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| 1 | Approach to medical therapy in perianal Crohn’s disease显示文摘Perianal Crohn’s disease remains a challenging condition to treat and can have a substantial negative impact on quality of life.It often requires combined surgical and medical interventions.Anti-tumor necrosis factor(anti-TNF)therapy,including infliximab and adalimumab,remain preferred medical therapies for perianal Crohn’s disease.Infliximab has been shown to be efficacious in improving fistula closure rates in randomized controlled trials.Clinicians can be faced with a number of questions relating to the optimal use of anti-TNF therapy in perianal Crohn’s disease.Specific issues include evaluation for the presence of perianal sepsis,the treatment target of therapy,the ideal time to commence treatment,whether additional medical therapy should be used in conjunction with anti-TNF therapy,and the duration of treatment.This article will discuss key studies which can assist clinicians in addressing these matters when they are considering or have already commenced anti-TNF therapy for the treatment of perianal Crohn’s disease.It will also discuss current evidence regarding the use of vedolizumab and ustekinumab in patients who are failing to achieve a response to anti-TNF therapy for perianal Crohn’s disease.Lastly,new therapies such as local injection of mesenchymal stem cell therapy will be discussed. | Abhinav Vasudevan David H Bruining Edward V Loftus Jr William Faubion Eric C Ehman Laura Raffals | 2021 | World Journal of Gastroenterology2021，27，25： | 4 |
| 2 | HCV ‐associated B ‐cell non‐ H odgkin lymphomas and new direct antiviral agents显示文摘 | Paul Carrier Arnaud Jaccard Jérémie Jacques Tessa Tabouret Marilyne Debette‐Gratien Julie Abraham Laura Mesturoux Pierre Marquet Sophie Alain Denis Sautereau Marie Essig Véronique Loustaud‐Ratti | 2015 | Liver Int2015，，10： | 2 |
| 3 | Asiatic Callosciurus squirrels as seed dispersers of exotic plants in the Pampas显示文摘 | S. Yasmin BOBADILLA Veronica V, BENITEZ M. Laura GUICHON | 2016 | Current Zoology2016，62，3： | 2 |
| 4 | Near room-temperature magnetoealoria properties of Gd-Ga alloys 显示文摘 | Tanjore V Jayaraman Laura Boone Jeffrry E Shield | 2014 | J Magn Magn Mater2014，363，： | 1 |
| 5 | The influence of the auditory prosthesis type on deaf children's voice quality显示文摘 | JESUS V G JOSEP M V R LAURA G S | 2010 | Int J Pediatric Otorhinolaryngol2010，74，： | 1 |
| 6 | Stem cell factor in mast cells and increased mast cell density in idiopathic and ischemic cardiomyopathy显示文摘 | Vincenzo P Isabella M Eloisa A Barbel LS Laura V Monika A | 1998 | Am Heart Assoc1998，97，10： | 1 |
| 7 | Daily and seasonal variation of CO2 in the city of Rome in relationship with the traffic volume 显示文摘 | Loretta G Laura V | 2005 | Atmospheric Environment2005，39，： | 1 |
| 8 | Mag- netocaloric effect and refrigerant capacity in melt-spun Gd- Mn alloy显示文摘 | Tanjore V Jayaraman Laura Boone Jeffrry E Shield | 2013 | J Magn Magn Mater2013，345，： | 1 |
| 9 | Hyperplasia of the mandibular condyle:clinical,histopathologic,and treatment considerations in a series of 36 patients显示文摘 | Laura V A Florencio M Raúl G G | 2011 | Journal of Oral&Maxillofacial Surgery Official Journal of the American Association of Oral&Maxillofacial Surgeons2011，69，2： | 1 |
| 10 | Clinical and Electrophysiological Aspects of Charcot-Marie-Tooth Disease显示文摘 | Laura M Scaioli V | 2006 | Neuro Molecular Medicine2006，8，： | 1 |
| 11 | The on-line asymmetric traveling salesman problem显示文摘 | Ausiello G Bonifaci V Laura L | 2008 | Journal of Discrete Algorithms2008，6，2： | 1 |
| 12 | Production of a defensin-like antifungal protein NFAP from Neosartorya fischeri in Pichia pastoris and its antifungal activity against filamentous fungal isolates from human infections显示文摘 | Máté Virágh Dóra V?r?s Zoltán Kele Laura Kovács ádám Fizil Gergely Lakatos Gergely Maróti Gyula Batta Csaba Vágv?lgyi László Galgóczy | 2014 | Protein Expression and Purification2014，，： | 1 |
| 13 | Current Microbiology显示文摘 | Laura A Silo-Suh Eric V Stabb Sandra J Raffel | 1998 | 37(1):6-111998，37，1： | 1 |
| 14 | Ventilator - associated pneu- monia in an adult clinical surgical intensive care unit of a brazilian uni- versity hospltal: incidence, risk factors, etiology, and antibiotic resist- ance 显示文摘 | Laura de A Carolina V Renata C | 2008 | Braz J Infect Dis2008，12，1： | 1 |
| 15 | Clinical and electrophysiological aspects of Charcot-Marie-Tooth disease显示文摘 | Pareyson D Scaioli V Laura M | 2006 | Neuromolecular Med2006，8，12： | 1 |
| 16 | Effect of culture parameters on the production of the edible mushroom Grifola frondosa (maitake) in tropical weathers显示文摘 | Sandra M B Maryeimy V L Laura L | | 0，，08： | 1 |
| 17 | Recombineering mycobacteria and their phages显示文摘 | Julia C V K Laura J M Graham F H | 2008 | Nat Rev Microbiol2008，6，11： | 1 |
| 18 | Structural organization of the tight junctions显示文摘 | Luca P Laura Ti Cristina V | 2008 | Biochimicaet Biophysica Acta2008，177，8： | 1 |
| 19 | Human expo- sure to bisphenol A (BPA) 显示文摘 | LAURA N V RUSS H MICHELE M | 2007 | Reproductive Toxicolo- gy2007，24，2： | 1 |
| 20 | Piddock, Clinically Relevant Chromosomally Encoded Multidrug Resistance Efflux Pumps in Bacteria 显示文摘 | Laura J V | 2006 | Clinical Microbiology Review2006，19，2： | 1 |
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