior Acute Myocardial Infarction显示文摘 | Kiyoshi Hibi Kazuo Kimura Tomoyori Nakatogawa Jun Okuda Satoshi Umemura Paul G. Yock | 2003 | Circulation: Journal of the American Heart Association2003，，20： | 2 |
| 4 | Impact of Ultrasound Attenuation and Plaque Rupture as Detected by Intravascular Ultrasound on the Incidence of No-Reflow Phenomenon After Percutaneous Coronary Intervention in ST-Segment Elevation Myocardial Infarction显示文摘 | Mitsuaki Endo Kiyoshi Hibi Tomoaki Shimizu Naohiro Komura Ikuyoshi Kusama Fumiyuki Otsuka Takayuki Mitsuhashi Noriaki Iwahashi Jun Okuda Kengo Tsukahara Masami Kosuge Toshiaki Ebina Satoshi Umemura Kazuo Kimura | 2010 | JACC: Cardiovascular Interventions2010，，5： | 1 |
| 5 | Indenyl effect in do-transition metal complexes: Synthesis, molecular structure and lactone polymerization activity of 显示文摘 | Jun Okuda Peter Konig Werner Massa | 1995 | J Organomet Chem1995，501，： | 1 |
| 6 | Simple and Accurate Electrocardiographic Criteria to Differentiate Takotsubo Cardiomyopathy From Anterior Acute Myocardial Infarction显示文摘 | Masami Kosuge Toshiaki Ebina Kiyoshi Hibi Satoshi Morita Jun Okuda Noriaki Iwahashi Kengo Tsukahara Tatsuya Nakachi Masayoshi Kiyokuni Toshiyuki Ishikawa Satoshi Umemura Kazuo Kimura | 2010 | Journal of the American College of Cardiology2010，，： | 1 |
| 7 | Pandemic spread of an O3:K6clone of Vibrio parahaemolyticus and emergence of related strains evidenced by arbiitrarily primed PCR and toxRS sequence analyses显示文摘 | Jun Okuda Masanori Ishibashi | 2000 | Journal of Clinical Microbiology2000，38，： | 1 |
| 8 | Simple and Accurate Electrocardiographic Criteria to Differentiate Takotsubo Cardiomyopathy From Anterior Acute Myocardial Infarction显示文摘 | Masami Kosuge Toshiaki Ebina Kiyoshi Hibi Satoshi Morita Jun Okuda Noriaki Iwahashi Kengo Tsukahara Tatsuya Nakachi Masayoshi Kiyokuni Toshiyuki Ishikawa Satoshi Umemura Kazuo Kimura | 2010 | Journal of the American College of Cardiology2010，，22： | 1 |
| 9 | Identification of Vibrio parahaemolyticus Strains at the Species Level by PCR Targeted to the toxR Gene显示文摘 | Yung Bu Kim Jun Okuda Chiho Matsumoto | 1999 | J Clin Microbiol1999，37，4： | 1 |
| 10 | Highly heteroselective ring-opening polymerization of raclactide initiated by bis(phenolato)scandium complexes显示文摘 | Ma Haiyan Thomas P Spaniol Jun Okuda | | 0，，46： | 1 |
| 11 | Evidence for active acetylcholine metabolism in human amniotic epithelial cells: applicable to intracerebral allografting for neurologic disease显示文摘 | Norio Sakuragawa Hidemi Misawa Keiko Ohsugi Kouji Kakishita Takashi Ishii Ramasamy Thangavel Jun Tohyama Mohamed Elwan Yasunobu Yokoyama Osamu Okuda Hajime Arai Ikuko Ogino Kiyoshi Sato | 1997 | Neuroscience Letters1997，，1： | 1 |
| 12 | Identification of Vibrio parahaemolyticus strains at the species level by PCR targeted to the toxR gene 显示文摘 | Yung bu kim Jun okuda Chiho matsumoto | 1999 | J Clin Microbiol1999，，： | 1 |
| 13 | Protective immunity against influenza A virus induced by immunization with DNA plasmid containing influenza M gene显示文摘 | Kenji Okuda Atsushi Ihata Setsuko Watabe Eiichi Okada Tadashi Yamakawa Kenji Hamajima Jun Yang Norihisa Ishii Masatoshi Nakazawa Katsuji Okuda Katsuhiro Ohnari Katsuhisa Nakajima Ke-Qin Xin | 2001 | Vaccine2001，，27： | 1 |
| 14 | The validity of multi-center common normal database for identifying myocardial ischemia: Japanese Society of Nuclear Medicine working group database显示文摘 | Kenichi Nakajima Shinro Matsuo Masaya Kawano Naoya Matsumoto Jun Hashimoto Keiichiro Yoshinaga Junichi Taki Koichi Okuda | 2010 | Annals of Nuclear Medicine2010，，2： | 1 |
| 15 | Characterization of Japanese standards for myocardial sympathetic and metabolic imaging in comparison with perfusion imaging显示文摘 | Shinro Matsuo Kenichi Nakajima Shohei Yamashina Kazuyuki Sakata Mitsuru Momose Jun Hashimoto Shinichiro Kumita Masaya Kawano Koichi Okuda | 2009 | Annals of Nuclear Medicine2009，，6： | 1 |
| 16 | A novel species of alkaliphilic Bacillus that produces an oxidatively stable alkaline serine protease显示文摘 | Katsuhisa Saeki Jun Hitomi Mitsuyoshi Okuda Yuji Hatada Yasushi Kageyama Mikio Takaiwa Hiromi Kubota Hiroshi Hagihara Tohru Kobayashi Shuji Kawai Susumu Ito | 2002 | Extremophiles2002，，1： | 1 |
| 17 | Identification of Vibrio parahacmolyticus strains at the spccies level by PCR targeted to the toxR gene显示文摘 | Yung BU Kim Jun Okuda Chiho Matsumoto | 1999 | J Clin Microbiol1999，37，4： | 1 |
| 18 | Development of Super-High Strength Al-Zn-Mg-Cu P/M Alloys显示文摘 | Kusui Jun Fujii Koichi Yokoe K. Yokota T. Osamura Kozo Kubota O. Okuda Hiroshi | 1996 | 1996 (217)1996，，217： | 1 |
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