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| 1 | Transplantation of UC-MSCs on collagen scaffold activates follicles in dormant ovaries of POF patients with long history of infertility显示文摘Premature ovarian failure(POF) is a refractory disease for clinical treatment with the goal of restoring fertility. In this study,umbilical cord mesenchymal stem cells on a collagen scaffold(collagen/UC-MSCs) can activate primordial follicles in vitro via phosphorylation of FOXO3 a and FOXO1. Transplantation of collagen/UC-MSCs to the ovaries of POF patients rescued overall ovarian function, evidenced by elevated estradiol concentrations, improved follicular development, and increased number of antral follicles. Successful clinical pregnancy was achieved in women with POF after transplantation of collagen/UC-MSCs or UC-MSCs. In summary, collagen/UC-MSC transplantation may provide an effective treatment for POF. | Lijun Ding Guijun Yan Bin Wang Lu Xu Yan Gu Tong Ru Xiaoying Cui Lei Lei Jingyu Liu Xiaoqiang Sheng Bin Wang Chunxue Zhang Yanjun Yang Ruiwei Jiang Jianjun Zhou Na Kong Feifei Lu Huaijun Zhou Yannan Zhao Bing Chen Yali Hu Jianwu Dai Haixiang Sun | 2018 | Science China(Life Sciences)2018，61，12： | 43 |
| 2 | Chinese deserts and sand fields in Last Glacial Maximum and Holocene Optimum显示文摘The Last Glacial Maximum (LGM, c. 26-16 ka) and the Holocene Optimum (HO, c. 9-5 ka) were characterized by cold-dry and warm-wet climates respectively in the recently geological Earth. How Chinese deserts and sand fields responded to these distinctive climatic changes is still not clear, however. To reconstruct environments of the deserts and sand fields during the LGM and HO is helpful to understand the forcing mechanisms of environment change in this arid region, and to test paleoclimatic modeling results. Through our long-term field and laboratory investigations, 400 optically stimulated luminescence (OSL) ages and more than 100 depositional records in the Chinese deserts and sand fields were obtained; on the basis of these data, we reconstruct spatial distributions of the deserts and sand fields during the LGM and HO. Our results show that the sand fields of Mu Us, Hunshandake, Horqin and Hulun Buir in northern and northeastern China had expanded 25%, 37%, 38% and 270%, respectively, during the LGM; the sand fields of Gonghe in the northeastern Qinghai-Tibetan Plateau had expanded 20%, and the deserts of Badain Jaran, Tengger in central northern China had expanded 39% and 29% separately during the LGM; the deserts of Taklimakan, Gurbantünggüt and Kumtag in northwestern China had expanded 10%-20% respectively, compared to their modern areas. On the other hand, all of the sand fields were nearly completely covered by vegetation during the HO; the deserts in northwestern and central northern China were reduced by around 5%-20% in area during this time. Lakes in this arid region were probably expanded during the HO but this conclusion needs more investigation. Compared with the geological distributions of deserts and sand fields, human activity has clearly changed (expanded) the area of active sand dunes at the present time. Our observations show that environmental conditions of Chinese deserts and sand fields are controlled by regional climate together with human activity. | LU HuaYu YI ShuangWen XU ZhiWei ZHOU YaLi ZENG Lin ZHU FangYing FENG Han DONG LiNa ZHUO HaiXin YU KaiFeng MASON Joseph WANG XiaoYong CHEN YingYong LU Qi WU Bo DONG ZhiBao QU JianJun WANG XunMing GUO ZhengTang | 2013 | Chinese Science Bulletin2013，58，23： | 40 |
| 3 | Clinical significance of serum miR-21 in breast cancer compared with CA153 and CEA显示文摘Objective:MicroRNA-21(miR-21)has been shown to be a key regulator of carcinogenesis.There were few reports about the comparison of serum miR-21 with conventional tumor markers.This study aimed to explore the diagnostic value of circulating miR-21 as a tumor marker in breast cancer(BC)and compare it with CA153 and carcinoembryonic antigen(CEA).Methods:Circulating miR-16 and miR-21 were amplified and quantitatively detected by real-time PCR in 89 BC patients and 55 healthy controls.The levels of CA153 and CEA were measured through electrochemiluminescence assays.Then the sensitivity in diagnosis of BC was compared among miR-21,CA153 and CEA.Results:The level of serum miR-21 was significantly higher in BC patients than controls(P<0.001).The sensitivity and specificity of miR-21 were 87.6%and 87.3%,respectively,whereas the sensitivities of CEA and CA153 were only 22.47%and 15.73%.Conclusions:Compared with CEA and CA153,serum miR-21 has a higher sensitivity in diagnosis of BC.Although not correlated with the status of ER,PR and clinical stages,serum miR-21 may be a potential diagnostic indicator for BC,especially for the early stage. | Jianjian Gao Qingyun Zhang Jianjun Xu Lijuan Guo Xuefeng Li | 2013 | Chinese Journal of Cancer Research2013，25，6： | 36 |
| 4 | Preoperative neutrophil-to-lymphocyte ratio plus platelet-to-lymphocyte ratioin predicting survival for patients with stage Ⅰ-Ⅱgastric cancer显示文摘Background:The preoperative neutrophil-to-lymphocyte ratio(NLR) and the platelet-to-lymphocyte ratio(PLR) are associated with poor prognosis of gastric cancer.We aimed to determine whether the combination of NLR and PLR(NLR-PLR) could better predict survival of patients after curative resection for stage Ⅰ-Ⅱ gastric cancer.Methods:We collected data from the medical records of patients with stage Ⅰ-Ⅱ gastric cancer undergoing curative resection between December 2000 and November 2012 at the Sun Yat-sen Cancer Center.The preoperative NLRPLR was calculated as follows:patients with both elevated NLR(≥2.1) and PLR(≥ 120) were given a score of 2,and patients with only one or neither were given a score of 1 or 0,respectively.Results:Kaplan-Meier analysis and log-rank tests revealed significant differences in overall survival(OS) among patients with NLR-PLR scores of 0,1 and 2(P < 0.001).Multivariate analysis showed that OS was independently associated with the NLR-PLR score[hazard ratio(HR) = 1.51,95%confidence interval(CI) 1.02-2.24,P = 0.039]and TNM stage(HR = 1.36,95%CI 1.01-1.83,P= 0.041).However,other systemic inflammation-based prognostic scores,including the modified Glasgow prognostic score,the prognostic nutritional index,and the combination of platelet count and NLR,were not.In TNM stage-stratified analysis,the prognostic significance of NLR-PLR was maintained in patients with stage Ⅰ(P < 0.001) and stage Ⅱ cancers(P= 0.022).In addition,the area under the receiver operating characteristic curve for the NLR-PLR score was higher than those of other systemic inflammation-based prognostic scores(P = 0.001).Conclusion:The preoperative NLR-PLR score is a useful predictor of postoperative survival in the patients with stage l-ll gastric cancer and may help identify high-risk patients for rational therapy and timely follow-up. | Xiaowei Sun Xuechao Liu Jianjun Liu Shangxiang Chen Dazhi Xu Wei Li Youqing Zhan Yuanfang Li Yingbo Chen Zhiwei Zhou | 2016 | Chinese Journal of Cancer2016，35，7： | 25 |
| 5 | Assessing the relative role of climate change and human activities in sandy desertification of Ordos region, China显示文摘Climate change and human activities are driving forces of sandy desertification and the relative role of them in sandy desertification is the hot point in related researches. A study was carried to assess the relative role of climate change and human activities in sandy desertification of Ordos region in China. Potential NPP and the difference between potential and actual NPP were selected as indicators to assess the relative role of climate change and human activities in sandy desertification, respectively. Assessing methods were built based on some scenarios for the reversion and expansion of sandy desertification and the relative role of climate change and human activities in sandy desertification of Ordos region were assessed from 1981 to 2000. The results showed that although some local places experienced an expansion of sandy desertification, the change of sandy desertification of Ordos region from 1981 to 2000 showed a stably reversing trend. The relative role of climate change and human activities in sandy desertification of Ordos region varied at different temporal and spatial scales in the reversion and expansion processes. In the reversion of sandy desertification, climate change was the dominant factor in the period of 1981 to 1990 and the reversed areas mainly induced by climate change including Mu Us sandy land and the transition zone between temperate steppe and temperate deciduous scrubs in north east of Ordos region; however, human activities controlled the reversed process during the period from 1991 to 2000 and the areas mainly induced by human activities distributed in all banners of Ordos region. In the expansion of sandy desertification, human activities were the dominant factor in the period of 1981 to 1990 and the expanded areas mainly included the regions around common boundary of Hanggin, Dalad Banners and Dongsheng City; however, climate change dominated the expansion of sandy desertification from 1991 to 2000, the expanded areas equably distributed in the whole of Ordos region except the south east of Otog Qian, Uxin and Jungar Banners. | XU DuanYang KANG XiangWu LIU ZhiLi ZHUANG DaFang PAN JianJun | 2009 | Science China Earth Sciences2009，52，6： | 19 |
| 6 | From concept to reality-A review to the primary test stand and its preliminary application in high energy density physics显示文摘Pulsed power technology,whereas the electrical energy stored in a relative long period is released in much shorter timescale,is an efficient method to create high energy density physics(HEDP)conditions in laboratory.Around the beginning of this century,China Academy of Engineering Physics(CAEP)began to build some experimental facilities for HEDP investigations,among which the Primary Test Stand(PTS),a multi-module pulsed power facility with a nominal current of 10 MA and a current rising time~90 ns,is an important achievement on the roadmap of the electro-magnetically driven inertial confinement fusion(ICF)researches.PTS is the first pulsed power facility beyond 10 TW in China.Therefore,all the technologies have to be demonstrated,and all the engineering issues have to be overcome.In this article,the research outline,key technologies and the preliminary HEDP experiments are reviewed.Prospects on HEDP research on PTS and pulsed power development for the next step are also discussed. | Jianjun Deng Weiping Xie Shuping Feng Meng Wang Hongtao Li Shengyi Song Minghe Xia Ji Ce An He Qing Tian Yuanchao Gu Yongchao Guan Bin Wei Xianbin Huang Xiaodong Ren Jiakun Dan Jing Li Shaotong Zhou Hongchun Cai Siqun Zhang Kunlun Wang Qiang Xu Yujuan Wang Zhaohui Zhang Guilin Wang Shuai Guo Yi He Yiwei Zhou Zhanji Zhang Libing Yang Wenkang Zou | 2016 | Matter and Radiation at Extremes2016，1，1： | 19 |
| 7 | Assessment of the relative role of climate change and human activities in desertification:显示文摘Climate change and human activities are the two kinds of driving forces in desertification,and assessing their relative role in desertification is of great significance to deeply understanding the driving mechanisms and preventing desertification expansion.This paper has systematically reviewed the progress of the researches on assessing the relative role of climate change and human activities in desertification from qualitative,semi-quantitative and quantitative aspects respectively.The authors found that there were still some problems in the previous researches.For example,the subjectivity in assessment was obvious,the assessment cannot be easily repeated,and the assessment and its results were always based on administrative regions and less taken and expressed in a continuous space.According to the progress of previous researches and the works conducted by the authors recently,we put forward a quantitative approach by selecting NPP as a common indicator to measure the relative role of climate change and human activities in desertification and dividing the ecological process of 'driving force effect-dynamic response of desertified land' into several scenarios.Meanwhile,validation and scale of assessment should be taken into account when quantitative assessment of the relative role of climate change and human activities in desertification are carried out. | XU Duanyang LI Chunlei ZHUANG Dafang PAN Jianjun | 2011 | Journal of Geographical Sciences2011，21，5： | 16 |
| 8 | Interannual and Interdecadal Variability of Winter Precipitation over China in Relation to Global Sea Level Pressure Anomalies显示文摘Based on the method of rotated principal component (RPC) analysis and wavelet transforms, the win-ter precipitation from 36 stations over China for the period 1881-1993 is examined. The results show thatthe three leading space-time modes correspond, in sequence, to winter rainfall anomalies over the reaches ofthe Yangtze River, the bend of the Yellow River, and the northeastern region of China. The three modes ex-hibit interannual oscillations with quasi-biennial and 8-year periods as well as interdecadal oscillationswith 16- and 32-year periods. The interannual oscillation (< 10 years) occurs in phase over the differentareas, and its maximum amplitude migrates northward considerably with prominent interdecadal variations.However, the interdecadal oscillations (10-32 years) are out of phase over the different regions, and theamplitude variations have the characteristics of stationary waves.The rainfall anomalies appear to be closely re lated to the anti-phase changes of mean sea-level pres-sure (SLP) over the Asian mainland and the North Pacific. When the SLP rises over the North Pacific anddecreases over the Asian mainland, the precipitation over East China increases noticeably. The linkage be-tween the rainfall over China and the SLP anomalies apparently results from the strength of the East Asianwinter monsoon and its associated temperature and moisture advection. | Jianjun Xu Johnny C.L Chan | 2002 | Advances in Atmospheric Sciences2002，19，5： | 15 |
| 9 | Evaluation of the Trend Uncertainty in Summer Ozone Valley over the Tibetan Plateau in Three Reanalysis Datasets显示文摘Trend uncertainty in the ozone valley over the Tibetan Plateau(OVTP)and the South Asian high(SAH)during1979–2009 in ERA-Interim(interim reanalysis data from the ECMWF),JRA-55(55-yr reanalysis data from the Japan Meteorological Agency),and NCEP-CFSR(Climate Forecast System Reanalysis)datasets was evaluated.The results showed that the NCEP-CFSR OVTP became strong in the summers of 1979–2009,whereas it became weak according to ERA-Interim and JRA-55.Satellite data merged with TOMS(Total Ozone Mapping Spectrometer)and OMI(Ozone Monitoring Instrument)agreed with the OVTP trend of NCEP-CFSR.The OVTP strengthening in NCEP-CFSR may have been caused by SAH intensification,a rising tropopause,and increasing ozone over non-TP(non-Tibetan Plateau)areas(27°–37°N,<75°E and>105°E).Analogously,the OVTP weakening in ERA-Interim and JRA-55 may have been affected by weakening SAH,descending tropopause,and decreasing non-TP ozone. | Dong GUO Yucheng SU Xiuji ZHOU Jianjun XU Chunhua SHI Yu LIU Weiliang LI Zhenkun LI | 2017 | Journal of Meteorological Research2017，31，2： | 13 |
| 10 | The assimilation experimentin the southwestern South China Sea in summer 2000显示文摘We performed an assimilation experiment of the southern South China Sea in summer 2000, and the altimeter data were assimilated into Princeton Ocean Model (POM). The result was evaluated with the in situ data. There were obvious improvements of the currents in the southern South China Sea, and the modeling uncertainty coming from the error of wind stress forcing was reduced. This experiment provides us a new idea about improving the modeling of the ocean currents. | XIAO Xianjun WANG Dongxiao XU Jianjun | 2006 | Chinese Science Bulletin2006，51，B12： | 13 |
| 11 | Danggui Buxue decoction ameliorates lipid metabolic defects involved in the initiation of diabetic atherosclerosis;identification of active compounds显示文摘OBJECTIVE: To determine the constituent compounds of Danggui buxue decoction(DBD) involved and the potential mechanisms mediating its effects, with specific reference to lipids playing a role in the initiation of diabetic atherosclerosis.METHODS: Liquid chromatography-tandem mass spectrometry was used to identify and quantify the absorbed bioactive compounds(ABCs) present in DBD. Goto-Kakizaki(GK) rats were randomly allocated to a diabetes atherosclerosis(DA) group, a DBD group, and an ABC group(10 per group), which were all high-fat diet-fed. The treated rats were administered DBD(4 g/kg) or ABCs(in amounts equal to those present in DBD) once daily for 28 d, and a control group of Wistar rats were administered vehicle. Body mass gain, fasting blood glucose, and homeostasis assessment of insulin resistance(HOMAIR) were measured. Serum triglyceride(TG), cholesterol(CHOL), high density lipoprotein-cholesterol(HDL-C), low-density lipoprotein-cholesterol(LDLC) and tumor necrosis factor-α(TNF-α) concentrations were determined. Hematoxylin and eosin staining and microscopy were used to characterize the abdominal aorta and the expression of lipogenic genes was quantified in this vessel.RESULTS: Seven ABCs were identified in rat serum:ferulic acid, formononetin, calycosin, astragaloside,caffeic acid, ligustilide, and butyphthalide. DBD significantly reduced HOMA-IR, the serum concentrations of TG, CHOL, and LDL-C, and the expression of the lipogenic genes monocyte chemotactic protein1, Fas, intercellular adhesion molecule 1, and Cd36 in aorta;and significantly increased the mRNA expression of Scd1 in aorta.CONCLUSION: DBD affects lipid metabolism in the early stage of atherosclerosis in diabetic GK rats,with the mechanism likely involving the regulation of lipid metabolic genes in vessels. The contribution of ABCs to the effect of DBD on lipid metabolism was 24%-101%. | Xue Mei Bian Yong Liu Yalin Zhou Junjie Xu Jianjun Zhang Liang Huang Xi | 2020 | Journal of Traditional Chinese Medicine2020，40，3： | 13 |
| 12 | Microstructures of metallic film and diamond growth from Fe-Ni-C system显示文摘The microstructures of metallic film surrounding diamond have been systemically studied using the transmission electron microscopy (TEM) and the atom force microscopy (AFM). The film can be divided into three layers (inner layer near diamond, external layer near graphite and middle layer). The graphite cannot be directly transformed into diamond in the film at HTHP: there exists a parallelrelationship between (111) of γ-(Fe,Ni) and (110) of Fe3C in the inner layer; the sawtooth-like step morphology found by AFM on the film is similar to that of corresponding diamond surface. A new model for diamond growth at HPHT is proposed from the parallel relationship and sawtooth-like step morphology. It is believed that Fe3C may be a transitional phase in the course of diamond growth, γ-(Fe,Ni) in the inner layer can absorb carbon atom groups with lamella structure from Fe3C, and then the carbon groups stack on growing diamond. | XU Bin LI Musen YIN Longwei CUI Jianjun LIU Yuxian GONG Jianhong | 2002 | Chinese Science Bulletin2002，47，15： | 12 |
| 13 | Chang'E-1 Lunar Mission:An Overview and Primary Science Results显示文摘Chang'E-1 is the first lunar mission in China,which was successfully launched on Oct.24th,2007.It was guided to crash on the Moon on March 1,2009,at 52.36°E,1.50°S,in the north of Mare Fecunditatis.The total mission lasted 495 days,exceeding the designed life-span about four months.1.37Terabytes raw data was received from Chang'E-1.It was then processed into 4Terabytes science data at different levels.A series of science results have been achieved by analyzing and applicating these data,especially 'global image of the Moon of China's first lunar exploration mission'.Four scientific goals of Chang'E-1 have been achieved.It provides abundant materials for the research of lunar sciences and cosmochemistry.Meanwhile these results will serve for China's future lunar missions. | Ouyang Ziyuan Li Chunlai Lu Chang Liu Jianzhong Zou Yongliao Zhang Hongbo Jianjun Zuo Wei Su Yah Wen Weibin Bian Wei Zhao Baochang Wang Jianyu Yang Jianfeng Chang Jin Wang Huanyu Zhang Xiaohui Wang Shijin Wang Min Ren Xin Mu Lingli Kong Deqing Wang Xiaoqian Wang Fang Geng Liang Zhang Zhoubin Zheng Lei Zhu Xinying Zheng Yongchun Li Junduo Zou Xiaoduan Xu Chun Shi Shuobiao Gao Yifei Gao Guannan | 2010 | 空间科学学报2010，30，5： | 11 |
| 14 | Osteogenic growth peptide enhances the proliferation of bone marrow mesenchymal stem cells from osteoprotegerin-deficient mice by CDK2/cyclin A显示文摘支持骨头形成是在骨质疏松症治疗的基本策略之一,破裂修理。作为骨头形成上的激发器之一, osteogenic 生长肽(OGP ) 在 vitro 并且在 vivo, osteoprotegerin (OPG ) 在被建议了被包含增加造骨细胞的增长和区别。在这研究,我们在骨头髓上评估了 OGP 的效果从在由 3-(4,5-dimethylthiazol-2-yl ) 的 vitro 的 OPG 缺乏的老鼠的间充质的干细胞(MSC )-2,5-diphenyltetrazolium 溴化物试金,碱的磷酸酶(高山) 活动试金,即时聚合酶链反应,和西方的污点分析。结果证明 OGP 刺激了 MSC 增长并且在 mRNA 和蛋白质层次两个都在 MSC 增加了 CDK2 和 cyclin A 的表示。然而, OGP 的 differentiative 效果都没作为高山活动和 Runx2 的表示层次被显示出, Osterix 没被 OGP 显著地增加。我们的学习建议 OGP 可以由刺激 MSC 增长而非区别在 OPG 缺乏的老鼠增加骨头形成,并且可能由触发 CDK2/cyclin 一条小径。 | Qinming Fei Changjun Guo Xiaoya Xu Jianjun Gao Jian Zhang Tongyi Chen Dafu Cui | 2010 | Acta Biochimica et Biophysica Sinica2010，42，11： | 11 |
| 15 | Comprehensive Management of Daily Living Activities,behavioral and Psychological Symptoms,and Cognitive Function in Patients with Alzheimer's Disease:A Chinese Consensus on Alzheimer's Disease显示文摘Alzheimer's disease(AD)is the most common cognitive disorder in the elderly.Its main clinical manifestations are cognitive decline(C),behavioral and psychological symptoms(B),and a decline in the activities of daily living(A),also known as ABC symptoms.Early identification and evaluation of ABC symptoms are helpful for establishing the accurate diagnosis,comprehensive treatment,and prognosis of AD.To guide Chinese clinical practice for optimization of the comprehensive management of AD,in 2018,The Academy of Cognitive Disorder of China gathered 22 neurologists and gerontologists in China to build a consensus on the comprehensive management of AD.Based on a review of the evidence,the consensus summarizes the pathogenesis,pathological changes,clinical manifestations,evaluation,diagnosis,drug and non-drug treatment,and patient care for AD.Focus group discussion was used to establish a flowchart of comprehensive ABC management for AD patients.The new consensus provides a feasible AD management process for clinicians. | Jianjun Jia Jun Xu Jun Liu Yongjun Wang Yanjiang Wang Yunpeng Cao Qihao Guo Qiuming Qu Cuibai Wei Wenshi Wei Junjian Zhang Enyan Yu | 2021 | Neuroscience Bulletin2021，37，7： | 10 |
| 16 | Interdecadal variability in the tropical Indian Ocean and its dynamic explanation显示文摘Interdecadal variability in the tropical Indian Ocean has been analyzed based on the long-term climatic observational data. Case study showed that strong interannual signals formed at the surface can penetrate the depth of seasonal thermocline, where the anomalies last a couple of years. Artificial time series based on damping with exponential decay of selected strong events agree well with the detected interdecadal variability in the tropical Indian Ocean. | Dongxiao Wang Guoxiong Wu Jianjun Xu | 1999 | Chinese Science Bulletin1999，44，17： | 9 |
| 17 | Petrogenetic differences between the Middle-Late Jurassic Cu-Pb-Zn-bearing and W-bearing granites in the Nanling Range,South China: A case study of the Tongshanling and Weijia deposits in southern Hunan Province显示文摘The Middle-Late Jurassic Cu-Pb-Zn-bearing and W-bearing granites in the Nanling Range have distinctly different mineralogical and geochemical signatures. The Cu-Pb-Zn-bearing granites are dominated by metaluminous amphibole-bearing granodiorites, which have higher CaO/(Na2O+K2O) ratios, light/heavy rare earth element(LREE/HREE) ratios, and δEu values,lower Rb/Sr ratios, and weak Ba, Sr, P, and Ti depletions, exhibiting low degrees of fractionation. The W-bearing granites are highly differentiated and peraluminous, and they have lower CaO/(Na2O+K2O) ratios, LREE/HREE ratios, and δEu values,higher Rb/Sr ratios, and strong Ba, Sr, P, and Ti depletions. The Cu-Pb-Zn-bearing granites were formed predominantly between155.2 and 167.0 Ma with a peak value of 160.6 Ma, whereas the W-bearing granites were formed mainly from 151.1 to 161.8Ma with a peak value of 155.5 Ma. There is a time gap of about 5 Ma between the two different types of ore-bearing granites.Based on detailed geochronological and geochemical studies of both the Tongshanling Cu-Pb-Zn-bearing and Weijia W-bearing granites in southern Hunan Province and combined with the other Middle-Late Jurassic Cu-Pb-Zn-bearing and W-bearing granites in the Nanling Range, a genetic model of the two different types of ore-bearing granites has been proposed. Asthenosphere upwelling and basaltic magma underplating were induced by the subduction of the palaeo-Pacific plate. The underplated basaltic magmas provided heat to cause a partial melting of the mafic amphibolitic basement in the lower crust, resulting in the formation of Cu-Pb-Zn mineralization related granodioritic magmas. With the development of basaltic magma underplating,the muscovite-rich metasedimentary basement in the upper-middle crust was partially melted to generate W-bearing granitic magmas. The compositional difference of granite sources accounted for the metallogenic specialization, and the non-simultaneous partial melting of one source followed by the other brought about a time gap of about 5 Ma between the Cu-Pb-Zn-bearing and W-bearing granites. | HUANG XuDong LU JianJun Stanislas SIZARET WANG RuCheng MA DongSheng ZHANG RongQing ZHAO Xu WU JinWei | 2017 | Science China Earth Sciences2017，60，7： | 9 |
| 18 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 19 | Regional eco-efficiency evaluation and spatial pattern analysis of the Yangtze River Economic Zone显示文摘The environmental ecology of the Yangtze River Economic Zone(YREZ)faces ecological function decline,deterioration and degradation under intense human activities,long-term development and utilization and its economy has developed rapidly over recent decades.Eco-efficiency is considered as a measure of coordinated development of economy,resources,environment and ecology,and is currently considered a very important issue.In this paper,based on the slack-based measure and data envelope analysis model,we take 129 prefecture-level cities of the YREZ as the study unit and measure the eco-efficiency of the YREZ in 2000,2005,2010 and 2015,which considers undesired output.The evaluation of the status quo of the regional eco-efficiency development was carried out at provincial,prefectural and city scales.The spatial autocorrelation test model and standard deviation ellipse were used to analyze the spatially distributed characteristics and the evolutionary regularity of eco-efficiency.Our study suggested that the eco-efficiency value varied significantly at different spatiotemporal scales and the overall distribution presented an'N-shaped'pattern,the value is the largest downstream and the smallest upstream.Regional eco-efficiency presented certain volatility in growth and a clear spatial positive agglomeration trend from 2000 to 2015.The spatial distribution of each agglomeration area was also significantly different,forming some high-high agglomeration areas at the center of the shaft with Shanghai and surrounding cities,and some low-low agglomeration areas at the center with middle reaches and upstream cities.The low-high over-aggregation and high-low polarization clusters were fewer.At the same time,with the change of the research period,the degree of positive agglomeration became increasingly pronounced and the eco-efficiency gap of the neighborhoodunit reduced.The regional eco-efficiency value of the YREZ presented a spatial distribution pattern in the northeast-southwest axis and the evolutionary pattern of the regional eco-efficiency similarly showed a northeast-southwest orientation. | HA Lin TU Jianjun YANG Jianping XU Chunhai PANG Jiaxing LU Debin YAO Zuolin ZHAO Wenyu | 2020 | Journal of Geographical Sciences2020，30，7： | 8 |
| 20 | hSSB1 regulates both the stability and the transcriptional activity of p53显示文摘肿瘤 suppressor p53 为涉及对多样的 genotoxic 应力的反应的几个细胞的过程是必要的,包括房间周期拘捕, DNA 修理, apoptosis 和老朽。p53 的规定的研究主要集中了于它的稳定性和 transactivation;然而,为 p53 的新规章的分子经常也被识别了。这里,我们报导那人的 ssDNA 绑定蛋白质 SSB1 (hSSB1 ) ,新奇 DNA 联系损坏的蛋白质,能与 p53 交往并且保护 p53 免受调停 ubiquitin 的降级的伤害。而且, hSSB1 也与 acetyltransferase p300 联系并且被在 lysine382 影响 p53 的 acetylation 为 p53 目标基因 p21 的有效 transcriptional 激活要求。机能上地, G2/M 检查点的 hSSB1 击倒导致废除部分依赖于 p53 或 p300。一起,我们的结果显示那 hSSB1 可以调整 DNA 损坏检查点由断然 modulating p53 和它的下游的目标 p21。 | Shuangbing Xu Yuanzhong Wu Qiong Chen Jingying Cao Kaishun Hu Jianjun Tang Yi Sang Fenju Lai Li Wang Ruhua Zhang Sheng-Ping Li Yi-Xin Zeng Yuxin Yina Tiebang Kang | 2013 | Cell Research2013，23，3： | 7 |
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