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| 1 | Reactive capillary hemangiomas: a novel dermatologic toxicity following anti-PD-1 treatment with SHR-1210显示文摘Objective: SHR-1210 is a new and promising anti-PD-1 agent for solid tumors. During the phase I study of SHR-1210, we encountered a novel but prevalent immune-related dermatologic toxicity: reactive capillary hemangiomas(RCHs). Thus we tried to summarize the features of RCHs and estimate their relationship with tumor response.Methods: This prospective observational study systematically enrolled 98 patients with advanced solid tumors from April 27th,2016 to June 8th, 2017 in the context of the phase I clinical study of SHR-1210. This report focused on the skin toxicities. Patients underwent entire skin inspection every two weeks while taking medication. The clinical course of RCHs was recorded and their association with tumor response was estimated. The data cut-off date was November 15th, 2017.Results: After a median follow-up of 242(range, 29–567) days, RCHs were observed in 85.7%(84/98) of patients on cutaneous/mucosal surfaces; 84.5%(71/84) of the RCHs were evaluated as grade 1 adverse events. No grade 3 or 4 RCHs were observed. The time of onset of RCHs was dose dependent and shortest in the 400 mg-dose cohort(P < 0.001). Spontaneous and complete regression of RCHs was observed both during and after treatment. The objective response rate of tumors for patients with RCHs was 28.9%(24/83). However, no responders were observed among the patients without RCHs.Conclusions: RCHs were prevalent but manageable during treatment with SHR-1210. It might add to the expanding literature regarding immune-related dermatologic adverse events. | Xuelian Chen Lanying Ma Xi Wang Hongnan Mo Dawei Wu Bo Lan Dong Qu Hongtu Zhang Jing Huang Binghe Xu | 2019 | Cancer Biology & Medicine2019，16，1： | 53 |
| 2 | Adsorption equilibrium for Z-ligustilide on C18-bonded silica from supercritical carbon dioxide显示文摘Adsorption equilibrium is of great importance for the preparative supercritical fluid chromatography(pre-SFC) in defining supercritical adsorption behavior and the industrial amplification.This paper presents adsorption isotherms of Z-ligustilide from supercritical carbon dioxide(SC-CO_2) on C18-bonded silica.Adsorption behavior was studied at 305.15 K,313.15 K and 323.15 K with SC-CO_2 density varying from 0.687 g·cm^(-3) to0.863 g·cm^(-3) with the elution by characteristic points(ECP) method.The adsorption amount of Z-ligustilide from SC-CO_2 on C18-bonded silica decreased with the increasing density of the mobile phase as well as the increasing temperature.Adsorption equilibrium data were fitted by Langmuir and Freundlich isotherm models,and the Langmuir isotherm model performed better for describing the whole adsorption process on the column.The monolayer saturation adsorption capacity of Z-ligustilide is in the range of 3.0 × 10^(-4) mg·cm^(-3) to5.5 × 10^(-4) mg·cm^(-3) with an average value of 4.0 × 10^(-4) mg·cm^(-3). | Huisheng Lü Shuangyan Liu Yonghui Li Fanmei Meng Dawei Yao Xufei Mo | 2016 | Chinese Journal of Chemical Engineering2016，24，12： | 1 |
| 3 | The review and prospect of neutron radiography in China显示文摘Neutron radiography is one of radiography non-destructive testing.It is a valuable complementary of X and γ rays radiography.The present status and history of neutron radiography in China was described briefly,facilities of neutron radiography and their development were introduced in this paper. | Tang Bin Mo Dawei Huo Heyong Wu Yang Liu Bin Sun Yong | 2009 | Engineering Sciences2009，7，4： | 0 |
| 4 | Neutron imaging at Peking University显示文摘Neutron imaging techniques were investigated at Peking University based on a 4.5 MV Van de Graaff accelerator.The thermal neutron radiography,fast neutron radiography and fast neutron resonance radiography were tested.The low neutron flux limits the image quality.A new radio frequency quadrupole (RFQ) accelerator based on neutron source with a yield of 1 012 n/s is being set up. | Zou Yubin Guo Zhiyu Tang Guoyou Mo Dawei | 2009 | Engineering Sciences2009，7，4： | 0 |
| 5 | Dimensionality-driven metal to Mott insulator transition in two-dimensional 1T-TaSe_(2)显示文摘Two-dimensional materials represent a major frontier for research into exotic many-body quantum phenomena.In the extreme two-dimensional limit,electron-electron interaction often dominates over other electronic energy scales,leading to strongly correlated effects such as quantum spin liquid and unconventional superconductivity.The dominance is conventionally attributed to the lack of electron screening in the third dimension.Here,we discover an intriguing metal to Mott insulator transition in 1T-TaSe_(2) that defies conventional wisdom.Specifically,we find that dimensionality crossover,instead of reduced screening,drives the transition in atomically thin 1T-TaSe_(2).A dispersive band crossing the Fermi level is found to be responsible for the bulk metallicity in the material.Reducing the dimensionality,however,effectively quenches the kinetic energy of these initially itinerant electrons,and drives the material into aMott insulating state.The dimensionality-driven metal to Mott insulator transition resolves the long-standing dichotomy between metallic bulk and insulating surface of 1T-TaSe_(2).Our work further reveals a new pathway for modulating two-dimensional materials that enables exploring strongly correlated systems across uncharted parameter space. | Ning Tian Zhe Huang Bo Gyu Jang Shuaifei Guo Ya-Jun Yan Jingjing Gao Yijun Yu Jinwoong Hwang Cenyao Tang Meixiao Wang Xuan Luo Yu Ping Sun Zhongkai Liu Dong-Lai Feng Xianhui Chen Sung-Kwan Mo Minjae Kim Young-Woo Son Dawei Shen Wei Ruan Yuanbo Zhang | 2024 | National Science Review2024，11，3： | 0 |
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