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| 1 | Cerebral ischemia and neuroregeneration显示文摘Cerebral ischemia is one of the leading causes of morbidity and mortality worldwide. Although stroke(a form of cerebral ischemia)-related costs are expected to reach 240.67 billion dollars by 2030, options for treatment against cerebral ischemia/stroke are limited. All therapies except anti-thrombolytics(i.e., tissue plasminogen activator) and hypothermia have failed to reduce neuronal injury, neurological deficits, and mortality rates following cerebral ischemia, which suggests that development of novel therapies again st stroke/cerebral ischemia are urgently needed. Here, we discuss the possible mechanism(s) underlying cerebral ischemia-induced brain injury, as well as current and future novel therapies(i.e., growth factors, nicotinamide adenine dinucleotide, melatonin, resveratrol, protein kinase C isozymes, pifithrin, hypothermia, fatty acids, sympathoplegic drugs, and stem cells) as it relates to cerebral ischemia. | Reggie H.C.Lee Michelle H.H.Lee Celeste Y.C.Wu Alexandre Couto e Silva Harlee E.Possoit Tsung-Han Hsieh Alireza Minagar Hung Wen Lin | 2018 | Neural Regeneration Research2018，13，3： | 30 |
| 2 | LncRNAs-directed PTEN enzymatic switch governs epithelial–mesenchymal transition显示文摘Despite the structural conservation of PTEN with dual-specificity phosphatases,there have been no reports regarding the regulatory mechanisms that underlie this potential dual-phosphatase activity.Here,we report that K27-linked polyubiquitination of PTEN at lysines 66 and 80 switches its phosphoinositide/protein tyrosine phosphatase activity to protein serine/threonine phosphatase activity.Mechanistically,high glucose,TGF-β,CTGF,SHH,and IL-6 induce the expression of a long non-coding RNA,GAEA(Glucose Aroused for EMT Activation),which associates with an RNA-binding E3 ligase,MEX3C,and enhances its enzymatic activity,leading to the K27-linked polyubiquitination of PTEN.The MEX3C-catalyzed PTEN^K27-polyUb activates its protein serine/threonine phosphatase activity and inhibits its phosphatidylinositol/protein tyrosine phosphatase activity.With this altered enzymatic activity,PTEN^K27-polyUb dephosphorylates the phosphoserine/threonine residues of TWIST1,SNAI1,and YAP1,leading to accumulation of these master regulators of EMT.Animals with genetic inhibition of PTEN^K27-polyUb,by a single nucleotide mutation generated using CRISPR/Cas9(Pten^K80R/K80R),exhibit inhibition of EMT markers during mammary gland morphogenesis in pregnancy/lactation and during cutaneous wound healing processes.Our findings illustrate an unexpected paradigm in which the lncRNA-dependent switch in PTEN protein serine/threonine phosphatase activity is important for physiological homeostasis and disease development. | Qingsong Hu Chunlai Li Shouyu Wang Yajuan Li Bo Wen Yanyan Zhang Ke Liang Jun Yao Youqiong Ye Heidi Hsiao Tina K.Nguyen Peter K.Park Sergey D.Egranov David H.Hawke Jeffrey R.Marks Leng Han Mien-Chie Hung Bing Zhang Chunru Lin Liuqing Yang | 2019 | Cell Research2019，29，4： | 8 |
| 3 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 3 |
| 4 | Antifungal and antiviral products of marine organisms显示文摘 | Randy Chi Fai Cheung Jack Ho Wong Wen Liang Pan Yau Sang Chan Cui Ming Yin Xiu Li Dan He Xiang Wang Evandro Fei Fang Sze Kwan Lam Patrick Hung Kui Ngai Li Xin Xia Fang Liu Xiu Yun Ye Guo Qing Zhang Qing Hong Liu Ou Sha Peng Lin Chan Ki Adnan A Bekhit Alaa | 2014 | Applied Microbiology and Biotechnology2014，，8： | 2 |
| 5 | Efficacy of transient elastography in screening for large esophageal varices in patients with suspicious or proven liver cirrhosis显示文摘 | Huay‐Min WANG Gin‐Ho LO Wen‐Chi CHEN Ping‐I HSU Hsien‐Chung YU Chiun‐Ku LIN Hoi‐Hung CHAN Wei‐Lun TSAI Feng‐Woei TSAY Tsan‐Ping LIU E‐Ming WANG Kwok‐Hung LAI | 2012 | Journal of Digestive Diseases2012，，8： | 2 |
| 6 | Determination of bioactive components in Chinese herbal formulae and pharmacokinetics of rhein in rats by UPLC-MS/MS显示文摘 | Hou Mei Ling Chang Li Wen Lin Chi Hung | 2014 | Molecules2014，4，19： | 1 |
| 7 | Changes in Serum Levels of HBV DNA and Alanine Aminotransferase Determine Risk for Hepatocellular Carcinoma显示文摘 | Chuen–Fei Chen Wen–Chung Lee Hwai–I. Yang Hung–Chuen Chang Chin–Lan Jen Uchenna H. Iloeje Jun Su Chuhsing K. Hsiao Li–Yu Wang San–Lin You Sheng–Nan Lu Chien–Jen Chen | 2011 | Gastroenterology2011，，4： | 1 |
| 8 | Suppression of bovine ephemeral fever virus by RNA interference显示文摘 | Sue T. Chuang Wen T. Ji Yu T. Chen Chi H. Lin Yao C. Hsieh Hung J. Liu | 2007 | Journal of Virological Methods2007，，1： | 1 |
| 9 | What Japanese semiconductor enterprises can learn from the asset - light business model for sustainable competitive advantage 显示文摘 | Hung - Ching Wen Jen - Hung Huang Yih - Lin Cheng | 2012 | Asian Business & Management2012，，5： | 1 |
| 10 | Cloning and gene expression analysis of sponge gourd ascorbate peroxidase gene and winter squash superoxide dismutase gene under respective flooding and chilling stresses显示文摘 | Chih Ming Chiang Wen Shuo Kuo Kuan Hung Lin | 2014 | Horticulture, Environment, and Biotechnology2014，，2： | 1 |
| 11 | Influence of TiO2 buffer layer and post-annealing on the quality of Ti- doped ZnO thin films 显示文摘 | Lin Y C Hsu C Y Hung S K Wen D C | 2013 | Ceramics International2013，39，5： | 1 |
| 12 | The structural and optoeleetronie properties of Ti-doped ZnO thin films prepared by introducing a Cr buffer layer and post-annealing 显示文摘 | Lin Y C Hsu C Y Hung S K Chang C H Wen D C | 2012 | Applied Surface Science2012，258，24： | 1 |
| 13 | The impact of 5,10-methenyhe- trahydrofolate synthetase polymorphism on diabetic nephropathy in the Taiwanese population显示文摘 | Lin CJ Wen MJ Hung YJ | 2012 | Genet Test Mol Biomarkers2012，16，2： | 1 |
| 14 | Intentional cryopreservation of epididymal spermatozoa from percutaneous aspiration for dissociated intracytoplasmic sperm injection cycles 显示文摘 | Yu Hung Lin Liee Wen Huang Kok Min Seow | 2004 | Acta Obstet Gynecol Scand2004，83，： | 1 |
| 15 | Differential CD133 expression distinguishes malignant from be- nign papillary lesions of the breast显示文摘 | CHIH - HUNG LIN CHIA - HSING LIU CHIEN - HUI WEN | 2015 | Virchows Arch2015，466，2： | 1 |
| 16 | The Emerging Role of SOX2 in Cell Proliferation and Survival and Its Crosstalk with Oncogenic Signaling in Lung Cancer显示文摘 | Yu‐Ting Chou Chih‐Chan Lee Shih‐Hsin Hsiao Sey‐En Lin Sheng‐Chieh Lin Chih‐Hung Chung Chi‐Hsiu Chung Yu‐Rong Kao Yuan‐Hung Wang Chien‐Tsun Chen Yau‐Huei Wei Cheng‐Wen Wu | 2013 | Stem Cells2013，，12： | 1 |
| 17 | In vitro suppression of oral squamous cell carcinoma growth by ultrasound - me- diated delivery of eureumin microemulsions显示文摘 | Hung - Yin Lin James L Thomas Huan - Wen Chen | 2012 | International Journal of Nanomedicine2012，7，： | 1 |
| 18 | Remote- controllable power outlet system for home power manage- ment 显示文摘 | Chia Hung Lien Ying Wen Bai Ming Bo Lin | 2007 | IEEE Transactions on Consumer Electronics2007，53，4： | 1 |
| 19 | Risk of oral antifungal agent‐induced liver injury in T aiwanese显示文摘 | Wei‐Yu Kao Chien‐Wei Su Yi‐Shin Huang Yueh‐Ching Chou Yi‐Chih Chen Wen‐Hung Chung Ming‐Chih Hou Han‐Chieh Lin Fa‐Yauh Lee Jaw‐Ching Wu | 2014 | Br J Clin Pharmacol2014，，1： | 1 |
| 20 | Predictive value of ERCC1, ERCC2, and XRCC1 overexpression for stage III colorectal cancer patients receiving FOLFOX‐4 adjuvant chemotherapy显示文摘 | Ming‐Yii Huang Hsiang‐Lin Tsai Chih‐Hung Lin Ching‐Wen Huang Cheng‐Jen Ma Chun‐Ming Huang Chee‐Yin Chai Jaw‐Yuan Wang | 2013 | J Surg Oncol2013，，7： | 1 |
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