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| 1 | Circular RNA is enriched and stable in exosomes: a promising biomarker for cancer diagnosis显示文摘 | Yan Li Qiupeng Zheng Chunyang Bao Shuyi Li Weijie Guo Jiang Zhao Di Chen Jianren Gu Xianghuo He Shenglin Huang | 2015 | Cell Research2015，25，8： | 323 |
| 2 | Mesozoic tectono-magmatic activities in South China:Retrospect and prospect显示文摘The South China Block was formed through the collisional orogeny between the Cathaysia Block and the Yangtze Block in the Early Neoproterozoic.The northern,western and southern sides of the South China Block were affected by disappearance of the Paleo-Tethyan Ocean during the Paleozoic.The southern and northern sides of the South China Block were respectively collided with the Indo-China Block and North China Block in the latest Paleozoic to form the basic framework of the Eastern China.The Eastern China has been affected by the westward subduction of the Pacific Plate since the Mesozoic.Therefore,the South China Block was influenced by the three major tectonic systems,leading to a superposed compound tectonics.The comparative study of the Mesozoic geology between the South China Block and its surrounding areas suggests that although the Mesozoic South China Block was adjacent to the subduction zone of the western Pacific,no juvenile arc-type crust has been found in the eastern margin.The main Mesozoic geology in South China is characterized by reworking of ancient continental margins to intracontinental tectonics,lacking oceanic arc basalts and continental arc andesites.Therefore,a key to understanding of the Mesozoic geology in South China is to determine the temporal-spatial distribution and tectonic evolution of Mesozoic magmatic rocks in this region.This paper presents a review on the tectonic evolution of the South China Block through summarizing the magmatic rock records from the compressional to extensional tectonic process with the transition at the three juncture zones and using the deformation and geophysic data from the deep part of the South China continental lithosphere.Our attempt is to promote the study of South China’s geology and to make it as a typical target for development of plate tectonic theory. | MAO JianRen LI ZiLong YE HaiMin | 2014 | Science China Earth Sciences2014，57，12： | 64 |
| 3 | An Experimental Investigation of a new Method for Protecting Bends from Erosion in Gas-Particle Flows显示文摘Bend erosion is a fairly serious problem in conveyer pipe system. This paper intends to introduce a new antierosion method for bend: ribbed anti-erosion method. Experimental research has been done by fixing ribs in the range of 10°- 70°on the outer-wall of inside 90°-bend. As a result the experiment got anti-erosion efficiency: 93.02%. It shows that ribbed bend technology is a simple and efficient anti-erosion method. Besides, the experiments indicate that rectangle ribs tend to do more obvious anti-erosion effect than square ribs do when they have equal height. | Yao Jun Fan Jianren Zhang Benzhao Cen Kefa (Department of Energy Engineering, Zhejiang University, Hangzhou 310027, China) | 2000 | Journal of Thermal Science2000，9，2： | 15 |
| 4 | Geochemical characteristics,cooling history and mineralization significance of Zhangtiantang pluton in South Jiangxi Province,P.R. China显示文摘The zircon SHRIMP dating of the Zhangtiantang granite gave an age of 159±7 Ma.,which shows that the granite was produced at the early Late Jurassic.The Ar-Ar plateau ages of biotite and K-feldspar from the Zhangtiantang pluton are 153.2±1.1 Ma and 135.8±1.2 Ma,respectively.The Ar-Ar anti-isochrone ages of biotite and K-feldspar are 152.5±1.7Ma and 135.4±2.7Ma,respectively.The ages represent the isotopic closure ages of minerals in the pluton.The Zhangtiantang granites are regarded as peraluminous crust-derived type granites to possess the typical geochemical characteristics of calc-alkaline rocks on continental margin,with enriched Si,K,Al(average value of A/CNK as 1.18),HREE,Rb,U,and Th,heavily depleted V,Cr,Co,Ni,Ti,Nb-Ta,Zr,Sr,P,and Ba,strongly negative Eu and common corundum normative(average value of C as 1.84).The εNd(t) values of the Zhangtiantang granite are-5.84 to-7.79,and t2DM values are 1.69 to 1.83 Ga,which indicates partial melting of continental-crust metamorphic sedimentary rocks during the Middle Proterozoic.The cooling history of the Zhangtiantang granitic pluton indicates that the cooling velocity of pluton was faster(about 67℃ /Ma) from zircon(158 Ma) to biotite(152 Ma),and was slower(about12℃ /Ma) from biotite(152.5 Ma) to K-feldspar(135.8 Ma).It can be deduced that the temporal gap(about 10 Ma) between the granite formmation and W-Sn mineralization in South China may be related to ordinary magma-hydrothermal processes by the variational cooling curve of the pluton.The Zhangtiantang pluton was formed in a compressive setting,with differentiation evolution and mineralization occurring in a relative relaxation setting. | MAO Jianren LI Zilong ZHAO Xilin ZHOU Jie YE Haimin ZENG Qitao | 2010 | Chinese Journal Of Geochemistry2010，29，1： | 11 |
| 5 | Geochronology and Geochemical Characteristics of the Early Mesozoic Tangquan Pluton in Southwestern Fujian and Its Tectonic Implications显示文摘The Tangquan granodioritic pluton in Datian County, southwestern Fujian, China, which extends in a NE direction with an exposed area of about 130 km2, used to be considered a product of Early Cretaceous magmatism. The present study suggests for the first time that the pluton was formed in the Early Jurassic by using multiple methods for isotopic dating, which give zircon U-Pb ages of 186.8 Ma and 179.0 Ma, Rb-Sr isochron age of 162.02(4.5 Ma, and biotite 40Ar/39Ar plateau age of 158.1(0.7 Ma. The cooling rate for the pluton was relatively low (4.76°C/Ma) during the early stage (183(162 Ma) because of the compressional environment. It was emplaced in a higher cooling rate (50°C/Ma) in an extensional environment during the later stage (162(158 Ma). The granodiorites are metaluminous(peraluminous, relatively enriched in Na2O and depleted in K2O, and characteristic of I-type granites of crust-mantle mixed sources. They are moderately enriched in Rb, Th, Hf and LREE, and depleted in Ti, Nb, Ta and Sr, and have geochemical features of cal-alkaline rocks of an island arc or active continental margin. Their (87Sr/86Sr)i ratio varies from 0.70769 to 0.70822, εNd(t) from -9.68 to -10.07 and TDM from 1.52 to 1.55 Ga. They were formed by mixing of mantle-derived mafic magma with the granitic magma resulting from partial melting of crust-derived materials in an upwelling of the asthenospheric mantle in South China during the Early Mesozoic. | MAO Jianren, HU Qing, XU Naizheng, XIE Fanggui and TAO Kuiyuan, Nanjing Institute of Geology and Mineral Resources, Nanjing, Jiangsu 210016 E-mail: mjrmh@sina.com Hao Ziguo and Zhu Xiling | 2003 | Acta Geologica Sinica(English Edition)2003，77，3： | 10 |
| 6 | Precise Dating and Geological Significance of the Caledonian Shangyou Pluton in South Jiangxi Province显示文摘摘要:为 Shangyou 花岗石标明日期年龄的锆石虾是 464 吗?? | MAO Jianren ZENG Qingtao LI Zilong HU Qing ZHAO Xilin YE Haimin | 2008 | Acta Geologica Sinica(English Edition)2008，82，2： | 6 |
| 7 | Transitional phenomenon of particle dispersion in gas-solid two-phase flows显示文摘Without using any turbulent model, direct numerical simulation of a three-dimensional gas-solid two-phase turbulent jet was performed by finite volume method. The effects on dispersion of particles with different Stokes numbers by the transitional behavior of turbulent structures were investigated. To produce high-resolution results and reduce the computation and storage, the fractional-step projection algorithm was used to solve the governing equations of gas phase fluid. The low-storage, three-order Runge-Kutta scheme was used for time integration. The governing equations of particles were solved in the Lagrangian framework. These numerical schemes were validated by the good agreement be-tween the statistical results of flow field and the related experimental data. In the study of particle dis-persion, it was found that the effects on particle dispersion by the spanwise vortex structures were prominent. The new behaviors of particle dispersion were also observed during the evolution of the flow field, i.e. the transitional phenomenon of particle dispersion occurs for the particles with small and intermediate Stokes numbers. | LUO Kun FAN JianRen CEN KeFa | 2007 | Chinese Science Bulletin2007，52，3： | 5 |
| 8 | New Macroscopic Problematic Fossil from the Early Cambrian Yanjiahe Biota,Yichang,Hubei,China显示文摘Yanjiahella 情报。nov,从在 Yichang 的早寒武纪的 Yanjiahe 生物区系的特殊石块 taxon,湖北省,旁边被描绘:1 ) 一个全面身体计划梗和一个花萼创作了(也在某种类武装) ;2 ) 梗与仔细 spaced,横向的皱纹和一条中间的、纵的山脉;并且 3 ) 与三维的放射的有条纹或刻痕之状态保存的一个花萼,以及在一些标本的可能的 madreporite。能被分到这个类的三种,它是 Y。ancarpa sp。nov, Y。monocarpa sp。nov,和 Y。biscarpa sp。nov。Yanjiahella 以形态学和一些生物结构比得上某些棘皮动物类的动物 taxa,它可能从早早的寒武纪的 Yangtze 站台显示祖先的棘皮动物类的动物系的早进化和多样化。在 Yanjiahe 生物区系的通常认为的棘皮动物类的动物的发现关于 deuterostome 门棘皮类的起源和进化提供重要线索。 | GUO Junfeng LI Yong HAN Huiping OU Qiang ZHOU Jianren ZHENG Yajuan | 2012 | Acta Geologica Sinica(English Edition)2012，86，4： | 5 |
| 9 | LES/FDF simulation of particle dispersion in a gas-particle two phase plane wake flow显示文摘A filtered density function (FDF) transport equation was derived for the fluid velocity seen by the particles in gas-particle two-phase flow. An LES/FDF simulation of a two-phase plane wake flow was carried out. The simulation results were compared with both the experimental photograph and the simulation results without using the FDF model, and proved that the LES/FDF model can clearly improve the spatial dispersion of the particle phase. | JIN HanHui CHEN SuTao CHEN LiHua FAN JianRen | 2009 | Science China(Technological Sciences)2009，52，10： | 4 |
| 10 | Chronology and cooling history of the Tianmenshan pluton in South Jiangxi Province and their geological significance显示文摘Geochronological studies on the crust-derived Tianmenshan pluton were undertaken by SHRIMP zircon U-Pb dating and Ar-Ar dating of biotite,muscovite and K-feldspar,giving a petrogenetic age of 167 Ma.Owing to the closure systems in different minerals,the cooling history of the pluton can be determined with an age-temperature diagram.The late hydrothermal event has been recognized,which is related probably with mineralization.In terms of the comparative geochronological and petrologic records,it is concluded that there are some constrains on tectonic evolution and that the formation of the Tianmenshan pluton proceeded in a transition period from Indosinian post-orogeny extension to strong compressive tectonics.And the timing of the hydrothermal event matches the compressive climax of the Yanshanian orogeny.The temporal gap between granite emplacement and wolframite mineralization could last 10-20 Ma owing to the low cooling rate of the pluton. | ZENG Qingtao MAO Jianren HU Qing ZHAO Xilin YE Haimin | 2008 | Chinese Journal Of Geochemistry2008，27，3： | 4 |
| 11 | Differential effects of rapamycin on Bursaphelenchus xylophilus with different virulence and differential expression of autophagy genes under stresses in nematodes显示文摘Pine wilt disease(PWD)caused by the pine wood nematode(PWN),Bursaphelenchus xylophilus,is a devastating disease for Pinus spp.The virulence and resilience of PWN are closely linked to the spread and development of PWD.Numerous studies have shown that autophagy has important physiological and pathological functions in eukaryotes.But little is known about the relationships between autophagy and PWNs’virulence and resistance.In this study,through observation under the microscope and recording,we found the induction of autophagy by rapamycin could dramatically improve movement ability of PWNs with different virulence,and the highly virulent AMA3 isolate moved more than the low virulent YW4 isolate when autophagy was over-induced.High concentrations of rapamycin substantially improved the feeding and reproduction of AMA3 but not YW4.Conserved domains of autophagy genes BxATG3,BxATG4,and BxATG7 were first cloned from PWNs by reverse transcription-polymerase chain reaction(RT-PCR).Expression profiling of these three autophagy genes under biotic and abiotic stresses in PWNs with different virulence was determined by quantitative RT-PCR.The results revealed the expression levels of these three autophagy genes in PWNs with different virulence were increased significantly when nematodes were subject to high and low temperatures,oxidative stress,and defensive responses of pine trees.The expression levels of autophagy genes under biotic and abiotic stresses in AMA3 were higher than those in YW4,and different genes showed different performance.Our study clarified that autophagy was closely related to virulence and resistance of PWN,and the ability of a highly virulent isolate to regulate autophagy activity under stresses was stronger than that of a low virulent isolate. | Hongbin Liu Fan Wu Xiaoqin Wu Jianren Ye | 2019 | Acta Biochimica et Biophysica Sinica2019，51，3： | 4 |
| 12 | Serum DKK1 as a protein biomarker for the diagnosis of hepatocellular carcinoma: a large-scale, multicentre study显示文摘 | Qiujin Shen Jia Fan Xin-Rong Yang Yexiong Tan Weifeng Zhao Yang Xu Ning Wang Yongdong Niu Zheng Wu Jian Zhou Shuang-Jian Qiu Ying-Hong Shi Bin Yu Ning Tang Wei Chu Min Wang Jinhua Wu Zhigang Zhang Shengli Yang Jianren Gu Hongyang Wang Wenxin Qin | 2012 | Lancet Oncology2012，，8： | 4 |
| 13 | Three-dimensional Numerical Study on Thermal Performance of a Super Large Natural Draft Cooling Tower of 220m Height显示文摘Based on the heat and mass transfer theory and the characteristics of general-purpose software FLUENT, a three-dimensional numerical simulation platform, composed of lots of user defined functions(UDF), has been developed to simulate the thermal performance of natural draft wet cooling towers(NDWCTs). After validation, this platform is used to analyse thermal performances of a 220m high super large cooling tower designed for inland nuclear plant under different operational conditions. Variations of outlet temperature of the cooling tower caused by changes of water flow rates, inlet water temperatures are investigated. Effects of optimization through non-uniform water distributions on outlet water temperature are discussed, and the influences on the flow field inside the cooling tower are analyzed in detail. It is found that the outlet water temperature will increase as the water flow rate increases, but the air flow rate will decrease. The outlet water temperature will decrease 0.095K and 0.205K, respectively, if two non-uniform water distribution approaches are applied. | JIN Tai ZHANG Li LUO Kun FAN Jianren | 2013 | Journal of Thermal Science2013，22，3： | 4 |
| 14 | Numerical study on three-dimensional CJ detonation waves interacting with isotropic turbulence显示文摘The three-dimensional structures of a cellular detonation wave interacting with different turbulent flows were investigated using a one-step irreversible Arrhenius kinetics model. High-resolution bandwidth-optimized WENO scheme of spatial discretization and total variation diminishing temporal integration are used to solve the three dimensional chemically reactive Navier–Stokes equations.The turbulent vertical and entropic forcing effects on the three dimensional detonation wave structures and dynamics are analyzed, as well as the detonation effects on turbulent vortex structures. It has been found that the turbulence field imposed has created small scale wrinkles embedded in the detonation front, apart from the large scale features of detonation without turbulence. The detonation propagating velocity over the leading shock front varies from 0.8 to 1.6 times of CJ velocity and its probability density function(pdf) skews towards sub-CJ velocity and peaks at about 0.9. The recorded detonation velocity always preferentially decays with time, with very rapid accelerations through triple point interactions. Its pdf also skews to sub-CJ velocity, while its overall shape agrees well with V–3. The reaction zone is greatly influenced by the vortex, much more irregular and elongated for the turbulent cases. Distributed burning pockets are more likely to be found there. The turbulent kinetic energy is amplified across the detonation, and periodically oscillates downstream the detonation. The off-diagonal components of Reynolds stress also show a rapid rise across the detonation and present to be non-zero downstream of detonation. Vortex structures are compound results of theconvected vortex and the generated vortex by the collision of triple points. The convection term and baroclinic generation term in the transport equation of enstrophy are compared in detail. | Tai Jin Kun Luo Qi Dai Jianren Fan | 2016 | Science Bulletin2016，61，22： | 3 |
| 15 | On coherent structures in a three-dimensional transitional plane jet显示文摘Direct numerical simulation of coherent structures in the three-dimensional transitional jet with a moderate Reynolds number of 5000 was conducted. The finite volume method was used to discretize the governing equations in space and the low-storage, three-order Runge-Kutta scheme was used for time integration. The comparisons between the statistical results of the flow field and the related experimental data were performed to validate the reliability of the present numerical schemes. The emphasis was placed on the study of the spatial evolution of the three-dimensional coherent vortex structures as well as their interactions. It is found that the evolution of the spanwise vortex structures in three-dimensional space is similar to that in two-dimensional jet. The spanwise vortex structures are subject to three-dimensional instability and induce the formation of the streamwise and lateral vortex structures. Going with the breakup and mixing of the spanwise vortex structures, the streamwise and transverse vortex tubes also fall to pieces and the mixing arranged small-scale structures are formed in the flow field. Finally, the arrangement relationship among the spanwise, the streamwise and the lateral vortex structures was analyzed and their interactions were also discussed. | Kun Luo Jie Yan JianRen Fan KeFa Cen | 2008 | Science China(Technological Sciences)2008，51，4： | 3 |
| 16 | Paleotemperatures from fluid inclusions in halite: method verification and a 100,000 year paleotemperature record, Death Valley, CA显示文摘 | Tim K. Lowenstein Jianren Li Christopher B. Brown | 1998 | Chemical Geology1998，，3： | 3 |
| 17 | Identification and characterization of a novel peptide ligand of Tie2 for targeting gene therapy显示文摘有免疫球蛋白和表皮的生长因素相同 domain-2 (Tie2 ) 的酷氨酸 kinase 在稳固的肿瘤为基因治疗被看作了一个合理目标。以便为指向的基因治疗识别 Tie2 的新奇的肽 ligand,我们屏蔽了一个噬菌体显示肽图书馆并且识别了候选人肽 ligand NSLSNASEFRAPY (指明的 GA5 ) 。有约束力的试金和 Scatchard 分析表明 GA5 能明确地与 2.1 的一个分离常数绑在 Tie2 ?鷐 吗?? | Xianghua Wu Zonghai Li Ming Yao Huamao Wang Sumin Qu Xianlian Chen Jinjun Li Ye Sun Yuhong Xu Jianren Gu | 2008 | Acta Biochimica et Biophysica Sinica2008，40，3： | 2 |
| 18 | Direct numerical simulation of particle-fluid flows in turbulent mixing layer显示文摘The coherent structures of a three-dimensional temporally mixing layer and the associated dispersion patterns of particles are numerically studied using a pseudospectral method for fluid and the Lagrangian approach for tracing particles at different Stokes numbers without consideration of particle-particle interactions. The results show that the particles with Stokes number of the order of unity have the largest concentration near the outer edges of the large-scale spanwise vortex structures. The study validates the effect of the streamwise large-scale structures on the particle distribution along the spanwise and transverse directions and it enhances with the development of the three-dimensionality of the mixing layer, which results in a ‘mushroom’ shape of the particle distribution in the spanwise direction. | ZHENG Youqu, FAN Jianren, ZHA Xudong and CEN Kefa(Department of Energy Engineering, Zhejiang University, Hangzhou 310027, China) | 2002 | Progress in Natural Science:Materials International2002，12，3： | 2 |
| 19 | Amplification of MPZL1/PZR promotes tumor cell migration through Src-mediated phosphorylation of cortactin in hepatocellular carcinoma显示文摘我们以前在 hepatocellular 癌(HCC ) 识别了体的拷贝数字改变(CNA ) 的 1 241 个区域。在现在的学习,我们发现那新奇周期性的焦点的 amplicon, 1q24.1-24.2,在 HCC 指向 MPZL1 基因。尤其是,在 MPZL1 和 HCC 标本的 intrahepatic 转移的表示层次之间有积极关联。MPZL1 能显著地提高 HCC 房间的迁移、变形的潜力。而且,我们发现 MPZL1 由支持 HCC 房间移植的机制之一由导致支持 metastatic 蛋白质的 phosphorylation 和激活, cortactin。另外,我们发现 Src kinase 调停 cortactin 的 phosphorylation 和激活由 MPZL1 overexpression 导致了。一起拿,这些调查结果建议 MPZL1 是拷贝数字扩大的一个周期性的区域在 HCC 目标为 1q24.1-24.2 的新奇支持 metastatic 基因。 | Deshui Jia Ying Jing Zhenfeng Zhang Li Liu Jie Ding Fangyu Zhao Chao Ge Qifeng Wang Taoyang Chen Ming Yao Jinjun Li Jianren Gu Xianghuo He | 2014 | Cell Research2014，24，2： | 2 |
| 20 | DNS analysis of incipient drop impact dynamics using an accurate level set method显示文摘A series of 2D direct numerical simulations were performed with an accurate level set method for single drop impacts.The adopted ACLS method was validated to be efficient with perfect mass conservation in both normal and oblique impacts.A square-root correction for neck bases was modified in accuracy as well as scope of applications.In addition,process of jet formation and evolution was studied to reveal internal dynamics in drop impacts.It's found that pressure gradient and vortex are coexisting and completive reasons for jet topology while the inclined angle has a significant effect on them.Mechanisms of jet formation and evolution are different in the front and back necks.With the help of PDF distribution and correction calculation,a compromise in the competition is observed.This work lays a solid foundation for further studies of dynamics in gas-liquid flows. | Min Chai Kun Luo Changxiao Shao Song Chen Jianren Fan | 2017 | Chinese Journal of Chemical Engineering2017，25，1： | 2 |
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