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| 1 | Duodenal gangliocytic paraganglioma with lymph node metastases: a case report and comparative review of 31 cases显示文摘Gangliocytic paraganglioma(GP) is a rare tumor of uncertain origin most often located in the second portion of the duodenum. It is composed of three cellular components: Epithelioid endocrine cells, spindlelike/sustentacular cells, and ganglion-like cells. While this tumor most often behaves in a benign manner, cases with metastasis are reported. We describe the case of a 62-year-old male with a periampullary GP with metastases to two regional lymph nodes who was successfully treated with pancreaticoduodenectomy. Using Pub Med, EMBASE, EBSCOhost MEDLINE and CINAHL, and Google Scholar, we searched the literature for cases of GP with regional lymph node metastasis and evaluated the varying presentations, diagnostic workup, and disease management of identified cases. Thirty-one cases of GP with metastasis were compiled(30 with at least lymph node metastases and one with only distant metastasis to bone), with age at diagnosis ranging from 16 to 74 years. Ratio of males to females was 19:12. The most common presenting symptoms were abdominal pain(55%) and gastrointestinal bleeding or sequelae(42%). Twenty-five patients underwent pancreaticoduodenectomy. Five patients were treated with local resection alone. One patient died secondary to metastatic disease, and one died secondary to perioperative decompensation. The remainder did well, with no evidence of disease at follow-up from the most recent procedure(except two in which residual disease was deliberately left behind). Of the 26 cases with sufficient histological description, 16 described a primary tumor that infiltrated deep to the submucosa, and 3 described lymphovascular invasion. Of the specific immunohistochemistry staining patterns studied, synaptophysin(SYN) stained all epithelioid endocrine cells(18/18). Neuron specific enolase(NSE) and SYN stained most ganglion-like cells(7/8 and 13/18 respectively), and S-100 stained all spindle-like/sustentacular cells(21/21). Our literature review of published cases of GP with lymph node metastasis underscores the excellent prognosis of GP regardless of specific treatment modality. We question the necessity of aggressive surgical intervention in select patients, and argue that local resection of the mass and metastasis may be adequate. We also emphasize the importance of pre-surgical assessment with imaging studies, as well as post-surgical follow-up surveillance for disease recurrence. | Sahara J Cathcart Aaron R Sasson Jessica A Kozel Jennifer M Oliveto Quan P Ly | 2017 | World Journal of Clinical Cases2017，5，6： | 9 |
| 2 | Robotic surgery in pediatric urology显示文摘While robotic surgery has shown clear utility and advantages in the adult population,its role in pediatrics remains controversial.Pediatric-sized robotic instruments and equipment are not readily available yet,so certain modifications can be made in order to make robotic surgery successful in children.While the cost of robotic surgery remains high compared to open procedures,patients experience greater satisfaction and quality of life with robotic surgery.Robotic pyeloplasty is a standard of care in older children,and has even been performed in infants and re-do surgery.Other robotic procedures performed in children include heminephroureterectomy,ureteroureterostomy,ureteral reimplantation,urachal cyst excision,bladder diverticulectomy,and bladder reconstructive procedures such as augmentation,appendicovesicostomy,antegrade continence enema,bladder neck reconstruction and sling,as well as other procedures.Robotic surgery has also been used in oncologic cases such as partial nephrectomy and retroperitoneal lymph node dissection.Future improvements in technology with production of pediatric-sized robotic instruments,along with increases in robotictrained pediatric urologists and surgeon experience along each’s learning curve,will help to further advance the field of robotic surgery in pediatric urology. | Adam Howe Zachary Kozel Lane Palmer | 2017 | Asian Journal of Urology2017，4，1： | 6 |
| 3 | Differential localization of complement component 3 within the capsular matrix of Cryptococcus neoformans显示文摘 | Gates MA Kozel TR | 2006 | Infect Immun2006，74，6： | 1 |
| 4 | Contribution of dopamine receptors to periaqueductal gray-mediated antinociception 显示文摘 | Meyer PJ Morgan MM Kozell LB | 2009 | Psychopharmacology ( Berl )2009，204，： | 1 |
| 5 | A pilot study of functional magnetic resonance imaging brain correlates of deception in healthy young men 显示文摘 | KOZEL F A REVELL L J LORBERBAUM J P | 2004 | The Journal of neuropsychiatry and clinical neuroscienc- es2004，16，3： | 1 |
| 6 | Defciency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced bearing loss in mice显示文摘 | Kozel P J Davis R R Krieg E F | 2002 | Hear Res2002，164，12： | 1 |
| 7 | A replication study of the neural correlates of deception 显示文摘 | KOZEL F A PADGETT T M GEDRGE M S | 2004 | Behavioral neuroscience2004，118，4： | 1 |
| 8 | Natural course ofphysical and chronic urticaria and angioedema in 220 patients 显示文摘 | Kozel MM Mekkes JR Bossuyt PM | 2001 | J Am Acad Dermatol2001，45，3： | 1 |
| 9 | Chronic urticaria: aetiology, management and current and future treatment options显示文摘 | Kozel MM Sabroe RA | 2004 | Drugs2004，64，22： | 1 |
| 10 | Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noise-induced heating loss in mice 显示文摘 | Kozel P J Davis R R Krieg E F | 2002 | Hear Res2002，164，12： | 1 |
| 11 | Experimental laser destruction of trigeminal sensory root显示文摘 | Kozel AI Ismagilova ST | 2000 | Bull Exp Biol Med2000，129，： | 1 |
| 12 | Should WOC nurses measure health-related quality of life in patients undergoing intestinal ostomy surgery显示文摘 | Pittman J Kozell K Gray M | | 0，，03： | 1 |
| 13 | Somatostatin in the treatment of chylothorax 显示文摘 | Demos NJ Kozel J Scerbo JE | 2001 | Chest2001，119，3： | 1 |
| 14 | Protective and immunochemical activities of monoclonal antibodies reactive with the Bacillus anthracis polypeptide capsule显示文摘 | Kozel TR Thorkildson P Brandt S | 2007 | Infect Immun2007，75，1： | 1 |
| 15 | Left prefrontal transcranial magnet ic stimulation(TMS)treatment of depression in bipolar affeetive dis- order:A pilot study of acute safety and effieacy显示文摘 | Nahas Z Kozel F A Li X | 2003 | Bipolar Disord2003，5，1： | 1 |
| 16 | The capsule of Cryptococcus neoformans passively inhibits phagocytosis of the yeast by macrophages显示文摘 | Kozel TR Gotschlich EC | 1982 | JournalofImmunology1982，129，4： | 1 |
| 17 | Transforming pedagogy in nursing education:A caring learning environment for adult student显示文摘 | Bankert E G Kozel V V | 2005 | NursEduc Perspect2005，26，4： | 1 |
| 18 | Deficiency in plasma membrane calcium ATPase isoform 2 increases susceptibility to noiseinduced heating loss in mice 显示文摘 | KOZEL P J DAVIS R R KRIEG E F | 2002 | Hear Res2002，164，1： | 1 |
| 19 | Fe - dependent and Fe - independent op- sonization of Cryptococeus neoformans by antieapsular monoclonal antibodies : Importance of epitope specificity 显示文摘 | Netski D Kozel T R | 2002 | Infection and Immunity2002，70，6： | 1 |
| 20 | Fractional anisot- ropy changesafter several weeks of daily left high-fre- quency repetitive transcranial magnetic stimulation of the prefrontal cortex to treat major depression显示文摘 | Kozel FA Johnson KA Nahas Z | 2011 | JECT2011，27，1： | 1 |
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