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| 1 | Chinese Multidisciplinary Expert Consensus on the Diagnosis and Treatment of Hyperuricemia and Related Diseases显示文摘 | Zou, He-Jian Wu, Hu-Sheng Zhou, Jing-Guo Zeng, Xue-Jun Dai, Lie Wu, Hua-Xiang Zhu, Xiao-Xia Mei, Chang-Lin Hao, Chuan-Ming Chen, Nan Liu, Bi-Cheng Chen, Jiang-Hua Yang, Li Nie, Jing Yu, Chen Peng, Ai Yu, Sheng-Qiang Li, Lin Ge, Jun-Bo Huo, Yong Zhang, Shu-Yang Chen, Yun-Dai Dong, Yu-Gang Liang, Chun Dai, Yu-Xiang Gao, Xin Li, Chang-Gui Zhao, Jia-Jun Chen, Hai-Bing Cheng, Zhi-Feng Lin, Huan-Dong Guan, Yang-Tai Wang, Kai Luo, Ben-Yan Dai, Ruo-Lian Jiang, Quan Xue, Luan Liang, Chao-Chao Chen, Ming Fan, Song | 2017 | Chinese Medical Journal2017，，20： | 30 |
| 2 | Percutaneous coronary intervention for chronic total occlusion in 1263 patients:a single-center report显示文摘背景冠的长期的全部的吸藏(CTO ) 在 interventional 心病学仍然是最挑战性的损害子集之一,甚至与医药设备和操作符专家知识的开发。这研究被进行检验在损害特征和程序的成功和在里面医院的发生之间的关系在为在沈阳经历了在1995年6月和2005年12月之间的一种总线标准的有 CTO 的 1263 个病人的 CTO.Methods 临床、冠的 angiographic 数据的经皮的冠的干预(一种总线标准)以后的主要不利心脏的事件(向) PLA 的医院将军是回顾地在那里的 analyzed.Results 是与吝啬的吸藏 tim 位于 1596 个容器的 1625 CTO 损害1647 冠的 stents 的一个总数被植入到目标损害。全面病人和损害成功率分别地是 90.8 %(1147/1263 ) 和 88.9 %(1445/1625 ) 。一种总线标准的成功率与吸藏的长持续时间被拒绝,突然的错过树桩,衔接担保在堵塞长度的 15 公里,对严重石灰化或扭曲和 ostial 或 CTO 损害(P 0.05 ) 的远侧的地点中等。程序的失败发生在 116 个病人,由指南电线(81.0%) 或汽球(19.0%) 的不可能引起了通过 occlusion.There 不在过程期间是死亡,但是 2 个病人患了尖锐 stent 血栓,另外的 9 个病人有尖锐或迟了的心囊的穿孔。那些复杂并发症都成功地被对待。在过程以后, 3patients 死了,因为稍尖的 stent 血栓和 1underwent, 4 经历了迫切目标容器 revascularization 冠在在里面医院期间由于冠的管绕过接枝外科时期。全面在里面医院向率是 0.6%(8/1263 ) 。没有在里面医院 MACE.Conclusions, Drug-eluting stents 在一个富有经验的心中心在 198 个病人被使用,与冠的 CTO 损害为病人获得一种总线标准和有利临床的结果的相对高的成功率是可能的。 | HAN Ya-ling WANG Shou-li JING Quan-min LI Yi ZHANG Jian MA Ying-yan LUAN Bo | 2006 | Chinese Medical Journal2006，，14： | 18 |
| 3 | Multi-wire plaque crushing as a novel technique in treating chronic total occlusions显示文摘背景:通过堵塞片断的汽球导管的失败占 10%-15% 所有过程在为长期的全部的吸藏(CTO ) 的经皮的冠的干预(一种总线标准) 期间。我们寻求了匾压碎为便于汽球导管多电线过去调查一种原来的技术。方法:在 2000 年 7 月和 2007 年 10 月之间,没有通过汽球过去的有 164 CTO 损害的 152 个病人被压碎技术的多电线匾对待。这种技术的主要过程是与为匾压碎在汽球失败以后位于 CTO 损害的真腔的原来的电线一起插入 1 或 2 根电线然后撤退压碎的电线在吸藏片断以内得到扩大的腔,因此便于过去的汽球。结果:全面损害和技术成功率是 91.5%(150/164 ) 。211 根压碎的电线的一个总数在一种总线标准期间被使用,包括 1 压碎为 117 的电线(71.3%) 为 47 的损害和 2 压碎电线(28.7%) 损害。(121/211 ) 约 57.3% 所有压碎的电线是已经在一样的过程使用的那些。技术失败发生在 14 损害(8.5%) 。技术失败由于压碎进入假腔的电线(92.9% , 13/14 ) 并且冠的穿孔(7.1% , 1/14 ) 。主要程序的复杂并发症包括了冠的穿孔(1 个盒子) 和严重冠的解剖(2 个盒子) ,所有哪个成功地被对待。结论:多电线匾压碎技术在便于汽球导管在 CTO 一种总线标准期间过去是有效的。它与程序的复杂并发症的低率可行、节俭、相对安全。 | HAN Ya-ling LI Yi WANG Shou-li JING Quan-min MA Ying-yan WANG Geng LUAN Bo WANG Bin WANG Zhu-lu WANG Dong-mei | 2008 | Chinese Medical Journal2008，，6： | 17 |
| 4 | Endovascular stent-grafts for acute and chronic type B aortic dissection: comparison of clinical outcomes显示文摘 | JING Quan-min HAN Ya-ling WANG Xiao-zeng DENG Jie LUAN Bo JIN Hong-xu LIU Xiao-jiang LI Fei | 2008 | Chinese Medical Journal2008，，22： | 16 |
| 5 | Pifithrin-α reduces cerebral vasospasm by attenuating apoptosis of endothelial cells in a subarachnoid haemorrhage model of rat显示文摘背景:服的血管痉挛追随者潜水艇 arachnoid 出血(SAH ) 的机制没被理解。这里,我们假设了 p53 导致的 endothelial 的那 apoptosis,它在 apoptosis (美洲狮) 的调整调节的人上面的目标基因他们破折号 p53 在服的血管痉挛的开发起了一个重要作用。我们也观察了一个 p53 禁止者的效果, pifithrin-alpha (PFT-alpha ) 在减少 p53 和美洲狮的表示以后,因而减少 endothelial 的 apoptosis 和减轻的服的血管痉挛。方法:称 300-350 g 的男 Sprague-Dawley 老鼠随机被划分成五个组:一个控制组(假冒的外科) ,一个 SAH 组,一个 SAH+dimethyl 硫氢化物(DMSO ) 组, SAH + PFT-alpha (0.2 mg/kg ) 组织, SAH + PFT-alpha (2.0 mg/kg ) 组织。PFT-alpha 在 SAH 以后立即 intraperitoneally 被注射。老鼠被牺牲在 SAH 以后的 24 个小时。西方的污点和免疫组织化学的染色被用来检测 p53,美洲狮和 caspase-3 蛋白质的层次。另外,死亡和神经病学的分数为每个组被估计。统计意义被 ANOVA 由 Tukey 测试跟随了的以一个方法执行的变化的分析保证。神经病学并且死亡分数被 Dunn 的方法和菲希尔分析准确测试分别地。结果:在 SAH ,西方的污点和免疫以后,组织化学的染色在 endothelial 和积极 endothelial 都是的标记的调停的 dUTP 刻痕结束( TUNEL )显著地在基部的动脉( P<0.05 )增加了的 TdT 的数字显示出 p53 ,美洲狮和 caspase-3 的层次,但是显著地由 PFT-alpha ( P<0.05 )减少了。这些变化被增加直径和基部的动脉(P<0.05 ) 的衰退的墙厚度伴随,以及减少了死亡和老鼠(P<0.05 ) 的神经病学的赤字。结论:PFT-alpha 能保护服的容器免受血管痉挛的开发的伤害并且改进神经病学的结果以及经由压制 p53 在服的容器的 endothelial 导致的 apoptosis 减少死亡。 | YAN Jun-hao YANG Xiao-mei CHEN Chun-hua HU Qin ZHAO Jing SHI Xian-zhong LUAN Li-ju YANG Lei QIN Li-hua ZHOU Chang-man | 2008 | Chinese Medical Journal2008，，5： | 13 |
| 6 | Piglets cloned from induced pluripotent stem cells显示文摘 | Nana Fan Jijun Chen Zhouchun Shang Hongwei Dou Guangzhen Ji Qingjian Zou Lu Wu Lixiazi He Fang Wang Kai Liu Na Liu Jianyong Han Qi Zhou Dengke Pan Dongshan Yang Bentian Zhao Zhen Ouyang Zhaoming Liu Yu Zhao Lin Lin Chongming Zhong Quanlei Wang Shouqi Wang Ying Xu Jing Luan Yu Liang Zhenzhen Yang Jing Li Chunxia Lu Gabor Vajta Ziyi Li Hongsheng Ouyang Huayan Wang Yong Wang Yang Yang Zhonghua Liu Hong Wei Zhidong Luan Miguel A Esteban Hongkui Deng Huanming Yang Duanqing Pei Ning Li Gang Pei Lin Liu Yutao Du Lei Xiao Liangxue Lai | 2013 | Cell Research2013，23，1： | 12 |
| 7 | Experimental study of rotor blades vibration and noise in multistage high pressure compressor and their relevance显示文摘Rotor blades fault of aeroengine compressor is mostly caused by mechanical and aerodynamic excitation.And the excitation factor of high intensity sound wave to rotor blades should not be ignored.Experimental researches are conducted on a multistage high pressure compressor.When high level vibration occurs on the first stage of rotor blades, the noise spectrum presents typical characteristic for discrete multi-tone in the compressor.The amplitude of blade vibration displacement and the sound pressure level of characteristic frequency noise increases and decreases simultaneously and reaches the maximum value at the same time.This frequency merely occur on a certain speed range and is locked in a specific range which presents no variation with the rotating speed.When high level vibration occurs on the first stage of rotor blades, the noise spectrum presents a sharp peak and the propagation state of the characteristic frequency is a helix structure in the compressor.It can be confirmed that acoustic resonance occurs in the multistage compressor.The acoustic resonance frequency and its side band frequencies are generated by modulation of a rotating noise source at the rotor speed which is the excitation source of the rotor blades vibration. | Fengtong ZHAO Xiaodong JING Mingsui YANG Deyou WANG Yundong SHA Xiaochi LUAN | 2020 | Chinese Journal of Aeronautics2020，33，3： | 11 |
| 8 | Long-term outcomes of drug-eluting versus bare-metal stent implantation in patients with chronic total coronary artery occlusions显示文摘在那里的背景为长期的全部的吸藏(CTO ) 的治疗是 drug-eluting stents (DES ) 的功效上的有限数据。学习的目的是与赤裸金属的 stent ( BMS )相比为 CTO 评估 DES 培植的长期的临床的结果在1995年6月和2006年12月之间的 implantation.Methods ,有至少一 de novo CTO 损害的成功的开运河的 1184 个病人的一个总数连续地被登记,包括 660 (55.7%)经历了 DES 并且 524 (44.3%)经历了 BMS 培植。所有病人被跟随在上面为为主要不利心脏的事件(向) 的出现的多达 5 年。长期的幸存率与临床的 Kaplan-Meier method.Results 基线被估计,除了在 DES 组的病人收到了更长双的 antiplatelet 治疗之外, angiographic 特征在二个组之间是可比较的((7.4 ??????????????? 陈 ? 陈吗?? | HAN Ya-ling ZHANG Jian LI Yi WANG Shou-li JING Quan-min YI Xian-hua MA Ying-yan LUAN Bo WANG Geng WANG Bin | 2009 | Chinese Medical Journal2009，，6： | 9 |
| 9 | Expression of human cytomegalovirus components in the brain tissues of patients with Rasmussen's encephalitis显示文摘Rasmussen's encephalitis(RE) is a rare and severe progressive epileptic syndrome with unknown etiology. Infection by viruses, including human cytomegalovirus(HCMV), has been speculated to be a potential trigger for RE. However, no viral antigens have been detected in the brains of patients with RE; thus, a possible clinical linkage between viral infections and RE has not been firmly established. In this study, we evaluated the expression of HCMV pp65 antigen in brain sections from 26 patients with RE and 20 non-RE patients by immunohistochemistry and in situ hybridization, and assessed the associations between HCMV infection and clinical parameters.Elevated expression of HCMV pp65 protein and DNA was observed in 88.5%(23/26) and 69.2%(18/26) of RE cases, respectively. In the non-RE group, HCMV pp65 antigen was detected only in two cases(10%), both of which were negative for DNA staining. Additionally, the intensity of HCMV pp65 staining was correlated with a shorter duration of the prodromal stage, younger age of seizure onset, and more severe unilateral cortical atrophy. Elevated expression of HCMV pp65 was observed in RE brain tissue and was correlated with the clinical features of RE disease. In summary, our results suggested that HCMV infection may be involved in the occurrence and progression of RE disease. Thus, further studies are needed to determine whether early treatment with anti-HCMV antibodies could modulate the course of RE. | Yao Zhang Yisong Wang Sichang Chen Shuai Chen Yuguang Guan Changqing Liu Tianfu Li Guoming Luan Jing An | 2017 | Virologica Sinica2017，32，2： | 9 |
| 10 | Coronary collateral circulation: Effects on outcomes of acute anterior myocardial infarction after primary percutaneous coronary intervention显示文摘背景将突然地与左前面的 desending 动脉吸藏与前面的心肌的梗塞(MI ) 在病人的结果上调查并行的冠的循环的效果。从在 2004 年 1 月和 2008 年 12 月之间的症状的发作在开始的 12 h 有主要经皮的冠的干预(一种总线标准) 的有尖锐前面的 MI 的 189 个病人的方法数据是回顾的分析。所有病人的左前面的下降动脉(男孩) 被堵塞。男孩与主要一种总线标准被再开。根据并行的发行量,所有病人被分类到二个组:没有并行的组(n = 111 ) ,没有 angiographic 担保充满男孩或方面分支的病人(并行的索引 0 ) 并且并行的组(n = 78 ) ,并且有 angiographic 担保充满男孩或方面分支的病人(并行的索引 1, 2 或 3 ) 。在一年后续,因为心失败的死亡,梗塞, stent 血栓(圣) ,目标容器 revascularization 和重新接纳的出现被观察。在一年的结果,没有并行的循环,死亡与那些相比在有并行的循环的病人是更低的(1% 对 8% , P = 0.049 ) 而在因为心失败的梗塞,圣,目标容器 revascularization 和重新接纳的出现没有差别。出现端点合成没有并行的循环,与那些相比在有并行的循环的病人是更低的(12% 对 26% ;P = 0.014 ) 。结论先存在并行的循环可以预示令人满意的预后到有在在 MI 的开始的 12 h 的主要一种总线标准以后的尖锐前面的 MI 的病人发作。 | Bin Wang Ya-Ling Han Yi Li Quan-Min Jing Shou-Li Wang Ying-Yan Ma Geng Wang Bo Luan Xiao-Zeng Wang | 2011 | Journal of Geriatric Cardiology2011，8，2： | 7 |
| 11 | Analysis of chronic kidney disease staging with different estimated glomerular filtration rate equations in Chinese centenarians显示文摘Background: Accurate estimation of the glomerular filtration rate (GFR) and staging of chronic kidney disease (CKD) are important. Currently, there is no research on the differences in several estimated GFR equations for staging CKD in a large sample of centenarians. Thus, this study aimed to investigate the differences in CKD staging with the most commonly used equations and to analyze sources of discrepancy. Methods: A total of 966 centenarians were enrolled in this study from June 2014 to December 2016 in Hainan province, China. The GFR with the Modification of Diet in Renal Disease (MDRD), Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) and Berlin Initiative Study 1 (BIS1) equations were estimated. Agreement between these equations was investigated with the k statistic and Bland-Altman plots. Sources of discrepancy were investigated by partial correlation analysis. Results: The k values of the MDRD and CKD-EPI equations, MDRD and BIS1 equations, and CKD-EPI and BIS1 equations were 0.610, 0.253, and 0.381, respectively. Serum creatinine (Scr) explained 10.96%, 41.60% and 17.06% of the variability in these three comparisons, respectively. Serum uric acid (SUA) explained 3.65% and 5.43% of the variability in the first 2 comparisons, respectively. Gender was associated with significant differences in these 3 comparisons (P<0.001). Conclusions: The strengths of agreement between the MDRD and CKD-EPI equations were substantial, but those between the MDRD and BIS 1 equations and the CKD-EPI and BIS 1 equations were fair. The difference in CKD staging of the first 2 comparisons strongly depended on Scr, SUA and gender, and that of CKD-EPI and BIS1 equations strongly depended on Scr and gender. The incidence at various stages of CKD staging was quite different. Thus, a new equation that is more suitable for the elderly needs to be built in the future. | Qiu-Xia Han Dong Zhang Ya-Li Zhao Liang Liu Jing Li Fu Zhang Fu-Xin Luan Jia-Yu Duan Zhang-Suo Liu Guang-Yan Cai Xiang-Mei Chen Han-Yu Zhu | 2019 | Chinese Medical Journal2019，，5： | 6 |
| 12 | Inner Envelope CHLOROPLAST MANGANESE TRANSPORTER 1 Supports Manganese Homeostasis and Phototrophic Growth in Arabidopsis显示文摘 | Bin Zhang Chi Zhang Congge Liu Yanping Jing Yuan Wang Ling Jin Lei Yang Aigen Fu Jisen Shi Fugeng Zhao Wenzhi Lan Sheng Luan | 2018 | Molecular Plant2018，11，7： | 6 |
| 13 | Comparative effects of percutaneous coronary intervention for infarct-related artery only or for both infarct- and non-infarct- related arteries in patients with ST-elevation myocardial infarction and multi-vessel disease显示文摘梗塞相关的动脉( IRA )的背景快速的开运河与圣举起心肌的梗塞( MI )为病人在主要经皮的冠的干预(一种总线标准)期间成为了主要目标,但是为在这设定的遗体 unclear.This 研究的 non-IRA 损害的治疗的策略试图仅仅为 IRA 比较在一种总线标准之间的长期的效果并且与圣举起 MI 并且在 242 个合格病人为在有多容器 disease.Methods A 的圣举起 MI 病人的 IRA 和 non-IRA | HAN Ya-ling WANG Bin WANG Xiao-zeng LI Yi WANG Shou-li JING Quan-min WANG Geng MA Ying-yan LUAN Bo | 2008 | Chinese Medical Journal2008，，23： | 6 |
| 14 | Species Exclusion Between an Invasive and an Indigenous Whitefly on Host Plants with Differential Levels of Suitability显示文摘The whitefly Bemisia tabaci has risen to international prominence since the 1980s due to the rapid spread around the globe by the two species B and Q within this species complex.The invasion of B has often been associated with the displacement of indigenous whiteflies.As the genetic structure of B.tabaci is diverse,more case studies of the competitive relationships between B and indigenous species of the whitefly species complex will help to understand further the mechanisms underlying the invasion of B.We examined the competitive interactions between B and ZHJ2,a widely distributed indigenous whitefly in Asia,on host plants with differential levels of suitability to the two species in the laboratory,and also tested the effect of insecticide application on the competitive relationships.Three species of plants were tested including cotton,a plant showing similar levels of suitability to both species,squash,a plant showing higher suitability to B than to ZHJ2,and kidney bean,a plant showing higher suitability to ZHJ2 than to B.In the case of no insecticide application,B displaced ZHJ2 on cotton,squash,and kidney bean by the 6th,3rd and 10th generation,respectively.With the application of imidacloprid,the displacement of ZHJ2 by B on cotton occurred by the 5th generation.As the displacement progressed,the proportion of B females increased,and the proportion of ZHJ2 females decreased on cotton and squash.In contrast,on kidney bean the proportion of B females remained unchanged while that of ZHJ2 increased.These results show the strong capacity of the invasive B to displace ZHJ2,and indicate that host plants with differential levels of suitability to the two species may affect the speed but not the trend of displacement and insecticide application may accelerate the process of displacement. | LUAN Jun-bo XU Jing LIN Ke-ke Myron P Zalucki LIU Shu-sheng | 2012 | Journal of Integrative Agriculture2012，11，2： | 6 |
| 15 | Synthesis of novel chiral N,P-containing multidentate ligands and their applications in asymmetric transfer hydrogenation显示文摘Novel chiral PN_4-type multidentate aminophosphine ligands have been successfully synthesized by Schiff-base condensation of bis(o-formylphenyl)phenylphosphane and various chiral amino-sulfonamides.Their structures were fully characterized by IR,EI-MS and NMR.The catalytic systems,prepared in situ from the multidentate ligands and iridium(I) complexes,showed high activity in asymmetric transfer hydrogenation of propiophenone in 2-propanol solution,leading to corresponding optical alcohol with up to 75%ee. | Shen Luan Yu Yan Yun Li Zhen Rong Dong Juan Ni Zhang Qi Li Jing Xing Gao | 2011 | Chinese Chemical Letters2011，22，11： | 5 |
| 16 | Extensive profiling of the expressions of tRNAs and tRNA-derived fragments(tRFs)reveals the complexities of tRNA and tRF populations in plants显示文摘Evidence is emerging that t RNA-derived fragments(t RFs)are regulatory molecules.Studies of t RFs in plants have been based on conventional small RNA sequencing,and focused on profiling of t RF-5 and t RF-3 species.A more comprehensive and quantitative analysis of the entire t RF population is highly necessary.Here,we employ t RNA-seq and YAMAT-seq,and develop a bioinformatics tool to comprehensively profile the expressions of t RNAs and t RFs in plants.We show that in Arabidopsis,approximately half of t RNA genes are extremely weakly expressed,accounting for only 1%of total t RNA abundance,while~12%of t RNA genes contribute to~80%of t RNA abundance.Our t RNA sequencings in various plants reveal that t RNA expression profiles exhibit a cross-species conserved pattern.By characterizing the composition of a highly heterogeneous t RF population,we show that t RNA halves and previously unnoticed 10–16-nt tiny t RFs represent substantial portions.The highly accumulated 13-nt and 16-nt tiny t RFs in Arabidopsis indicate that tiny t RFs are not random t RNA degradation products.Finally,we provide a user-friendly database for displaying the dynamic spatiotemporal expressions of t RNAs and t RFs in the model plants Arabidopsis and rice. | Xuan Ma Chunyan Liu Xiaocong Kong Jing Liu Siju Zhang Shanshan Liang Weijiang Luan Xiaofeng Cao | 2021 | Science China(Life Sciences)2021，64，4： | 5 |
| 17 | Asymptotics for Certain Harmonic Functions and the Martin Compactification on the Quaternionic Heisenberg Group显示文摘在这篇论文,我们在各种各样的情况中为 thequaternionic 海森堡组做热核的 asymptotic 估计。我们也使用这些结果在 quaternionic 海森堡组上推出某些泛音功能的 asymptoticestimates。而且 quaternionic 海森堡组的 MartinCompactification 被构造,并且我们证明这个组的 Martinboundary 是到 quaternionic 地里的联合起来的球的 homeomorphic。 | Jing Wen LUAN Fu Liu ZHU | 2005 | Acta Mathematica Sinica,English Series2005，21，6： | 4 |
| 18 | Back-n white neutron source at CSNS and its applications显示文摘Back-streaming neutrons from the spallation target of the China Spallation Neutron Source(CSNS)that emit through the incoming proton channel were exploited to build a white neutron beam facility(the so-called Back-n white neutron source),which was completed in March 2018.The Back-n neutron beam is very intense,at approximately 29107 n/cm2/s at 55 m from the target,and has a nominal proton beam with a power of 100 kW in the CSNS-I phase and a kinetic energy of 1.6 GeV and a thick tungsten target in multiple slices with modest moderation from the cooling water through the slices.In addition,the excellent energy spectrum spanning from 0.5 eV to 200 MeV,and a good time resolution related tothe time-of-flight measurements make it a typical white neutron source for nuclear data measurements;its overall performance is among that of the best white neutron sources in the world.Equipped with advanced spectrometers,detectors,and application utilities,the Back-n facility can serve wide applications,with a focus on neutron-induced cross-sectional measurements.This article presents an overview of the neutron beam characteristics,the experimental setups,and the ongoing applications at Backn. | Jing-Yu Tang Qi An Jiang-Bo Bai Jie Bao Yu Bao Ping Cao Hao-Lei Chen Qi-Ping Chen Yong-Hao Chen Zhen Chen Zeng-Qi Cui Rui-Rui Fan Chang-Qing Feng Ke-Qing Gao Xiao-Long Gao Min-Hao Gu Chang-Cai Han Zi-Jie Han Guo-Zhu He Yong-Cheng He Yang Hong Yi-Wei Hu Han-Xiong Huang Xi-Ru Huang Hao-Yu Jiang Wei Jiang Zhi-Jie Jiang Han-Tao Jing Ling Kang Bo Li Chao Li Jia-Wen Li Qiang Li Xiao Li Yang Li Jie Liu Rong Liu Shu-Bin Liu Xing-Yan Liu Ze Long Guang-Yuan Luan Chang-Jun Ning Meng-Chen Niu Bin-Bin Qi Jie Ren Zhi-Zhou Ren Xi-Chao Ruan Zhao-Hui Song Kang Sun Zhi-Jia Sun Zhi-Xin Tan Xin-Yi Tang Bin-Bin Tian Li-Jiao Wang Peng-Cheng Wang Zhao-Hui Wang Zhong-Wei Wen Xiao-Guang Wu Xuan Wu Li-Kun Xie Xiao-Yun Yang Yi-Wei Yang Han Yi Li Yu Tao Yu Yong-Ji Yu Guo-Hui Zhang Lin-Hao Zhang Qi-Wei Zhang Xian-Peng Zhang Yu-Liang Zhang Zhi-Yong Zhang Lu-Ping Zhou Zhi-Hao Zhou Ke-Jun Zhu 无 | 2021 | Nuclear Science and Techniques2021，32，1： | 4 |
| 19 | Risk clinicopathological factors for lymph node metastasis in poorly differentiated early gastric cancer and their impact on laparoscopic wedge resection显示文摘AIM:To investigate the predictive factors of lymph node metastasis(LNM) in poorly differentiated early gastric cancer(EGC),and enlarge the possibility of using laparoscopic wedge resection(LWR).METHODS:We retrospectively analyzed 85 patients with poorly differentiated EGC who underwent surgical resection between January 1992 and December 2010.The association between the clinicopathological factors and the presence of LNM was retrospectively analyzed by univariate and multivariate logistic regression analyses.Odds ratios(OR) with 95%CI were calculated.We further examined the relationship between the positive number of the three significant predictive factors and the LNM rate.RESULTS:In the univariate analysis,tumor size(P = 0.011),depth of invasion(P = 0.007) and lymphatic vessel involvement(P < 0.001) were significantly associated with a higher rate of LNM.In the multivariate model,tumor size(OR = 7.125,95%CI:1.251-38.218,P = 0.041),depth of invasion(OR = 16.624,95%CI:1.571-82.134,P = 0.036) and lymphatic vessel involvement(OR = 39.112,95%CI:1.745-123.671,P = 0.011) were found to be independently risk clinicopathological factors for LNM.Of the 85 patients diagnosed with poorly differentiated EGC,12(14.1%) had LNM.The LNM rates were 5.7%,42.9% and 57.1%,respectively in cases with one,two and three of the risk factors respectively in poorly differentiated EGC.There was no LNM in 29 patients without the three risk clinicopathological factors.CONCLUSION:LWR alone may be sufficient treatment for intramucosal poorly differentiated EGC if the tumor is less than or equal to 2.0 cm in size,and when lymphatic vessel involvement is absent at postoperative histological examination. | Zhi-Bin Huo Shu-Bo Chen Jing Zhang Hua Li Dian-Chao Wu Tong-Shan Zhai Shang-Feng Luan | 2012 | World Journal of Gastroenterology2012，18，44： | 4 |
| 20 | Visualization of aging-associated chromatin alterations with an engineered TALE system显示文摘在实时房间的特定的 genomic loci 的可视化在多样的生物过程期间是为在染色质建筑学的动态变化的调查的一个前提,例如细胞的老化。然而,当前的精确 genomic 成像方法被缺乏妨碍荧光灯有高特性和 signal-to-noise 的探针形成对照。我们发现那常规抄写像使活跃之物的受动器(故事) 趋于形成蛋白质总数,从而在成像应用程序损害他们的性能。通过屏蔽,我们发现有故事的那熔化 thioredoxin 阻止了总数形成,开基于故事的 genomic 成像的完整的力量。用熔化 thioredoxin 的故事(TTALE ) ,我们在各种各样的 genomic loci 完成了高质量的成像并且观察联系老化(epi ) 在在人和老鼠早衰模型的 telomeres 和着丝点的 genomic 改变。重要地,我们鉴别 ribosomal DNA 的摩擦为人的老化作为一个分子的标记重复。我们的学习为精确在 vitro 并且在 vivo 监视染色质动力学建立一个简单、柔韧的成像方法。 | Ruotong Ren Liping Deng Yanhong Xue Keiichiro Suzuki Weiqi Zhang Yang Yu Jun Wu Liang Sun Xiaojun Gong Huiqin Luan Fan Yang Zhenyu Ju Xiaoqing Ren Si Wang Hong Tang Lingling Geng Weizhou Zhang Jian Li Jie Qiao Tao Xu Jing Qu Guang-Hui Liu | 2017 | Cell Research2017，27，4： | 4 |
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