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| 1 | Thermal and Magnetic Peculiarities of Metal-Containing Carbon Nano-Phase Formed in the Reaction of Fine-Dispersed Aluminium with Dichlorethane in Paraffin Medium显示文摘 | Hikmet C. Ibrahimov Joerg F. Friedrich Etibar H. Ismailov Eldar B. Zeynalov Aygun Z. Aliyeva Nadir M.I. Seidov Musa I. Rustamov | 2012 | 材料科学与工程(中英文A版)2012，2，2： | 3 |
| 2 | Ultrasound biomicroscopic evaluation of anterior segment cysts as a risk factor for ocular hypertension and closure angle glaucoma显示文摘AIM:To investigate the relationship between the ultrasound biomicroscopic(UBM) features of anterior-segment cysts(ASCs) and increased intraocular pressure(IOP) as a risk factor for closed-angle glaucoma(CAG).·METHODS:Totally 24 eyes with recently diagnosed ASCs were divided into two groups.First group with ASC and ocular normotension(n =13),second group with ASC and ocular hypertension(n =11).An ophthalmologic examination,including tonometry,slit-lamp biomicro-scopy(SLBM),gonioscopy,fundoscopy,pentacam,and UBM,was performed.The features of the ASCs were compared with the IOP.·RESULTS:ASCs were accurately diagnosed and delineated in 24 eyes using UBM.IOP was elevated in those ASCs with a secondary aetiology(P =0.027),iridociliary location(P =0.006),deformed shape(P =0.013),increased size(P =0.001) and elongated pupillary aperture(P =0.009).However,the count(P =0.343) of ASCs,anterior chamber depth(ACD;P =0.22) and axial lenght(AL;P =0.31) were not associated with ocular hypertension.Correlations were found between the IOP and ASC size(r =-0.712;P =0.003),anterior chamber angle(ACA;r =-0.985;P <0.001),angle opening area(AOA;r =0.885;P<0.001),angulation of iris(r =-0.776,P <0.001),and affected iris quadrant(r =-0.655,P =0.002).·CONCLUSION:Ocular hypertension in some eyes with ASC might be associated with various mechanisms,including secondary aetiology,iridociliary location,deformed shape,increased size and elongated pupill,which can be determined by UBM. | Abdurrahim Dusak Mehmet Baykara Guven Ozkaya Cuneyt Erdogan Hikmet Ozcetin Ercan Tuncel | 2013 | International Journal of Ophthalmology(English edition)2013，6，4： | 3 |
| 3 | CRISPR/Cas: a Nobel Prize award-winning precise genome editing technology for gene therapy and crop improvement显示文摘Since it was first recognized in bacteria and archaea as a mechanism for innate viral immunity in the early 2010 s,clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein(Cas)has rapidly been developed into a robust,multifunctional genome editing tool with many uses.Following the discovery of the initial CRISPR/Cas-based system,the technology has been advanced to facilitate a multitude of different functions.These include development as a base editor,prime editor,epigenetic editor,and CRISPR interference(CRISPRi)and CRISPR activator(CRISPRa)gene regulators.It can also be used for chromatin and RNA targeting and imaging.Its applications have proved revolutionary across numerous biological fields,especially in biomedical and agricultural improvement.As a diagnostic tool,CRISPR has been developed to aid the detection and screening of both human and plant diseases,and has even been applied during the current coronavirus disease 2019(COVID-19)pandemic.CRISPR/Cas is also being trialed as a new form of gene therapy for treating various human diseases,including cancers,and has aided drug development.In terms of agricultural breeding,precise targeting of biological pathways via CRISPR/Cas has been key to regulating molecular biosynthesis and allowing modification of proteins,starch,oil,and other functional components for crop improvement.Adding to this,CRISPR/Cas has been shown capable of significantly enhancing both plant tolerance to environmental stresses and overall crop yield via the targeting of various agronomically important gene regulators.Looking to the future,increasing the efficiency and precision of CRISPR/Cas delivery systems and limiting off-target activity are two major challenges for wider application of the technology.This review provides an in-depth overview of current CRISPR development,including the advantages and disadvantages of the technology,recent applications,and future considerations. | Chao LI Eleanor BRANT Hikmet BUDAK Baohong ZHANG | 2021 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2021，22，4： | 3 |
| 4 | Comparison of trifocal toric and bifocal toric intraocular lens implantation in patients with cataract and high corneal astigmatism显示文摘AIM:To investigate and compare the quality of life,satisfaction,contrast sensitivity,glare,depth perception,and intraocular lens(IOL)rotation in patients who underwent trifocal toric and bifocal toric IOLs.METHODS:A total of 80 eyes of 40 patients were included in this prospective study.Twenty patients in each group were implanted with trifocal toric and bifocal toric IOL,respectively.Preoperative and postoperative 6-month measurements were recorded for both patient groups.Comprehensive anterior and posterior segment examinations,distance-intermediate-near visual acuity values and the visual function scale questionnaire results were evaluated at these examinations.Patient satisfaction,contrast sensitivity,glare,intermediate-near and distance stereopsis and IOL rotation were also evaluated.RESULTS:No significant difference was found between the groups in terms of distance and near visual acuities(P=0.269,P=0.451).Intermediate visual acuity was significantly increased in the trifocal toric group(P<0.001).The visual function scale results were increased after surgery in both groups(P=0.001 and P<0.001),with no difference determined between them(P=0.158 and P=0.691).The number of patients wearing glasses was low in both groups and there was no significant difference between the groups(P>0.05).The overall satisfaction in the trifocal toric group was significantly higher than in the bifocal toric group(P=0.03).The highest sensitivity was observed at 6 cpd spatial frequency in all patients under photopic conditions(1.80±0.24 logU,1.74±0.20 logU).Distance-intermediate-near binocular depth perception results in both groups were higher in the trifocal toric group(P=0.02,0.048,0.003,respectively).Although there was no significant difference for 3 meters stereopsis,the trifocal toric group had higher depth perception(P=0.577).Mean rotation was 5.76°±3.93°in the trifocal toric group and 12°±7.1°in the bifocal toric group.CONCLUSION:Better results in the middle distance are obtained in the trifocal toric group and less IOL rotation due to digital system-coordinated surgery.Moreover,the overall satisfaction in the trifocal toric group is significantly higher than in the bifocal toric group. | Merve Bozkurt Gencer Hikmet Basmak Erdogan Yasar Ozkan Onal | 2021 | International Journal of Ophthalmology(English edition)2021，14，12： | 2 |
| 5 | Molecular Characterization of a Full Genome Turkish Hepatitis C Virus 1b Isolate (HCV-TR1): A Predominant Viral Form in Turkey显示文摘 | Esra Yildiz Asli Oztan Funda Sar Ergun Pinarbasi Rengul Cetin-Atalay Hikmet Akkiz Mehmet Ozturk | 2002 | Virus Genes2002，，2： | 1 |
| 6 | Analysis of a mechanical vapor compression desalination system显示文摘 | Hikmet S Aybar | 2002 | Desalination2002，142，2： | 1 |
| 7 | Effect of Post-Oxidizing on Tribological and Corrosion Behaviour of Plasma Nitrided AISI 5140 Steel显示文摘 | Akgun Alsaran Hikmet Altun Mehmet Karakan | 2004 | Surface and Coatings Technology2004，176，： | 1 |
| 8 | Evaluation of the relationship between heart type fatty acid binding protein levels and the risk of cardiac damage in patients with obstructive sleep apnea syndrome显示文摘 | Burcu O Erdem A Hikmet F | 2008 | Sleep Breath2008，12，3： | 1 |
| 9 | Forecasting of a ground-coupled heat pump performance using neural networks with statistical data weighting pre-processing 显示文摘 | Hikmet Esen Mustafa Inalli Abdulkadir Sengur | 2008 | International Journal of Thermal Sciences2008，47，4： | 1 |
| 10 | Serum uric acid levels predict the severity and morphology of coronary atherosclerosis detect- ed by muhidetector computed tomography 显示文摘 | Ergtin Baris Kaya Hikmet Yorgun Ugur Canpolat | 2010 | Atheroselerosis2010，213，1： | 1 |
| 11 | Artificial neural networks and adaptive neuro-fuzzy assessments for groundcoupled heat pump system 显示文摘 | Hikmet Esen Mustafa Inalli Abdulkadir Sengur | 2008 | Energy and Buildings2008，40，6： | 1 |
| 12 | Analysis of a mechanical vapor compression desalination system显示文摘 | Hikmet S Aybar | 2002 | Desalination2002，142，2： | 1 |
| 13 | Water quality and impacts of pollution sources for Eyrnir and Mogan Lakes (Turkey)显示文摘 | Gamze K Figen Unlu E Hikmet K | 2003 | Environment International2003，29，1： | 1 |
| 14 | The significance of E266K polymorphism in the NOD1 gene on Helicobacter Pylori infection: an effective force on pathogenesis?显示文摘 | Banu Kara Hikmet Akkiz Figen Doran Suleyman Bayram Eren Erken Yuksel Gumurdullu Macit Sandikci | 2010 | Clinical and Experimental Medicine2010，，2： | 1 |
| 15 | Circulating nitric oxide(NO), asymmetric dimethylarginine (ADMA),homocysteine, and oxidative status in obstructive sleep apnea-hypopnea syndrome(OSAHS) 显示文摘 | OZKAN Y HIKMET F | 2008 | Sleep Breath2008，12，： | 1 |
| 16 | Reproducibility and Tolerability of the ICare Rebound Tonometer in School Children显示文摘 | Afsun Sahin Hikmet Basmak Leyla Niyaz Nilgun Yildirim | 2007 | Journal of Glaucoma2007，，2： | 1 |
| 17 | Temperature distributions in boreholes of a vertical ground-coupled heat pump system 显示文摘 | Hikmet Esen Mustafa Inalli Yuksel Esen | 2009 | Renewable Energy2009，34，12： | 1 |
| 18 | Massive Lower Gastrointestinal Hemorrhage Secondary to Rectal Hemorrhoids in Elderly Patients Receiving Anticoagulant Therapy: Case Series显示文摘 | Burhan Ozdil Hikmet Akkiz Macit Sandikci Can Kece Arif Cosar | 2010 | Digestive Diseases and Sciences2010，，9： | 1 |
| 19 | Transmission techniques for digital terrestrial TV broadcasting 显示文摘 | Hikmet S Georges K and Jsabelle J | 1995 | IEEE Communications Magazine1995，33，2： | 1 |
| 20 | Studies on the influence of chloride ion concentration and pH on the corrosion and electrochemical behavior of AZ63 magnesium alloy 显示文摘 | HIKMET Altun SADRI Sen | 2004 | Materials and Design2004，25，： | 1 |
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