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| 1 | The role and modulation of autophagy in experimental models of myocardial ischemia-reperfusion injury显示文摘称为 autophagy 品质上的一个生理的序列由移开蛋白质总数和损坏细胞质的成分决定细胞的生存能力,并且显著地作出贡献到心肌的 ischemia-reperfusion (I/R ) 的度损害。这紧安排的分解代谢的细胞的 ‘ housekeeping’过程向房间提供精力的新来源适应紧张的条件。当支持幸存的机制,而是增加的证据建议它能也导致房间的遗赠,这个过程首先被描述。Autophagy 包括心肌的 I/R 损害在多重心脏的条件的致病被含有。然而,争论至于 autophagy 是否充当保护的机制或在心贡献 I/R 损害的有害效果坚持。这争吵可以在试验性的模型和种包括可变性源自几个因素,并且方法论过去常估计 autophagy。这评论在向操作 autophagy 显著地在压力大多数的条件下面增加心脏的 myocytes 的幸存受到 I/R,和成长兴趣的孤立的心脏的房间在 autophagy 的调整和角色上提供更新的知识是 I/R 损害。这的不安 evolutionarily 保存了细胞内部的清洁的 autophagy 机制,由指向的调整通过在其它之中, rapamycin ( mTOR )的哺乳动物的目标禁止者,腺苷 激活monophosphate 的蛋白质 kinase ( AMPK )调节的人,钙降低代理人, resveratrol , longevinex , sirtuin 使活跃之物, proapoptotic 基因 Bnip3 , IP3 和 lysosome 禁止者,可以对 I/R 授与抵抗到心房间导致的房间死亡。因此,在质问心肌层的 autophagy 的治疗学的操作可以有益于梗塞以后的心脏的愈合并且改变。 | Carol Chen-Scarabelli Pratik R. Agrawal Louis Saravolatz Cadigia Abuniat Gabriele Scarabelli Anastasis Stephanou Leena Loomba Jagat Narula Tiziano M. Scarabelli Richard Knight | 2014 | Journal of Geriatric Cardiology2014，11，4： | 37 |
| 2 | Decreased expression of Klotho in cardiac atria biopsy samples from patients at higher risk of atherosclerotic cardiovascular disease显示文摘BackgroundKlotho 蛋白质(α - 并且 β) 是基于膜的传播调整细胞新陈代谢的蛋白质,以及成纤维细胞生长因素(FGF ) 的 lifespan modulating 活动。最近的数据证明了更高的血浆传播 Klotho 层次减少心血管的风险,建议 Klotho 有在心血管的疾病的一个保护的角色。然而,尽管到目前为止它在各种各样的机关被识别了,它是未知的是否,并且高心血管的风险是否能影响 Klotho 的心脏的表示 cardiomyocytes 快车 Klotho 和 FGF , FGF 和另外的 molecules.MethodsWe 与心血管的疾病和 10 匹配年龄的控制使遭到,估计的10年的低风险经历的一名估计的10年的高动脉粥样硬化患者选择了 20 个病人为除冠的动脉以外的原因的心脏的外科绕过。在心肌的活体检视,我们由免疫组织化学评估了 Klotho 和 FGF 是否在 cardiomyocytes 被表示,并且更高心血管的风险是否影响涉及 endoplasmic 蜂窝胃应力的另外的分子的表示,氧化应力,发炎并且 fibrosis.ResultsOnly ,有更高心血管的风险的病人的 cardiomyocytes 显示出 Klotho 的更低的表示,但是 FGF 的更高的表情。而且,更高心血管的风险与增加的表示被联系氧化并且网状的应力,发炎和 fibrosis.ConclusionsThis 学习的 endoplasmic 第一次证明 Klotho 蛋白质在人的 cardiomyocytes 被表示, Klotho 的那心脏的表情在更高心血管的风险病人是下面调整的,当压力相关的分子的表示显著地被增加时。 | Giovanni Corsetti Evasio Pasini Tiziano M Scarabelli Claudia Romano Pratik R Agrawal Carol Chen-Scarabelli Richard Knight Louis Saravolatz Jagat Narula Mario Ferrari-Vivaldi Vincenzo Flati Deodato Assanelli Francesco S Dioguardi | 2016 | Journal of Geriatric Cardiology2016，13，8： | 7 |
| 3 | 血管钙化:血管钙化与主要急性冠状动脉事件的演变关系显示文摘冠状动脉(简称冠脉)钙化是冠脉粥样硬化的明确证据。Agatston评分反映钙化程度和密度,其与患者发生主要急性冠脉事件的风险密切相关。动脉粥样硬化发生后,内皮细胞受损,低密度脂蛋白胆固醇(LDLc)渗透至管壁内膜下,内膜下胶原蛋白中的蛋白聚糖对LDLc具有高亲和力,将脂蛋白胆固醇复合物滞留其中。随着内皮损伤的修复,LDLc被捕获至内膜下,滞留的LDLc诱导上覆内皮的炎性反应,使内皮表达趋化肽,趋化肽吸引血液中的单核细胞,使单核细胞沿浓度梯度进入组织,成为巨噬细胞,巨噬细胞吞噬并消化动脉粥样硬化中刺激性的LDLc。在消化LDLc的过程中,巨噬细胞中的酶使LDLc复合物氧化,氧化的低密度脂蛋白(LDL)对巨噬细胞产生毒性,当其数量充足时,可导致巨噬细胞死亡,促进动脉粥样硬化的炎性反应。在坏死性炎性病灶中,调控组织中钙、磷浓度的机制失调,使得磷酸钙的溶度积过高,从而产生微小的磷酸钙晶体。随着炎性反应的持续存在,更多的磷酸钙晶体形成并聚集。当这些聚集的磷酸钙晶体超过1 mm时,就成为临床CT可识别的冠脉钙化。连续的门控心脏CT扫描证实,一旦形成CT可见的钙化,其大小不会明显减少,但可能会增加。 | H.William Strauss Takehiro Nakahara Navneet Narula Jagat Narula 俞雯吉(译) 王跃涛(审校 | 2021 | 中华核医学与分子影像杂志2021，41，12： | 4 |
| 4 | A pathobiologic link between risk factors profile and morphological markers of carotid instability显示文摘 | Alessandro Mauriello Giuseppe M. Sangiorgi Renu Virmani Santi Trimarchi David R. Holmes Frank D. Kolodgie David G. Piepgras Giulia Piperno Doriana Liotti Jagat Narula Paolo Righini Arnaldo Ippoliti Luigi G. Spagnoli | 2009 | Atherosclerosis2009，，2： | 2 |
| 5 | Transition from open to robotic assisted liver resection:A retrospective comparative study.Is experience of laparoscopic liver resections needed?显示文摘Objective:The authors present outcomes of robotic liver resections in comparison with open technique questioning the need to have experience of laparoscopy for such procedures before transition to robotic assisted.Materials and methods:Retrospective review of liver resections done robotically from February 2015 to June 2017 compared to matched control cohort of open cases from January 2012 to December 2016.Results:Twenty-one patients in the study groupwere comparedwithmatched control of 42 open cases(1:2 ratio).The types of procedure were similar in both the groups.There were 4 left lateral hepatectomy,3 left hepatectomy,and 1 left hepatectomy with hepatico-jejunostomy,3 right hepatectomy,3 right posterior sectorectomy,4 bisegmentectomy and 4 mono-segmentectomy.There were 9 patients with primary liver cancer,2 each with livermetastasis and carcinoma gall bladder and 8 patients had benign liver disease.Mean blood losswas 370±311ml in the robotic group compared to 451±330ml in control group(p=0.06).Minor complications developed in 19.0%of robotic cases compared to 40.5%in open surgery,while major complications occurred in 4.7%of robotic cases compared to 7.1%of open cases.Mean hospital staywas 5.3±0.8 days for the robotic group and 7.7±4.2 days for open group(p=0.02).Local tumor recurrence occurred in 1 out of 13 resections done for malignancy in the robotic group and 7 out of 26 in the open group.Conclusion:This study highlights the utility of surgical robots for segmental and complex liver resections with equivalent outcomes and decreased length of hospital stay compared to open surgery without having experience of same with the laparoscopy. | Sanjay Goja Sanjay Kumar Yadav Rohan Jagat Chaudhary Manoj Kumar Singh Arvinder Singh Soin | 2019 | Laparoscopic, Endoscopic and Robotic Surgery2019，2，4： | 2 |
| 6 | Changes in Plaque Lipid Content after Short-Term, Intensive versus Standard Statin Therapy: The YELLOW Trial显示文摘 | Annapoorna S. Kini Usman Baber Jason C. Kovacic Atul Limaye Ziad A. Ali Joseph Sweeny Akiko Maehara Roxana Mehran George Dangas Gary S. Mintz Valentin Fuster Jagat Narula Samin K. Sharma Pedro R. Moreno | 2013 | Journal of the American College of Cardiology2013，，： | 2 |
| 7 | Left Ventricular Form and Function Revisited: Applied Translational Science to Cardiovascular Ultrasound Imaging显示文摘 | Partho P. Sengupta Vijay K. Krishnamoorthy Josef Korinek Jagat Narula Mani A. Vannan Steven J. Lester Jamil A. Tajik James B. Seward Bijoy K. Khandheria Marek Belohlavek | 2007 | Journal of the American Society of Echocardiography2007，，5： | 2 |
| 8 | Promoting cardiovascularhealth worldwide: strategies, challenges, and opportunities显示文摘 | JOSE M C JAGAT N JAVIER C | 2014 | Revista Espafiola de Cardiologia:English edition2014，67，9： | 1 |
| 9 | Treatment of Cornual Heterotopic Pregnancy via Selective Reduction without Feticide Drug显示文摘 | Zhang Qiong Li Yanping Deep Jagat Prasad Zhu Lin | 2011 | The Journal of Minimally Invasive Gynecology2011，，6： | 1 |
| 10 | Spatial orientation of the ventricular muscle band: Physiologic contribution and surgical implications显示文摘 | Francisco Torrent-Guasp Manel Ballester Gerald D. Buckberg Francesc Carreras Albert Flotats Ignasi Carrió Ana Ferreira Louis E. Samuels Jagat Narula | 2001 | The Journal of Thoracic and Cardiovascular Surgery2001，，2： | 1 |
| 11 | Detection of High-Risk Atherosclerotic Plaque显示文摘 | Jerome L. Fleg Gregg W. Stone Zahi A. Fayad Juan F. Granada Thomas S. Hatsukami Frank D. Kolodgie Jacques Ohayon Roderic Pettigrew Marc S. Sabatine Guillermo J. Tearney Sergio Waxman Michael J. Domanski Pothur R. Srinivas Jagat Narula | 2012 | JACC: Cardiovascular Imaging2012，，9： | 1 |
| 12 | Role of Caspases in Ox-LDL–Induced Apoptotic Cascade in Human Coronary Artery Endothelial Cells显示文摘 | Jiawei Chen Jawahar L. Mehta Nezam Haider Xingjian Zhang Jagat Narula Dayuan Li | 2004 | Circulation Research: Journal of the American Heart Association2004，，3： | 1 |
| 13 | Noninvasive localization of human atherosclerotic lesions with indium 111-labeled monoclonal Z2D3 antibody specific for proliferating smooth muscle cells显示文摘 | CARRIO I JAGAT N LOURDES P | 1998 | J Nucl Cardiol1998，5，6： | 1 |
| 14 | Assessment of Myocardial Mechanics Using Speckle Tracking Echocardiography: Fundamentals and Clinical Applications显示文摘 | Holly Geyer Giuseppe Caracciolo Haruhiko Abe Susan Wilansky Scipione Carerj Federico Gentile Hans-Joachim Nesser Bijoy Khandheria Jagat Narula Partho P. Sengupta | 2010 | Journal of the American Society of Echocardiography2010，，4： | 1 |
| 15 | Evaluation of in situ fracture versus phaco chop techniques显示文摘 | Jagat Ram Thomas A. Wesendahl Gerd U. Auffarth David J. Apple | 1998 | Journal of Cataract & Refractive Surgery1998，，11： | 1 |
| 16 | Apoptosis and heart 显示文摘 | Jagat N Mcgan KA Wilensmith J | 1997 | Chest1997，112，5： | 1 |
| 17 | Treatment of Cornual Heterotopic Pregnancy via Selective Reduction without Feticide Drug显示文摘 | Zhang Qiong Li Yanping Deep Jagat Prasad Zhu Lin | 2011 | The Journal of Minimally Invasive Gynecology2011，，6： | 1 |
| 18 | A highly efficientsynthesis of the C13 side-chain of Taxol using Shibasaki' sasymmetric Henry reaction 显示文摘 | Jagat C B Siddhartha G J Joshodeep B el al | 2004 | Tetrahedron Lett2004，45，18： | 1 |
| 19 | Recognizing Global Burden of Cardiovascular Disease and Related Chronic Diseases显示文摘 | Bridget B. Kelly Jagat Narula Valentín Fuster | 2012 | Mt Sinai J Med2012，，6： | 1 |
| 20 | Assessment of Myocardial Mechanics Using Speckle Tracking Echocardiography: Fundamentals and Clinical Applications显示文摘 | Holly Geyer Giuseppe Caracciolo Haruhiko Abe Susan Wilansky Scipione Carerj Federico Gentile Hans-Joachim Nesser Bijoy Khandheria Jagat Narula Partho P. Sengupta | 2010 | Journal of the American Society of Echocardiography2010，，： | 1 |
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