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| 1 | Dietary L-theanine alleviated lipopolysaccharide-induced immunological stress in yellow-feathered broilers显示文摘L-theanine, a natural nonprotein amino acid with a high biological activity, is reported to exert anti-stress properties. An experiment with a 3 ? 2 factorial arrangement was conducted to investigate the effects of dietary L-theanine on growth performance and immune function in lipopolysaccharide(LPS)-challenged broilers. A total of 432 one-day-old male yellow-feathered broilers were randomly assigned to 3 dietary treatments(control, antibiotic and L-theanine diets) with 2 subgroups of each(6 replicate cages;12 birds/cage). Birds from each subgroup of the 3 dietary treatments were intra-abdominally injected with the same amount of LPS or saline at 24, 25, 26 d of age. Both dietary L-theanine and antibiotic improved(P < 0.05) the growth performance of birds before LPS injection(d 1 to 21). The effect of dietary L-theanine was better(P < 0.05) than that of antibiotic. Lipopolysaccharide decreased feed intake(FI) and body weight gain(BWG) from d 22 to 28(P < 0.05), BWG and feed to gain ratio(F:G) from d 29 to 56(P < 0.05), increased mortality in different growth periods(P < 0.05), elevated the levels of serum cortisol, a1-acid glycoprotein(a1-AGP), interleukin-6(IL-6) on d 24 and 25(P < 0.05), reduced immune organ indexes and contents of jejunal mucosal secretory immunoglobulin A(s Ig A) on d 28(P < 0.05). The decreased FI and BWG, as well as increased F:G and mortality in LPS-challenged birds, were alleviated by dietary L-theanine or antibiotic from d 29 to 56 and from d 1 to 56. Dietary L-theanine mitigated the elevated serum a1-AGP level on d 25, serum IL-6 concentration on d 24 and 26, and the decreased jejunal mucosal s Ig A content on d 28 of the LPS-challenged birds. The results indicated that L-theanine had potential to alleviate LPS-induced immune stress in broilers. | Rui Li Zehe Song Jianfei Zhao Dongxiao Huo Zhiyong Fan De-Xing Hou Xi He | 2018 | Animal Nutrition2018，，3： | 13 |
| 2 | Antioxidant Effect of Human Selenium-containing Single-chain Fv in Rat Cardiac Myocytes显示文摘Reactive oxygen species(ROS) plays a key role in human heart diseases. Glutathione peroxidase(GPX) functions as an antioxidant as it catalyzes the reduction of hydroperoxide. In order to investigate the antioxidant effect of human selenium-containing single-chain Fv(Se-scFv-B3), a new mimic of GPX, a model system of hydrogen peroxide(H2O2)-induced rat cardiac myocyte damage was established. The cardiac myocyte damage was characterized in terms of cell viability, lipid peroxidation, cell membrane integrity, and intracellular H2O2 level. The Se-scFv-B3 significantly reduced H2O2-induced cell damage as shown by the increase of cell viability, the decline of malondialdehyde(MDA) production, lactate dehydrogenase(LDH) release, and intracellular H2O2 level. So Se-scFv-B3 may have a great potential in the treatment of human heart diseases induced by ROS. | HUO Rui SHI Yi XU Jun-jie YAN Fei LV Shao-wu SU Jia-ming DUAN Yu-jing FAN Jia NING Bo CONG Deng-li YAN Gang-lin LUO Gui-min WEI Jing-yan | 2009 | Chemical Research in Chinese Universities2009，25，2： | 8 |
| 3 | Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities显示文摘Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one(2). Compounds 1 and 2 were named as Juglanstetralone A(1) and Juglanstetralone B(2). Compound 1 showed more significant anti-tumor activity than 2 against gastric cancer BGC-823 cells, wih the IC50 of 125.89 ?g?mL –1. | GUO Li-Na ZHANG Rui GUO Xue-Ying CUI Tao DONG Wei HUO Jin-Hai WANG Wei-Ming | 2015 | Chinese Journal of Natural Medicines2015，13，9： | 8 |
| 4 | A Power and Area Optimization Approach of Mixed Polarity Reed-Muller Expression for Incompletely Specified Boolean Functions显示文摘力量和芦苇思考(RM ) 电路的区域优化广泛地被担心了。然而,几乎没有退出的力量和区域,优化来临能获得所有 Pareto 原版的最佳的答案问题并且足够有效。而且,他们没认为 dont 是照顾术语,它使电路成为性能不能进一步优化。在这糊,我们建议混合极性 RM 的一条力量和区域优化途径为不完全地指定的布尔功能的表示(MPRM ) 基于非统治的排序基因算法 II (NSGA-II ) 。第一,不完全地指定的布尔功能不完全地被转变成零极性由使用的指定 MPRM (ISMPRM ) 一篇小说 ISMPRM 获得算法。第二,极性和分配 ISMPRM 的照顾术语没作为染色体被编码。最后, Pareto 最佳的答案被使用 NSGA-II 获得,在里面哪个 MPRM 相应于给定的染色体被使用一个染色体获得变换算法。结果上重要力量和区域改进能与存在力量和区域优化相比被做的电路表演 RM 接近的不完全地指定的布尔功能和 MCNC 基准电路。 | Zhen-Xue He Li-Min Xiao Li Ruan Fei Gu Zhi-Sheng Huo Guang-Jun Qin Ming-Fa Zhu F Long-Bing Zhang Rui Liu Xiang Wang | 2017 | Journal of Computer Science & Technology2017，32，2： | 4 |
| 5 | Photochemical reaction of magnesium tetraphenyl porphyrin with sulfur dioxide显示文摘有硫二氧化物(SO2 ) 的镁 tetraphenyl 卟啉(MgTPP ) 的光化学的反应被不变的荧光,紫外鈥搗i s 吸收, MS,和 XRD 在 dichloromethane (CH2Cl2 ) 调查分光镜的技术。这些系列证明在照耀下面, MgTPP 与 SO2 反应了形成 1:1 分子起初使内收步。在保留照耀并且维持 SO2 的流动的过程期间, SO2 被简化为 S2 吗?被 MgTPP 和结果用 MS 和 XRD 技术检测。与 SO2 理解 MgTPP 的光化学的反应具有基本光化学的反应机制面对 SO2 与叶绿素的这个班联系了的对阐明的关键兴趣。 | Jian Bin Zhang Chun Ping Li Tian Rui Huo Zhan Ying Liu Li Hua Liu Tong Zhang Dong Yan Zhang Xiong Hui Wei | 2010 | Chinese Chemical Letters2010，21，7： | 2 |
| 6 | PASSIVE-ACTIVE CONTROL OF POWER FLOW IN AN ISOLATION SYSTEM MOUNTED ON FLEXIBLE FOUNDATIONS显示文摘A general model of flexible isolation systems which involves both the passive and active control factors is established by inserting actuators into an passive isolation system. And the power flow transmission function in such a system as with multi disturbance, multi mounts, passive isolators and actuators is deduced. By means of the numerical simulation method, the influence of actuators on power flow transmission characteristic is studied. And as a conclusion, the passive active synthetic control strategy of power flow is summarized. | Huo Rui Shi Yin Institute of Naval Ship Equipment Noise & Vibration, Naval University of Engineering Song Kongjie Shandong University of Technology | 2001 | Chinese Journal of Mechanical Engineering2001，14，2： | 2 |
| 7 | Power flow transmission influenced by vibration source impedance for a compound system显示文摘In this paper we present the effect of vibration source on the power flow transmission in a compound flexible system. Considering the internal impedance of the source, a general model is here proposed, and the generalized transfer equations of the system and the closed form solutions for power flow in the fiexible system are then developed, with which the effects of the source characteristics on power flow transmission are discussed. The investigation shows that when the source and receiver impedances are comparable, substantial error can occur in the power flow estimation if the source is assumed to be an ideal constant force source (CFS)or a constant velocity source (CVS). | XIONG Yeping SONG Konajie and HUO Rui(Institute of Engineerng Mechanics, Shandong Univerity of Technology Jinan 250061) | 1996 | Chinese Journal of Acoustics1996，15，4： | 2 |
| 8 | Inverted U-Shaped Associations between Glycemic Indices and Serum Uric Acid Levels in the General Chinese Population:Findings from the China Cardiometabolic Disease and Cancer Cohort(4C)Study显示文摘Objective The relationship between serum uric acid(SUA)levels and glycemic indices,including plasma glucose(FPG),2-hour postload glucose(2 h-PG),and glycated hemoglobin(HbA1 c),remains inconclusive.We aimed to explore the associations between glycemic indices and SUA levels in the general Chinese population.Methods The current study was a cross-sectional analysis using the first follow-up survey data from The China Cardiometabolic Disease and Cancer Cohort Study.A total of 105,922 community-dwelling adults aged≥40 years underwent the oral glucose tolerance test and uric acid assessment.The nonlinear relationships between glycemic indices and SUA levels were explored using generalized additive models.Results A total of 30,941 men and 62,361 women were eligible for the current analysis.Generalized additive models verified the inverted U-shaped association between glycemic indices and SUA levels,but with different inflection points in men and women.The thresholds for FPG,2 h-PG,and HbA1 c for men and women were 6.5/8.0 mmol/L,11.0/14.0 mmol/L,and 6.1/6.5,respectively(SUA levels increased with increasing glycemic indices before the inflection points and then eventually decreased with further increases in the glycemic indices).Conclusion An inverted U-shaped association was observed between major glycemic indices and uric acid levels in both sexes,while the inflection points were reached earlier in men than in women. | ZHU Yuan Yue ZHENG Rui Zhi WANG Gui Xia CHEN Li SHI Li Xin SU Qing XU Min XU Yu CHEN Yu Hong YU Xue Feng YAN Li WANG Tian Ge ZHAO Zhi Yun QIN Gui Jun WAN Qin CHEN Gang GAO Zheng Nan SHEN Fei Xia LUO Zuo Jie QIN Ying Fen HUO Ya Nan LI Qiang YE Zhen ZHANG Yin Fei LIU Chao WANG You Min WU Sheng Li YANG Tao DENG Hua Cong ZHAO Jia Jun CHEN Lu Lu MU Yi Ming TANG Xu Lei HU Ru Ying WANG Wei Qing NING Guang LI Mian LU Jie Li BI Yu Fang | 2021 | Biomedical and Environmental Sciences2021，34，1： | 2 |
| 9 | Essential role of Msx1 in regulating anterior-posterior patterning of the secondary palate in mice显示文摘Development of the secondary palate displays molecular heterogeneity along the anterior-posterior axis;however, the underlying molecular mechanism remains largely unknown. MSX1 is an anteriorly expressed transcription repressor required for palate development. Here, we investigate the role of Msx1 in regional patterning of the secondary palate. The Wnt1-Cre-mediated expression of Msx1(Rosa Msx1^(Wnt1-Cre))throughout the palatal mesenchyme leads to cleft palate in mice, associated with aberrant cell proliferation and cell death. Osteogenic patterning of the hard palate in Rosa Msx1^(Wnt1-Cre)mice is severely impaired, as revealed by a marked reduction in palatine bone formation and decreased expression of the osteogenic regulator Sp7. Overexpression and knockout of Msx1 in mice show that the transcription repressor promotes the expression of the anterior palate-specific Alx1 but represses the expression of the medialposterior palate genes Barx1, Meox2, and Tbx22. Furthermore, Tbx22 constitutes a direct Msx1 target gene in the secondary palate, suggesting that Msx1 can directly repress the expression of medial-posterior specific genes. Finally, we determine that Sp7 is downstream of Tbx22 in palatal mesenchymal cells,suggesting that a Msx1/Tbx22/Sp7 axis participates in the regulation of palate development. Our findings unveil a novel role for Msx1 in regulating the anterior-posterior growth and patterning of the secondary palate. | Shicheng Zhu Hanjing Song Liangjun Zhong Suman Huo Yukun Fang Wanxin Zhao Xueqin Yang Zhong-Min Dai Rui He Mengsheng Qiu Zunyi Zhang Xiao-Jing Zhu | 2022 | Journal of Genetics and Genomics2022，49，1： | 2 |
| 10 | Power flow transmission of an asymmetrical flexible system excited by an off-centre force显示文摘 | Song Kongjie Lin Li Huo Rui Zhu Chuanmin | 1999 | Mechanical engineering(English edition)1999，12，3： | 1 |
| 11 | 显示文摘 | Rui Huo Jing-Yu Yang You-Qin Liu | 2016 | Materials Research Bulletin2016，76，： | 1 |
| 12 | Model- ing sediment transport in river networks显示文摘 | WANG Xuming HAO Rui HUO Jie | 2008 | Physica A2008，387，： | 1 |
| 13 | Power flow transmission of an asymmetrical flexible system excited by an off-centre force显示文摘 | Song Kongjie Ji lin Huo Rui | | 0，，03： | 1 |
| 14 | Power flow transmission of anasymmetricat flexible system excited by an off center force 显示文摘 | Song Kongjie Huo Rui etal | 1999 | Chinese Journal of Mechanical Engineering1999，12，3： | 1 |
| 15 | Evaluation on Salt Tolerance of 25 Species of Poplar Cuttings in Lab显示文摘The growth and morphological characteristics of 25 species of poplar were investigated. The cuttings were cultivated in Hoagland Nutrient Solution, which was made with sodium chloride (NaCl) solutions of concentration of 1.00, 3.00, 4.00, 5.00, 6.00, and 8.00 g/L, respectively. Under such salt stress, the new branch length and biomass accumulation of cuttings decreased as the salt concentration increased. The root/shoot ratio of most of species showed an escalation and then reduction tendency. Under low concentration of salt (NaCl ≤4.00 g/L), the root/shoot ratio of 11 species increased, compared to NaCl =1.00 g/L. After salt treatments, with the increase of salinity concentration, the content of chlorophyll of 8 species decreased. Based on the analysis of growth and morphological appearance, it turned out that 6 species had high salt-tolerant, 7 species were moderate salt-tolerant, 7 species were low salt-tolerant and 5 species failed to resist salt stress. | JI Meifeng YIN Jiandao LIU Zhenying HUO Jia’nan GUO Rui | 2011 | Chinese Forestry Science and Technology2011，10，3： | 1 |
| 16 | EDOA: an efficient delay optimization approach for mixed-polarity Reed-Muller logic circuits under the unit delay model显示文摘Delay optimization has recently attracted signif-icant attention. However, few studies have focused on the delay optimization of mixed-polarity Reed-Muller (MPRM) logic circuits. In this paper, we propose an efficient delay op-timization approach (EDOA) for MPRM logic circuits under the unit delay model, which can derive an optimal MPRM logic circuit with minimum delay. First, the simplest MPRM expression with the fewest number of product terms is ob-tained using a novel Reed-Muller expression simplification approach (RMESA) considering don't-care terms. Second, a minimum delay decomposition approach based on a Huffman tree construction algorithm is utilized on the simplest MPRM expression. Experimental results on MCNC benchmark cir-cuits demonstrate that compared to the Berkeley SIS 1.2 and ABC, the EDOA can significantly reduce delay for most cir-cuits. Furthermore, for a few circuits, while reducing delay, the EDOA incurs an area penalty. | Zhenxue HE Limin XIAO Fei GU Li RUAN Zhisheng HUO Mingzhe LI Mingfa ZHU Longbing ZHANG Rui LIU Xiang WANG | 2019 | Frontiers of Computer Science2019，13，5： | 1 |
| 17 | Preparation and Characteristic Identification of Monoclonal Antibody Against Sulfamethazine显示文摘Two artificial antigens were synthesized successfully by diazotizing method, sulfamethazine(SM2)-human serum albumin (HSA) was used for the immunogen, and SM2-ovalbumin(OVA) was used for the coating antigen. The coupled reaction was successful by confirmation of the ultraviolet scanning spectrometer, and the conjugation ratio of SM2 with HSA and OVA was 9:1 and 15:1, respectively. Using cell-fusion and limiting dilution method to reclone 5 times to get 3 hybridoma strains, which could stably secret monoclonal antibody (Mab), named CB7, BC4 and BB12. The subtype of BC4 Mab was IgG1 and chain, the molecular weight was 162 ku, the numbers of chromosomal were about 90, the affinity constant was 6.1×1012 M-1. No cross reactivity was seen between the Mab and the other 4 sulfonamides, as well as the 2 carries proteins. The Mab antibody had excellent stability. | DING Liangjun LI Jichang FU Rui ZHOU Yanjun HUO Guicheng | 2006 | Journal of Northeast Agricultural University(English Edition)2006，13，2： | 1 |
| 18 | Chromaticity of paths显示文摘 | ZHAO HAIXING HUO BOFENG LIU RUYING | 2000 | Math Study2000，，33： | 1 |
| 19 | Power Flow Transmission of an Asymmetrical Flexible System Excited by an Off-centre Force显示文摘 | Song Kongiie Lin Li Huo Rui etc | 1999 | Mechanical Engineering (English Edition)1999，12，3： | 1 |
| 20 | Modeling sediment transport in fiver networks显示文摘 | WANG Xuming HAO Rui HUO Jie | 2008 | Physica A:Statistical Mechanics and its Applications2008，387，25： | 1 |
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