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| 1 | Oral polymorphonuclear neutrophil characteristics in relation to oral health: a cross-sectional, observational clinical study显示文摘Polymorphonuclear neutrophils(PMNs) have a major role in the innate immune system. However, little is known about PMN contribution in relation to oral health. The objective of this study was to investigate the numbers and functional characteristics of oral PMNs(o PMNs) compared with circulatory PMNs(c PMNs). Oral rinse and venous blood samples were obtained from 268 systemically and orally healthy volunteers in a cross-sectional observational study. PMN counts, cell cycle analysis and cellular activation state were investigated. Also, reactive oxygen species(ROS) production was analyzed, with and without bacterial stimulation(Fusobacterium nucleatum). In males, 1.2 × 10~6± 1.0 × 10~6 oPMNs were collected, and showed a tendency to correlate with the levels of gingival bleeding(r = 0.215, P = 0.008). Comparable o PMNs counts were found among females(1.0 × 10~6± 0.7 × 10~6). More late-stage apoptotic/necrotic cells were found among the o PMNs(53.1%) compared with the c PMNs(8.5%; Po0.001). Without additional stimulation, o PMNs were more activated than c PMNs, as indicated by higher expression of CD11 b, CD63 and CD66 b, and higher constitutive ROS levels(Po0.001). Notably, in response to bacterial stimulation, o PMNs released comparable ROS levels as c PMNs(P = 0.042). In conclusion, this study provides data on viable o PMNs showing high levels of activation in orally and systemically healthy individuals, free of apparent caries lesions and periodontal disease. These data suggests that although the o PMNs are in a more mature stage of their life cycle compared with the c PMNs, o PMNs are still responsive to stimulation, which indicates their functional potential and possible contribution to a healthy oral ecosystem. | Patrick Rijkschroeff Ineke DC Jansen Fridus A van der Weijden Bart IF Keijser Bruno G Loos Elena A Nicu | 2016 | International Journal of Oral Science2016，8，3： | 2 |
| 2 | 卒中介入治疗培训指南:国际多学会共识文件显示文摘1背景
缺血性卒中是全球人口死亡和残疾的首要原因。很多急性大血管闭塞(emergent large vesselocclusion,ELVO)患者都会遗留长期残疾。事实上,这些颅内大动脉闭塞经常会导致大面积脑损伤,进而造成患者死亡或严重致残。 | Lavine SD Cockroft K Hoh B Bambakidis N Khalessi AA Woo H Riina H Siddiqui A Hirsch JA Chong W Rice H Wenderoth J Mitchell P Coulthard A Signh TJ Phatorous C Khangure M Klurfan P ter Brugge K Iancu D Gunnarsson T Pongpech S Rodesch G Soderman M Taylor A Krings T Orbach D Picard L Suh DC Zheng HQ Jansen O Muto M Szikora I Pierot L Brouwer P Gralla J Renowden S Andersson T Fiehler J Turjman F White P Januel AC Spelle L Kulcsar Z Chapot R Biondi A Dima S Taschner C Szajner M Krajina A Sakai N Matsumaru Y Yoshknura S Ezura M Fujinaka T Iihara K Ishii A Higashi T Hirohata M Hyodo A Ito Y Kawanishi M Kiyosue H Kobayashi E Kobayashi S Kuwayama N Matsumoto Y Miyachi S Murayama Y Nagata I Nakahara I Nemoto S Niimi Y Oishi H Satomi J Satow T Sugiu K Tanaka M Terada T Yamagami H Diaz O Lylyk P Jayaraman MV Patsalides A Gandhi CD Lee SK Abruzzo T Albani B Ansari SA Arthur AS Baxter BW Bulsara KR Chen M Almandoz JE Fraser JF Heck DV Hetts SW Hussain MS Klucznik RP Leslie-Mawzi TM Mack WJ McTaggart RA Meyers PM Mocco J Prestigiacomo CA Pride GL Rasmussen PA Starke RM Sunenshine PJ Tarr RW Frei DF Pabo M Nogueira RG Zaidat OO Jovin T Linfante I Yavagal D Liebeskind D Novakovic R Pongpech S 许岩 孙瑞 郭芮兵 | 2017 | 国际脑血管病杂志2017，25，5： | 2 |
| 3 | Effect of pressure history on shrinkage and residual stresses-injection molding with constrained shrinkage显示文摘 | JANSEN K M B TITOMANLIO G | 1996 | Polymer Engineering and Science1996，36，15： | 1 |
| 4 | Effect of yeast extract on speciation and bioavailability of nickel and cobalt in anaerobic bioreactors显示文摘 | GONZALEZ-GIL G JANSEN S ZANDVOORT MH | 2003 | Biotechnol Bioeng2003，，82： | 1 |
| 5 | ^31p and ^14N NMR studies of the up take of phosphorus and nitro- gen compounds in the marine macroalgae Ulva lactuca 显示文摘 | Lundberg P Welch R G Jansen P etal | 1989 | Plant Physiol1989，89，： | 1 |
| 6 | Thyroid hormone regulates earnitine pahnitoyl transferase I a gene expression through elements in the promoter and first intron 显示文摘 | Jansen M S Cook G A Song S L | 2000 | J Biol Chem2000，275，34： | 1 |
| 7 | Innovative ceramic materials for porous medium burners I显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Miiller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，5： | 1 |
| 8 | Trueness verification and traceability assessment of results from commercial systems for t of six enzyme activities in serum:An international study in the EC4 framework of the calibration 2000 project 显示文摘 | Jansen R Schumann G Baadenhuijsen H | 2006 | Clin Chim Acta2006，368，12： | 1 |
| 9 | Innovative ceramic materials for porous medium burners Ⅱ显示文摘 | Pickenacker O Pickenacker K Wawrzinek K Trimis D Pritzkow W E C Muller C Goedtke P Papenburg U Adler J Standke G Heymer H Tauscher W Jansen F | 1999 | Interceram:International Ceramic Review1999，48，6： | 1 |
| 10 | Hydrogen peroxide decomposition by a non -heme iron (Ⅲ) catalase mimic:a DFT study显示文摘 | Sicking W Korth H G Jansen G | 2007 | Chem Eur J2007，13，： | 1 |
| 11 | Scatter hoarding by the Central American agouti:a test of optimal cache spacing theory显示文摘 | Gálvez D Kranstauber B Kays RW Jansen PA | | 0，，06： | 1 |
| 12 | Tile efficacy of bisphospho- nates in the prevention of vertebral, hip, and nonvertebral - nonhip fractures in osteoporosis : a network meta - analysis 显示文摘 | Jansen JP Bergman G J Huels J | 2011 | Sernin Arthritis Rheum2011，40，： | 1 |
| 13 | The Founder’s Self-AssessedCompetence and Venture Performance 显示文摘 | Chandler G N and E Jansen | 1992 | Journal of BusinessVenturing1992，7，3： | 1 |
| 14 | In-mold shrinkage and stress prediction in injection molding显示文摘 | TITOMANLIO G JANSEN K M B | 1996 | Polymer Engineering and Science1996，36，15： | 1 |
| 15 | Psychological contract breach and job attitudes:A meta-analysis of age as a moderator 显示文摘 | Bal P M De Lange A H Jansen P G W Der Velde M E G V | 2008 | Journal of Vocational Behavior2008，72，1： | 1 |
| 16 | Very rap- id clearance after a joint bleed in the canine knee cannot prevent ad- verse effects on cartilage and synovial tissue 显示文摘 | JANSEN NWD ROOSENDAAL G WENTING MJG | 2009 | Osteoarthritis and Cartilage2009，17，4： | 1 |
| 17 | A fast general purpose algorithm for the computation of auto-and cross-correlation integrals from single channel data 显示文摘 | Widman G Lehnertz K Jansen P | 1998 | Physica D1998，121，： | 1 |
| 18 | Increased glutamine synthetase but normal EAAT2 expression in platelets of ALS patients显示文摘 | Bos I W Hoogland G Meine Jansen C F | 2006 | Neurochem Int2006，48，4： | 1 |
| 19 | Psychophysical evidence of no ciceptor sensitization in vulvar vestibulitis syndrome显示文摘 | Bohm Starke N Hilliges M Brodda Jansen G | 2001 | Pain2001，94，2： | 1 |
| 20 | Electroencephalogram and visual e- voked potential generation in a mathematical model of coupled cortical columns 显示文摘 | JANSEN B H RIT V G | 1995 | Biol Cybern1995，73，4： | 1 |
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