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| 1 | Mesenchymal stem cell treatment improves outcome of COVID-19 patients via multiple immunomodulatory mechanisms显示文摘The infusion of coronavirus disease 2019(COVID-19)patients with mesenchymal stem cells(MSCs)potentially improves clinical symptoms,but the underlying mechanism remains unclear.We conducted a randomized,single-blind,placebo-controlled(29 patients/group)phase II clinical trial to validate previous findings and explore the potential mechanisms.Patients treated with umbilical cord-derived MSCs exhibited a shorter hospital stay(P=0.0198)and less time required for symptoms remission(P=0.0194)than those who received placebo.Based on chest images,both severe and critical patients treated with MSCs showed improvement by day 7(P=0.0099)and day 21(P=0.0084).MSC-treated patients had fewer adverse events.MSC infusion reduced the levels of C-reactive protein,proinflammatory cytokines,and neutrophil extracellular traps(NETs)and promoted the maintenance of SARS-CoV-2-specific antibodies.To explore how MSCs modulate the immune system,we employed single-cell RNA sequencing analysis on peripheral blood.Our analysis identified a novel subpopulation of VNN2+hematopoietic stem/progenitorlike(HSPC-like)cells expressing CSF3R and PTPRE that were mobilized following MSC infusion.Genes encoding chemotaxis factors—CX3CR1 and L-selectin—were upregulated in various immune cells.MSC treatment also regulated B cell subsets and increased the expression of costimulatory CD28 in T cells in vivo and in vitro.In addition,an in vivo mouse study confirmed that MSCs suppressed NET release and reduced venous thrombosis by upregulating kindlin-3 signaling.Together,our results underscore the role of MSCs in improving COVID-19 patient outcomes via maintenance of immune homeostasis. | Rongjia Zhu Tingdong Yan Yingmei Feng Yan Liu Hongcui Cao Gongxin Peng Yanlei Yang Zhen Xu Jingqi Liu Wei Hou Xiaoyue Wang Zhe Li Luchan Deng Shihua Wang Jing Li Qin Han Hongling Li Guangliang Shan Yinghao Cao Xingyan An Jianshe Yan Zhonghui Zhang Huafei Li Xuebin Qu Jiaqi Zhu Shumin Zhou Jiao Wang Fengchun Zhang Jinming Gao Ronghua Jin Dayong Xu Yan-Qing Ma Tao Huang Shuang Peng Zhi Zheng Ilia Stambler Eric Gilson Lee Wei Lim Alexey Moskalev Antonio Cano Sasanka Chakrabarti Brun Ulfhake Huanxing Su Haoying Xu Sihuan Xu Feng Wei Holly MBrown-Borg Kyung-Jin Min Georgina Ellison-Hughes Calogero Caruso Kunlin Jin Robert Chunhua Zhao | 2021 | Cell Research2021，31，12： | 5 |
| 2 | Fatigue Topology Optimization Design Based on Distortion Energy Theory and Independent Continuous Mapping Method显示文摘Fatigue failure is a common failure mode under the action of cyclic loads in engineering applications,which often occurs with no obvious signal.The maximum structural stress is far below the allowable stress when the structures are damaged.Aiming at the lightweight structure,fatigue topology optimization design is investigated to avoid the occurrence of fatigue failure in the structural conceptual design beforehand.Firstly,the fatigue life is expressed by topology variables and the fatigue life filter function.The continuum fatigue optimization model is established with the independent continuous mapping(ICM)method.Secondly,fatigue life constraints are transformed to distortion energy constraints explicitly by taking advantage of the distortion energy theory.Thirdly,the optimization formulation is solved by the dual sequence quadratic programming(DSQP).And the design scheme of lightweight structure considering the fatigue characteristics is obtained.Finally,numerical examples illustrate the practicality and effectiveness of the fatigue optimization method.This method further expands the theoretical application of the ICM method and provides a novel approach for the fatigue optimization problem. | Hongling Ye Zonghan Li Nan Wei Pengfei Su Yunkang Sui | 2021 | Computer Modeling in Engineering & Sciences2021，，7： | 1 |
| 3 | Structure and second-order NLO property of the molecules bridged through n-vertex bis-substituted carborane (n=5, 6, 7)显示文摘Density functional theory (DFT) B3LYP at 6-31G* level is employed to optimize the structures of the molecules bridged through n-vertex bis-substituted carborane (n=5, 6, 7) and combined with finite field (FF) formalism to calculate the second-order NLO properties. The results indicate that the structures of n-vertex bis-substituted carborane (n=5, 6, 7) are changed due to bridged donor and acceptor moieties. The distances between two C atoms are becoming longer. And the stability and dipole moment are in- fluenced by changing substituted positions of C atoms. The isomers with the substituents connecting with C atoms of lower coordination number have better stability and larger values of polarizability. One-dimensional structure of the molecules bridged through n-vertex bis-substituted carborane (n=5, 6, 7) is in favor of intramolecular charge-transfer. Meanwhile, the isomer with a larger change of dipole moment has larger value of second-order NLO properties during the charge-transfer process. | QIU YongQingt CHEN Hui SUN ShiLing FAN HongLing SU ZhongMin | 2007 | Chinese Science Bulletin2007，52，17： | 0 |
| 4 | Pulmonary Vein Stenosis:A Review显示文摘Pulmonary vein stenosis(PVS)is an extremely rare and lethal disease caused by multiple etiologies.PVS has a bimodal distribution in the population,affecting children and adults.Congenital PVS is the usual PVS type in children,which sometimes develops after cardiothoracic surgery.Acquired PVS,in turn,is the most common PVS type in adults.A review of the relevant literature has shown that PVS after radiofrequency ablation of atrial fibrillation is the most common,as well as that caused by compression of proliferative fibrous tissues or tumor in the mediastinum(eg,PVS caused by fibrosing mediastinitis,lung tumors,metastases,etc).This article provides a comprehensive review of PVS in terms of embryology and anatomy,etiology and triggers,classification,clinical symptoms and signs,treatment,and prognosis,intending to promote the understanding and treatment of this disease. | Mengfei Jia Juan Wang Kaiyu Jiang Hongling Su Yu Li Zhaoxia Guo Hai Zhu Aqian Wang Xin Pan Yunshan Cao | 2023 | Cardiology Discovery2023，3，2： | 0 |
| 5 | Chronic Pulmonary Artery Stenosis:Time to Think as a Disease Entity显示文摘Chronic pulmonary artery stenosis(CPAS)is characterized by a reduction or complete obstruction of the cross-sectional area of the pulmonary artery owing to various causes.The condition exhibits similar pathophysiological progress,leading to pulmonary hypertension(PH),reduced physical endurance,right heart failure,and death.Although CPAS is often regarded as a subgroup of PH,it can manifest independently for an extended duration before the onset of PH and can significantly impact patient quality of life.It may therefore be more appropriate to consider PH as pathophysiological progression of CPAS,thereby recognizing CPAS as a distinct disease entity. | Wenjie Dong Jingwen Zhang Hongling Su Yunshan Cao | 2023 | Cardiology Discovery2023，3，4： | 0 |
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