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| 1 | 低温胁迫对玉米发芽及幼苗生理特性的影响显示文摘为探究低温胁迫对玉米发芽及幼苗生理特性影响,文章以杂交玉米品种天农9和天合1为试验材料,采用低温培养(发芽期6℃,苗期4℃)方法,分析低温胁迫下玉米发芽(发芽率)、幼苗农艺性状(株高、根长、地上部及地下部干鲜重)和生理生化指标(SPAD值、Pn、MDA含量、POD活性、SOD活性、脯氨酸含量和可溶性蛋白含量)变化。结果表明,低温胁迫抑制玉米种子发芽和幼苗生长,降低幼苗株高、根长、地上部地下部干鲜重、叶绿素含量和净光合速率提高MDA含量、POD活性、SOD活性、脯氨酸含量和可溶性蛋白含量。不同品种间差异显著,天合1对低温胁迫更敏感。研究成果为解决玉米生产冷害问题提供理论依据。 | 杨德光 孙玉珺 Ali Raza Irfan 刘昕萌 吕金莹 尉菊萍 宫磊 刘哲 白冰 | 2018 | 东北农业大学学报2018，49，5： | 36 |
| 2 | Krüppel-like factors 4 and 5:the yin and yang regulators of cellular proliferation显示文摘Krüppel-like factors (KLFs) are evolutionarily conserved zinc finger-containing transcription factors with diverseregulatory functions in cell growth, proliferation, differentiation, and embryogenesis. KLF4 and KLF5 are two closelyrelated members of the KLF family that have a similar tissue distribution in embryos and adults. However, the two KLFsoften exhibit opposite effects on regulation of gene transcription, despite binding to similar, if not identical, cis-actingDNA sequences. In addition, KLF4 and 5 exert contrasting effects on cell proliferation in many instances; while KLF4is an inhibitor of cell growth, KLF5 stimulates proliferation. Here we review the biological properties and biochemicalmechanisms of action of the two KLFs in the context of growth regulation. | Amr M.GHALEB Mandayam O.NANDAN Sengthong CHANCHEVALAP W.Brian DALTON Irfan M.HISAMUDDIN Vincent W.YANG | 2005 | Cell Research2005，15，2： | 21 |
| 3 | Antibacterial activity of lemongrass(Cymbopogon citratus) oil against some selected pathogenic bacterias显示文摘Objective:To find the effectiveness of essential oil of lemongrass for the treatment of pathogenic organisms.Methods:Lemongrass oil was investigated for activity against Staphylococcus aureus (S.aureus),Bacillus cereus(B.cereus),Bacillus subtilis(B.subtilis),Escherichia coli(E.coli), Klebsiella pneumoniae(K.pneumoniae) and Pseudomonas aeruginosa(P.aeruginosa),using Agar Diffusion Method and Broth Dilution Method.Minimum inhibitory concentration(MIC) and minimum bactericidal concentration(MBC) were determined by the Broth Dilution Method. The antibiotic susceptibility test against the test organisms was performed by Disc Diffusion Method.Results:Lemongrass was found effective against all the test organisms except P. aeruginosa.Gram positive organisms were found more sensitive to lemon grass oil as compared to gram negative organisms.The test organisms were found inhibited by Lemon grass oil at lower concentrations in Broth Dilution Method as compared to Agar Diffusion Method.Conclusions: The tested organisms,particularly gram-negative organisms had shown high resistance towards different antibiotics whereas they were found to be inhibited by lemongrass oil even at lower concentration.Thus lemongrass oil is effective against drug resistant organisms.It can be suggested that use of lemongrass oil would be helpful in the treatment of infections caused by multidrug resistant organisms. | Mohd Irfan Naik Bashir Ahmad Fomda Ebenezar Jaykumar Javid Ahmad Bhat | 2010 | Asian Pacific Journal of Tropical Medicine2010，3，7： | 14 |
| 4 | Evaluation of the adsorption potential of titanium dioxide nanoparticles for arsenic removal显示文摘The adsorption potential of titanium dioxide(TiO2) nanoparticles for removing arsenic from drinking water was evaluated.Pure and iron-doped TiO2 particles are synthesized via sol-gel method.The synthesized TiO2 nanoparticles were then immobilized on ordinary sand for adsorption studies.Adsorption isotherms were conducted on the synthesized nanoparticles as well as the sand coated with TiO2 nanoparticles under varying conditions of air and light,namely,the air-sunlight(A-SL),air-light(AL),air-dark(AD) and nitrogen-dark(ND).X-ray diffraction(XRD) analysis showed that the pure and iron-doped TiO2 nanoparticles were in 100% anatase crystalline phase with crystal sizes of 108 and 65 nm,respectively.Adsorption of arsenic on the three adsorbents was non-linear that could be described by the Freundlich and Langmuir adsorption models.Iron doping enhanced the adsorption capacity of TiO2 nanoparticles by arresting the grain growth and making it visible light responsive resulting in a higher affnity for arsenic.Similarly,the arsenic removal by adsorption on the sand coated with TiO2 nanoparticles was the highest among the three types of sand used.In all cases,As(V) was adsorbed more compared with As(Ⅲ).The solution pH appeared to be the most important factor in controlling the amount of arsenic adsorbed. | NABI Deedar ASLAM Irfan QAZI Ishtiaq A | 2009 | Journal of Environmental Sciences2009，21，3： | 14 |
| 5 | Compartmentalized Metabolic Engineering for Artemisinin Biosynthesis and Effective Malaria Treatment by Oral Delivery of Plant Cells显示文摘Artemisinin 对药抵抗的疟疾的寄生虫是高度有效的,它将近影响全球人口和杀死的一半 > 500 000 个人每年。artemisinin 的主要费用是过去常从 Artemisia annua 提取并且净化这药的昂贵的过程。这显然不必要的步的消除将在地方性的区域使这有势力抗疟药药买得起到全球人口生活。这里,我们报导了非蛋白质药 artemisinin biosynthesized 的口头的交货(0.8 mg/g 干燥重量) 在在由设计二的烟草的临床上有意义的层次,新陈代谢的小径指向了到三不同细胞的分隔空间(叶绿体,原子核,和线粒体) 。二倍地转基因的线显示出 isopentenyl 焦磷酸盐的三方面的改进,并且指向 AACPR, DBR2,和 CYP71AV1 到叶绿体导致了更高的表示和 dihydroartemisinic 酸的有效相片氧化到 artemisinin。从转基因的烟草植物的叶子的部分净化的摘录在变形体感染 falciparum 的红血房间的 vitro 生长前进禁止了。artemisinin 减少了的整个未经触动的植物房间 bioencapsulating 的口头的喂在与商业药比较的质问老鼠的 parasitemia 层次。如此的新奇 synergistic 途径应该通过可食的植物的新陈代谢的工程便于 artemisinin 和另外的药的便宜生产和交货。 | Karan Malhotra Mayavan Subramaniyan Khushboo Rawat Md. Kalamuddin M. Irfan Qureshi Pawan Malhotra Asif Mohmmed Katrina Cornish Henry Daniell Shashi Kumar1 | 2016 | Molecular Plant2016，9，11： | 14 |
| 6 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 7 | 巴基斯坦政府门户网站公众初始接受的影响因素研究——基于使用意向和执行意向双重视角显示文摘目前巴基斯坦政府网站的公众使用还处于起步阶段。提高政府门户网站的公众初始接受度,是巴基斯坦政府发展电子政务、提高公信力、打造便民政府的关键举措,探索公众对政府网站初始采纳的影响因素具有重要意义。本研究从使用意向和执行意向双重视角重新审视传统的技术接受模型。研究结果表明,执行意向在实际行为形成过程中发挥显著的直接效应,同时通过中介效应提升使用意向对实际行为的解释力;情景线索对于执行意向具有显著正向作用。研究结果对于巴基斯坦深化政府电子政务服务、建设服务型政府网站具有理论指导意义,同时也在理论上深化了政府网站采纳的理论研究。 | Irfan Ali Shah 王芳 | 2019 | 情报学报2019，38，5： | 9 |
| 8 | The role of chemosensory protein 10 in the detection of behaviorally active compounds in brown planthopper, Nilaparvata lugens显示文摘Chemosensory proteins(CSPs)play important roles in insects’chemoreception,although their specific functional roles have not been fully elucidated.In this study,we conducted the developmental expression patterns and competitive binding assay as well as knock‐down assay by RNA interference both in vitro and in vivo to reveal the function of NlugCSP10 from the brown planthopper(BPH),Nilaparvata lugens(Stål),a major pest in rice plants.The results showed that NlugCSP10 messenger RNA was significantly higher in males than in females and correlated to gender,development and wing forms.The fluorescence binding assays revealed that NlugCSP10 exhibited the highest binding affinity with cis‐3‐hexenyl acetate,eicosane,and(+)‐β‐pinene.Behavioral assay revealed that eicosane displayed attractant activity,while cis‐3‐hexenyl acetate,similar to(+)‐β‐pinene significantly repelled N.lugens adults.Silencing of NlugCSP10,which is responsible for cis‐3‐hexenyl acetate binding,significantly disrupted cis‐3‐hexenyl acetate communication.Overall,findings of the present study showed that NlugCSP10 could selectively interrelate with numerous volatiles emitted from host plants and these ligands could be designated to develop slow‐release mediators that attract/repel N.lugens and subsequently improve the exploration of plans to control this insect pest. | Muhammad Irfan Waris Aneela Younas Muhammad Muzammal Adeel Shuang-Gang Duan Sundas Rana Quershi Rana Muhammad Kaleem Ullah Man-Qun Wang | 2020 | Insect Science2020，27，3： | 9 |
| 9 | A review on promising phytochemical, nutritional and glycemic control studies on Moringa oleifera Lam. in tropical and sub-tropical regions显示文摘Plants have provided sources to find novel compounds. These plants are being used as therapeutic purposes since the birth of mankind. The traditional healers normally utilize medicinal plants as crude drugs while scientists using the folk claim as guides to explore medicinal plants. Moringa oleifera is a famous edible plant having therapeutic and nutritive values. The present study was designed to cumulate the research data regarding to what extent, phytochemical, nutritional and glycemic control studies has been explored using its different extracts. The articles indicated that the powder, aqueous, methanol and ethanol extracts of Moringa oleifera(leaves, pods, seeds, stem and root bark) have significant therapeutic herbal potential to treat diabetes mellitus. Collectively, the mechanism behind is intestinal glucose inhibition, insulin release as well as decrease in insulin resistance probably regeneration of b-cells of pancreas, increase in glutathione and reduction in malondialdehyde. Conclusively, this article give descriptive information about antidiabetic effect, claimed marker compounds and proposed antihyperglycemic mechanism of a single plant. It can be suggested a potential herbal source to treat diabetes mellitus as being widely accepted by major population as nutrition and therapeutic agent. | Hafiz Irfan Muhammad Mohd Zaini Asmawi Nurzalina Abdul Karim Khan | 2016 | Asian Pacific Journal of Tropical Biomedicine2016，6，10： | 8 |
| 10 | Current practice of anticoagulant in the treatment of splanchnic vein thrombosis secondary to acute pancreatitis显示文摘Background:Severe acute pancreatitis is a common diagnosis in emergency general surgery and can be a cause of significant morbidity and mortality.A consequence of severe acute pancreatitis is thrombus in the splanchnic veins.These thrombi can potentially lead to bowel ischemia or hepatic failure.However,another complication of severe acute pancreatitis is retroperitoneal bleeding.At this time,it is unclear if treating patients for splanchnic vein thrombosis in the context of severe acute pancreatitis is associated with any outcome benefit.A systematic review might clarify this question.Data sources:A two-fold search strategy(one broad and one precise)looked at all published literature.The review was registered on PROSPERO(ID:CRD42018102705).MEDLINE,EMBASE,PubMed,Cochrane and Web of Science databases were searched and potentially relevant papers were reviewed indepen-dently by two researchers.Any disagreement was reviewed by a third independent researcher.Primary outcome was reestablishment of flow in the thrombosed vein versus bleeding complications.Results:Of 1462 papers assessed,a total of 16 papers were eligible for inclusion.There were no ran-domized controlled trials,2 were case series,5 retrospective single-center studies and 9 case reports.There were a total of 198 patients in these studies of whom 92(46.5%)received anticoagulation therapy.The rates of recanalization of veins in the treated and non-treated groups was 14%and 11%and bleeding complications were 16%and 5%,respectively.However,the included studies were too heterogeneous to undertake a meta-analysis.Conclusions:The systematic review highlights the lack evidence addressing this clinical question.There-fore a randomized controlled trial would be appropriate to undertake. | William Norton Gabija Lazaraviciute George Ramsay Irene Kreis Irfan Ahmed Mohamed Bekheit | 2020 | Hepatobiliary & Pancreatic Diseases International2020，19，2： | 8 |
| 11 | Pancreaticoduodenectomy: a comparison of superior approach with classical Whipple's technique显示文摘BACKGROUND: Pancreaticoduodenectomy (PD) is the standard procedure for resecting tumors arising from the periampullary area and the pancreatic head. Nevertheless this procedure is inherently difficult and associated with high morbidity and mortality. Besides, the technique applied for exposing the portal and superior mesenteric veins is time-consuming, difficult and associated with the risk of major venous injury. Recently we have introduced a modified approach for making this part of the procedure quick, safe and bloodless, which constitutes the subject of this study. METHODS: Patients who underwent pylorus preserving pancreaticoduodenectomy (PPPD) either by superior approach technique (group 1) or by classical Whipple's technique (group 2) were retrospectively identified. Age-sex composition, body mass index (BMI), total operative time, operative blood loss, intraoperative blood transfusion requirement, morbidity, mortality and length of hospital stay were compared between the two groups. RESULTS: Between January 1997 and December 2011, 72 patients underwent PPPD by the superior approach technique (group 1) and 38 underwent PPPD by the classical Whipple's technique (group 2) at our institution. Statistically significant differences were observed in operative time (208.1±46.3 minutes in group 1 vs 322.0±33.8 minutes in group 2), operative blood loss (601.0±250.3 mL in group 1 vs 1371.5±471.8 mL in group 2), and intraoperative blood transfusion requirement [10 (13.9%) patients in group 1 and 24 (63.2%) in group 2]. Among 18 (16.4%) obese patients, significant differences in operativetime, operative blood loss and intraoperative blood transfusion requirement were observed between groups 1 and 2. There was no significant inter-group difference in complication rate among obese patients, but comparing obese patients with normal weight patients revealed higher rates of complications like pancreatic fistula (27.8% vs 6.5%), delayed gastric emptying (16.7% vs 5.4%), and infective complications like wound infection and intra abdominal collection (44.4% vs 5.4%). CONCLUSIONS: On the basis of analytical data, we conclude that the superior approach technique is effective for PD compared with the classical Whipple's technique. It allows fast, safe and virtually bloodless dissection for exposure of the superior mesenteric and portal veins during early steps of PD. PD is normally a difficult and tedious procedure carrying a remote risk of major venous injury leading to substantial blood loss. | Omar Javed Shah Mushtaq A Gagloo Irfan Jan Khan Rayees Ahmad Saleema Bano | 2013 | Hepatobiliary & Pancreatic Diseases International2013，12，2： | 8 |
| 12 | Spontaneous fungal peritonitis: Micro-organisms, management and mortality in liver cirrhosis-A systematic review显示文摘BACKGROUND Spontaneous peritonitis is an infection of ascitic fluid without a known intraabdominal source of infection. spontaneous fungal peritonitis (SFP) is a potentially fatal complication of decompensated cirrhosis, defined as fungal infection of ascitic fluid in the presence of ascitic neutrophil count of greater than 250 cells/mL. AIM To determine the prevalence of fungal pathogens, management and outcomes (mortality) of SFP in critically ill cirrhotic patients. METHODS Studies were identified using PubMed, EMBASE, Cochrane Central Register of Controlled Trials and Scopus databases until February 2019. Inclusion criteria included intervention trials and observation studies describing the association between SFP and cirrhosis. The primary outcome was in-hospital, 1-mo, and 6- mo mortality rates of SFP in cirrhotic patients. Secondary outcomes were fungal microorganisms identified and in hospital management by anti-fungal medications. The National Heart, Lung and Blood Institute quality assessment tools were used to assess internal validity and risk of bias for each included study. RESULTS Six observational studies were included in this systematic review. The overall quality of included studies was good. A meta-analysis of results could not be performed because of differences in reporting of outcomes and heterogeneity of the included studies. There were 82 patients with SFP described across all the included studies. Candida species, predominantly Candida albicans was the fungal pathogen in majority of the cases (48%-81.8%) followed by Candida krusei (15%- 25%) and Candida glabrata (6.66%-20%). Cryptococcus neoformans (53.3%) was the other major fungal pathogen. Antifungal therapy in SFP patients was utilized in 33.3% to 81.8% cases. The prevalence of in hospital mortality ranged from 33.3% to 100%, whereas 1-mo mortality ranged between 50% to 73.3%. CONCLUSION This systematic review suggests that SFP in end stage liver disease patient is associated with high mortality both in the hospital and at 1-mo, and that antifungal therapy is currently underutilized. | Tooba Tariq Furqan B Irfan Mehdi Farishta Brian Dykstra Eric Martin Sieloff Archita P Desai | 2019 | World Journal of Hepatology2019，11，7： | 7 |
| 13 | Out of hospital cardiac arrest resuscitation outcome in North India—CARO study显示文摘BACKGROUND: To evaluate the outcome of cardiopulmonary resuscitation(CPR) in out-ofhospital cardiac arrests(OHCA) in India and factors infl uencing the outcome.METHODS: The outcome and related factors like demographics, aspects of the OHCA event, return of spontaneous circulation(ROSC) and survival to discharge, among the 80 adult patients presenting to emergency department experiencing OHCA considered for resuscitation between January 2014 to April 2015, were analyzed, according to the guidelines of the Utstein consensus conference.RESULTS: The survival rate to hospital admission was 32.5%, the survival rate to hospital discharge was 8.8% and with good cerebral performance category(CPC1) neurological status was 3.8%. Majority of OHCA was seen in elderly individuals between 51 to 60 years, predominately in males. Majority of OHCA were witnessed arrests(56.5%) with 1.3% bystander CPR rate, 92.5% arrests occurred at home, 96% presented with initial non-shockable rhythm and 92.5% with presumed cardiac etiology but survival was better in those who experienced OHCA at public place, in witnessed arrests, in patients who had shockable presenting rhythm and in those where CPR duration was ≤20 minutes.CONCLUSION: Witnessed arrests, early initiation of CPR by bystanders, CPR duration ≤20 minutes, initial presenting shockable rhythm, OHCA with non-cardiac etiology are associated with a good outcome. To improve the outcome of CPR and the low survival rates after an OHCA event in India, focused strategies should be designed to set up an emergency medical system(EMS), to boost the rates of bystander CPR and education of the lay public in basic CPR. | Chennappa Kalvatala Krishna Hakim Irfan Showkat Meenakshi Taktani Vikram Khatri | 2017 | World Journal of Emergency Medicine2017，8，3： | 7 |
| 14 | 柞蚕蛹解除滞育过程中海藻糖合成酶基因的表达变化显示文摘【目的】克隆柞蚕Antheraea pernyi海藻糖合成酶(trehalose-6-phosphate synthase,TPS)基因,并对其进行组织表达分析,探讨该基因在柞蚕滞育蛹解除滞育过程中的表达规律,为阐明柞蚕滞育期间碳水化合物代谢规律与蛹滞育解除的关系提供数据支持。【方法】利用PCR及3'RACE技术从柞蚕幼虫脂肪体组织中克隆得到TPS基因,并进行生物信息学分析;RT-PCR检测该基因在柞蚕幼虫各组织中的表达分布,进一步采用Real-time PCR分析柞蚕滞育蛹解除滞育过程中该基因在脂肪体组织和血淋巴中的表达量变化。【结果】克隆获得柞蚕海藻糖合成酶基因并命名为ApTPS。其开放阅读框长2 487 bp,编码828个氨基酸,蛋白预测分子量为93.19 k D,等电点(p I)4.61;无信号肽,无跨膜区。蛋白质亚细胞定位预测该蛋白定位于细胞质中;蛋白质结构域分析表明,ApTPS有两个保守功能区:TPS(第22-497位氨基酸)和TPP(第532-772位氨基酸)。组织特异性分析表明,ApTPS基因在柞蚕幼虫脂肪体中表达量最高;柞蚕解除滞育过程中,ApTPS在脂肪体和血淋巴中的表达量均有所升高,且显著高于对照组(P<0.05),但血淋巴中表达量的升高滞后于脂肪体。【结论】结果提示ApTPS参与了柞蚕蛹滞育中碳水化合物代谢调控并在其中发挥重要作用,与柞蚕蛹滞育解除关系密切。 | 黄伶 孙良振 王勇 汝玉涛 Muhammad IRFAN 姜义仁 石生林 杨瑞生 李喜升 秦利 | 2016 | 昆虫学报2016，59，9： | 7 |
| 15 | Schizonepeta tenuifolia inhibits collagen stimulated platelet function via suppressing MAPK and Akt signaling显示文摘The prevalence of cardiovascular diseases(CVDs)is increasing at a rapid pace in developed countries,and CVDs are the leading cause of morbidity and mortality.Natural products and ethnomedicine have been shown to reduce the risk of CVDs.Schizonepeta(S.)tenuifolia is a medicinal plant widely used in China,Korea,and Japan and is known to exhibit anti-inflammatory,antioxidant,and immunomodulatory activities.We hypothesized that given herbal plant exhibit pharmacological activities against CVDs,we specifically explored its effects on platelet function.Platelet aggregation was evaluated using standard light transmission aggregometry.Intracellular calcium mobilization was assessed using Fura-2/AM,and granule secretion(ATP release)was measured in a luminometer.Fibrinogen binding to integrin a_(Ⅱb)β_3,was assessed using flow cytometry.Phosphorylation of mitogen-activated protein kinase(MAPK)signaling molecules and activation of the protein kinase B(Akt)was assessed using Western blot assays.S.tenuifolia,extract potently and significantly inhibited platelet aggregation,calcium mobilization,granule secretion,and fibrinogen binding to integrin a_(Ⅱb)β_3.Moreover,all extracts significantly inhibited MAPK and Akt phosphorylation.S.tenuifolia extract inhibited platelet aggregation and granule secretion,and attenuated collagen mediated GPVI downstream signaling,indicating the potential therapeutic effects of these plant extracts on the cardiovascular system and platelet function.We suggest that S.tenuifolia extract may be a potent candidate to treat platelet-related CVDs and to be used as an antiplatelet and antithrombotic agent. | Bo-Ra Jeon Muhammad Irfan Minki Kim Seung Eun Lee Jeong Hoon Lee Man Hee Rhee | 2019 | The Journal of Biomedical Research2019，33，4： | 6 |
| 16 | Structural and functional roles of ether lipids显示文摘醚类脂化合物例如 plasmalogens,是在甘油脊梁的 sn-1 位置的烃链被一张醚契约在依附的导出 peroxisome 的 glycerophospholipids,与在更普通的 diacyl phospholipids 的一张酉旨契约对比。这个看起来简单的生物化学的变化有深刻结构、功能的含意。尤其是,醚类脂化合物的趋势建议他们在便于膜熔化有一个角色,这处理在模型膜形成非薄片状的转换六角形的结构。醚类脂化合物为类脂化合物木排 microdomains 的组织和稳定性也是重要的,涉及细胞的发信号的充满胆固醇的膜区域。除了他们的结构的角色,醚类脂化合物的一个子集被认为作为内长的抗氧化剂工作,并且新兴的研究建议他们涉及房间区别和发信号的小径。这里,我们在人的混乱考察醚类脂化合物和他们的潜在的意义的生物学,包括神经病学的疾病,癌症,和新陈代谢的混乱。 | John M. Dean Irfan J. Lodhi | 2018 | Protein & Cell2018，9，2： | 6 |
| 17 | Predictors of response to antiviral therapy in patients with chronic hepatitis C from Pakistani population显示文摘背景丙肝病毒(HCV ) 在全世界组成一个主要公共健康问题,特别在开发象巴基斯坦一样的国家。在这研究,我们估计了在长期的丙肝病人的治疗在这研究由性,年龄,和病毒的 load.Methods 分类的干扰素(INF ) 的结果,有遗传型 3 的 750 个 HCV 积极病人被选择,从哪个 616 完成了全部治疗。他们的个人历史,支持处理的 HCV RNA 和浆液丙氨酸 transaminase (中高音) 是 quantified.Patients 与 INF- 2b 的联合治疗被对待 300 万个单位(三次一个星期) 正 ribavirin (1000-1200mg 每天) 为 24 个星期。在 24 个星期以后,他们的 HCV RNA 和浆液中高音水平是从 616 个病人,的 quantified.Results (63.5%) 391 对治疗学的政体(加 ribavirin 的 INF- 2b ) 作出回应。在应答者之中, 27.1% 是男人, 36.4% 是女人。最好的治疗反应在有 Iow 的病人被观察病毒的负担 8 ?????牴湡睳汥 吗?? | Hafsa Aziz Muhammad Amin Athar Shahnaz Murtaza Javaid Irfan Yasir Waheed Iram Bilal Abida Raza | 2011 | Chinese Medical Journal2011，，9： | 6 |
| 18 | A review of recent advancements in finite element formulation for sandwich plates显示文摘Use of composite structures is exponentially growing in different fields due to their higher strength-to-weight ratio. This application trend requires that accurate theoretical explanations and their finite element models be developed for analyzing sandwich plates before finalizing the designs. This paper reviews the recent research trends of finite element formulations developed for analyzing sandwich plates. This paper reviews the finite element models developed after the year 2000. Initially, the finite element formulations based on first order shear deformation theory, higher order shear deformation theories, mixed solid-shell elements, zig-zag theories and global–local theories are presented. Then, some finite element formulations developed to analyze a very new class of structures called piezoelectric structures are presented. At the end, some formulations to analyze a very critical phenomenon called buckling are presented. | Shehzaib IRFAN Faisal SIDDIQUI | 2019 | Chinese Journal of Aeronautics2019，32，4： | 5 |
| 19 | Influence of Seed Priming on Performance and Water Productivity of Direct Seeded Rice in Alternating Wetting and Drying显示文摘Direct seeded rice is promising alternative to traditional transplanting, but requires appropriate crop and water management to maintain yield performance and achieve high water productivity. Present study evaluated the effect of seed priming and irrigation on crop establishment, tillering, agronomic traits, paddy yield, grain quality and water productivity of direct seeded rice in alternate wetting and drying(DSR-AWD) in comparison with direct seeded rice at field capacity(DSRFC). Seed priming treatments were osmo-priming with KCl(2.2%), Ca Cl2(2.2%) and moringa leaf extracts(MLE, 3.3%) including hydro-priming as control. Among the treatments, seed osmo-primed with MLE emerged earlier and had higher final emergence, followed by osmo-priming with Ca Cl2. Tillering emergence rate and number of tillers per plant were the highest for seed priming with Ca Cl2 in DSRAWD. Total productive and non-productive tillers, panicle length, biological and grain yields, harvest index were highest for seed priming with MLE or Ca Cl2 in DSR-AWD. Similarly, grain quality, estimated in terms of normal grains, abortive and chalky grains, was also the highest in DSR-AWD with MLE osmo-priming. Benefit cost ratio and water productivity was also the highest in DSR-AWD for seed priming with MLE. In conclusion, seed priming with MLE or Ca Cl2 can be successfully employed to improve the direct seeded rice performance when practiced with alternate wetting and drying irrigation. | Hafeez Ur REHMAN Muhammad KAMRAN Shahzad Maqsood Ahmed BASRA Irfan AFZAL Muhammad FAROOQ | 2015 | Rice science2015，22，4： | 5 |
| 20 | Thermo-diffusion effects on MHD stagnation point flow towards a stretching sheet in a nanofuid显示文摘Thermodiffusion effects on stagnation point flow of a nanofuid towards a stretching surface with applied magnetic field is presented.Similarity transforms are applied to reduce the equations that govem the flow to a system of nonlinear ordinary differential equations.Runge-K utta-Fehlberg method is applied to solve the sy stem.Results are compared with existing solutions that are special cases to our problem.Concrete graphical analysis is carried out to study the effects of different emerging parameters such as stretching ratio A,mag netic infuence parameter M,Prandtl number Pr,Lewis number Le,Brownian motion parameter Nb,thermophoresis parameter Nr,nanofluid Lewis number Ln,modified Dufour parameter Nd and Dufour solutal number Ld coupled with comprehensive discussions.Numerical effects of local Nusselt number,local Sherwood number and nanofluid Sherwood number are also discussed. | Umar Khan Naveed Ahmed Sheikh Irfan Ullah Khan Syed Taluseef Mohyud-din | 2014 | Propulsion and Power Research2014，3，3： | 5 |
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