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| 1 | LncRNA Dum interacts with Dnmts to regulate Dppa2 expression during myogenic differentiation and muscle regeneration显示文摘新兴的研究在少些在染色质水平,但是相对调整基因表示记录长非编码的 RNA (LncRNAs ) 的角色被知道他们怎么调整 DNA methylation。这里,我们识别 lncRNA, Dum (发展联系 pluripotency 2 (Dppa2 ) 在上游的有约束力的肌肉 lncRNA ) 在骨胳的 myoblast 房间。Dum 的表示动态地在 vitro 并且在 vivo 在 myogenesis 期间被调整。它被在 myoblast 区别之上有约束力的 MyoD transcriptionally 也导致。功能的分析证明它支持 myoblast 区别和导致损坏的肌肉新生。机械学地, Dum 被发现它的附近的基因到沉默, Dppa2,在通过招募的 cis Dnmt1, Dnmt3a 和 Dnmt3b。而且, intrachromosomal 在 Dum 地点和 Dppa2 倡导者之间循环为 Dum/Dppa2 相互作用是必要的。一起,我们识别了与 Dnmts 交往调整 myogenesis 的新奇 lncRNA。 | Lijun Wang Yu Zhao Xichen Bao Xihua Zhu Yvonne Ka-yin Kwok Kun Sun Xiaona Chen Yongheng Huang Ralf Jauch Miguel A Esteban Hao Sun Huating Wang | 2015 | Cell Research2015，25，3： | 34 |
| 2 | The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters显示文摘最近的研究在众多的生物过程增加了我们长 noncoding RNA (lncRNAs ) 的理解,但是很少在体的房间 reprogramming 检验了他们的角色。通过表示介绍并且功能的屏蔽,我们鉴别了大 intergenic noncoding RNA p21 (lincRNA-p21 ) 损害 reprogramming。尤其是, lincRNA-p21 被 p53 导致,但是不在 reprogramming 支持 apoptosis 或房间老朽。相反, lincRNA-p21 与 H3K9 methyltransferase SETDB1 和维护 DNA methyltransferase DNMT1 联系,它被 RNA 有约束力的蛋白质 HNRNPK 便于。因而, lincRNA-p21 由在 pluripotency 基因倡导者支撑 H3K9me3 或 CpG methylation 阻止 reprogramming。我们的结果在 reprogramming 提供卓见进 lncRNAs 的角色并且建立在 p53 和 heterochromatin 规定之间的一个新奇连接。 | Xichen Bao Haitao Wu Xihua Zhu Xiangpeng Guo Andrew P Hutchins Zhiwei Luo Hong Song Yongqiang Chen Keyu Lai Menghui Yin Lingxiao Xu Liang Zhou Jiekai Chen Dongye Wang Baoming Qin Jon Frampton Hung-Fat Tse Duanqing Pei Huating Wang Biliang Zhang Miguel A Esteban | 2015 | Cell Research2015，25，1： | 21 |
| 3 | Effects of Short-Term Forest Bathing on Human Health in a Broad-Leaved Evergreen Forest in Zhejiang Province,China显示文摘Objective To investigate the effects of short-term forest bathing on human health.Methods Twenty healthy male university students participated as subjects and were randomly divided into two groups of 10.One group was sent on a two-night trip to a broad-leaved evergreen forest,and the other was sent to a city area.Serum cytokine levels reflecting inflammatory and stress response,indicators reflecting oxidative stress,the distribution of leukocyte subsets,and plasma endothelin-1 (ET-1) concentrations were measured before and after the experiment to evaluate the positive health effects of forest environments.A profile of mood states (POMS) evaluation was used to assess changes in mood states.Results No significant differences in the baseline values of the indicators were observed between the two groups before the experiment.Subjects exposed to the forest environment showed reduced oxidative stress and pro-inflammatory level,as evidenced by decreased malondialdehyde,interleukin-6,and tumor necrosis factor α levels compared with the urban group.Serum cortisol levels were also lower than in the urban group.Notably,the concentration of plasma ET-1 was much lower in subjects exposed to the forest environment.The POMS evaluation showed that after exposure to the forest environment,subjects had lower scores in the negative subscales,and the score for vigor was increased.Conclusion Forest bathing is beneficial to human health,perhaps through preventive effects related to several pathological factors. | MAO Gen Xiang LAN Xiao Guang CAO Yong Bao CHEN Zhuo Mei HE Zhi Huat LV Yuan Dong WANG Ya Zhen HU Xi Lian WANG Guo Fu YAN Jing | 2012 | Biomedical and Environmental Sciences2012，25，3： | 20 |
| 4 | Kinetics of the accumulation of group 2 innate lymphoid cells in IL-33-induced and IL-25-induced murine models of asthma:a potential role for the chemokine CXCL16显示文摘ILC2s are implicated in asthma pathogenesis, but little is known about the mechanisms underlying their accumulation in airways.We investigated the time course of ILC2 accumulation in different tissues in murine models of asthma induced by a serial per-nasalchallenge with ovalbumin (OVA), house dust mice (HDM), IL-25 and IL-33 and explored the potential roles of ILC2-attractingchemokines in this phenomenon. Flow cytometry was used to enumerate ILC2s at various time points. The effects of cytokines andchemokines on ILC2 migration were measured in vitro using a chemotaxis assay and in vivo using small animal imaging. Comparedwith saline and OVA challenge, both IL-25 and IL-33 challenge alone induced significant accumulation of ILC2s in the mediastinallymph nodes, lung tissue and bronchoalveolar lavage fluid of challenged animals, but with a distinct potency and kinetics. In vitro,IL-33 and CXCL16, but not IL-25 or CCL25, directly induced ILC2 migration. Small animal in vivo imaging further confirmed that asingle intranasal provocation with IL-33 or CXCL16 was sufficient to induce the accumulation of ILC2s in the lungs followinginjection via the tail vein. Moreover, IL-33-induced ILC2 migration involved the activation of ERK1/2, p38, Akt, JNK and NF-κB, whileCXCL16-induced ILC2 migration involved the activation of ERK1/2, p38 and Akt. These data support the hypothesis that epitheliumderived IL-25 and IL-33 induce lung accumulation of ILC2s, while IL-33 exerts a direct chemotactic effect in this process. AlthoughILC2s express the chemokine receptors CXCR6 and CCR9, only CXCL16, the ligand of CXCR6, exhibits a direct chemoattractanteffect. | Yan Li Shihao Chen Yafei Chi Yiran Yang Xiwen Chen Huating Wang Zhe Lv Jingjing Wang Linjie Yuan Ping Huang Kewu Huang Chris JCorrigan Wei Wang Sun Ying | 2019 | Cellular & Molecular Immunology2019，16，1： | 13 |
| 5 | Myofiber necroptosis promotes muscle stem cell proliferation via releasing Tenascin-C during regeneration显示文摘Necroptosis,a form of programmed cell death,is characterized by the loss of membrane integrity and release of intracellular contents,the execution of which depends on the membrane-disrupting activity of the Mixed Lineage Kinase Domain-Like protein(MLKL)upon its phosphorylation.Here we found myofibers committed MLKL-dependent necroptosis after muscle injury.Either pharmacological inhibition of the necroptosis upstream kinase Receptor Interacting Protein Kinases 1(RIPK1)or genetic ablation of MLKL expression in myofibers led to significant muscle regeneration defects.By releasing factors into the muscle stem cell(MuSC)microenvironment,necroptotic myofibers facilitated muscle regeneration.Tenascin-C(TNC),released by necroptotic myofibers,was found to be critical for MuSC proliferation.The temporary expression of TNC in myofibers is tightly controlled by necroptosis;the extracellular release of TNC depends on necroptotic membrane rupture.TNC directly activated EGF receptor(EGFR)signaling pathway in MuSCs through its N-terminus assembly domain together with the EGF-like domain.These findings indicate that necroptosis plays a key role in promoting MuSC proliferation to facilitate muscle regeneration. | Shen'ao Zhou Wei Zhang Gaihong Cai Yingzhe Ding Caixia Wei Sheng Li Yu Yang Jie Qin Dan Liu Hao Zhang Xiexiang Shao Jianhua Wang Hongye Wang Wenjun Yang Huating Wang She Chen Ping Hu Liming Sun | 2020 | Cell Research2020，30，12： | 4 |
| 6 | Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L显示文摘 | Zhisong Chen Benny Kwong Huat Tan Soh Ha Chan | 2008 | International Immunopharmacology2008，，8： | 1 |
| 7 | Activation of Tlymphocytes by polysaccharide-protein complex from Ly-cium barbarum L显示文摘 | Chen Z Kwong Huat Tan B Chan SH | 2008 | Int Immunopharmacol2008，8，12： | 1 |
| 8 | Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L显示文摘 | Chen Z Kwong Huat Tan B Chan SH | 2008 | Int Immunopharmacol2008，8，12： | 1 |
| 9 | Activation of T lymphocytes by polysaccharide-protein complex from Lycium barbarum L显示文摘 | Chen Z Kwong Huat Tan B Chan SH | 2008 | Int Immunopharmacol2008，8，12： | 1 |
| 10 | Biological indicators of sub-optimal health status显示文摘OBJECTIVE:To investigate biological indicators of sub-optimal health status and provide means of objective assessment of sub-optimal health status.METHODS:We set the unified standards for diagnosing a SHS.We tested various laboratory indicators in 407 cases that we selected randomly from2807 subjects and collected 15 mL of fasting venous blood from each case.We measured serum immunoglobulin A(IgA)and immunoglobulin G(IgG)concentrations,serum beta endorphins(β-EP),cortisol(C),testosterone(T),plasma adrenocorticotropic hormone(ACTH)and serum T lymphocyte subsets CD3+and CD4+.RESULTS:Mean serum testosterone concentrations and their ratio to cortisol(C)concentrations weresignificantly higher in the healthy group than in those with sub-optimal health status(P<0.01).Mean serum CD3+concentrations were significantly higher in those with sub-optimal health status than in the healthy group(P<0.05).CONCLUSION:Decreased serum testosterone/cortisol ratio may be an objective indication of sub-optimal health status.Changes in neuroendocrine and immunological indicators may explain some of the symptoms,including malaise and poor work performance,attributable to persistent or relapsing fatigue in subjects with sub-optimal health status. | Limin Wang Xin Zhao Jiaxu Chen Xiaoling Guo Xin Liang Danhui Yi Huating Cui Yueyun Liu | 2013 | Journal of Traditional Chinese Medicine2013，33，5： | 1 |
| 11 | Simu- lataneous Base and Tool Calibration for Self-calibration Modular Parallel Robot 显示文摘 | YANG guilin CHEN I-Ming YEO Song Huat | 2002 | Robotica2002，20，4： | 1 |
| 12 | Expression of IGFBP2 in gastric c~vfnoma and relationship with clinicopathologic parameters and cell proliferation显示文摘 | Zh~g L Huat~g W Chen J | 2007 | Dig Dis Sci2007，52，1： | 1 |
| 13 | Activation of T lymphocytes by polysaccharide–protein complex from Lycium barbarum L.显示文摘 | Zhisong Chen Benny Kwong Huat Tan Soh Ha Chan | 2008 | International Immunopharmacology2008，，12： | 1 |
| 14 | Workspace generation and planning singularity-free path for parallel manipulators 显示文摘 | Anjan Kumar Dash I-Ming Chen Song Huat Yeo | 2005 | Mechanism and Machine Theory2005，40，2005： | 1 |
| 15 | Activation of T Lymphocytes by polysaccharide - protein complex from Lycium barbarum L显示文摘 | Chen Z Kwong Huat Tan B Chan SH | 2008 | lnt hn- munopharmacol2008，8，12： | 1 |
| 16 | Preparation and properties of graphene nanosheets–polystyrene nanocomposites via in situ emulsion polymerization显示文摘 | Huating Hu Xianbao Wang Jingchao Wang Li Wan Fangming Liu Han Zheng Rong Chen Chunhui Xu | 2009 | Chemical Physics Letters2009，，4： | 1 |
| 17 | Yangtze River of China: historical analysis of discharge variability and sediment flux 显示文摘 | CHEN Zhongyuan L! Jiufa SHEN Huating | 2001 | Geomorphology2001，41，： | 1 |
| 18 | Preparation and properties of graphene nanosheets–polystyrene nanocomposites via in situ emulsion polymerization显示文摘 | Huating Hu Xianbao Wang Jingchao Wang Li Wan Fangming Liu Han Zheng Rong Chen Chunhui Xu | 2009 | Chemical Physics Letters2009，，4： | 1 |
| 19 | Newsmap: A Knowledge map for online news 显示文摘 | Ong Thian - huat Chen Hsinchun Sunmg waiki | 2005 | Decision Support system2005，39，4： | 1 |
| 20 | Newsmap: A knowledge map for online news 显示文摘 | THIAN - HUAT ONG HSINCHUN CHEN WAI - KI SUNG | 2005 | Decision Sup- port System2005，39，4： | 1 |
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