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| 1 | Different treatment strategies and molecular features between right-sided and left-sided colon cancers显示文摘The colon is derived from the embryological midgut and hindgut separately,with the right colon and left colon having different features with regards to both anatomical and physiological characteristics.Cancers located in the right and left colon are referred to as right colon cancer(RCC) and left colon cancer(LCC),respectively,based on their apparent anatomical positions.Increasing evidence supports the notion that not only are there differences in treatment strategies when dealing with RCC and LCC,but molecular features also vary between them,not to mention the distinguishing clinical manifestations.Disease-free survival after radical surgery of both RCC and LCC are similar.In the treatment of RCC,the benefit gained from adjuvant FOLFIRI chemotherapy is superior,or at least similar,to LCC,but inferior to LCC if FOLFOX regimen is applied.On the other hand,metastatic LCC exhibits longer survival than that of RCC in a palliative chemotherapy setting.For KRAS wild-type cancers,LCC benefits more from cetuximab treatment than RCC.Moreover,advanced LCC shows a higher sensitivity to bevacizumab treatment in comparison with advanced RCC.Significant varieties exist at the molecular level between RCC and LCC,which may serve as the cause of all apparent differences.With respect to carcinogenesis mechanisms,RCC is associated with known gene types,such as MMR,KRAS,BRAF,and mi RNA-31,while LCC is associated with CIN,p53,NRAS,mi RNA-146 a,mi RNA-147 b,and mi RNA-1288.Regarding protein expression,RCC is related to GNAS,NQO1,telomerase activity,P-PDH,and annexin A10,while LCC is related to Topo I,TS,and EGFR.In addition,separated pathways dominate progressionto relapse in RCC and LCC.Therefore,RCC and LCC should be regarded as two heterogeneous entities,with this heterogeneity being used to stratify patients in order for them to have the optimal,current,and novel therapeutic strategies in clinical practice.Additional research is needed to uncover further differences between RCC and LCC. | Hong Shen Jiao Yang Qing Huang Meng-Jie Jiang Yi-Nuo Tan Jian-Fei Fu Li-Zhen Zhu Xue-Feng Fang Ying Yuan | 2015 | World Journal of Gastroenterology2015，21，21： | 33 |
| 2 | Expanding the Range of CRISPR/Cas9 Genome Editing in Rice显示文摘 | Xixun Hu Chun Wang Yaping FU Qing Liu Xiaozhen Jiao Kejian Wang | 2016 | Molecular Plant2016，9，6： | 31 |
| 3 | A new cytotoxic 2-(2-phenylethyl)chromone from Chinese eaglewood显示文摘新复合 8-chloro-5,6,7-trihydroxy-2-(3-hydroxy-4-methoxyphenethyl )-5,6,7,8-tetrahydro-4H-chromen-4-one (1 ) 从中国沉香被孤立[Aquilaria sinensis (愁相) Gilg ] 。它的结构被阐明根据光谱数据。与 14.6 渭 g /mL 的 IC50 价值由 MTT 方法在 vitro 对人的胃的癌症房间线(SGC-7901 ) 加重 1 显示出的 cytotoxicity。 | Jun Liu Jiao Wu You Xing Zhao Yuan Yuan Deng Wen Li Mei Hao Fu Dai | 2008 | Chinese Chemical Letters2008，19，8： | 25 |
| 4 | Human umbilical cord-derived mesenchymal stem cell therapy in patients with COVID-19:a phase 1 clinical trial显示文摘No effective drug treatments are available for coronavirus disease 2019(COVID-19).Host-directed therapies targeting the underlying aberrant immune responses leading to pulmonary tissue damage,death,or long-term functional disability in survivors require clinical evaluation.We performed a parallel assigned controlled,non-randomized,phase 1 clinical trial to evaluate the safety of human umbilical cord-derived mesenchymal stem cells(UC-MSCs)infusions in the treatment of patients with moderate and severe COVID-19 pulmonary disease.The study enrolled 18 hospitalized patients with COVID-19(n=9 for each group).The treatment group received three cycles of intravenous infusion of UC-MSCs(3×107 cells per infusion)on days 0,3,and 6.Both groups received standard COVID-treatment regimens.Adverse events,duration of clinical symptoms,laboratory parameters,length of hospitalization,serial chest computed tomography(CT)images,the PaO2/FiO2 ratio,dynamics of cytokines,and IgG and IgM anti-SARS-CoV-2 antibodies were analyzed.No serious UC-MSCs infusion-associated adverse events were observed.Two patients receiving UC-MSCs developed transient facial flushing and fever,and one patient developed transient hypoxia at 12 h post UC-MSCs transfusion.Mechanical ventilation was required in one patient in the treatment group compared with four in the control group.All patients recovered and were discharged.Our data show that intravenous UC-MSCs infusion in patients with moderate and severe COVID-19 is safe and well tolerated.Phase 2/3 randomized,controlled,double-blinded trials with long-term follow-up are needed to evaluate the therapeutic use of UC-MSCs to reduce deaths and improve long-term treatment outcomes in patients with serious COVID-19. | Fanping Meng Ruonan Xu Siyu Wang Zhe Xu Chao Zhang Yuanyuan Li Tao Yang Lei Shi Junliang Fu Tianjun Jiang Lei Huang Peng Zhao Xin Yuan Xing Fan Ji-Yuan Zhang Jinwen Song Dawei Zhang Yanmei Jiao Limin Liu Chunbao Zhou Markus Maeurer Alimuddin Zumla Ming Shi Fu-Sheng Wang | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 16 |
| 5 | A comprehensive generic-level phylogeny of the sunflower family: Implications for the systematics of Chinese Asteraceae显示文摘葵花家庭(Asteraceae ) 最大并且最多样的 flowering 植物家庭,包括 24 000-30 000 种类和 1600-1700 类。在中国, Asteraceae 也是最大的家庭,与在 248 个类的约 2336 土生土长的种类。在过去的二十年,分子的种系发生的分析极大地作出贡献到我们 Asteraceae 的 systematics 的理解。不过,关于在整个的通用水平的中国 Asteraceae 的关系的大规模分析和知识由于在采样的困难是远非完全的。在这研究,我们介绍了一三标记(rbcL, ndhF,和 matK ) Asteraceae 的发展史,包括 506 个类(即,约三分之一个个 Asteraceae 类) 。学习取样了 200 个中国类(即,约 80% 中国 Asteraceae 类) 。新发展史的脊梁与更早的研究大部分适合,与认出的 13 个亚科和 45 个部落。中国 Asteraceae 在 7 个亚科( Mutisioideae , Wunderlichioideae , Carduoideae , Pertyoideae , Gymnarrhenoideae , Cichorioideae ,和 Asteroideae )和 22 个部落被散布( Mutiseae , Hyalideae , Cardueae , Pertyeae , Gymnarrheneae , Vernonieae , Cichorieae , Doroniceae , Senecioneae , Astereae , Anthemideae , Gnaphalieae , Calenduleae , Inuleae , Athroismeae , Helenieae , Coreopsideae , Neurolaeneae , Tageteae , Millieae , Eupatorieae ,和 Heliantheae )。中国 Asteraceae 缺乏 6 个基础亚科和 23 个部落。几种以前模糊的关系被澄清。我们的分析也在中国 Asteraceae 以内解决了一些未受到安置的类。最后,我们的种系发生的树被用来为中国 Asteraceae 的所有类修订分类。总共,在中国的 255 个类, 22 个部落,和 7 个亚科被认出。 | Zhi-Xi Fu Bo-Han Jiao Bao Nie Guo-Jin Zhang Tian-Gang Gao | 2016 | Journal of Systematics and Evolution2016，54，4： | 12 |
| 6 | Clinical characteristics and prognosis of young patients with colorectal cancer in Eastern China显示文摘AIM:To explore the clinical characteristics and prognosis of young patients with colorectal cancer patients in Eastern China.METHODS:A total of 1335 patients with colorectal cancer treated from December 1985 to December 2005at the Second Affiliated Hospital of Zhejiang University School of Medicine were studied retrospectively.The patients were divided into two groups,a younger group(aged≤30 years)and an older group(aged>30 years),and comparison was made in the clinical characteristics and prognosis between the two groups.Chisquare test was used for data analysis of all categorical variables,and overall survival(OS)was calculated by the Kaplan-Meier method.A multivariate analysis was performed using the Cox model.RESULTS:There were 42(3.1%)and 1293(96.9%)cases in the younger group and older group,respectively.Univariate analysis showed that the 5-and10-year OS in the younger group were 33.9%and26.1%,respectively,and those in the older group were60.1%and 52.2%,respectively.Younger group had poor survival(χ2=14.146,P=0.000).Multivariate analysis revealed that age was not a dependent factor for prognosis(OR=0.866,95%CI:0.592-1.269,P=0.461).Stratified analysis indicated that in stageⅢandⅣdisease,the 5-and 10-year OS were 24.6%and14.8%in the younger group,and 40.4%and 33.3%in the older group,respectively,with a significant difference between the two groups(χ2=5.101,P=0.024).In the subgroup of radical surgery,the 5-and 10-year OS were 44.3%and 34.2%in the younger group,and69.6%and 60.5%in the older group,with a difference being significant between the two groups(χ2=7.830,P=0.005).CONCLUSION:Compared with older patients,the younger patients have lower survival,especially in the subgroups of stageⅢandⅣdisease and radical surgery. | Jian-Fei Fu Yan-Qin Huang Jiao Yang Cheng-Hao Yi Hai-Long Chen Shu Zheng | 2013 | World Journal of Gastroenterology2013，19，44： | 11 |
| 7 | Rapid generation of genetic diversity by multiplex CRISPR/Cas9 genome editing in rice显示文摘The clustered regularly interspaced short palindromic repeats(CRISPR)-associated endonuclease 9(CRISPR/Cas9) system has emerged as a promising technology for specific genome editing in many species. Here we constructed one vector targeting eight agronomic genes in rice using the CRISPR/Cas9 multiplex genome editing system. By subsequent genetic transformation and DNA sequencing, we found that the eight target genes have high mutation efficiencies in the T_0 generation. Both heterozygous and homozygous mutations of all editing genes were obtained in T_0 plants. In addition, homozygous sextuple, septuple, and octuple mutants were identified. As the abundant genotypes in T_0 transgenic plants, various phenotypes related to the editing genes were observed. The findings demonstrate the potential of the CRISPR/Cas9 system for rapid introduction of genetic diversity during crop breeding. | Lan Shen Yufeng Hua Yaping Fu Jian Li Qing Liu Xiaozhen Jiao Gaowei Xin Junjie Wang Xingchun Wang Changjie Yan Kejian Wang | 2017 | Science China(Life Sciences)2017，60，5： | 11 |
| 8 | Scorpion toxin BmKI directly activates Nav1.8 in primary sensory neurons to induce neuronal hyperexcitability in rats显示文摘在主要感觉神经原的电压门钠隧道(VGSC ) 在把疼痛信号传给中央神经系统起一个关键作用。BmK 我, site-3 钠从蝎子 Buthus martensi Karsch 的隧道特定的毒素,在老鼠导致疼痛行为。然而,我不是的 BmK 指向的 VGSC 的子类型完全变清。我们因此调查了 BmK 的效果我在当前的振幅, gating 和 Na 在 DRG 神经原与 neuronal hyperexcitability 被联系的 v 1.8, 。它被发现我 dose-dependently 增加了的那 BmK Na v 1.8 电流在小型(< 25 ? m ) 尖锐地分裂的 DRG 神经原,它在快、慢的 inactivation 上与它的抑制相关。而且,电压依赖者激活和不变的 inactivation Na v 1.8 在一个 hyperpolarized 方向被转移。因此, BmK 我减少了 neuronal 易兴奋性的阀值并且增加了在 DRG 神经原开火的行动潜力。在结论,我们的数据清楚地表明了我调制了的那 BmK Na v 1.8 显著地,建议我为学习 Na v 1.8。并且 Nav1.8 是与 BmK 我唤起疼痛有关的一个重要目标。 | Pin Ye Yunlu Jiao Zhenwei Li Liming Hua Jin Fu Feng Jiang Tong Liu Yonghua Ji | 2015 | Protein & Cell2015，6，6： | 10 |
| 9 | Wheat genomic study for genetic improvement of traits in China显示文摘Bread wheat(Triticum aestivum L.)is a major crop that feeds 40%of the world’s population.Over the past several decades,advances in genomics have led to tremendous achievements in understanding the origin and domestication of wheat,and the genetic basis of agronomically important traits,which promote the breeding of elite varieties.In this review,we focus on progress that has been made in genomic research and genetic improvement of traits such as grain yield,end-use traits,flowering regulation,nutrient use efficiency,and biotic and abiotic stress responses,and various breeding strategies that contributed mainly by Chinese scientists.Functional genomic research in wheat is entering a new era with the availability of multiple reference wheat genome assemblies and the development of cutting-edge technologies such as precise genome editing tools,highthroughput phenotyping platforms,sequencing-based cloning strategies,high-efficiency genetic transformation systems,and speed-breeding facilities.These insights will further extend our understanding of the molecular mechanisms and regulatory networks underlying agronomic traits and facilitate the breeding process,ultimately contributing to more sustainable agriculture in China and throughout the world. | Jun Xiao Bao Liu Yingyin Yao Zifeng Guo Haiyan Jia Lingrang Kong Aimin Zhang Wujun Ma Zhongfu Ni Shengbao Xu Fei Lu Yuannian Jiao Wuyun Yang Xuelei Lin Silong Sun Zefu Lu Lifeng Gao Guangyao Zhao Shuanghe Cao Qian Chen Kunpu Zhang Mengcheng Wang Meng Wang Zhaorong Hu Weilong Guo Guoqiang Li Xin Ma Junming Li Fangpu Han Xiangdong Fu Zhengqiang Ma Daowen Wang Xueyong Zhang Hong-Qing Ling Guangmin Xia Yiping Tong Zhiyong Liu Zhonghu He Jizeng Jia Kang Chong | 2022 | Science China(Life Sciences)2022，65，9： | 9 |
| 10 | Rosiglitazone sensitizes hepatocellular carcinoma cell lines to 5-fluorouracil antitumor activity through activation of the PPARγ signaling pathway显示文摘 | Liang-qi CAO Xiao-li WANG Qian WANG Ping XUE Xing-yuan JIAO He-ping PENG Hai-wu LU Qiang ZHENG Xi-lin CHEN Xiao-hui HUANG Xin-hui FU Jing-song CHEN | 2009 | Acta Pharmacologica Sinica2009，30，9： | 9 |
| 11 | Expert consensus on the glycemic management of critically ill patients显示文摘Introduction The incidence of hyperglycemia is 40-60%in critically ill patients and is up to 60-80%in those who have undergone car-diac surgery.[1]The results of an epidemiological study in the United States showed that 28.6%of diabetic patients and 9.3%of non-diabetic patients had elevated mean daily glucose on the day of ICU admission.[2]In critically ill patients,elevated blood glucose is primarily the result of stress,and stress-induced hy-perglycemia is an independent risk factor associated with prog-nosis,regardless of a previous diagnosis of diabetes.Nutritional therapy has become an integral treatment option for patients in the ICU,[3,4]though nearly 30%of patients with enteral nu-trition and 44-50%with parenteral nutrition(PN)experience elevated glucose.[5,6]Intensive insulin therapy(IIT)is an impor-tant treatment for controlling hyperglycemia in critically ill pa-tients,but it also carries a corresponding risk of hypoglycemia. | Zhixiong Wu Jiao Liu Dong Zhang Kai Kang Xiangrong Zuo Qianghong Xu Aijun Pan Wei Fang Fen Liu You Shang Haiyan Yin Juntao Hu Jinglun Liu Jiangquan Fu Wei Zhang Yuan Zong Min Shao Feng Zhao Mei Meng Yanfei Mao Yingchuan Li Dechang Chen | 2022 | Journal of Intensive Medicine2022，2，3： | 9 |
| 12 | Clinicopathological,treatment,and prognosis study of 43 gastric neuroendocrine carcinomas显示文摘AIM To provide more information and therapeutic methods about gastric neuroendocrine carcinomas(G-NECs) which occur rarely but are highly malignant and clinically challenging.METHODS We retrospectively analyzed the clinicopathological characteristics, treatments, and prognosis of 43 G-NEC patients at our hospital between January 2007 and December 2014. The diagnosis was based on the 2010 World Health Organization criteria.RESULTS Forty-three G-NECs containing 39 small cell carcinomas and 4 large cell NECs with Ki67 > 60% were included in this study, accounting for only 0.95% of all gastric carcinomas. The median patient age was 62 years (range, 33-82) and the male-to-female ratio was 4.4:1. All patients underwent surgery, including 38 curative resections and 5 palliative resections. Among these 43 patients, nearly half(48.84%) of these tumors were located in the cardiac region of the stomach, regional lymph node metastasis was found in 31 cases(72.09%), and liver metastasis was found in 6 cases(13.95%). Follow-up information was got for 40 patients. Twentythree die of this disease with a median survival of 31 mo(range 1-90). The 1-year, 2-year, 3-year, and 5-year survival rate was 77.50%, 57.04%, 44.51%, and 35.05%, respectively. Survival was better in patients with tumor located in the cardiac region of the stomach, less than 7 lymph nodes metastasis and no liver metastasis. Five patients did not undergo postoperative chemotherapy, and the median survival time for these patients was 15 mo. For the remaining 34 patients who received postoperative chemotherapy, the median survival time was 44 mo and those received etoposide, cisplatin, and Paclitaxel survived the best. One patient with resected liver metastasis who received postoperative Capecitabine plus Oxaliplatin and Paclitaxel systemic chemotherapy plus octreotide LAR(30 mg intramuscularly, every 4 wk, for 2 years) has survived for 74 mo with no recurrence.CONCLUSION G-NECs are mostly nonfunctioning, which lead to a delay in detection. Local and/or distant metastases were noticed in most patients when diagnosed, and they required postoperative medical treatment. Adjuvant etoposide, cisplatin plus Paclitaxel systemic chemotherapy is recommended for these patients. | De-Jun Liu Xue-Liang Fu Wei Liu Lu-Ying Zheng Jun-Feng Zhang Yan-Miao Huo Jiao Li Rong Hua Qiang Liu Yong-Wei Sun | 2017 | World Journal of Gastroenterology2017，23，3： | 9 |
| 13 | CD147-spike protein is a novel route for SARS-CoV-2 infection to host cells显示文摘In face of the everlasting battle toward COVID-19 and the rapid evolution of SARS-CoV-2,no specific and effective drugs for treating this disease have been reported until today.Angiotensin-converting enzyme 2(ACE2),a receptor of SARS-CoV-2,mediates the virus infection by binding to spike protein.Although ACE2 is expressed in the lung,kidney,and intestine,its expressing levels are rather low,especially in the lung.Considering the great infectivity of COVID-19,we speculate that SARS-CoV-2 may depend on other routes to facilitate its infection.Here,we first discover an interaction between host cell receptor CD147 and SARS-CoV-2 spike protein.The loss of CD147 or blocking CD147 in Vero E6 and BEAS-2B cell lines by anti-CD147 antibody,Meplazumab,inhibits SARSCoV-2 amplification.Expression of human CD147 allows virus entry into non-susceptible BHK-21 cells,which can be neutralized by CD147 extracellular fragment.Viral loads are detectable in the lungs of human CD147(hCD147)mice infected with SARS-CoV-2,but not in those of virus-infected wild type mice.Interestingly,virions are observed in lymphocytes of lung tissue from a COVID-19 patient.Human T cells with a property of ACE2 natural deficiency can be infected with SARS-CoV-2 pseudovirus in a dosedependent manner,which is specifically inhibited by Meplazumab.Furthermore,CD147 mediates virus entering host cells by endocytosis.Together,our study reveals a novel virus entry route,CD147-spike protein,which provides an important target for developing specific and effective drug against COVID-19. | Ke Wang Wei Chen Zheng Zhang Yongqiang Deng Jian-Qi Lian Peng Du Ding Wei Yang Zhang Xiu-Xuan Sun Li Gong Xu Yang Lei He Lei Zhang Zhiwei Yang Jie-Jie Geng Ruo Chen Hai Zhang Bin Wang Yu-Meng Zhu Gang Nan Jian-Li Jiang Ling Li Jiao Wu Peng Lin Wan Huang Liangzhi Xie Zhao-Hui Zheng Kui Zhang Jin-Lin Miao Hong-Yong Cui Min Huang Jun Zhang Ling Fu Xiang-Min Yang Zhongpeng Zhao Shihui Sun Hongjing Gu Zhe Wang Chun-Fu Wang Yacheng Lu Ying-Ying Liu Qing-Yi Wang Huijie Bian Ping Zhu Zhi-Nan Chen | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 9 |
| 14 | Multi-quasiparticle rotational bands in neutron-rich erbium isotopes显示文摘Multi-quasiparticle states and rotational bands in neutron-rich erbium isotopes have been investigated by the configuration-constrained pairing-deformation-frequency self-consistent total-Routhian-surface (TRS) method with particle-number-conserved pairing. Specifically, the recently observed Kn=4-bands in 168,170,172 Er have been found to experience a configuration change in our calculation. Some other multi-quasiparticle states with uncertain configuration assignments have been reinvestigated by calculating their collective rotations. The configuration-constrained TRS calculation can reproduce experimental data consistently. | FU XiMing JIAO ChangFeng XU FuRong ZHANG ZhenHua | 2013 | Science China(Physics,Mechanics & Astronomy)2013，56，8： | 8 |
| 15 | Hepatitis B virus X protein represses miRNA-148a to enhance tumorigenesis显示文摘 | Xu Xiaojie Fan Zhongyi Kang Lei Han Juqiang Jiang Chengying Zheng Xiaofei Zhu Ziman Jiao Huabo Lin Jing Jiang Kai Ding Lihua Zhang Hao Cheng Long Fu Hanjiang Song Yi Jiang Ying Liu Jiahong Wang Rongfu Du Nan Ye Qinong | 2013 | Journal of Clinical Investigation2013，，2： | 7 |
| 16 | Degradation of microcystin-RR in water by chlorine dioxide显示文摘Due to the potent hepatotoxicity and tumor-promoting activity of microcystins, a successful removal of these toxins during drinking water treatment processes is of increasing concern. The oxidation kinetics of MC-RR by chlorine dioxide (ClO2) was studied with HPLC and characterization of the reaction products was performed with UV-spectrometry, TOC and LC-MS. Our experimental results show that the oxidation process is a second order overall and a first order with respect to ClO2 and MC-RR. The activation energy of MC-RR degradation by ClO2 is 53.07 kJ/mol. The rate constant k of the action can be increased by in- creasing temperature and decreasing pH value and ranged from 6.11×102 L/(mol·min) to 5.29×102 L/(mol·min) at pH from 3.44 to 10.41 at 10 ℃. Reaction products were determined to be organic and volatile, because they could be almost removed from aqueous solution by heating for 15 min at 60 ℃ . In addition, the main oxidation products have m/z values of 1072 and are identified as di- hydroxy isomers of MC-RR. | JI Ying HUANG Jun-li FU Jiao WU Ming-song CUI Chong-wei | 2008 | Journal of China University of Mining and Technology2008，18，4： | 6 |
| 17 | CD147 antibody specifically and effectively inhibits infection and cytokine storm of SARS-CoV-2 and its variants delta,alpha,beta,and gamma显示文摘SARS-CoV-2 mutations contribute to increased viral transmissibility and immune escape,compromising the effectiveness of existing vaccines and neutralizing antibodies.An in-depth investigation on COVID-19 pathogenesis is urgently needed to develop a strategy against SARS-CoV-2 variants.Here,we identified CD147 as a universal receptor for SARS-CoV-2 and its variants.Meanwhile,Meplazeumab,a humanized anti-CD147 antibody,could block cellular entry of SARS-CoV-2 and its variants-alpha,beta,gamma,and delta,with inhibition rates of 68.7,75.7,52.1,52.1,and 62.3%at 60μg/ml,respectively.Furthermore,humanized CD147 transgenic mice were susceptible to SARS-CoV-2 and its two variants,alpha and beta.When infected,these mice developed exudative alveolar pneumonia,featured by immune responses involving alveoli-infiltrated macrophages,neutrophils,and lymphocytes and activation of IL-17 signaling pathway.Mechanistically,we proposed that severe COVID-19-related cytokine storm is induced by a'spike protein-CD147-CyPA signaling axis':Infection of SARS-CoV-2 through CD147 initiated the JAK-STAT pathway,which further induced expression of cyclophilin A(CyPA);CyPA reciprocally bound to CD147 and triggered MAPK pathway.Consequently,the MAPK pathway regulated the expression of cytokines and chemokines,which promoted the development of cytokine storm.Importantly,Meplazumab could effectively inhibit viral entry and inflammation caused by SARS-CoV-2 and its variants.Therefore,our findings provided a new perspective for severe COVID-19-related pathogenesis.Furthermore,the validated universal receptor for SARS-CoV-2 and its variants can be targeted for COVID-19 treatment. | Jiejie Geng Liang Chen Yufeng Yuan Ke Wang Youchun Wang Chuan Qin Guizhen Wu Ruo Chen Zheng Zhang Ding Wei Peng Du Jun Zhang Peng Lin Kui Zhang Yongqiang Deng Ke Xu Jiangning Liu Xiuxuan Sun Ting Guo Xu Yang Jiao Wu Jianli Jiang Ling Li Kun Zhang Zhe Wang Jing Zhang Qingguo Yan Hua Zhu Zhaohui Zheng Jinlin Miao Xianghui Fu Fengfan Yang Xiaochun Chen Hao Tang Yang Zhang Ying Shi Yumeng Zhu Zhuo Pei Fei Huo Xue Liang Yatao Wang Qingyi Wang Wen Xie Yirong Li Mingyan Shi Huijie Bian Ping Zhu Zhi-Nan Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，10： | 6 |
| 18 | Comprehensive analysis of CBM recovery in high rank coal reservoir of Jincheng area显示文摘Coalbed methane (CBM) predicting recovery in high rank coal reservoir varies greatly in Jincheng area and it seriously influences efficient and economic exploitation of CBM resource. In order to predict more accurate CBM recovery, we conducted history matching and productivity prediction of vertical well by using COMET 3 reservoir modeling software, innovatively adopted the gas desorption experiment of bulk coal at fixed test pressure, analyzed the recovery extent method of Daning multiple-hole horizontal well and Panzhuang well group, and calculated recovery by sorption isotherm method of 14 vertical CBM wells at the abandonment pressures 1.0, 0.7, 0.5 and 0.3 MPa, respectively. The results show that the reservoir simulation methods (numerical simulation method and the recovery extent method) is more reliable than the theoretical analysis of coal sample (sorption isotherm method and desorption experiment method). Also, desorption experiment method at fixed pressure is superior to sorption isotherm method. Through the comprehensive analysis and linear correction, CBM recovery ratios in high rank coal reservoir of Jincheng area were found to be 38.64%, 49.30%, 59.30%, and 69.20% at the abandonment pressures 1.0, 0.7, 0.5 and 0.3 MPa, respectively. The research results are of significant importance in the CBM exploration and development in Jincheng area. | Liu Aihua Fu Xuehai Luo Bin Luo Peipei Jiao Chunlin | 2013 | International Journal of Mining Science and Technology2013，23，3： | 6 |
| 19 | SCStore: Managing Scientific Computing Packages for Hybrid System with Containers显示文摘Managing software packages in a scientific computing environment is a challenging task, especially in the case of heterogeneous systems. It is error prone when installing and updating software packages in a sophisticated computing environment. Testing and performance evaluation in an on-the-fly manner is also a troublesome task for a production system. In this paper, we discuss a package management scheme based on containers. The newly developed method can ease the maintenance complexity and reduce human mistakes. We can benefit from the self-containing and isolation features of container technologies for maintaining the software packages among intricately connected clusters. By deploying the Super Computing application Strore(SCStore) over the WAN connected world-largest clusters, it proved that it can greatly reduce the effort for maintaining the consistency of software environment and bring benefit to achieve automation. | Wusheng Zhang Jiao Lin Weiping Xu Haohuan Fu Guangwen Yang | 2017 | Tsinghua Science and Technology2017，22，6： | 5 |
| 20 | Strongly coupled Ag/TiO2 heterojunctions for effective and stable photothermal catalytic reduction of 4-nitrophenol显示文摘 | Ying Gu Yanqing Jiao Xiaoguang Zhou Aiping Wu Bater Buhe Honggang Fu | 2018 | Nano Research2018，11，1： | 5 |
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