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| 1 | Interrogation of Streptomyces avermitilis for efficient production of avermectins显示文摘The 2015 Nobel Prize in Physiology or Medicine has been awarded to avermectins and artemisinin,respectively.Avermectins produced by Streptomyces avermitilis are excellent anthelmintic and potential antibiotic agents.Because wild-type strains only produce low levels of avermectins,much research effort has focused on improvements in avermectin production to meet the ever increasing demand for such compounds.This review describes the strategies that have been widely employed and the future prospects of synthetic biology applications in avermectin yield improvement.With the help of genome sequencing of S.avermitilis and an understanding of the avermectin biosynthetic/regulatory pathways,synthetic and systems biotechnology approaches have been applied for precision engineering.We focus on the design and synthesis of biological chassis,parts,devices,and modules from diverse microbes to reconstruct and optimize their dynamic processes,as well as predict favorable effective overproduction of avermectins by a 4Ms strategy(Mine,Model,Manipulation,and Measurement). | Jinsong Chen Mei Liu Xueting Liu Jin Miao Chengzhang Fu Heyong Gao Rolf Muller Qing Zhang Lixin Zhang | 2016 | Synthetic and Systems Biotechnology2016，1，1： | 10 |
| 2 | Enhanced carbon acquisition and use efficiency alleviate microbial carbon relative to nitrogen limitation under soil acidification显示文摘Background:Soil microbial communities cope with an imbalanced supply of resources by adjusting their element acquisition and utilization strategies.Although soil pH has long been considered an essential driver of microbial growth and community composition,little is known about how soil acidification affects microbial acquisition and utilization of carbon(C)and nitrogen(N).To close the knowledge gap,we simulated soil acidification and created a pH gradient by adding eight levels of elemental sulfur(S)to the soil in a meadow steppe.Results:We found that S-induced soil acidification strongly enhanced the ratio of fungi to bacteria(F:B)and microbial biomass C to N(MBC:MBN)and subsequently decreased the C:N imbalance between microbial biomass and their resources.The linear decrease in the C:N imbalance with decreasing soil pH implied a conversion from N limitation to C limitation.To cope with enhanced C versus N limitation,soil microbial communities regulated the relative production of enzymes by increasing the ratio ofβ-glucosidase(BG,C-acquiring enzyme)to leucine aminopeptidase(LAP,N-acquiring enzyme),even though both enzymatic activities decreased with S addition.Structural equation modeling(SEM)suggested that higher C limitation and C:N-acquiring enzyme stimulated microbial carbon-use efficiency(CUE),which counteracted the negative effect of metal stress(i.e.,aluminum and manganese)under soil acidification.Conclusions:Overall,these results highlight the importance of stoichiometric controls in microbial adaption to soil acidification,which may help predict soil microbial responses to future acid deposition. | Tianpeng Li Ruzhen Wang Jiangping Cai Yani Meng Zhirui Wang Xue Feng Heyong Liu Ronald F.Turco Yong Jiang | 2021 | Ecological Processes2021，10，1： | 2 |
| 3 | Nitrogen addition and mowing alter drought resistance and recovery of grassland communities显示文摘Nitrogen enrichment and land use are known to influence various ecosystems,but how these anthropogenic changes influence community and ecosystem responses to disturbance remains poorly understood.Here we investigated the effects of increased nitrogen input and mowing on the resistance and recovery of temperate semiarid grassland experiencing a three-year drought.Nitrogen addition increased grassland biomass recovery but decreased structural recovery after drought,whereas annual mowing increased grassland biomass recovery and structural recovery but reduced structural resistance to drought.The treatment effects on community biomass/structural resistance and recovery were largely modulated by the stability of the dominant species and asynchronous dynamics among species,and the community biomass resistance and recovery were also greatly driven by the stability of grasses.Community biomass resistance/recovery in response to drought was positively associated with its corresponding structural stability.Our study provides important experimental evidence that both nitrogen addition and mowing could substantially change grassland stability in both functional and structural aspects.Our findings emphasize the need to study changes across levels of ecological organization for a more complete understanding of ecosystem responses to disturbances under widespread environmental changes. | Zhuwen Xu Heyong Liu Yani Meng Jinfei Yin Haiyan Ren Mai-He Li Shan Yang Shiming Tang Yong Jiang Lin Jiang | 2023 | Science China(Life Sciences)2023，66，7： | 2 |
| 4 | Thrust Event of the Provenances Revealed by Zircon Fission Track Ages in Tangyuan Fault-Basin, NE China显示文摘 | Fang Shi Liu Zhaojun Wu Heyong | 2008 | Radiation Measurements2008，43，： | 1 |
| 5 | Graphite oxide as an efficient and durable metal-free catalyst for aerobic oxidative coupling of amines to imines 显示文摘 | Huang Hai Huang Jun Liu Yongmei He Heyong Cao Yong Fan Kangnian | 2012 | Green Chemistry2012，14，4： | 1 |
| 6 | Stabilityanalysis for neural networks with time-varyingintervaldelay 显示文摘 | HEYong LIU Guo-ping ReesD etal | 2007 | IEEE Transactionson NeuralNetworks2007，18，6： | 1 |
| 7 | A micro-fluidic sub-microliter sample introduction system for direct analysis of Chinese rice wine by inductively coupled plasma mass spectrometry using external aqueous calibration显示文摘 | Heyong Cheng Jinhua Liu Zigang Xu Xuefeng Yin | 2012 | Spectrochimica Acta Part B: Atomic Spectroscopy2012，，： | 1 |
| 8 | Photocatalytic degradation of Rhodamine B on TiO2 nanoparticles modified with porphyrin and iron-porphyrin显示文摘 | Heyong Huang Xiaotian Gu Jiahong Zhou Kang Ji Hailong Liu Yuying Feng | 2009 | Catalysis Communications2009，11，1： | 1 |
| 9 | The review and prospect of neutron radiography in China显示文摘Neutron radiography is one of radiography non-destructive testing.It is a valuable complementary of X and γ rays radiography.The present status and history of neutron radiography in China was described briefly,facilities of neutron radiography and their development were introduced in this paper. | Tang Bin Mo Dawei Huo Heyong Wu Yang Liu Bin Sun Yong | 2009 | Engineering Sciences2009，7，4： | 0 |
| 10 | The latest progress of thermal neutron tomography at SPRR-300 reactor显示文摘Thermal neutron radiography is a useful complementary tool of the other non-destructive testing methods for the hydrogenous materials and heavy metal subassembly.By the use of MC method program and the thermal neutron digital radiography facility at SPRR-300 reactor,the simulation and experimental study of the thermal neutron tomography has been developed.Its method and result has been introduced and analyzed. | Tang Bin Huo Heyong Liu Bin Sun Yong Wu Yang | 2009 | Engineering Sciences2009，7，4： | 0 |
| 11 | The pilot experimental study of 14 MeV fast neutron digital radiography显示文摘14 MeV Fast neutrons has good penetrability and the 14 MeV fast neutron radiography can meet the need of Non-Destructive Test of the structure and lacuna of heavy-massive sample, whose shell is made of heavy metal and in which there are some hydrogen materials, and the study of fast neutron digital radiography just begins in China. By the use of a D-T accelerator, a digital imaging system made up of a fast neutron scintillation screen made of ZnS(Ag) and polypropylene, lens and a scientific grade CCD, the experimental study of fast neutron radiography has been done between 4.3×1010-6.8×1010 n/s of neutron yield. Some 14 MeV fast neutron digital radiographs have been gotten. According to experimental radiographs and their data, the performance of the fast neutron scintillation screen and the basic characters of 14 MeV fast neutron radiography are analyzed, and it is helpful for the further research. | TANG Bin ZHOU ChangGen HUO HeYong WU Yang LIU Bin LOU BenChao SUN Yong | 2009 | Science China(Physics,Mechanics & Astronomy)2009，52，9： | 0 |
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