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| 1 | Cardiac autonomic nerve fiber regeneration in chronic heart failure Do Akt gene-transduced mesenchymal stem cells promote repair?显示文摘BACKGROUND: Transplantation of Akt-over-expressing mesenchymal stem cells (Akt-MSCs) has been shown to repair infarcted myocardium and improve cardiac function. However, little is known about the therapeutic effects of Akt-MSCs on cardiac autonomic neuropathy in chronic heart failure (CHF). OBJECTIVE: The present study used adriamycin-induced CHF rat models to observe the effect of Akt-MSCs on cardiac autonomic nervous regeneration and the factors mediating this effect. DESIGN, TIME AND SETTING: A randomized, controlled animal experiment was performed at the Central Laboratory of Basic Medical College, China Medical University, between September 2008 and April 2009. MATERIALS: Rabbit anti-choline acetyltransferase (ChAT), growth associated protein-43 (GAP-43), synaptophysin (SYN) polyclonal antibodies and the secondary antibody (goat anti-rabbit IgG) were purchased from Boster, China. Cat-A-Kit assay system was provided by Amersham, USA. METHODS: (1) Adult rat MSCs were isolated and cultured for the preparation of Akt-MSCs. (2) Forty male Wistar rats were intramyocardially administered adriamycin at 2 mg/kg over 3 days for a total of five times and once a week for additional five times thereafter to establish CHF models. At 2 weeks after final adriamycin treatment, 34 successful CHF rat models were randomized to three groups: Akt-MSCs (n = 11), simple MSCs (s-MSCs, n =11), and control (n = 12). Each group was intravenously administered Akt-MSCs (2×106 cells in 100 μL PBS), s-MSCs (2×106 cells in 100 μL PBS) or equal volume of phosphate buffered saline, once a day for a total of three times. MAIN OUTCOME MEASURES: At 4 weeks after final adriamycin treatment, myocardial norepi- nephrine (NE) content was detected using a Cat-A-Kit assay system. Myocardial ChAT, SYN and GAP-43 were performed by immunohistochemistry and Western blot analysis. Prior to, 2 and 4 weeks after adriamycin treatment, echocardiographic examination was performed and left ventricular ejection fraction (LVEF) was determined. RESULTS: Myocardial NE content, as well as SYN-positive and GAP-43-positive nerve fiber density and expression, and LVEF, was the greatest in the Akt-MSCs group, followed by the s-MSCs group, and lastly the control group (P < 0.05 or P < 0.01). ChAT expression was similar between Akt-MSCs and s-MSCs groups, but it was higher compared with the control group (P < 0.05). NE contents were negatively correlated to LVEF (r = -0.64, P = 0.015). CONCLUSION: Transplantation of MSCs, in particular Akt-MSCs, promotes cardiac nervous regeneration in failing heart, which might be mediated by GAP-43. | Hongliang Kong Zhanquan Li Shumei Zhao Li Zhu Yingjun Zhao Weiwei Zhang GuipingXu Wenjun Hao Huijun Li Guoxian Qi | 2010 | Neural Regeneration Research2010，5，1： | 13 |
| 2 | Nine-month angiographic and two-year clinical follow-up of polymer-free sirolimus-eluting stent versus durable-polymer sirolimus-eluting stent for coronary artery disease: the Nano randomized trial显示文摘 | Zhang Yaojun Chen Fang Takashi Muramatsu Xu Bo Li Zhanquan Ge Junbo He Qing Yang Zhijian Li Shumei Wang Lefeng Wang Haichang He Ben Li Kang Qi Guoxian Li Tianchang Zeng Hesong Peng Jianjun Jiang Tieming Zeng Qiutang Zhu Jianhua Fu Guosheng Christos V. Bourantas Patrick W. Serruys Huo Yong | 2014 | Chinese Medical Journal2014，，11： | 8 |
| 3 | Pathogenic mechanisms and control strategies of Botrytis cinerea causing post-harvest decay in fruits and vegetables显示文摘Botrytis cinerea is a significant necrotrophic plant pathogen causing devastating diseases on more than 500 plant species,especially on fresh fruits and vegetables,resulting in the economic losses ranging from$10 billion to$100 billion worldwide.This fungal pathogen invades nearly all parts of plants including stems,leaves,flowers,fruits,and seeds at both pre-harvest and post-harvest stages.Due to its wide host range and the huge economic losses that it causes,extensive investigations have been carried out to effectively control this plant pathogen.It is beneficial for exploring the pathogenic mechanisms of B.cinerea to provide fundamental basis for control strategies.In recent years,tremendous progress has been made in understanding these pathogenic genes and regulatory pathways,as well as the control strategies of B.cinerea.Here,the current knowledge will be summarized in this review. | Li Hua Chen Yong Zhang Zhanquan Li Boqiang Qin Guozheng Tian Shiping | 2018 | Food Quality and Safety2018，2，3： | 8 |
| 4 | Molecular basis for optimizing sugar metabolism and transport during fruit development显示文摘Sugars are fundamental metabolites synthesized in leaves and further delivered to fruit in fruit crops.They not only provide'sweetness'as fruit quality traits,but also function as signaling molecules to modulate the responses of fruit to environmental stimuli.Therefore,the understanding to the molec-ular basis for sugar metabolism and transport is crucial for improving fruit quality and dissecting responses to abiotic/biotic factors.Here,we provide a review for mol ecular components involved in sugar metabolism and transport,crostalk with hormone signaling and the roles of sugars in responses to abiotic and biotic stresses.Moreover,we also envisage the strategies for optimizing sugar metabolism during fruit quality maintenance. | Tong Chen Zhanquan Zhang Boqiang Li Guozheng Qin Shiping Tian | 2021 | aBIOTECH2021，2，3： | 2 |
| 5 | Microstructure Morphologies of Asphalt Binders using Atomic Force Microscopy显示文摘We investigated microstructure morphologies of three asphalts(SK, Karamay, and Esso) used in China using atomic force microscopy(AFM). The topography and phase contrast images were obtained. Topographic profile and three dimensional images were described. Roughnesses of microstructure were calculated. And the chemical compositions of asphalt were tested to explain the microstructural mechanism of the asphalt. The results show that the topography and phase image in atomic force microscopy are appropriate to evaluate the microstructure of the asphalt binder. There are significant differences in microstructural morphologies including bee-like structure, topographic profile, 3D image, and roughness for three asphalts in this study. There are three different phases in microstructure of asphalt binder. The oil source and chemical composition of asphalt, especially asphaltenes content have a great influence on the microstructure. | 李波 YANG Jinyu CHEN Zhanquan LI Hailian | 2016 | Journal of Wuhan University of Technology(Materials Science)2016，31，6： | 2 |
| 6 | Safety and Efficacy of Biodegradable Polymer-Coated Sirolimus-Eluting Stents in “Real-World” Practice显示文摘 | Yaling Han Quanmin Jing Bo Xu Lixia Yang Huiliang Liu Xiaoming Shang Tieming Jiang Zhanquan Li Hua Zhang Hui Li Jian Qiu Yingfeng Liu Yi Li Xuezhi Chen Runlin Gao | 2009 | JACC: Cardiovascular Interventions2009，，4： | 2 |
| 7 | Novel completed biodegradable polymer sirolimus-eluting stent versus durable polymer sirolimus-eluting stent in de novo lesions: nine-month angiographic and three-year clinical outcomes of HOPE trial显示文摘 | Yuan Fei Chen Xin Song Xiantao Wang Dongqi Zhang Zheng Li Weimin Li Zhanquan Li Hui Chen Xinyi Huo Yong Wang Lefeng Lu Caiyi Lu Qinghua Xu Bo Li Wei Lyu Shuzheng | 2014 | Chinese Medical Journal2014，，14： | 2 |
| 8 | Modeling of fixed bed reactor for coal tar hydrogenation via the kinetic lumping approach显示文摘Hydrogenation technology is an indispensable chemical upgrading process for converting the heavy feedstock into favorable lighter products.In this work,a new kinetic model containing four hydrocarbon lumps(feedstock,diesel,gasoline,cracking gas)was developed to describe the coal tar hydrogenation process,the Levenberg–Marquardt’s optimization algorithm was used to determine the kinetic parameters by minimizing the sum of square errors between experimental and calculated data,the predictions from model validation showed a good agreement with experimental values.Subsequently,an adiabatic reactor model based on proposed lumped kinetic model was constructed to further investigate the performance of hydrogenation fixed-bed units,the mass balance and energy balance within the phases in the reactor were taken into accounts in the form of ordinary differential equation.An application of the reactor model was performed for simulating the actual bench-scale plant of coal tar hydrogenation,the simulated results on the products yields and temperatures distribution along with the reactor are shown to be good consistent with the experimental data. | Fei Dai Yalin Zhang Endong Xia Zhanquan Zhang Zhihua Zhang Chunshan Li | 2018 | Carbon Resources Conversion2018，1，3： | 2 |
| 9 | Preparation and characterization of high melt strength polypropylene with long chain branched structure by the reactive extrusion process 显示文摘 | Cao Kun Li Yan Lu Zhanquan | 2011 | Journal of Applied Polymer Science2011，121，6： | 1 |
| 10 | Preparation and Char- acterization of High Melt Strength Polypropylene with Long Chain Branched Structure by the Reactive Extrusion Process 显示文摘 | Cao Kun Li Yan Lu Zhanquan | 2011 | JApplPolymSci2011，121，6： | 1 |
| 11 | Advances and Strategies for Controlling the Quality and Safety of Postharvest Fruit显示文摘Fresh fruits are highly valued by consumers worldwide,owing to their delicious flavors,abundant nutrients,and health-promoting characteristics,and as such,fruits make up an important component of a healthy diet.The postharvest quality and safety of fresh fruit involve complex interactions among the fruit,environmental factors,and postharvest pathogens.Efficient regulation of fruit senescence and pathogen resistance,as well as disease-causing abilities of postharvest pathogens,is critical to understanding the fundamental mechanisms that underlie fruit quality and safety.This paper provides a comprehensive review of recent advances and currently available strategies for maintaining fruit quality and controlling major postharvest pathogens,mainly Botrytis cinerea and Penicillium expansum,which may promote sustainable and environmental-friendly development of the fruit industry. | Tong Chen Dongchao Ji Zhanquan Zhang Boqiang Li Guozheng Qin Shiping Tian | 2021 | Engineering2021，7，8： | 1 |
| 12 | Preparation and Characterization of High Melt Strength Polypropylene with Long Chain Branched Structure by the Reactive Extrusion Pro- cess 显示文摘 | Cao Kun Li Yah Lu ZhanQuan | 2011 | JApplPolym Sci2011，121，6： | 1 |
| 13 | A facile one step synthesis of alumina monolith with bimodal pore structure from emulsion template显示文摘 | Li Xiang Liu Xinmei Zhang Zhanquan | 2012 | Materials Letters2012，68，1： | 1 |
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