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| 1 | Acupuncture's Role in Solving the Opioid Epidemic: Evidence, Cost-Effectiveness, and Care Availability for Acupuncture as a Primary, Non-Pharmacologic Method for Pain Relief and Management-White Paper 2017显示文摘The United States(U.S.) is facing a national opioid epidemic, and medical systems are in need of nonpharmacologic strategies that can be employed to decrease the public's opioid dependence. Acupuncture has emerged as a powerful, evidence-based, safe, cost-effective, and available treatment modality suitable to meeting this need. Acupuncture has been shown to be effective for the management of numerous types of pain conditions, and mechanisms of action for acupuncture have been described and are understandable from biomedical, physiologic perspectives. Further, acupuncture's cost-effectiveness can dramatically decrease health care expenditures, both from the standpoint of treating acute pain and through avoiding addiction to opioids that requires costly care, destroys quality of life, and can lead to fatal overdose. Numerous federal regulatory agencies have advised or mandated that healthcare systems and providers offer non-pharmacologic treatment options for pain. Acupuncture stands out as the most evidence-based, immediately available choice to fulfil these calls. Acupuncture can safely, easily, and cost-effectively be incorporated into hospital settings as diverse as the emergency department, labor and delivery suites, andneonatal intensive care units to treat a variety of commonly seen pain conditions. Acupuncture is already being successful y and meaningfully utilized by the Veterans Administration and various branches of the U.S. Military, in some studies demonstrably decreasing the volume of opioids prescribed when included in care. | arthur yin fan david w.miller bonnie bolash matthew bauer john mcdonald sarah faggert hongjian he yong ming li amy matecki lindy camardella mel hopper koppelman jennifer a.m.stone lindsay meade john pang | 2017 | Journal of Integrative Medicine2017，15，6： | 29 |
| 2 | Tissue-specific transcription reprogramming promotes liver metastasis of colorectal cancer显示文摘Metastasis,the development of secondary malignant growths at a distance from a primary tumor,is the cause of death for 90%of cancer patients,but little is known about how metastatic cancer cells adapt to and colonize new tissue environments.Here,using clinical samples,patient-derived xenograft(PDX)samples,PDX cells,and primary/metastatic cell lines,we discovered that liver metastatic colorectal cancer(CRC)cells lose their colon-specific gene transcription program yet gain a liver-specific gene transcription program.We showed that this transcription reprogramming is driven by a reshaped epigenetic landscape of both typical enhancers and super-enhancers.Further,we identified that the liver-specific transcription factors FOXA2 and HNF1A can bind to the gained enhancers and activate the liver-specific gene transcription,thereby driving CRC liver metastasis.Importantly,similar transcription reprogramming can be observed in multiple cancer types.Our data suggest that reprogrammed tissue-specific transcription promotes metastasis and should be targeted therapeutically. | Shuaishuai Teng Yang Eric Li Ming Yang Rui Qi Yiming Huang Qianyu Wang Yanmei Zhang Shanwen Chen Shasha Li Kequan Lin Yang Cao Qunsheng Ji Qingyang Gu Yujing Cheng Zai Chang Wei Guo Pengyuan Wang Ivan Garcia-Bassets Zhi John Lu Dong Wang | 2020 | Cell Research2020，30，1： | 11 |
| 3 | A fundamental theorem for eco-environmental surface modelling and its applications显示文摘We propose a fundamental theorem for eco-environmental surface modelling(FTEEM) in order to apply it into the fields of ecology and environmental science more easily after the fundamental theorem for Earth’s surface system modeling(FTESM). The Beijing-Tianjin-Hebei(BTH) region is taken as a case area to conduct empirical studies of algorithms for spatial upscaling, spatial downscaling, spatial interpolation, data fusion and model-data assimilation, which are based on high accuracy surface modelling(HASM), corresponding with corollaries of FTEEM. The case studies demonstrate how eco-environmental surface modelling is substantially improved when both extrinsic and intrinsic information are used along with an appropriate method of HASM. Compared with classic algorithms, the HASM-based algorithm for spatial upscaling reduced the root-meansquare error of the BTH elevation surface by 9 m. The HASM-based algorithm for spatial downscaling reduced the relative error of future scenarios of annual mean temperature by 16%. The HASM-based algorithm for spatial interpolation reduced the relative error of change trend of annual mean precipitation by 0.2%. The HASM-based algorithm for data fusion reduced the relative error of change trend of annual mean temperature by 70%. The HASM-based algorithm for model-data assimilation reduced the relative error of carbon stocks by 40%. We propose five theoretical challenges and three application problems of HASM that need to be addressed to improve FTEEM. | Tianxiang YUE Na ZHAO Yu LIU Yifu WANG Bin ZHANG Zhengping DU Zemeng FAN Wenjiao SHI Chuanfa CHEN Mingwei ZHAO Dunjiang SONG Shihai WANG Yinjun SONG Changqing YAN Qiquan LI Xiaofang SUN Lili ZHANG Yongzhong TIAN Wei WANG Ying’an WANG Shengnan MA Hongsheng HUANG Yimin LU Qing WANG Chenliang WANG Yuzhu WANG Ming LU Wei ZHOU Yi LIU Xiaozhe YIN Zong WANG Zhengyi BAO Miaomiao ZHAO Yapeng ZHAO Yimeng JIAO Ufra NASEER Bin FAN Saibo LI Yang YANG John PWILSON | 2020 | Science China Earth Sciences2020，63，8： | 7 |
| 4 | Pandemonium Breaks Out:Disruption of Salicylic Acid-Mediated Defense by Plant Pathogens显示文摘Salicylic acid (SA) or 2-hydroxybenoic acid is a phenolic plant hormone that plays an essential role in plant defense against biotrophic and semi-biotrophic pathogens. In Arabidopsis, SA is synthesized from chorismate in the chloroplast through the ICS1 (isochorismate synthase I) pathway during pathogen infectioru The transcription co-activator NPR1 (Non-Expresser of Pathogenesis-Related Gene 1), as the master regulator of SA signaling, interacts with transcription factors to induce the expression of anti-microbial PR (Pathogenesis-Related) genes. To establish successful in fections, plant bacterial, oomycete, fun gal, and viral pathogens have evolved at least three major strategies to disrupt SA-mediated defense? The first strategy is to reduce SA accumulation directly by converting SA into its inactive derivatives. The second strategy is to interrupt SA biosynthesis by targeting the ICS1 pathway. In the third major strategy, plant pathogens deploy different mechanisms to interfere with SA downstream signaling. The wide array of strategies deployed by plant pathogens highlights the crucial role of disruption of SA-mediated plant defense in plant pathogenesis. A deeper understanding of this topic will greatly expand our knowledge of how plant pathogens cause diseases and consequently pave the way for the development of more effective ways to corn trol these diseases. | Guang Qi Jian Chen Ming Chang Huan Chen Katherine Hall John Korin Fengquan Liu Daowen Wang Zheng Qing Fu | 2018 | Molecular Plant2018，11，12： | 5 |
| 5 | Cell cycle-related kinase reprograms the liver immune microenvironment to promote cancer metastasis显示文摘The liver is an immunologically tolerant organ and a common metastatic site of multiple cancer types.Although a role for cancer cell invasion programs has been well characterized,whether and how liver-intrinsic factors drive metastatic spread is incompletely understood.Here,we show that aberrantly activated hepatocyte-intrinsic cell cycle-related kinase(CCRK)signaling in chronic liver diseases is critical for cancer metastasis by reprogramming an immunosuppressive microenvironment.Using an inducible liverspecific transgenic model,we found that CCRK overexpression dramatically increased both B16F10 melanoma and MC38 colorectal cancer(CRC)metastasis to the liver,which was highly infiltrated by polymorphonuclear-myeloid-derived suppressor cells(PMNMDSCs)and lacking natural killer T(NKT)cells.Depletion of PMN-MDSCs in CCRK transgenic mice restored NKT cell levels and their interferon gamma production and reduced liver metastasis to 2.7% and 0.7%(metastatic tumor weights)in the melanoma and CRC models,respectively.Mechanistically,CCRK activated nuclear factor-kappa B(NF-κB)signaling to increase the PMN-MDSC trafficking chemokine C-X-C motif ligand 1(CXCL1),which was positively correlated with liver-infiltrating PMN-MDSC levels in CCRK transgenic mice.Accordingly,CRC liver metastasis patients exhibited hyperaaivation of hepatic CCRK/NF-κB/CXCL1 signaling,which was associated with accumulation of PMN-MDSCs and paucity of NKT cells compared to healthy liver transplantation donors.In summary,this study demonstrates that immunosuppressive reprogramming by hepatic CCRK signaling undermines antimetastatic immunosurveillance.Our findings offer new mechanistic insights and therapeutic targets for liver metastasis intervention. | Xuezhen Zeng Jingying Zhou Zhewen Xiong Hanyong Sun Weiqin Yang Myth T.S.Mok Jing Wang Jingqing Li Man Liu Wenshu Tang Yu Feng Hector Kwong-Sang W ang Shun-Wa Tsang King-Lau Chow Philip Chun Yeung John Wong Paul Bo-San Lai Anthony Wing-Hung Chan Ka Fai To Stephen Lam Chan Qiang Xia Jing Xue Xiao Chen Jun Yu Sui Peng Joseph Jao-Yiu Sung Ming Kuang Alfred Sze-Lok Cheng | 2021 | Cellular & Molecular Immunology2021，18，4： | 5 |
| 6 | A strain-isolation design for stretchable electronics显示文摘Stretchable electronics represents a direction of recent development in next-generation semiconductor devices.Such systems have the potential to offer the performance of conventional wafer-based technologies,but they can be stretched like a rubber band,twisted like a rope, bent over a pencil,and folded like a piece of paper.Isolating the active devices from strains associated with such deformations is an important aspect of design.One strategy involves the shielding of the electronics from deformation of the substrate through insertion of a compliant adhesive layer. This paper establishes a simple,analytical model and validates the results by the finite element method.The results show that a relatively thick,compliant adhesive is effective to reduce the strain in the electronics,as is a relatively short film. | Jian Wu Ming Li Wei-Qiu Chen Dae-Hyeong Kim Yun-Soung Kim Yong-Gang Huang Keh-Chih Hwang Zhan Kang John A.Rogers | 2010 | Acta Mechanica Sinica2010，26，6： | 3 |
| 7 | CO 2 emissions embodied in China’s exports from 2002 to 2008: A structural decomposition analysis显示文摘 | Ming Xu Ran Li John C. Crittenden Yongsheng Chen | 2011 | Energy Policy2011，，11： | 2 |
| 8 | MECHANICS ANALYSIS OF TWO-DIMENSIONALLY PRESTRAINED ELASTOMERIC THIN FILM FOR STRETCHABLE ELECTRONICS显示文摘Various methods have been developed to fabricate highly stretchable electronics.Recent studies show that over 100% two dimensional stretchability can be achieved by mesh structure of brittle functioning devices interconnected with serpentine bridges.Kim et al show that pressing down an inflated elastomeric thin film during transfer printing introduces two di-mensional prestrain,and therefore further improves the system stretchability.This paper gives a theoretical study of this process,through both analytical and numerical approaches.Simple analytical solutions are obtained for meridional and circumferential strains in the thin film,as well as the maximum strain in device islands,which all agree reasonably well with finite element analysis. | Ming Li JianUang Xiao Jian Wu Rak-Hwan Kim Zhan Kang Yonggang Huang John A. Rogers | 2010 | Acta Mechanica Solida Sinica2010，23，6： | 2 |
| 9 | Enhanced propellant performance via environmentally friendly curable surface coating显示文摘Surface coating of granular propellants is widely used in a multiplicity of propellants for small, medium and large caliber ammunition. All small caliber ball propellants exhibit burning progressivity due to application of effective deterrent coatings. Large perforated propellant grains have also begun utilizing plasticizing and impregnated deterrent coatings with the purpose of increasing charge weights for greater energy and velocity for the projectile. The deterrent coating and impregnation process utilizes volatile organic compounds(VOCs) and hazardous air pollutants(HAPs) which results in propellants that need to be forced air dried which impacts air quality. Propellants undergo temperature fluctuations during their life. Diffusion coefficients vary exponentially with variations in temperature. A small temperature increase can induce a faster migration, even over a short period of time, which can lead to large deviations in the concentration. This large concentration change in the ammunition becomes a safety or performance liability. The presence of both polymeric deterrents and nitroglycerin(NG) in the nitrocellulose matrix and organic solvents leads to higher diffusion rates. This results in continued emissions of VOCs and HAPs. Conventional polymers tend to partition within the propellant matrix. In other words,localized mixing can occur between the polymer and underlying propellant. This is due to solvent induced softening of the polymer vehicle over the propellant grain. In effect this creates a path where migration can occur. Since nitrate esters, like NG, are relatively small, it can exude to the surface and create a highly unstable and dangerous situation for the warfighter. Curable polymers do not suffer from this partitioning due to 'melting' because no VOC solvents are present. They remain surface coated. The small scale characterization testing, such as closed bomb testing, small scale sensitivity, thermal stability,and chemical compatibility, will be presented. The 30 mm gun demonstration firing data at hot, cold, and ambient temperatures will also be presented. | Thelma Manning Jeffrey Wyckoff Kenneth Klingaman Viral Panchal Eugene Rozumov John Bolognini Ming Wang Young Subhash Patel | 2017 | Defence Technology(防务技术)2017，13，3： | 2 |
| 10 | Adaptive image segmentation using a genetic algorithm 显示文摘 | Bir Bhanu Sungkee Lee John Ming | 1995 | IEEE Tran SMC1995，25，12： | 1 |
| 11 | Transgene and mitochondrial DNA are indicators of efficient composting of transgenic pig carcasses显示文摘 | Dave Murray Roy G. Meidinger Serguei P. Golovan John P. Phillips Ivan P. O’Halloran Ming Z. Fan Roger R. Hacker Cecil W. Forsberg | 2006 | Bioresource Technology2006，，9： | 1 |
| 12 | Hyperglycemia Affects Gastric Electrical Rhythm and Nausea During Intraduodenal Triglyceride Infusion显示文摘 | Geoffrey S. Hebbard Melvin Samsom Jane M. Andrews David Carman Ben Tansell Wei Ming Sun John Dent Michael Horowitz | 1997 | Digestive Diseases and Sciences1997，，3： | 1 |
| 13 | Pancreaticoduodenectomy with En Bloc Portal Vein Resection for Pancreatic Carcinoma with Suspected Portal Vein Involvement显示文摘 | Ronnie T. Poon M.S. Sheung Tat Fan M.D. Ph.D. Chung Mau Lo M.S. Chi Leung Liu M.S. Chi Ming Lam M.S. Wai Key Yuen M.B.B.S. Chun Yeung M.B.B.S. John Wong Ph.D | 2004 | World Journal of Surgery2004，，6： | 1 |
| 14 | A Novel Oncogenic Role of Inositol Phosphatase SHIP2 in ER‐Negative Breast Cancer Stem Cells: Involvement of JNK/Vimentin Activation显示文摘 | Chiung‐Hui Fu Ruey‐Jen Lin John Yu Wen‐Wei Chang Guo‐Shiou Liao Wen‐Ying Chang Ling‐Ming Tseng Yi‐Fang Tsai Jyh‐Cherng Yu Alice L. Yu | 2014 | Stem Cells2014，，8： | 1 |
| 15 | “Tumoral Pseudoblush” Identified within Gliomas at High-Spatial-Resolution Ultrahigh-Field-Strength Gradient-Echo MR Imaging Corresponds to Microvascularity at Stereotactic Biopsy显示文摘 | Gregory A. Christoforidis Ming Yang Amir Abduljalil Abhik R. Chaudhury Herbert B. Newton John M. McGregor Clara R. Epstein William T. C. Yuh Sydeaka Watson Pierre-Marie L. Robitaille | 2012 | Radiology2012，，： | 1 |
| 16 | Effect of materials and temperature on the forward extrusion of magnesium alloys 显示文摘 | Margam Chandrasekaran Yong Ming Shyan John | 2004 | Materials Science and Engineering A2004，381，： | 1 |
| 17 | Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers显示文摘 | Ramaswamy Govindan Li Ding Malachi Griffith Janakiraman Subramanian Nathan D. Dees Krishna L. Kanchi Christopher A. Maher Robert Fulton Lucinda Fulton John Wallis Ken Chen Jason Walker Sandra McDonald Ron Bose David Ornitz Donghai Xiong Ming You David J. | 2012 | Cell2012，，： | 1 |
| 18 | Effect of materials and temperature on the forward extrusion of magnesium alloys 显示文摘 | Margam Chandrasekaran Yong Ming Shyan John | 2004 | Materials Science and Engineering2004，381，12： | 1 |
| 19 | The 'Same'Project : Achieving 'One Curriculum for All'in Hong Kong 显示文摘 | Li Alison Man-Ching Tse Andrew Chung- Yee Lian Ming -Gon John | | International Journal of Whole Schooling0，52，： | 1 |
| 20 | A review of imaging techniques for systems biology 显示文摘 | R Kherlopian Ting Song Qi Duan Mathew A Neimark Ming J Po John K Gohagan and Andrew F | 2008 | BMC Systems Biology2008，2，74： | 1 |
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