|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Genome-wide analysis identified 17 new loci influencing intraocular pressure in Chinese population显示文摘Intraocular pressure(IOP) is a major risk factor for glaucoma. Genetic determinants of intraocular pressure can provide critical insights into the genetic architecture of glaucoma and, as a result, open new avenues for therapeutic intervention. We performed a genome-wide association study and replication analysis of 8,552 Chinese participants. In the genome-wide association study, we identified 51 loci that surpassed the significance of P<9×10^(-7), and we formally replicated these loci. A combined discovery and replication meta-analysis identified 21 genome-wide loci that surpassed the genome-wide significance of P<5×10^(-8), including 4 previously reported loci: rs145063132(7 p21.2, ETV1/DGKB), rs548030386(7 q31.2, ST7 near CAV1/CAV2), rs7047871(9 p24.2, GLIS3), and rs2472494(9 q31.1, ABCA1/SLC44 A1). Of the 17 newly identified loci, five were reported to have ocular related phenotypes: PTCH2(rs7525308 in 1 p34.1), LRIF1/DRAM2(rs1282146 in 1 p13.3), COLEC11(rs201143466 in 2 p25.3),SPTBN1(rs4514918 in 2 p16.2), and CRK(rs11078446 in 17 p13.3). The genetic loci identified in this study not only increase our understanding of the genes involved in intraocular pressure but also provide important genetic markers to improve future genetic screening and drug discovery for intraocular pressure disorders. | Lulin Huang Yuhong Chen Ying Lin Pancy O.S.Tam Yilian Cheng Yi Shi Bo Gong Fang Lu Jialiang Yang Haixin Wang Yi Yin Yong Cao Dan Jiang Ling Zhong Bai Xue Jing Wang Fang Hao Dean-Yao Lee Chi-Pui Pang Xinghuai Sun Zhenglin Yang | 2019 | Science China(Life Sciences)2019，62，2： | 4 |
| 2 | Integration of high-performance spin-orbit torque MRAM devices by 200-mm-wafer manufacturing platform显示文摘We demonstrate in-plane field-free-switching spin-orbit torque(SOT)magnetic tunnel junction(MTJ)devices that are capable of low switching current density,fast speed,high reliability,and,most importantly,manufactured uniformly by the 200-mm-wafer platform.The performance of the devices is systematically studied,including their magnetic properties,switch-ing behaviors,endurance and data retention.The successful integration of SOT devices within the 200-mm-wafer manufactur-ing platform provides a feasible way to industrialize SOT MRAMs.It is expected to obtain excellent performance of the devices by further optimizing the MTJ film stacks and the corresponding fabrication processes in the future. | Hongchao Zhang Xiangyue Ma Chuanpeng Jiang Jialiang Yin Shuqin Lyu Shiyang Lu Xiantao Shang Bowen Man Cong Zhang Dandan Li Shuhui Li Wenjing Chen Hongxi Liu Gefei Wang Kaihua Cao Zhaohao Wang Weisheng Zhao | 2022 | Journal of Semiconductors2022，43，10： | 2 |
| 3 | Predictive fuzzy PID control: theory, design and simulation显示文摘 | JIALIANG LU GUANRONG CHEN and HAO YING | 2001 | Information Sciences2001，137，14： | 1 |
| 4 | Dynamically reconfigurable subwavelength optical device for hydrogen sulfide gas sensing显示文摘The importance of tunable subwavelength optical devices in modern electromagnetic and photonic systems is indisputable.Herein,a lithography-free,wide-angle,and reconfigurable subwavelength optical device with high tunability operating in the near-infrared regions is proposed and experimentally demonstrated,based on a reversible nanochemistry approach.The reconfigurable subwavelength optical device basically comprises an ultrathin copper oxide(CuO)thin film on an optical thick gold substrate by utilizing the reversible chemical conversion of CuO to sulfides upon exposure to hydrogen sulfide gas.Proof-of-concept experimental results show that the maximal modulation depth of reflectance can be as high as 90%at the wavelength of 1.79μm with the initial thickness of CuO taken as 150 nm.Partially reflected wave calculations combined with the transfer matrix method are employed to analytically investigate the optical properties of the structure,which show good agreement with experimental results.We believe that the proposed versatile approaches can be implemented for dynamic control management,allowing applications in tunable photonics,active displays,optical encryption,and gas sensing. | ZHENGJI WEN JIALIANG LU WEIWEI YU HAO WU HAO XIE XIAOHANG PAN QIANQIAN XU ZIJI ZHOU CHONG TAN DONGJIE ZHOU CHANG LIU YAN SUN NING DAI JIAMING HAO | 2021 | Photonics Research2021，9，10： | 1 |
| 5 | The calculating method opti- mization and influencing factor analysis of deviation factor for abnor- mally pressured gas reservoirs显示文摘 | Shen Weijun Lu Jialiang Li Xizhe | 2014 | EJGE2014，19，17： | 1 |
| 6 | 'Predictive fuzzy PID control:theory, design and simulation 显示文摘 | Jialiang Lu Guanrong Chen Hao Ying | 2001 | Information Sciences (S0020-0255)2001，137，9： | 1 |
| 7 | Predictive Fuzzy PID Control:Theory, Design and Simulation 显示文摘 | Jialiang Lu Guanrong Chen Hao Ying | 2001 | Information Sciences2001，137，： | 1 |
| 8 | Detecting geo-relation phrases from web texts for triplet extraction of geographic knowledge:a context-enhanced method显示文摘As an effective organization form of geographic information,a geographic knowledge graph(GeoKG)facilitates numerous geography-related analyses and services.The completeness of triplets regarding geographic knowledge determines the quality of GeoKG,thus drawing considerable attention in the related domains.Mass unstructured geographic knowledge scattered in web texts has been regarded as a potential source for enriching the triplets in GeoKGs.The crux of triplet extraction from web texts lies in the detection of key phrases indicating the correct geo-relations between geo-entities.However,the current methods for key-phrase detection are ineffective because the sparseness of the terms in the web texts describing geo-relations results in an insufficient training corpus.In this study,an unsupervised context-enhanced method is proposed to detect geo-relation key phrases from web texts for extracting triplets.External semantic knowledge is introduced to relieve the influence of the sparseness of the georelation description terms in web texts.Specifically,the contexts of geo-entities are fused with category semantic knowledge and word semantic knowledge.Subsequently,an enhanced corpus is generated using frequency-based statistics.Finally,the geo-relation key phrases are detected from the enhanced contexts using the statistical lexical features from the enhanced corpus.Experiments are conducted with real web texts.In comparison with the well-known frequency-based methods,the proposed method improves the precision of detecting the key phrases of the geo-relation description by approximately 20%.Moreover,compared with the well-defined geo-relation properties in DBpedia,the proposed method provides quintuple key-phrases for indicating the geo-relations between geo-entities,which facilitate the generation of new triplets from web texts. | Peiyuan Qiu Li Yu Jialiang Gao Feng Lu | 2019 | Big Earth Data2019，3，3： | 1 |
| 9 | Physicochemical properties and ability to generate free radicals of ambient coarse, fine, and ultrafine particles in the atmosphere of Xuanwei, China, an area of high lung cancer incidence显示文摘 | Senlin Lu Fei Yi Xiaojie Hao Shang Yu Jingjing Ren Minghong Wu Feng Jialiang Shinich Yonemochi Qingyue Wang | 2013 | Atmospheric Environment2013，，： | 1 |
| 10 | Predictive fuzzy PID control:theory,design and simulation显示文摘 | LU Jialiang CHEN Guangrong YING Hao | 2001 | Information Sciences2001，137，14： | 1 |
| 11 | A Location Algorithm with Improved Accuracy Based on Correction of Noise High-Order Cumulant显示文摘The Non-line-of-sight(NLOS) error is the key issue for mobile user location in cellular wireless communication system. In this paper, we propose a robust and accurate approach using biased Kalman filter based on third-order cumulant to mitigate the NLOS error. The simulation results indicate that with less prior information about communication environments, the approach we present has a better location performance even in severe NLOS situations. | WANG Jianhui LU Zhiyu WANG Jialiang | 2017 | Chinese Journal of Electronics2017，26，1： | 1 |
| 12 | Redefining the Age of the Cenozoic Shanwang Formation in Shanwang Basin显示文摘Objective The Shanwang Basin is a small Cenozoic sedimentary basin located in Linqu county,Shandong province.The Shanwang Formation,especially the diatomaceous shale member,contains diverse and finely preserved flora and fauna fossils(Fig.1).Previous paleontological study and radiometric dating show that it was formed in the Miocene.However,on the precise age of the formation,there are such different opinions as Late Miocene。 | YU Jifeng ZHAO Xiangguang PANG Xinlong JASON Hilton FU Wenzhao ZHAO Xiuli SONG Zhaojun HU Jialiang LU Lei ZHANG Hongjun YANG Ziqun QIAO Wenyan SHI Suo | 2017 | Acta Geologica Sinica(English Edition)2017，91，4： | 1 |
| 13 | Genomic variation,origin tracing,and vaccine development of SARS-CoV-2:A systematic review显示文摘COVID-19 has spread globally to over 200 countries with more than 40 million confirmed cases and one million deaths as of November 1,2020.The SARS-CoV-2 virus,leading to COVID-19,shows extremely high rates of infectivity and replication,and can result in pneumonia,acute respiratory distress,or even mortality.SARS-CoV-2 has been found to continue to rapidly evolve,with several genomic variants emerging in different regions throughout the world.In addition,despite intensive study of the spike protein,its origin,and molecular mechanisms in mediating host invasion are still only partially resolved.Finally,the repertoire of drugs for COVID-19 treatment is still limited,with several candidates still under clinical trial and no effective therapeutic yet reported.Although vaccines based on either DNA/mRNA or protein have been deployed,their efficacy against emerging variants requires ongoing study,with multivalent vaccines supplanting the first-generation vaccines due to their low efficacy against new strains.Here,we provide a systematic review of studies on the epidemiology,immunological pathogenesis,molecular mechanisms,and structural biology,as well as approaches for drug or vaccine development for SARSCoV-2. | Tianbao Li Tao Huang Cheng Guo Ailan Wang Xiaoli Shi Xiaofei Mo Qingqing Lu Jing Sun Tingting Hui Geng Tian Leyi Wang Jialiang Yang | 2021 | The Innovation2021，2，2： | 1 |
| 14 | Predictive fuzzy PID control:theory design and simulation 显示文摘 | Jialiang Lu Guanrong Chen Hao Ying | 2001 | Information Sciences2001，137，： | 1 |
| 15 | Predictive fuzzy PID control: Theory, design and simulation显示文摘 | Jialiang Lu Guanrong Chen Hao Ying | 2001 | Information Sciences2001，137，14： | 1 |
| 16 | Mechanical properties and fracture surface roughness of thermally damaged granite under dynamic splitting显示文摘In order to understand the mechanical properties and the fracture surface roughness characteristics of thermally damaged granite under dynamic splitting,dynamic Brazilian splitting tests were conducted on granite samples after thermal treatment at 25,200,400,and 600℃.Results show that the dynamic peak splitting strength of thermally damaged granite samples increases with increasing strain rate,showing obvious strain‐rate sensitivity.With increasing temperature,thermally induced cracks in granite transform from intergranular cracks to intragranular cracks,and to a transgranular crack network.Thermally induced damages reduce the dynamic peak splitting strength and the maximum absorbed energy while increasing the peak radial strain.The fracture mode of the thermally damaged granite under dynamic loads is mode Ⅱ splitting failure.By using the axial roughness index Z2 a,the distribution ranges of the wedge‐shaped failure zones and the tensile failure zones in the fracture surfaces under dynamic Brazilian splitting can be effectively identified.The radial roughness index Z_(2)^(r)is sensitive to the strain rate and temperature.It shows a linear correlation with the peak splitting strength and the maximum absorbed energy and a linear negative correlation with the peak radial strain.Z_(2)^(r)can be used to quantitatively estimate the dynamic parameters based on the models proposed. | Yijin Qian Peng Jia Songze Mao Jialiang Lu | 2024 | Deep Underground Science and Engineering2024，3，1： | 0 |
| 17 | Single-cell technologies:From research to application显示文摘In recent years,more and more single-cell technologies have been developed.A vast amount of single-cell omics data has been generated by large projects,such as the Human Cell Atlas,the Mouse Cell Atlas,the Mouse RNA Atlas,the Mouse ATAC Atlas,and the Plant Cell Atlas.Based on these single-cell big data,thousands of bioinformatics algorithms for quality control,clustering,cell-type annotation,developmental inference,cell-cell transition,cell-cell interaction,and spatial analysis are developed.With powerful experimental single-cell technology and state-of-the-art big data analysis methods based on artificial intelligence,the molecular landscape at the single-cell level can be revealed. | Lu Wen Guoqiang Li Tao Huang Wei Geng Hao Pei Jialiang Yang Miao Zhu Pengfei Zhang Rui Hou Geng Tian Wentao Su Jian Chen Dake Zhang Pingan Zhu Wei Zhang Xiuxin Zhang Ning Zhang Yunlong Zhao Xin Cao Guangdun Peng Xianwen Ren Nan Jiang Caihuan Tian Zi-Jiang Chen | 2022 | The Innovation2022，3，6： | 0 |
| 18 | Application of ion-in-conjugation molecules in resistive memories and gas sensors: The role of conjugation显示文摘Ion-in-conjugation(IIC) materials are eme rging as an important class of organic electronic materials with wide applications in energy storage,resistive memories and gas sensors.Many IIC materials were designed and investigated,however the role of conjugation in IIC materials’ performance is yet investigated.Here we designed two molecules obtained by condensation of 4-butylaniline and oxocarbon acid.Squaric acid derivatives squaraine named SA-Bu and a croconamide named CA-Bu which only differ in their oxocarbon cores.While employing SA-Bu and CA-Bu as resistive memory and gas sensory materials,SA-Bu has attained promising performance in ternary memo ry and detection of NO_(2) as low as 10 parts-per-billion whereas CA-Bu show mainly binary memory behavior and negligible NO_(2) response.Theoretical calculations reveal that conjugation of CA-Bu was distorted by the increased steric hindrance,frustrating the charge transport and suppressing the conductivity.Our work demonstrates that the conjugation plays a crucial role in ion-in-materials promoting ternary RRAM devices and highperformance gas sensors manufacture. | Jialiang Wei Jie Li Chuang Yu Qimeng Sun Jinghui He Jianmei Lu | 2021 | Chinese Chemical Letters2021，32，8： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员