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| 1 | Improved survival of porcine acute liver failure by a bioartificial liver device implanted with induced human functional hepatocytes显示文摘 | Xiao-Lei Shi Yimeng Gao YupengYan HuchengMa Lulu Sun Pengyu Huang Xuan Ni Ludi Zhang Xin Zhao Haozhen Ren Dan Hu Yan Zhou Feng Tian Yuan Ji Xin Cheng Guoyu Pan Yi-Tao Ding LijianHui | 2016 | Cell Research2016，26，2： | 31 |
| 2 | Comparison of parathyroid hormone (1-34) and elcatonin in postmenopausal women with osteoporosis: an 18-month randomized, multicenter controlled trial in China显示文摘 | LI Ying XUAN Miao WANG Bo YANG Jun ZHANG Hong ZHANG Xiu-zhen GUO Xiao-hui Lü Xiao-feng XUE Qing-yun YANG Gang-yi JI Qiu-he LIU Zhi-min LI Cheng-jiang WU Tian-feng SHENG Zheng-yan LI Peng-qiu TONG Jiu-cui | 2013 | Chinese Medical Journal2013，，3： | 24 |
| 3 | Relation between electricity structure of the crust and deformation of crustal blocks on the northeastern margin of Qinghai-Tibet Plateau显示文摘Study on the electricity structure along a magnetotelluric (MT) sounding profile on the northeastern margin of Qinghai-Tibet Plateau indicates that four crustal blocks can be de-termined from southwest to northeast, namely Bayan Har block (BH), Qin-Qi block (QQ), Hai-yuan block (HY) or the North-South seismotectonic belt and Ordos block (OD). The BH, QQ and OD blocks display a similar electricity structure of the crust. The upper crust represents a high- resistivity layer and the upper part of lower crust represents a low-resistivity layer with the resis-tivity increasing gradually with depth from the lower part of lower crust to the upper mantle. The electricity structure of the crust in these three blocks is similar to that in the complete blocks on the southern and eastern margins of the Qinghai-Tibet Plateau and belongs to normal electricity layering of the crust in slightly deformed or complete intracontinental blocks. The crust in HY block as a boundary zone has been significantly deformed, hence its electricity layering was de-stroyed and the structure was complex and the block became a recent tectonically active and great seismo-active region. The contact belts between the blocks on the northeastern margin of Qinghai-Tibet Plateau exhibit both upthrusting outward and strike-slip movement different from those on the southern and eastern margins of the plateau. The genesis of the low-resistivity layer in the crust is analyzed and the thickness of the lithosphere is estimated in the paper. | ZHAO Guoze TANG Ji ZHAN Yan CHEN Xiaobin ZHUO Xianjun WANG Jijun XUAN Fei DENG Qianhui ZHAO Junmeng | 2005 | Science China Earth Sciences2005，48，10： | 20 |
| 4 | Inhibition of long non-coding RNA TUG1 on gastric cancer cell transference and invasion through regulating and controlling the expression of miR-144/c-Met axis显示文摘Objective: To discuss the expression of long noncoding RNA TUG1(lnc RNA-TUG1) in gastric carcinoma(GC) and its effects on the transferring and invading capacity of gastric carcinoma cells. Methods: Forty cases of carcinoma tissue and para-carcinoma tissue were selected from GC patients who underwent surgical removal in Zhejiang Provincial Hospital of Chinese Traditional Medicine and Wenzhou Central Hospital from January, 2013 to December, 2014; the expressing level of lnc RNA-TUG1 in GC and para-C tissues was detected by applying the q RT-PCR technique. The correlation between lnc RNA-TUG1 expression and patients' clinical data was classified and analyzed. SGC-7901 cells were transfected using lnc RNA-TUG1 specific si RNA. Changes of the transferring and invading capacity of si RNAtransfected SGC-7901 cells were scratch-tested and transwell-detected. q RT-PCR was applied to detect the expression level of micro RNA-144 after lnc RNA-TUG1 was silenced. Changes of c-Met m RNA and protein expressions was detected by q RT-PCR and western-blot test. Results: The expression level of lnc RNA-TUG1 in GC tissue was significant higher than that in para-C tissue(P<0.05) and the high expression level of lnc RNA-TUG1 in GC tissue was significantly correlated with tumor lymph nodes metastasis and advance TNM phasing(P<0.05). The transferring and invading capacity of SGC-7901 cells was highly inhibited after being transfected by lnc RNA-TUG1 specific si RNA(P<0.05). The results of q RT-PCR and western-blot proved that the expression of micro RNA-144 was significantly boosted and the expression level of c-Met m RNA and protein was inhibited after lnc RNA-TUG1 was silenced(P<0.05). Conclusions: lnc RNA-TUG1 shows an up-regulated expression in GC tissue and that bears a correlation with clinicopathological features of malignant tumor. lnc RNATUG1 can promote the transferring and invading capacity of GC by inhibiting the pathway of micro RNA-144/c-Met. | Ting-Ting Ji Xuan Huang Jie Jin Sheng-Hua Pan Xiao-Ju Zhuge | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，5： | 20 |
| 5 | Research advances in traditional Chinese medicine syndromes in cancer patients显示文摘Traditional Chinese medicine(TCM)syndrome,also known as TCM ZHENG or TCM pattern,is an integral and essential part of TCM theory that helps to guide the design of individualized treatments.A TCM syndrome,in essence,is a characteristic profi le of all clinical manifestations in one patient that can be readily identifi ed by a TCM practitioner.In this article,the authors reviewed the presentations of TCM syndromes in seven common malignancies(liver,lung,gastric,breast,colorectal,pancreatic and esophageal cancers),the objectivity and the standardization of TCM syndrome differentiation,the evaluation of TCM syndrome modeling in cancer research,and syndrome differentiation-guided TCM treatment of cancers.A better understanding of TCM syndrome theory,as well as its potential biological basis,may contribute greatly to the clinical TCM diagnosis and the treatment of cancer. | Qing Ji Yun-quan Luo Wen-hai Wang Xuan Liu Qi Li Shi-bing Su | 2016 | Journal of Integrative Medicine2016，14，1： | 17 |
| 6 | Carbon monoxide-induced adventitious rooting of hypo-cotyl cuttings from mung bean seedling显示文摘In this paper, the regulatory role of ex-ogenous carbon monoxide (CO) during the genera-tion and development of adventitious roots in mung bean (Phaseolus radiatus L. cv. Mingguang) hypo-cotyl cuttings was surveyed. The results indicated that, like nitric oxide (NO), CO donor Hematin in-duced adventitious rooting in dose- and time-de- pendent manners. These responses were also prov- en by the addition of gaseous CO aqueous solution with different concentrations. Additionally, the above CO-mediated effect was differently reversed when CO scavenger hemoglobin (Hb), CO specific syn-thetic inhibitor ZnPPIX, the auxin transport inhibitor NPA and nitric oxide synthase (NOS) inhibitor L-NAME were added with Hematin, respectively. Furthermore, after being treated with CO for 36 h, NO fluorescence was significantly enhanced and mainly distributed in the zone of vascular bundles whereas the specific NO scavenger cPTIO significantly inhib-ited NO fluorescence induced by CO, indicating that CO induces adventitious rooting of hypocotyl cuttings from mung bean seedling probably mediated by NO/NOS pathway. | XU Ji XUAN Wei HUANG Benkai ZHOU Yehua LING Tengfang XU Sheng SHEN Wenbiao | 2006 | Chinese Science Bulletin2006，51，6： | 16 |
| 7 | A randomized, multicenter controlled trial to compare the efficacy of recombinant human parathyroid hormone (1-34) with elcatonin in postmenopausal women with osteoporosis in China显示文摘背景 Recombinant 人的甲状旁腺的荷尔蒙(1-34 )(rhPTH (注射给的 1 -34)) 一新生物产品的第七班药,它被采用基因再结合准备技术。rhPTH (1 -34) 主要被用来对待骨质疏松症,特别为绝经后的 women.This,学习为在中国的 11 个城市的区域与骨质疏松症对待绝经后的女人把 rhPTH (1-34 ) 的临床的功效和安全与 elcatonin 作比较。有骨质疏松症的 205 个女人被注册在的方法一 6 月, multicenter,使随机化的、控制学习。他们被使随机化收到任何一个 rhPTH (1-34 ) 20 ug (200 U ) 日报或 elcatonin 20 U 周刊。腰部的脊骨(L1-4 ) 和大腿骨的颈骨头矿物质密度(BMD ) ,以及骨头周转的生物化学的标记被测量。不利事件是增加的 recorded.Results rhPTH (1-34 ) 腰部的 BMD 非常显著地在 3 个月和 6 个月做了 elcatonin (2.38% 对 0.59% , P < 0.05;5.51% 对 1.55% , P < 0.01 ) ,但是没有在在大腿骨的颈的这二个组的 BMD 的重要增加。在 rhPTH 的骨头标记有更大的吝啬的增加(1 个 -34) 组比在在 3 个月和 6 个月的 elcatonin 组(浆液骨头特定的碱的磷酸酶(BSAP )36.79% 对 0.31% ;92.42% 对 -0.17% ;尿 N-telopeptide/creatinine (NTX/Cr )48.91% 对 -5.32% ;68.82% 对 -10.86%) 。处理很好被容忍,没有重要差别,在任何不利事件和任何严肃的不利事件的比例在二个组之间检测(67.0% 对 59.0% ;0 对 0 ).Conclusions rhPTH (1-34 ) 比 elcatonin 在骨头形成上有更积极的效果,由腰部的 BMD 和骨头形成标记的更大的增长出现与在肝的仅仅温和的不利事件和没有重要变化,肾或 hematological 索引。 | ZHANG Xiu-zhen WANG Bo YANG Jun XUAN Miao SONG Li-ge LI Hong GUO Xiao-hui LU Xiao-feng XUE Qing-yun YANG Gang-yi JI Qiu-he SHEN Jie LIU Zhi-min LI Cheng-jiang WU Tian-feng TONG Xiao-cui JIA Yuan | 2009 | Chinese Medical Journal2009，，24： | 12 |
| 8 | Vam3, a derivative of resveratrol, attenuates cigarette smoke-induced autophagy显示文摘瞄准: 估价 Vam3 (Amurensis H ) 的功效, resveratrol 的二聚的衍生物,在禁止香烟导致烟的 autophagy。 | Ji SHI Ning YIN Ling-ling XUAN Chun-suo YAO Ai-min MENG Qi HOU | 2012 | Acta Pharmacologica Sinica2012，33，7： | 12 |
| 9 | Ultrathin Al2O3-coated reduced graphene oxide membrane for stable lithium metal anode显示文摘Lithium(Li) metal has been considered as the most attractive anode materials for Li-ion batteries(LIBs)due to its high theoretic specific capacity. The formation of unstable solid electrolyte interphase(SEI) and dendritic Li on the metal anode, however, hindered its practical application. Herein, to address the issues, a Li-free electrode with ultrathin Al_2O_3 coated on reduced graphene oxide(rGO) membrane that covers a Cu foil current collector was developed. The composite electrode exhibits excellent interfacial protection of lithium metal deposited between Cu foil and rGO electrochemically. Firstly, it affords good Li^+ permeability from the electrolyte. Secondly, the ultrathin Al_2O_3 has sufficient mechanical strength to inhibit the penetration of Li dendrite. Li metal was observed uniformly deposited between rGO membrane and Cu collector, and stable cycle performance of Li plating/stripping with Coulombic efficiency of ~91.75% at the 100 th cycle is achieved in organic carbonate electrolyte without any additives. | Fan Zhang Fei Shen ZhaoYang Fan Xin Ji Bin Zhao ZhouTing Sun YingYing Xuan XiaoGang Han | 2018 | Rare Metals2018，37，6： | 11 |
| 10 | Identification and characterization of an ancient class of small RNAs enriched in serum associating with active infection显示文摘 | Yunfang Zhang Ying Zhang Junchao Shi He Zhang Zhonghong Cao Xuan Gao Wanhua Ren Yunna Ning Lina Ning Yujing Cao Yongchang Chen Weizhi Ji Zi-jiang Chen Qi Chen Enkui Duan | 2014 | Journal of Molecular Cell Biology2014，8，2： | 10 |
| 11 | Numerical simulation of topography effects on the “00.7” severe rainfall in Beijing显示文摘In an effort to study the severe rainfall event of 4—5th July 2000 in Beijing (with 24h accumulated precipitation of 240 mm), we perform numerical simulations to investigate this event using the MM5v3.6 model. The model is initialized with the MM5/WRF 3DVAR analysis, which incorporates the ground-based GPS precipitable water vapor, automatic and conventional meteorological observations in its assimilation step. For 24 h accumulated precipitation forecast, the threat scores are 0.72, 0.76, 0.67 and 0.63, for thresholds of 1, 5, 10, and 20 mm, respectively. Holding other factors unchanged, sensitivity experiments were conducted with different topographic resolutions of 110, 50 and 3.7 km to investigate the topographic effects on precipitation over the Beijing area. In these sensitivity experiments, we attempt to preserve the realistic orographic distribution in the model topography under the condition of keeping the dynamic-thermodynamic consistency of the initial model atmosphere to the extent possible. Results indicate that the unique topographic distribution and variations in the Beijing area play an important role in determining the location, distribution and intensity of heavy precipitation. | ZHANG Chaolin JI Chongping KUO Yinghwa FAN Shuiyong XUAN Chunyi CHEN Min | 2005 | Progress in Natural Science:Materials International2005，15，9： | 8 |
| 12 | Association of Overlapped and Un-overlapped Comorbidities with COVID-19 Severity and Treatment Outcomes: A Retrospective Cohort Study from Nine Provinces in China显示文摘Objective Several COVID-19 patients have overlapping comorbidities. The independent role of each component contributing to the risk of COVID-19 is unknown, and how some non-cardiometabolic comorbidities affect the risk of COVID-19 remains unclear.Methods A retrospective follow-up design was adopted. A total of 1,160 laboratory-confirmed patients were enrolled from nine provinces in China. Data on comorbidities were obtained from the patients’ medical records. Multivariable logistic regression models were used to estimate the odds ratio(OR) and 95% confidence interval(95% CI) of the associations between comorbidities(cardiometabolic or non-cardiometabolic diseases), clinical severity, and treatment outcomes of COVID-19.Results Overall, 158(13.6%) patients were diagnosed with severe illness and 32(2.7%) had unfavorable outcomes. Hypertension(2.87, 1.30–6.32), type 2 diabetes(T2 DM)(3.57, 2.32–5.49),cardiovascular disease(CVD)(3.78, 1.81–7.89), fatty liver disease(7.53, 1.96–28.96), hyperlipidemia(2.15, 1.26–3.67), other lung diseases(6.00, 3.01–11.96), and electrolyte imbalance(10.40, 3.00–26.10)were independently linked to increased odds of being severely ill. T2 DM(6.07, 2.89–12.75), CVD(8.47,6.03–11.89), and electrolyte imbalance(19.44, 11.47–32.96) were also strong predictors of unfavorable outcomes. Women with comorbidities were more likely to have severe disease on admission(5.46,3.25–9.19), while men with comorbidities were more likely to have unfavorable treatment outcomes(6.58, 1.46–29.64) within two weeks.Conclusion Besides hypertension, diabetes, and CVD, fatty liver disease, hyperlipidemia, other lung diseases, and electrolyte imbalance were independent risk factors for COVID-19 severity and poor treatment outcome. Women with comorbidities were more likely to have severe disease, while men with comorbidities were more likely to have unfavorable treatment outcomes. | MA Yan ZHU Dong Shan CHEN Ren Bo SHI Nan Nan LIU Si Hong FAN Yi Pin WU Gui Hui YANG Pu Ye BAI Jiang Feng CHEN Hong CHEN Li Ying FENG Qiao GUO Tuan Mao HOU Yong HU Gui Fen HU Xiao Mei HU Yun Hong HUANG Jin HUANG Qiu Hua HUANG Shao Zhen JI Liang JIN Hai Hao LEI Xiao LI Chun Yan LI Min Qing LI Qun Tang LI Xian Yong LIU Hong De LIU Jin Ping LIU Zhang MA Yu Ting MAO Ya MO Liu Fen NA Hui WANG Jing Wei SONG Fang Li SUN Sheng WANG Dong Ting WANG Ming Xuan WANG Xiao Yan WANG Yin Zhen WANG Yu Dong WU Wei WU Lan Ping XIAO Yan Hua XIE Hai Jun XU Hong Ming XU Shou Fang XUE Rui Xia YANG Chun YANG Kai Jun YUAN Sheng Li ZHANG Gong Qi ZHANG Jin Bo ZHANG Lin Song ZHAO Shu Sen ZHAO Wan Ying ZHENG Kai ZHOU Ying Chun ZHU Jun Teng ZHU Tian Qing ZHANG Hua Min WANG Yan Ping WANG Yong Yan 无 | 2020 | Biomedical and Environmental Sciences2020，33，12： | 8 |
| 13 | Characterizing Spatial Patterns of Precipitation Based on Corrected TRMM_3B_(43) Data over the Mid Tianshan Mountains of China显示文摘The poor distribution of meteorological stations results in a limited understanding of the precipitation pattern in the Tianshan Mountains. The spatial patterns of precipitation over the mid Tianshan Mountains were characterized based on the TRMM 3B43 monthly precipitation data. By comparing satellite estimates with observed data, it shows that TRMM 3B43 data underestimate the precipitation in mountain region. Regression models were developed to improve the TRMM 3B43 data, using geographic location and topographic variables extracted from DEM using GIS technology. The explained variance in observed precipitation was improved from 64% (from TRMM 3B43 products alone) to over 82% and the bias reduced by over 30% when location and topographic variables were added. We recalculated all the TRMM 3B43 monthly precipitation grids for the period 1998 to 2009 using the best regression models, and then studied the variation patterns of precipitation over the mid Tianshan Mountains. The results are well explained by a general understanding of the patterns of precipitation and orographic effects. This indicated that the Tianshan Mountains strongly influences the amount and distribution of precipitation in the region. This is highlighted by the confinement of the precipitation maxima to the windward (northern slope). And complex vertical changes in the provenance and distribution of precipitation, like that a negative increasing rate of precipitation in the vertical direction exists in the north but does not in south. The results have also revealed large gradients and different patterns in seasonal precipitation that are not simply related to elevation, the distribution of precipitation may also be affected by other seasonal factors such as the sources of moist air, wind direction and temperature. | JI Xuan CHEN Yunfang | 2012 | Journal of Mountain Science2012，9，5： | 8 |
| 14 | Effects of ecological factors on secondary metabolites and inorganic elements of Scutellaria baicalensis and analysis of geoherblism显示文摘This study analyzed the effects of ecological factors on secondary metabolites of Scutellaria baicalensis using two sources:92individual roots of S.baicalensis from all over China,and secondary metabolites,medicinal materials and inorganic element contents obtained from the testing of 92 S.baicalensis rhizosphere soil samples.The study used environmental data from the Genuine Medicinal Material Spatial Analysis Database.Most of the chemical constituents of S.baicalensis were negatively correlated to latitude and positively correlated to temperature;generally,the contents of 21 chemical constituents were higher at low latitudes than that at high latitudes.By gradual regression analysis,it was found that the content of baicalin in S.baicalensis was negatively correlated to latitude and generally the content of inorganic elements in soil was excessively high(excluding Mg and Ca),which has a negative effect on the accumulation of chemical constituents in S.baicalensis.Based on the cluster analysis of 21 constituents,S.baicalensis from different places of origin was divided into two groups,and S.baicalensis was not genuine only in a specific small region.Within the zone from Chifeng,Inner Mongolia to Taibai,Shaanxi is suitable for accumulation of secondary metabolites of S.baicalensis and such a zone represents a suitable distribution and potential genuine producing area. | GUO LanPing WANG Sheng ZHANG Ji YANG Guang ZHAO ManXi MA WeiFeng ZHANG XiaoBo LI Xuan HAN BangXing CHEN NaiFu HUANG LuQi | 2013 | Science China(Life Sciences)2013，56，11： | 7 |
| 15 | Vam3, a resveratrol dimer, inhibits cigarette smoke- induced cell apoptosis in lungs by improving mitochondrial function显示文摘 | Ling-ling XUAN Ji SHI Chun-suo YAO Jin-ye BAI Feng QU Jin-lan ZHANG Qi HOU | 2014 | Acta Pharmacologica Sinica2014，35，6： | 5 |
| 16 | Combination of heterogeneous Fenton-like reaction and photocatalysis using Co–TiO_2 nanocatalyst for activation of KHSO_5 with visible light irradiation at ambient conditions显示文摘A novel coupled system using Co–Ti O2was successfully designed which combined two different heterogeneous advanced oxidation processes,sulfate radical based Fenton-like reaction(SR-Fenton)and visible light photocatalysis(Vis-Photo),for degradation of organic contaminants.The synergistic effect of SR-Fenton and Vis-Photo was observed through comparative tests of 50 mg/L Rhodamine B(Rh B)degradation and TOC removal.The Rhodamine B degradation rate and TOC removal were 100%and 68.1%using the SR-Fenton/Vis-Photo combined process under ambient conditions,respectively.Moreover,based on XRD,XPS and UV-DRS characterization,it can be deduced that tricobalt tetroxide located on the surface of the catalyst is the SR-Fenton active site,and cobalt ion implanted in the Ti O2lattice is the reason for the visible light photocatalytic activity of Co–Ti O2.Finally,the effects of the calcination temperature and cobalt concentration on the synergistic performance were also investigated and a possible mechanism for the synergistic system was proposed.This coupled system exhibited excellent catalytic stability and reusability,and almost no dissolution of Co2+was found. | Qingkong Chen Fangying Ji Qian Guo Jianping Fan Xuan Xu | 2014 | Journal of Environmental Sciences2014，26，12： | 5 |
| 17 | Bi-, Y-Codoped TiO2 for Carbon Dioxide Photocatalytic Reduction to Formic Acid under Visible Light Irradiation显示文摘 | Pengju Du Tongming Su Xuan Luo Xiantai Zhou Zuzeng Qin Hongbing Ji Jianhua Chen | 2018 | Chinese Journal of Chemistry2018，36，6： | 5 |
| 18 | Expression of miR-1304 in patients with esophageal carcinoma and risk factors for recurrence显示文摘BACKGROUND Esophageal carcinoma is a malignant gastrointestinal tumor with a very poor prognosis.MicroRNA(miR)-1304 is a newly discovered non-coding RNA,which shows differential expression in other cancers,and its clinical value in esophageal carcinoma remains unclear.AIM To explore the expression of miR-1304 in patients with esophageal carcinoma and its clinical value.METHODS The expression of miR-1304 in patients with esophageal carcinoma was analyzed based on the data on miR in esophageal carcinoma downloaded from The Cancer Genome Atlas database.Quantitative real-time polymerase chain reaction was adopted to determine the expression of miR-1304 in the tissues and serum of patients.The clinical diagnostic value of miR-1304 and independent factors for recurrence and prognosis of esophageal carcinoma were then analyzed.The potential target genes of miR-1304 were predicted,and then analyzed based on gene ontology,Kyoto Encyclopedia of Genes,and Genomes,and protein-protein interaction.RESULTS The expression of miR-1304 in the tissues and serum of patients with esophageal carcinoma increased,and was also increased according to the database.Patients with high expression of miR-1304 suffered increased rates of tumor≥3 cm,low differentiation and stage II+III.miR-1304 had a diagnostic value in identifying esophageal carcinoma,tumor size,differentiation and TNM stage.Tumor size,differentiation,TNM stage,and miR-1304 were independent risk factors for recurrence of esophageal carcinoma,and they had certain predictive and diagnostic value for the recurrence of esophageal carcinoma.Seventy-eight patients showed a 3-year survival rate of 38.46%,and patients with high expression of miR-1304 had a relatively lower survival rate.Multivariate analysis revealed that tumor size,differentiation,recurrence and miR-1304 were independent factors for the prognosis of patients.MiRTarBase,miRDB,and Targetscan predicted 20 target genes in total.Gene ontology enrichment analysis found 18 functions with aP<0.05,and Kyoto Encyclopedia of Genes,and Genomes analysis found 11 signal pathways with aP<0.05.String analysis of protein co-expression found 269 relationship pairs,of which co-expression with epidermal growth factor was the most common.CONCLUSION miR-1304 can be used as a potential indicator for the diagnosis and recurrence of esophageal carcinoma and for survival of patients with this disease. | Yun-Gang Luo Li-Wei Duan Xuan Ji Wen-Yuan Jia Yun Liu Mao-Lei Sun Guo-Min Liu | 2020 | World Journal of Gastroenterology2020，26，6： | 4 |
| 19 | Mycophenolic acid inhibits SLE-associated cytokine expression and promotes apoptosis of peripheral blood mononuclear cells from patients with systemic lupus erythematosus显示文摘瞄准:在 cytokine 生产和外部血的 apoptosis 上调查新奇抑制免疫力的药 mycophenolic (MPA ) 的效果有全身性红斑狼疮(SLE ) 的病人的单音的原子房间(PBMC ) 。方法:在从 41 个 SLE 病人的有教养的 PBMC 的上层清液的 IL-10, IL-12, IFN-gamma, sFas 和 sFasL 的层次被 ABC-ELISA 方法决定。IFN-gamma (+) IL-10 (-) , IFN-gamma (-) IL-10 (+) ,和 IFN-gamma (+) IL-10 (+) 的百分比在 CD4+ 房间的子集被三色的流动血细胞计数检测。apoptotic Th 房间的百分比被 AV-FITC/PI 流动血细胞计数检测。从 22 个性可比较、年龄可比较的健康的人的样品被用作正常控制。结果:IL-10, IL-12,和 IFN-gamma 的层次都显著地从 SLE 样品在有教养的 PBMC 的上层清液被提高,与正常控制相比。自发地从 SLE 由 PBMC 提高了 IL-10, IL-12,和 IFN-gamma 的生产并且由 phytohaemagglutinin (公众房产管理局) 刺激了被 MPA 显著地减少。当 MPA 被增加进文化时,在从 SLE 的有教养的 PBMC 的 CD4 (+) IFN-gamma (-) IL-10 (+) 和 CD4 (+) IFN-gamma (+) IL-10 (+) 房间子集的百分比显著地被增加,但是减少。在是为 48 h 的有教养的在试管内以后, SLE 病人的 PBMC 象 apoptosis 的一个更高的百分比一样显示出 sFasL 的更高的分泌物。MPA 显著地增加了 SLE PBMC 的 apoptotic 百分比,但是减少了 sFasL 和 sFas 的分泌物。结论:MPA 减少联系 SLE 的 cytokines 的反常生产,例如 IL-10, IL-12,和 IFN-gamma;禁止 CD4 (+) IFN-gamma (+) IL-10, CD4 (+) IFN-gamma (-) IL-10 (+) 和 CD4 (+) IFN-gamma (+) IL-10 (+) 子集的增加;并且在 SLE 支持 PBMC 的 apoptosis 病人,它可以为 SLE 与 MPA 的治疗学的机制被联系。 | Ding-lei SU Hui-juan WANG Xiao-hui JI Yuan-yuan LI Heng-bao XUAN Chun HENG Yu-feng LI | 2006 | Acta Pharmacologica Sinica2006，27，8： | 4 |
| 20 | Autophagy enhanced by curcumin ameliorates inflammation in atherogenesis via the TFEB-P300-BRD4 axis显示文摘Disturbance of macrophage-associated lipid metabolism plays a key role in atherosclerosis.Crosstalk between autophagy deficiency and inflammation response in foam cells(FCs) through epigenetic regulation is still poorly understood. Here, we demonstrate that in macrophages, oxidized lowdensity lipoprotein(ox-LDL) leads to abnormal crosstalk between autophagy and inflammation,thereby causing aberrant lipid metabolism mediated through a dysfunctional transcription factor EB (TFEB)-P300-bromodomain-containing protein 4(BRD4) axis. ox-LDL led to macrophage autophagy deficiency along with TFEB cytoplasmic accumulation and increased reactive oxygen species generation. This activated P300 promoted BRD4 binding on the promoter regions of inflammatory genes, consequently contributing to inflammation with atherogenesis. Particularly, ox-LDL activated BRD4-dependent super-enhancer associated with liquid-liquid phase separation(LLPS) on the regulatory regions of inflammatory genes. Curcumin(Cur) prominently restored FCs autophagy by promoting TFEB nuclear translocation, optimizing lipid catabolism, and reducing inflammation. The consequences of P300 and BRD4 on super-enhancer formation and inflammatory response in FCs could be prevented by Cur. Furthermore, the anti-atherogenesis effect of Cur was inhibited by macrophage-specific Brd4 overexpression or Tfeb knock-out in Apoe knock-out mice via bone marrow transplantation. The findings identify a novel TFEB-P300-BRD4 axis and establish a new epigenetic paradigm by which Cur regulates autophagy, inhibits inflammation, and decreases lipid content. | Xuesong Li Ruigong Zhu Hong Jiang Quanwen Yin Jiaming Gu Jiajing Chen Xian Ji Xuan Wu Haiping Fu Hui Wang Xin Tang Yuanqing Gao Bingjian Wang Yong Ji Hongshan Chen | 2022 | Acta Pharmaceutica Sinica B2022，12，5： | 4 |
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