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4篇 您的检索式:作者名="J.Cowan"
    题名 作者 年代 出处 被引量
1Transgenic Overexpression of CD39 Protects Against Renal Ischemia‐Reperfusion and Transplant Vascular Injury显示文摘S.Crikis B.Lu L. M.Murray‐Segal C.Selan S. C.Robson A. J. F.D’Apice H. H.Nandurkar P. J.Cowan K. M.Dwyer 2010American Journal of Transplantation2010,,12:1
2Transgenic Overexpression of CD39 Protects Against Renal Ischemia‐Reperfusion and Transplant Vascular Injury显示文摘S.Crikis B.Lu L. M.Murray‐Segal C.Selan S. C.Robson A. J. F.D’Apice H. H.Nandurkar P. J.Cowan K. M.Dwyer 2010American Journal of Transplantation2010,,12:1
3An Overview of Antiviral Peptides and Rational Biodesign Considerations显示文摘Viral diseases have contributed significantly to worldwide morbidity and mortality throughout history.Despite the existence of therapeutic treatments for many viral infections,antiviral resistance and the threat posed by novel viruses highlight the need for an increased number of effective therapeutics.In addition to small molecule drugs and biologics,antimicrobial peptides(AMPs)represent an emerging class of potential antiviral therapeutics.While AMPs have traditionally been regarded in the context of their antibacterial activities,many AMPs are now known to be antiviral.These antiviral peptides(AVPs)have been shown to target and perturb viral membrane envelopes and inhibit various stages of the viral life cycle,from preattachment inhibition through viral release from infected host cells.Rational design of AMPs has also proven effective in identifying highly active and specific peptides and can aid in the discovery of lead peptides with high therapeutic selectivity.In this review,we highlight AVPs with strong antiviral activity largely curated from a publicly available AMP database.We then compile the sequences present in our AVP database to generate structural predictions of generic AVP motifs.Finally,we cover the rational design approaches available for AVPs taking into account approaches currently used for the rational design of AMPs.Ying-Chiang J.Lee Jaden D.Shirkey Jongbeom Park Karishma Bisht Alexis J.Cowan 2022BioDesign Research2022,,1:0
4GREENHOUSE GAS AND AMMONIA EMISSION MITIGATION PRIORITIES FOR UK POLICY TARGETS显示文摘Agriculture is essential for providing food and maintaining food security while concurrently delivering multiple other ecosystem services. However,agricultural systems are generally a net source of greenhouse gases and ammonia. They, therefore, need to substantively contribute to climate change mitigation and net zero ambitions. It is widely acknowledged that there is a need to further reduce and mitigate emissions across sectors, including agriculture to address the climate emergency and emissions gap. This discussion paper outlines a collation of opinions from a range of experts within agricultural research and advisory roles following a greenhouse gas and ammonia emission mitigation workshop held in the UK in March 2022. The meeting identified the top mitigation priorities within the UK's agricultural sector to achieve reductions in greenhouse gases and ammonia that are compatible with policy targets. In addition, experts provided an overview of what they believe are the key knowledge gaps, future opportunities and cobenefits to mitigation practices as well as indicating the potential barriers to uptake for mitigation scenarios discussed.Sarah BUCKINGHAM Cairistiona F.E.TOPP Pete SMITH Vera EORY David R.CHADWICK Christina K.BAXTER Joanna M.CLOY Shaun CONNOLLY Emily C.COOLEDGE Nicholas J.COWAN Julia DREWER Colm DUFFY Naomi JFOX Asma JEBARI Becky JENKINS Dominika J.KROL Karina A.MARSDEN Graham A.MCAULIFFE Steven J.MORRISON Vincent O'FLAHERTY Rachael RAMSEY Karl G.RICHARDS Rainer ROEHE Jo SMITH Kate SMITH Taro TAKAHASHI Rachel E.THORMAN John WILLIAMS Jeremy WILTSHIRE Robert M.REES 2023Frontiers of Agricultural Science and Engineering2023,10,2:0
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