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| 1 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 2 | A novel 7-modified camptothecin analog overcomes breast cancer resistance protein-associated resistance in a mitoxantrone selected colon carcinoma cell line 显示文摘 | Perego P De Cesare M De Isabella P | 2001 | Cancer Res2001，61，16： | 1 |
| 3 | Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy显示文摘 | Vincenzo P Isabella M Eloisa A Barbel LS Laura V Monika A | 1998 | Am Heart Assoc1998，97，10： | 1 |
| 4 | Alliance management: a view from the past and a look to the future显示文摘 | Spckman R E Forbes T M Isabella L A Macavoy T C | 1998 | Journal of Management Studies1998，，35： | 1 |
| 5 | Systemic meta-analysis assessing the short term applicability of early conversion to mammalian target of rapamycin inhibitors in kidney transplant显示文摘AIM To consolidate the present evidence of effectiveness in renal functioning and graft survival following early introduction of mammalian target of rapamycin(m TOR) inhibitors with or without calcineurin inhibitors(CNIs) in renal transplant recipients.METHODS We analysed the current literature following PROSPERO approval describing the role of immunosuppressive agent, m TOR inhibitors as an alternative to CNI within six months of renal transplant by searching the Pub Med, EMBASE, Cochrane, Crossref, and Scopus using Me SH terms. RESULTS Six articles of early withdrawal of CNI and introduction of m TOR-inhibitors within six months of renal transplantation were sought. Glomerular filtration rate(GFR) and serum creatinine were significantly better in m TOR inhibitor group with equivalent survival at 12 mo, even though Biopsy Proven Acute rejection was significantly higher in m TOR-inhibitor group. CONCLUSION The evidence reviewed in this meta-analysis suggests that early introduction m TOR-inhibitors substantial CNI minimization. The m TOR inhibitors such as everolimus and sirolimus, due to their complementary mechanism of action and favourable nephrotoxicity profile; better glomerular filtration, lower serum creatinine with equivalent survival. Having said that, due to the higher rejection rate, may influence the use of these regimens to patients with moderate to high immunological risk patients. | Jayant Kumar Isabella Reccia Tomokazu Kusano Bridson M Julie Ajay Sharma Ahmed Halawa | 2017 | World Journal of Transplantation2017，7，2： | 1 |
| 6 | An alternative synthesis of tematloxacin, a potent antibacterial agent 显示文摘 | Daniel T W Chu Isabella M Lieo Akiyo K Claiborne | 1992 | Can J Chem1992，70，： | 1 |
| 7 | Significance of hepatic arterial responsiveness for adequate tissue oxygenation upon portal vein occlusion in cirrhotic livers显示文摘 | Isabella Mücke Sven Richter Michael D. Menger Brigitte Vollmar | 2000 | International Journal of Colorectal Disease (-)2000，，5： | 1 |
| 8 | Hierarchically as- sembled ZnO nanocrystallites for high-efficiency dye-sensi- tized solar cells显示文摘 | Nafiseh M Isabella C Antonio B | 2011 | Angew Chem2011，123，12： | 1 |
| 9 | Stent coating with titanium-nitride-oxide for reduction of neointimal hyperplasia显示文摘 | Windecker S Isabella M Pasquate GD | 2001 | Circulation2001，104，8： | 1 |
| 10 | Analysis of the hierar- chy of quorum-sensing regulation in Pseudomonas aeruginosa显示文摘 | WAGNER V E LI L L ISABELLA V M | 2007 | Anal Bioanal Chem2007，387，2： | 1 |
| 11 | HLA DR13 and HCV Vertical Infection显示文摘 | Isabella B Gina A Wilma M | 2002 | Pedia Res2002，51，6： | 1 |
| 12 | Alliance management: A view from the past and a look to the future 显示文摘 | SPEKMAN R E FORBES T M ISABELLA L A MACAVOR T C | 1998 | Journal of Management Studies1998，35，6： | 1 |
| 13 | Alliance management: A view from the past and a look to the future 显示文摘 | Spekman R E Forbes T M Isabella L A | 1998 | Journal of Management Studies1998，35，6： | 1 |
| 14 | Phylogeography and evo- lutionary history of reassortant H9N2 viruses with potential hu- man health implications 显示文摘 | Alice F Isabella M Annalisa S | 2011 | Virology2011，85，： | 1 |
| 15 | Induced Endometriosis in the Baboon (Papio anubis) Increase the Expression of the Proangiogenic Factor CYR61 (CCN1) in Eutopic and Ectopic Endometria 显示文摘 | Isabella Gashaw Julie M Hastings Kevin S Jackson | 2006 | Soc Study Repro2006，74，6： | 1 |
| 16 | Alliance Management: A View From The Past And A Look To The Future显示文摘 | Spekman Robert E Theodore M Forbes Ⅲ Lynn A Isabella | 1998 | Journal of Management Studies1998，35，： | 1 |
| 17 | Alliance Management: A View from the Past and a Look to the Future显示文摘 | Spekman R E Forbes T M Isabella L A Macavor T C | 1998 | Journal of Management Studies1998，，35： | 1 |
| 18 | Alliance management:a view from the past and a look to the future显示文摘 | SPEKMAN R E FORBES T M ISABELLA L | 1998 | Journal of Management Studies1998，35，6： | 1 |
| 19 | 查看详情显示文摘 | Zeman M Isabella O Jaeger K | | 0，，： | 1 |
| 20 | Concomitant facilitation of GABA<sub>A</sub> receptors and K<sub>V</sub>7 channels by the non‐opioid analgesic flupirtine显示文摘 | Felicia Klinger Petra Geier Mario M Dorostkar Giri K Chandaka Arsalan Yousuf Isabella Salzer Helmut Kubista Stefan Boehm | 2012 | British Journal of Pharmacology2012，，5： | 1 |
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