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| 1 | Role of microbial dysbiosis in the pathogenesis of esophageal mucosal disease:A paradigm shift from acid to bacteria?显示文摘Genomic sequencing,bioinformatics,and initial speciation(e.g.,relative abundance)of the commensal microbiome have revolutionized the way we think about the“human”body in health and disease.The interactions between the gut bacteria and the immune system of the host play a key role in the pathogenesis of gastrointestinal diseases,including those impacting the esophagus.Although relatively stable,there are a number of factors that may disrupt the delicate balance between the luminal esophageal microbiome(EM)and the host.These changes are thought to be a product of age,diet,antibiotic and other medication use,oral hygiene,smoking,and/or expression of antibiotic products(bacteriocins)by other flora.These effects may lead to persistent dysbiosis which in turn increases the risk of local inflammation,systemic inflammation,and ultimately disease progression.Research has suggested that the etiology of gastroesophageal reflux disease-related esophagitis includes a cytokine-mediated inflammatory component and is,therefore,not merely the result of esophageal mucosal exposure to corrosives(i.e.,acid).Emerging evidence also suggests that the EM plays a major role in the pathogenesis of disease by inciting an immunogenic response which ultimately propagates the inflammatory cascade.Here,we discuss the potential role for manipulating the EM as a therapeutic option for treating the root cause of various esophageal disease rather than just providing symptomatic relief(i.e.,acid suppression). | Steve M D'Souza Kevin Houston Lauren Keenan Byung Soo Yoo Parth J Parekh David A Johnson | 2021 | World Journal of Gastroenterology2021，27，18： | 8 |
| 2 | Operative considerations for rectovaginal fistulas显示文摘To describe the etiology, anatomy and pathophysiology of rectovaginal fistulas(RVFs); and to describe a systematic surgical approach to help achieve optimal outcomes. A current review of the literature was performed to identify the most up-to-date techniques and outcomes for repair of RVFs. RVFs present a difficult problem that is frustrating for patients and surgeons alike. Multiple trips to the operating room are generally needed to resolve the fistula, and the recurrence rate approaches40% when considering all of the surgical options. At present, surgical options range from collagen plugs and endorectal advancement flaps to sphincter repairs or resection with colo-anal reconstruction. There are general principles that will allow the best chance for resolution of the fistula with the least morbidity to the patient. These principles include: resolving the sepsis, identifying the anatomy, starting with least invasive surgical options, and interposing healthy tissue for complex or recurrent fistulas. | Kevin R Kniery Eric K Johnson Scott R Steele | 2015 | World Journal of Gastrointestinal Surgery2015，7，8： | 7 |
| 3 | Fabrication and study of supercapacitor electrodes based on oxygen plasma functionalized carbon nanotube fibers显示文摘Dry-spun Carbon Nanotube(CNT)fibers were surface-modified by atmospheric pressure oxygen plasma functionalization using a well controlled and continuous process.The fibers were characterized by scanning electron microscopy(SEM),Raman spectroscopy,and X-ray Photoelectron Spectroscopy(XPS).It was found from the conducted electrochemical measurements that the functionalized fibers showed a 132.8% increase in specific capacitance compared to non-functionalized fibers.Dye-adsorption test and the obtained Randles-Sevcik plot demonstrated that the oxygen plasma functionalized fibers exhibited increased surface area.It was further established by Brunauer-Emmett-Teller(BET)measurements that the surface area of the CNT fibers was increased from 168.22 m^2/g to 208.01 m^2/g after plasma functionalization.The pore size distribution of the fibers was also altered by this processing.The improved electrochemical data was attributed to enhanced wettability,increased surface area,and the presence of oxygen functional groups,which promoted the capacitance of the fibers.Fiber supercapacitors were fabricated from the oxygen plasma functionalized CNT fiber electrodes using different electrolyte systems.The devices with functionalized electrodes exhibited excellent cyclic stability(93.2% after 4000 cycles),flexibility,bendability,and good energy densities.At 0.5 m A/cm^2,the EMIMBF4 device revealed a specific capacitance,which is 27% and 65%greater than the specific capacitances of devices using EMIMTFSI and H2SO4 electrolytes,respectively.The practiced in this work plasma surface processing can be employed in other applications where fibers,yarns,ribbons,and sheets need to be chemically modified. | Paa Kwasi Adusei Seyram Gbordzoe Sathya Narayan Kanakaraj Yu-Yun Hsieh Noe T.Alvarez Yanbo Fang Kevin Johnson Colin McConnell Vesselin Shanov | 2020 | Journal of Energy Chemistry2020，29，1： | 4 |
| 4 | Using quality improvement methods to increase use of pain prevention strategies for childhood vaccination显示文摘AIM To increase evidence-based pain prevention strategy use during routine vaccinations in a pediatric primary care clinic using quality improvement methodology.METHODS Specific intervention strategies(i.e.,comfort positioning,nonnutritive sucking and sucrose analgesia,distraction) were identified,selected and introduced in three waves,using a Plan-Do-Study-Act framework.System-wide change was measured from baseline to post-intervention by:(1) percent of vaccination visits during which an evidence-based pain prevention strategy was reported as being used; and(2) caregiver satisfaction ratings following the visit.Additionally,self-reported staff and caregiver attitudes and beliefs about pain prevention were measured at baseline and 1-year post-intervention to assess for possible long-term cultural shifts.RESULTS Significant improvements were noted post-intervention.Use of at least one pain prevention strategy was documented at 99% of patient visits and 94% of caregivers were satisfied or very satisfied with the pain prevention care received.Parents/caregivers reported greater satisfaction with the specific pain prevention strategy used [t(143) = 2.50,P ≤ 0.05],as well as greater agreement that the pain prevention strategies used helped their children's pain [t(180) = 2.17,P ≤ 0.05] and that they would be willing to use the same strategy again in the future [t(179) = 3.26,P ≤ 0.001] as compared to baseline.Staff and caregivers also demonstrated a shift in attitudes from baseline to 1-year post-intervention.Specifically,staff reported greater agreement that the pain felt from vaccinations can result in harmful effects [2.47 vs 3.10; t(70) =-2.11,P ≤ 0.05],less agreement that pain from vaccinations is 'just part of the process' [3.94 vs 3.23; t(70) = 2.61,P ≤ 0.05],and less agreement that parents expect their children to experience pain during vaccinations [4.81 vs 4.38; t(69) = 2.24,P ≤ 0.05].Parents/caregivers reported more favorable attitudes about pain prevention strategies for vaccinations across a variety of areas,including safety,cost,time,and effectiveness,as well as less concern about the pain their children experience with vaccination [4.08 vs 3.26; t(557) = 6.38,P ≤ 0.001],less need for additional pain prevention strategies [3.33 vs 2.81; t(476) = 4.51,P ≤ 0.001],and greater agreement that their doctors' office currently offers pain prevention for vaccinations [3.40 vs 3.75; t(433) =-2.39,P ≤ 0.05].CONCLUSION Quality improvement methodology can be used to help close the gap in implementing pain prevention strategies during routine vaccination procedures for children. | Jennifer Verrill Schurman Amanda D Deacy Rebecca J Johnson Jolynn Parker Kristi Williams Dustin Wallace Mark Connelly Lynn Anson Kevin Mroczka | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 5 | Multidisciplinary approach for multifocal, bilobar hepatocellular carcinoma: A case report and literature review显示文摘BACKGROUND Hepatocellular carcinoma(HCC) is the second most lethal malignancy worldwide. There has been virtually no change in the survivability of HCC in spite of improvement in therapies. Surgery is considered the ideal first, curative intervention, however most patients present in advanced stages with unresectable disease. Therefore, systemic and liver-directed non-operative therapies are initially offered to downstage the disease. To ensure optimal management, a multidisciplinary team approach is often warranted. Our case highlights the benefits of a multidisciplinary approach in a young woman with multifocal, bilobar HCC.CASE SUMMARY A 36-year-old Chinese woman with untreated hepatitis B was found to have large bilobar HCC during work up for abdominal pain. Her initial serum alphafetoprotein was significantly elevated to 311136 ng/mL. Computed tomography scan demonstrated bulky bilobar liver masses, consistent with intermediate stage HCC, Barcelona Clinic Liver Cancer Stage B. Her case was discussed and a personalized care plan was developed at the Multidisciplinary Center for Advanced Minimally Invasive Liver Oncologic Therapies at the University of Washington. She initially underwent bilobar transarterial chemoembolization with partial response of the left lobar tumor. Salvage hypofractionated proton beam radiation therapy was delivered to the right lobe followed by two additional transarterial chemoembolizations to the left lobe with good response.Finally, to remove left lobar residual disease, she was taken to the operating roomfor a left hepatectomy eleven months after her initial presentation. She continues to be without evidence of disease.CONCLUSION Coordinating the multiple HCC treatment modalities is complex and our case highlights the benefits of a multidisciplinary approach. | Kevin P Labadie Stephanie K Schaub Derek Khorsand Guy Johnson Smith Apisarnthanarax James O Park | 2019 | World Journal of Hepatology2019，11，1： | 2 |
| 6 | Supplier risk assessment and monitoring for the automotive industry显示文摘 | Jennifer V Blackhurst Kevin P Scheibe Danny J Johnson | 2008 | International Journal of Physical Distribution & Logistics Management2008，38，2： | 1 |
| 7 | The relationship between nucleoside triphosphate hydrolase ( NTPase ) isoform and Toxoplasma strain virulence in rat and human toxoplasmosis显示文摘 | Johnson M Kevin B Maria CA | 2003 | Microbes and Infection2003，5，： | 1 |
| 8 | Mobilisation of metals in mineral tailings at the abandoned Sao Domingos copper mine (Portugal) by indigenous acidophilic bacteria显示文摘 | Bryan Christopher G Hallberg Kevin B Johnson D Barrie | 2006 | Hydrometallurgy2006，83，14： | 1 |
| 9 | Nuclear and mitochondrial genes contain similar phylogenetic signal for Pigeons and Doves (Aves: Columbiformes) 显示文摘 | Kevin P Johnson and Dale H Clayton | 2000 | Mol Phylogenet and Evol2000，14，1： | 1 |
| 10 | Experimental determination of partition coefficients for rare earth and high-field-strength elements between clinopyroxene, garnet, and basaltic melt at high pressures显示文摘 | Kevin T. M. Johnson | 1998 | Contributions to Mineralogy and Petrology (-)1998，，1： | 1 |
| 11 | Enu- meration and characterization of acidophilic microorgan- isms isolated from a pilot plant stirred-tank bioleaching operation 显示文摘 | Naoko O Mariekie G Kevin B H Johnson D B | 2003 | Applied and Environmental Microbiolo- gy2003，69，4： | 1 |
| 12 | Comparison of blood velocity measurements between ultrasound Doppler and accelerated phase-contrast MR angiography in small arteries with disturbed flow显示文摘 | Jingfeng Jiang Charles Strother Kevin Johnson Sara Baker Dan Consigny Oliver Wieben James Zagzebski | 2011 | Physics in Medicine and Biology2011，，6： | 1 |
| 13 | The influence of patient size on dose conversion coefficients: a hybrid phantom study for adult cardiac catheterization 显示文摘 | Johnson Perry Lee Choonsik Johnson Kevin | 2009 | Phys Med Biol2009，，54： | 1 |
| 14 | Acid mine drainage remediation options:a review显示文摘 | Barrie Johnson D Hallberg Kevin B | 2005 | Science of the Total Environment2005，338，： | 1 |
| 15 | Fractional Anisotropy Changes After Several Weeks of Daily Left High-Frequency Repetitive Transcranial Magnetic Stimulation of the Prefrontal Cortex to Treat Major Depression显示文摘 | F. Andrew Kozel Kevin A. Johnson Ziad Nahas Paul A. Nakonezny Paul S. Morgan Berry S. Anderson Samet Kose Xingbao Li Kelvin O. Lim Madhukar H. Trivedi Mark S. George | 2011 | The Journal of ECT2011，，1： | 1 |
| 16 | Transjugular intrahepatic portosystemic shunt improves oxygenation in hepatopulmonary syndrome显示文摘 | Jonathan L. Riegler Kevin A. Lang Stephen P. Johnson Jan H. Westerman | 1995 | Gastroenterology1995，，3： | 1 |
| 17 | Acid mine drainage remediation options: a review 显示文摘 | Barrie Johnson D Hallberg Kevin B | 2005 | Science of the Total Environment2005，338，： | 1 |
| 18 | Further characterization of high mobility group box 1 (HMGB1) as a proinflammatory cytokine: central nervous system effects显示文摘 | Kevin A. O’Connor Michael K. Hansen C. Rachal Pugh Molly M. Deak Joseph C. Biedenkapp Erin D. Milligan John D. Johnson Haichao Wang Steven F. Maier Kevin J. Tracey Linda R. Watkins | 2003 | Cytokine2003，，6： | 1 |
| 19 | Effect of Dietary Linoleic Acid on Markers of Inflammation in Healthy Persons: A Systematic Review of Randomized Controlled Trials显示文摘 | Guy H. Johnson Kevin Fritsche | 2012 | Journal of the Academy of Nutrition and Dietetics2012，，7： | 1 |
| 20 | Acid mine drainage remediation options : a review 显示文摘 | Johnson Barrie D Hallberg Kevin B | 2005 | Sei Total Environ2005，338，： | 1 |
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