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| 1 | Comparative study of esomeprazole and lansoprazole in triple therapy for eradication of Helicobacter pylori in Japan显示文摘AIM:To evaluate the efficacy and safety of esomeprazole-based triple therapy compared with lansoprazole therapy as first-line eradication therapy for patients with Helicobacter pylori(H.pylori)in usual post-marketing use in Japan,where the clarithromycin(CAM)resistance rate is 30%.METHODS:For this multicenter,randomized,openlabel,non-inferiority trial,we recruited patients(≥20years of age)with H.pylori infection from 20 hospitals in Japan.We randomly allocated patients to esomeprazole therapy(esomeprazole 20 mg,CAM 400 mg,amoxicillin(AC)750 mg for the first 7 d,with all drugs given twice daily)or lansoprazole therapy(lansoprazole30 mg,CAM 400 mg,AC 750 mg for the first 7 d,with all drugs given twice daily)using a minimization method with age,sex,and institution as adjustment factors.Our primary outcome was the eradication rate by intention-to-treat(ITT)and per-protocol(PP)analyses.H.pylori eradication was confirmed by a urea breath test from 4 to 8 wk after cessation of therapy.RESULTS:ITT analysis revealed the eradication rates of 69.4%(95%CI:61.2%-76.6%)for esomeprazole therapy and 73.9%(95%CI:65.9%-80.6%)for lansoprazole therapy(P=0.4982).PP analysis showed eradication rate of 76.9%(95%CI:68.6%-83.5%)for esomeprazole therapy and 79.8%(95%CI:71.9%-86.0%)for lansoprazole therapy(P=0.6423).There were no differences in adverse effects between the two therapies.CONCLUSION:Esomeprazole showed non-inferiority and safety in a 7 day-triple therapy for eradication of H.pylori compared with lansoprazole. | Tsutomu Nishida Masahiko Tsujii Hirohisa Tanimura Shusaku Tsutsui Shingo Tsuji Akira Takeda Atsuo Inoue Hiroyuki Fukui Toshiyuki Yoshio Osamu Kishida Hiroyuki Ogawa Masahide Oshita Ichizo Kobayashi Shinichiro Zushi Makoto Ichiba Naoto Uenoyama Yuichi Yasunaga Ryu Ishihara Mamoru Yura Masato Komori Satoshi Egawa Hideki Iijima Tetsuo Takehara | 2014 | World Journal of Gastroenterology2014，20，15： | 13 |
| 2 | Non-transmissible Sendai virus vector encoding c-myc suppressor FBP-interacting repressor for cancer therapy显示文摘AIM:To investigate a novel therapeutic strategy to target and suppress c-myc in human cancers using far up stream element(FUSE)-binding protein-interacting repressor(FIR).METHODS:Endogenous c-Myc suppression and apoptosis induction by a transient FIR-expressing vector was examined in vivo via a HA-tagged FIR(HA-FIR)expression vector.A fusion gene-deficient,non-transmissible,Sendai virus(SeV)vector encoding FIR cDNA,SeV/dF/FIR,was prepared.SeV/dF/FIR was examined for its gene transduction efficiency,viral dose dependency of antitumor effect and apoptosis induction in HeLa(cervical squamous cell carcinoma)cells and SW480(colon adenocarcinoma)cells.Antitumor efficacy in a mouse xenograft model was also examined.The molecular mechanism of the anti-tumor effect and c-Myc suppression by SeV/dF/FIR was examined using Spliceostatin A(SSA),a SAP155 inhibitor,or SAP155siRNA which induce c-Myc by increasing FIR△exon2 in HeLa cells.RESULTS:FIR was found to repress c-myc transcription and in turn the overexpression of FIR drove apoptosis through c-myc suppression.Thus,FIR expressing vectors are potentially applicable for cancer therapy.FIR is alternatively spliced by SAP155 in cancer cells lacking the transcriptional repression domain within exon 2(FIR△exon2),counteracting FIR for c-Myc protein expression.Furthermore,FIR forms a complex with SAP155 and inhibits mutual well-established functions.Thus,both the valuable effects and side effects of exogenous FIR stimuli should be tested for future clinical application.SeV/dF/FIR,a cytoplasmic RNA virus,was successfully prepared and showed highly efficient gene transduction in in vivo experiments.Furthermore,in nude mouse tumor xenograft models,SeV/dF/FIR displayed high antitumor efficiency against human cancer cells.SeV/dF/FIR suppressed SSA-activated c-Myc.SAP155 siRNA,potentially produces FIR△exon2,and led to c-Myc overexpression with phosphorylation at Ser62.HA-FIR suppressed endogenous c-Myc expression and induced apoptosis in HeLa and SW480 cells.A c-myc transcriptional suppressor FIR expressing SeV/dF/FIR showed high gene transduction efficiency with significant antitumor effects and apoptosis induction in HeLa and SW480 cells.CONCLUSION:SeV/dF/FIR showed strong tumor growth suppression with no significant side effects in an animal xenograft model,thus SeV/dF/FIR is potentially applicable for future clinical cancer treatment. | Kazuyuki Matsushita Hideaki Shimada Yasuji Ueda Makoto Inoue Mamoru Hasegawa Takeshi Tomonaga Hisahiro Matsubara Fumio Nomura | 2014 | World Journal of Gastroenterology2014，20，15： | 2 |
| 3 | Prevalence of ulcerative colitis and Crohn’s disease in Japan显示文摘 | Keiko Asakura Yuji Nishiwaki Nagamu Inoue Toshifumi Hibi Mamoru Watanabe Toru Takebayashi | 2009 | Journal of Gastroenterology2009，，7： | 1 |
| 4 | Development and Manufacturing System of Alloy 690 for PWR Steam Generator Tubing显示文摘 | Nagano Hiroo Yamanaka Kazuo Kobayashi Kenichi Inoue Mamoru | 1988 | Sumitomo Metals1988，40，4： | 1 |
| 5 | LOX Index, a Novel Predictive Biochemical Marker for Coronary Heart Disease and Stroke显示文摘 | Inoue Nobutaka Okamura Tomonori Kokubo Yoshihiro Fujita Yoshiko Sato Yuko Nakanishi Mamoru Yanagida Kazuki Kakino Akemi Iwamoto Shin Watanabe Makoto Ogura Sayoko Otsui Kazunori Matsuda Haruo Uchida Kagehiro Yoshimoto Ryo Sawamura Tatsuya | 2010 | Clinical Chemistry2010，，4： | 1 |
| 6 | Effect of recombinant human granulocyte colony-stimulating factor (rhG-CSF) on cytotoxicity of PSK-induced peritoneal polymorphonuclear leukocytes (PMNs)显示文摘 | Haruki Kato Mamoru Inoue Yoshiharu Yamamura Yutaka Kawahito Shigehiko Mukai Shigeru Sugino Motoharu Kondo | 1992 | Biotherapy1992，，3： | 1 |
| 7 | Pyrolysis and combustion toxicity of wood treated with CCA显示文摘 | Dr. Toshimi Hirata Mr. Mamoru Inoue Mr. Yasuo Fukui | 1992 | Wood Science and Technology1992，，1： | 1 |
| 8 | Seismic Design of Offshore Wind Turbine Withstands Great East Japan Earthquake and Tsunami显示文摘 | Takashi Matsunobu Shinzo Inoue Yoshiyuki Tsuji Kenji Yoshida Mamoru Komatsuzaki | 2014 | Journal of Energy and Power Engineering2014，8，12： | 1 |
| 9 | Clinical efficacy of a combination of Percoll continuous density gradient and swim-up techniques for semen processing in HIV-1 serodiscordant couples显示文摘为了评估从 HIV-1 的精液为人的免疫不全病毒类型 1 的移动( HIV-1 )包括 Percoll 连续密度坡度和修改游泳起来技术的联合的一个过程的临床的功效,感染了男性, 129 的一个总数结合 HIV-1 积极男搭挡和 HIV-1 在在2002年1月和2012年4月之间的 Keio 大学医院被对待的否定女搭挡( serodiscordant 夫妇)被检查。从 129 HIV-1 的 183 精液的一个总数感染了男性被处理。在游泳起来以后,我们成功地在恢复收集了能动精子在 normozoospermia (126/126 精液) 的情况下象 100.0% 一样高的率, oligozoospermia (6/6 ) ,和 asthenozoospermia (36/36 ) 。oligoasthenozoospermia 的恢复率是 86.7%(13/15 ) 。在处理精液,仅仅四精液(4/181:2.2%) 在感染的男性的血显示出与那些一致的病毒的核苷酸序列。在使用这些精子以后,女病人的水平感染和新生儿的没有垂直感染都没被观察。而且,没有明显的不利效果在后代被观察。这个协议允许我们收集在高度的否定能动精子评估的 HIV-1,甚至在男因素盒子中。我们断定我们的协议为减少的 HIV-1 感染并且为产出一个健康孩子是临床上有效的。 | Osamu Inoue Naoaki Kuji Hiroe Ito Mitsutoshi Yamada Toshio Hamatani Aimi Oyadomari Shingo Kato Hideji Hanabusa Keiichi Isaka Mamoru Tanaka | 2017 | Asian Journal of Andrology2017，19，2： | 0 |
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